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Poisoning

Free Subscription Articles published in Toxicol Sci Retrieve available abstracts of 44 articles: HTML format

Single Articles

April 2026
1. ZENG XX, He WW, Liao W, Xiao X, et al
   Alleviating effects of fat mass and obesity-associated protein on fluoride-induced neurotoxicity in rat brain, primary neurons, and SH-SY5Y cells.
   Toxicol Sci. 2026;209:kfag031.
   PubMed     Abstract available
   
   
   
2. TANG X, Martins AC, Tukker AM, Kim H, et al
   Emergent latent neurotoxic effects of manganese following nominal chronic exposures in human stem cell and Caenorhabditis elegans models.
   Toxicol Sci. 2026;209:kfag040.
   PubMed     Abstract available
   
   
   March 2026
3. CHANG X, Allen DG, Kleinstreuer NC, Mumtaz MM, et al
   Application of in vitro to in vivo extrapolation (IVIVE) to inform chemical health guidance value derivation-sample case studies comparing neuro-, hepato-, and developmental toxicities.
   Toxicol Sci. 2026;209:kfag017.
   PubMed     Abstract available
   
   
   February 2026
4. KOWAL T, Wang S, Cheng M, Liu R, et al
   Computational integration of in vivo single cell and in vitro bulk transcriptomics across 236 human and mouse datasets differentiates physiological versus non-physiological hepatic cell lines for hepatotoxicity screening.
   Toxicol Sci. 2026;209:kfaf171.
   PubMed     Abstract available
   
   
   
5. HAMADA N, Ito Y, Niimi H, Atarashi M, et al
   Nrf2 contributes to the protective effect of iron overload on thioacetamide-induced chronic liver injury in rats.
   Toxicol Sci. 2026;209:kfaf165.
   PubMed     Abstract available
   
   
   
6. KREUTZ A, Chang X, Lawless M, Proenca S, et al
   Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation.
   Toxicol Sci. 2026;209:kfaf147.
   PubMed     Abstract available
   
   
   January 2026
7. LIU R, Liu H, Chen H, An K, et al
   N6-methyladenosine reader YTHDF3-mediated Lcn2 mRNA stability promotes the hepatotoxicity of crizotinib.
   Toxicol Sci. 2026;209:kfaf154.
   PubMed     Abstract available
   
   
   
8. JAIN S, Williams G, Mukherjee R, Orr A, et al
   Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice.
   Toxicol Sci. 2026;209:kfaf151.
   PubMed     Abstract available
   
   
   December 2025
9. UMBAUGH DS, Nguyen NT, Curry SC, Rule JA, et al
   The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure.
   Toxicol Sci. 2025;208:256-268.
   PubMed     Abstract available
   
   
   
10. LI T, Qu Y, Chen A, Thakkar S, et al
    Beyond QSARs: Quantitative Knowledge-Activity Relationships (QKARs) for enhanced drug toxicity prediction.
    Toxicol Sci. 2025;208:269-278.
    PubMed     Abstract available
    
    
    November 2025
11. CAPECE GE, Patel AK, Hu D, Roychowdhury T, et al
    Context-dependent contribution of peptidyl arginine deiminase 4 (PAD4) to neutrophil extracellular trap formation and liver injury in acute and chronic hepatotoxicant challenge.
    Toxicol Sci. 2025;208:136-154.
    PubMed     Abstract available
    
    
    
12. IRELAND D, Word LJ, Collins ES
    Statistical analysis of multi-endpoint phenotypic screening increases sensitivity of planarian neurotoxicity testing.
    Toxicol Sci. 2025;208:104-121.
    PubMed     Abstract available
    
    
    September 2025
13. REINA-GONZALEZ P, Ay M, Langley M, Plunk E, et al
    Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration.
    Toxicol Sci. 2025;207:20-28.
    PubMed     Abstract available
    
    
    June 2025
14. POOLE LG, Wei Z, Schulte A, Cline HM, et al
    Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury.
    Toxicol Sci. 2025;205:417-427.
    PubMed     Abstract available
    
    
    
15. LIU X, Wang K, Zhang X, Qi J, et al
    Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity.
    Toxicol Sci. 2025;205:297-309.
    PubMed     Abstract available
    
    
    
16. ALI NA, Kennon-McGill S, Parker LD, James LP, et al
    NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen.
    Toxicol Sci. 2025;205:274-278.
    PubMed     Abstract available
    
    
    
17. NEWELL AJ, Patisaul HB
    Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing.
    Toxicol Sci. 2025;205:245-273.
    PubMed     Abstract available
    
    
    May 2025
18. SANCHEZ-GUERRERO G, Umbaugh DS, Smith SH, Akakpo JY, et al
    Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity.
    Toxicol Sci. 2025;205:220-232.
    PubMed     Abstract available
    
    
    
19. BEAMISH CR, Becker J, Tam LM, Love T, et al
    Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a Drosophila model of congenital Minamata disease.
    Toxicol Sci. 2025;205:106-123.
    PubMed     Abstract available
    
    
    April 2025
20. BAJAJ P, Brennan RJ, Laurent S, Sauzeat S, et al
    Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant.
    Toxicol Sci. 2025;204:228-241.
    PubMed     Abstract available
    
    
    
21. PANNALA VR, Hari A, AbdulHameed MDM, Balik-Meisner MR, et al
    Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model.
    Toxicol Sci. 2025;204:154-168.
    PubMed     Abstract available
    
    
    
22. SHINOZAWA T, Miyamoto K, Baker KS, Faber SC, et al
    TAK-994 mechanistic investigation into drug-induced liver injury.
    Toxicol Sci. 2025;204:143-153.
    PubMed     Abstract available
    
    
    January 2025
23. LIVOTI LA, Sison-Young R, Reddyhoff D, Fisher CP, et al
    Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.
    Toxicol Sci. 2025;203:35-40.
    PubMed     Abstract available
    
    
    
24. HAMMOND S, Meng X, Barber J, Mosedale M, et al
    Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities.
    Toxicol Sci. 2025;203:11-27.
    PubMed     Abstract available
    
    
    
25. FAS L, Chen M, Tong W, Wenz F, et al
    Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs.
    Toxicol Sci. 2025;203:79-87.
    PubMed     Abstract available
    
    
    October 2024
26. KRAMER NE, Fillmore CE, Slane EG, Barnett LMA, et al
    Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice.
    Toxicol Sci. 2024;201:282-299.
    PubMed     Abstract available
    
    
    September 2024
27. ZHAO Y, Park JY, Yang D, Zhang M, et al
    A computational framework to in silico screen for drug-induced hepatocellular toxicity.
    Toxicol Sci. 2024;201:14-25.
    PubMed     Abstract available
    
    
    August 2024
28. CHO T, Hayes A, Henderson JT, Uetrecht J, et al
    The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapine.
    Toxicol Sci. 2024;200:382-393.
    PubMed     Abstract available
    
    
    
29. BURON N, Porceddu M, Loyant R, Martel C, et al
    Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals.
    Toxicol Sci. 2024;200:369-381.
    PubMed     Abstract available
    
    
    
30. MEZENCEV R, Feshuk M, Kolaczkowski L, Peterson GC, et al
    The association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures: an analysis of the data from Toxicity Reference Database (ToxRefDB).
    Toxicol Sci. 2024;200:404-413.
    PubMed     Abstract available
    
    
    June 2024
31. JEE A, Sernoskie SC, Uetrecht J
    The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury.
    Toxicol Sci. 2024;200:146-164.
    PubMed     Abstract available
    
    
    May 2024
32. SCULLION KM, MacIntyre IM, Sloan-Dennison S, Clark B, et al
    Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).
    Toxicol Sci. 2024;199:203-209.
    PubMed     Abstract available
    
    
    March 2024
33. AKAKPO JY, Olivos H, Shrestha B, Midey A, et al
    Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging.
    Toxicol Sci. 2024;198:328-346.
    PubMed     Abstract available
    
    
    February 2024
34. TAKIMOTO N, Ishii Y, Mitsumoto T, Takasu S, et al
    Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
    Toxicol Sci. 2024;198:40-49.
    PubMed     Abstract available
    
    
    
35. XU C, Yan F, Zhao Y, Jaeschke H, et al
    Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARgamma and autophagy.
    Toxicol Sci. 2024;198:50-60.
    PubMed     Abstract available
    
    
    
36. O'SHAUGHNESSY KL, Sasser AL, Bell KS, Riutta C, et al
    Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.
    Toxicol Sci. 2024;198:128-140.
    PubMed     Abstract available
    
    
    
37. WIJAYA LS, Gabor A, Pot IE, van de Have L, et al
    A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury.
    Toxicol Sci. 2024;198:14-30.
    PubMed     Abstract available
    
    
    December 2023
38. GHOSH P, Magee N, Akakpo JY, Ahamed F, et al
    Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2.
    Toxicol Sci. 2023;197:53-68.
    PubMed     Abstract available
    
    
    
39. OGESE MO, Lister A, Farrell L, Gardner J, et al
    A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment.
    Toxicol Sci. 2023;197:38-52.
    PubMed     Abstract available
    
    
    October 2023
40. RUSSOMANNO G, Sison-Young R, Livoti LA, Coghlan H, et al
    A systems approach reveals species differences in hepatic stress response capacity.
    Toxicol Sci. 2023;196:112-125.
    PubMed     Abstract available
    
    
    September 2023
41. FERGANY A, Zong C, Ekuban FA, Suzuki A, et al
    Deletion of IL-1beta exacerbates acrylamide-induced neurotoxicity in mice.
    Toxicol Sci. 2023;195:246-256.
    PubMed     Abstract available
    
    
    July 2023
42. ZHUO X, Howell BA, Shen H, Woodhead JL, et al
    Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
    Toxicol Sci. 2023;194:235-245.
    PubMed     Abstract available
    
    
    March 2023
43. ALI SE, Waddington JC, Lister A, Sison-Young R, et al
    Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
    Toxicol Sci. 2023;192:106-116.
    PubMed     Abstract available
    
    
    
44. MAASS C, Schaller S, Dallmann A, Bothe K, et al
    Considering developmental neurotoxicity in vitro data for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study.
    Toxicol Sci. 2023;192:59-70.
    PubMed     Abstract available
    
    

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