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Articles published in Clin Chem

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    July 2021
  1. KIMENAI DM, Shah ASV, McAllister DA, Lee KK, et al
    Sex Differences in Cardiac Troponin I and T and the Prediction of Cardiovascular Events in the General Population.
    Clin Chem. 2021 Jul 8. pii: 6317557. doi: 10.1093.
    PubMed     Abstract available


    January 2021
  2. CHAPMAN AR, Sandoval Y
    Type 2 Myocardial Infarction: Evolving Approaches to Diagnosis and Risk-Stratification.
    Clin Chem. 2021;67:61-69.
    PubMed     Abstract available


  3. WESTWOOD ME, Armstrong N, Worthy G, Fayter D, et al
    Optimizing the Use of High-Sensitivity Troponin Assays for the Early Rule-out of Myocardial Infarction in Patients Presenting with Chest Pain: A Systematic Review.
    Clin Chem. 2021;67:237-244.
    PubMed     Abstract available


  4. DAMEN SAJ, Cramer GE, Dieker HJ, Gehlmann H, et al
    Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury.
    Clin Chem. 2021;67:227-236.
    PubMed     Abstract available


  5. JOHANSEN MO, Nielsen SF, Afzal S, Vedel-Krogh S, et al
    Very Low-Density Lipoprotein Cholesterol May Mediate a Substantial Component of the Effect of Obesity on Myocardial Infarction Risk: The Copenhagen General Population Study.
    Clin Chem. 2021;67:276-287.
    PubMed     Abstract available


  6. APPLE FS, Daniels LB, Mills NL, Nordestgaard B, et al
    Biomarkers in Cardiovascular Disease: Utility in Diagnosis, Risk Assessment, and Therapy.
    Clin Chem. 2021;67:1-3.
    PubMed    


  7. NORDESTGAARD LT, Christoffersen M, Afzal S, Nordestgaard BG, et al
    Triglycerides as a Shared Risk Factor between Dementia and Atherosclerotic Cardiovascular Disease: A Study of 125 727 Individuals.
    Clin Chem. 2021;67:245-255.
    PubMed     Abstract available


  8. KOBYLECKI CJ, Nordestgaard BG, Afzal S
    Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study.
    Clin Chem. 2021;67:265-275.
    PubMed     Abstract available


  9. DURAN EK, Pradhan AD
    Triglyceride-Rich Lipoprotein Remnants and Cardiovascular Disease.
    Clin Chem. 2021;67:183-196.
    PubMed     Abstract available


  10. WENGER NK
    Cardiovascular Disease in Women: Understanding the Journey.
    Clin Chem. 2021;67:24-29.
    PubMed    


  11. LOPEZ-AYALA P, Boeddinghaus J, Koechlin L, Nestelberger T, et al
    Early Rule-Out Strategies in the Emergency Department Utilizing High-Sensitivity Cardiac Troponin Assays.
    Clin Chem. 2021;67:114-123.
    PubMed     Abstract available


  12. BORGES FK, Devereaux PJ
    Physicians Should Obtain Perioperative Cardiac Troponin Measurements in At-Risk Patients Undergoing Noncardiac Surgery.
    Clin Chem. 2021;67:50-53.
    PubMed    


  13. TALL AR
    HDL in Morbidity and Mortality: A 40+ Year Perspective.
    Clin Chem. 2021;67:19-23.
    PubMed    


  14. KAVSAK PA, Kittanakom S
    Impact of Switching Sample Types for High-Sensitivity Cardiac Troponin I Assays in the 0/1 Hour Algorithms.
    Clin Chem. 2021;67:319-321.
    PubMed    


    December 2020
  15. APPLE FS, Collinson PO, Kavsak PA, Body R, et al
    The IFCC Clinical Application of Cardiac Biomarkers Committee's Appraisal of the 2020 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation: Getting Cardiac Troponin Right.
    Clin Chem. 2020 Dec 30. pii: 6055539. doi: 10.1093.
    PubMed     Abstract available


  16. SANDOVAL Y, Chapman AR, Mills NL, Than M, et al
    Sex-Specific Kinetics of High-Sensitivity Cardiac Troponin I and T following Symptom Onset and Early Presentation in Non-ST-Segment Elevation Myocardial Infarction.
    Clin Chem. 2020 Dec 6. pii: 6024903. doi: 10.1093.
    PubMed    


  17. APPLE FS, Fantz CR, Collinson PO
    Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts.
    Clin Chem. 2020 Dec 5. pii: 6024814. doi: 10.1093.
    PubMed     Abstract available



  18. Corrigendum to: A Possible Mechanism behind Faster Clearance and Higher Peak Concentrations of Cardiac Troponin I Compared with Troponin T in Acute Myocardial Infarction.
    Clin Chem. 2020;66:1573.
    PubMed    


    November 2020
  19. KIMENAI DM, Appelman Y, den Ruijter HM, Shah ASV, et al
    Ten Years of High-Sensitivity Cardiac Troponin Testing: Impact on the Diagnosis of Myocardial Infarction.
    Clin Chem. 2020 Nov 30. pii: 6012962. doi: 10.1093.
    PubMed    


  20. BAUDHUIN LM, De Backer J, Ingles J, Milewicz DM, et al
    The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective.
    Clin Chem. 2020 Nov 30. pii: 6012976. doi: 10.1093.
    PubMed    


  21. HOOGEVEEN RC, Ballantyne CM
    Residual Cardiovascular Risk at Low LDL: Remnants, Lipoprotein(a), and Inflammation.
    Clin Chem. 2020 Nov 30. pii: 6012967. doi: 10.1093.
    PubMed     Abstract available


  22. KAMSTRUP PR
    Lipoprotein(a) and Cardiovascular Disease.
    Clin Chem. 2020 Nov 25. pii: 6000718. doi: 10.1093.
    PubMed     Abstract available


    September 2020
  23. SANDOVAL Y, Apple FS, Saenger AK, Collinson PO, et al
    99th Percentile Upper-Reference Limit of Cardiac Troponin and the Diagnosis of Acute Myocardial Infarction.
    Clin Chem. 2020;66:1167-1180.
    PubMed     Abstract available


  24. WU AHB, Kavsak PA, Aakre KM, Christenson RH, et al
    Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay's Limit of Detection?
    Clin Chem. 2020;66:1146-1149.
    PubMed    


    July 2020
  25. SANDOVAL Y, Smith SW, Sexter A, Schulz K, et al
    Incidence and Prognostic Impact of Infection in Patients with Type 1 and 2 Myocardial Infarction.
    Clin Chem. 2020 Jul 26. pii: 5876610. doi: 10.1093.
    PubMed    


    April 2020
  26. SANDOVAL Y, Smith SW, Schulz K, Sexter A, et al
    Rapid Identification of Patients at High Risk for Acute Myocardial Infarction Using a Single High-Sensitivity Cardiac Troponin I Measurement.
    Clin Chem. 2020;66:620-622.
    PubMed    


    March 2020
  27. FLOWERS KC, Hunt C, Collinson PO
    Interanalyzer Analytical Variation of a High-Sensitivity Cardiac Troponin T Assay Can Exceed the Cutoff of the European Society of Cardiology 1-Hour Algorithm for Ruling Out Non-ST-Segment Elevated Myocardial Infarction.
    Clin Chem. 2020;66:495-496.
    PubMed    


  28. GORE MO, de Lemos JA
    Clinical Relevance of the 99th Percentile Upper Reference Limit for High-Sensitivity Cardiac Troponin Assays.
    Clin Chem. 2020;66:403-405.
    PubMed    


  29. APPLE FS, Wu AHB, Sandoval Y, Sexter A, et al
    Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank.
    Clin Chem. 2020;66:434-444.
    PubMed     Abstract available


    February 2020
  30. STARNBERG K, Friden V, Muslimovic A, Ricksten SE, et al
    A Possible Mechanism behind Faster Clearance and Higher Peak Concentrations of Cardiac Troponin I Compared with Troponin T in Acute Myocardial Infarction.
    Clin Chem. 2020;66:333-341.
    PubMed     Abstract available


    January 2020
  31. COELHO-LIMA J, Mohammed A, Cormack S, Jones S, et al
    Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion.
    Clin Chem. 2020;66:247-256.
    PubMed     Abstract available


    November 2019
  32. EL-KHOURY JM, Remaley AT, Nordestgaard BG, Kaufman HW, et al
    Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL.
    Clin Chem. 2019 Nov 7. pii: clinchem.2019.307306.
    PubMed    


    September 2019
  33. NESTELBERGER T, Boeddinghaus J, Greenslade J, Parsonage WA, et al
    Two-Hour Algorithm for Rapid Triage of Suspected Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay.
    Clin Chem. 2019 Sep 30. pii: clinchem.2019.305193.
    PubMed     Abstract available


  34. BOEDDINGHAUS J, Twerenbold R, Nestelberger T, Koechlin L, et al
    Clinical Use of a New High-Sensitivity Cardiac Troponin I Assay in Patients with Suspected Myocardial Infarction.
    Clin Chem. 2019 Sep 30. pii: clinchem.2019.304725.
    PubMed     Abstract available


    June 2019
  35. IKEZAKI H, Fisher VA, Lim E, Ai M, et al
    Direct Versus Calculated LDL Cholesterol and C-Reactive Protein in Cardiovascular Disease Risk Assessment in the Framingham Offspring Study.
    Clin Chem. 2019 Jun 25. pii: clinchem.2019.304600.
    PubMed     Abstract available


    May 2019
  36. HJORT M, Eggers KM, Lindhagen L, Agewall S, et al
    Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries.
    Clin Chem. 2019 May 9. pii: clinchem.2018.301085.
    PubMed     Abstract available


    April 2019
  37. VON ECKARDSTEIN A
    Iron in Coronary Heart Disease-J-Shaped Associations and Ambivalent Relationships.
    Clin Chem. 2019 Apr 30. pii: clinchem.2019.303420.
    PubMed    


  38. LYNGBAKKEN MN, Rosjo H, Holmen OL, Dalen H, et al
    Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trondelag Health Study.
    Clin Chem. 2019 Apr 17. pii: clinchem.2018.301069.
    PubMed     Abstract available


  39. BOEDDINGHAUS J, Nestelberger T, Twerenbold R, Koechlin L, et al
    High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction.
    Clin Chem. 2019 Apr 15. pii: clinchem.2018.300061.
    PubMed     Abstract available


    March 2019
  40. GRAMMER TB, Scharnagl H, Dressel A, Kleber ME, et al
    Iron Metabolism, Hepcidin, and Mortality (the Ludwigshafen Risk and Cardiovascular Health Study).
    Clin Chem. 2019 Mar 27. pii: clinchem.2018.297242.
    PubMed     Abstract available


  41. VYLEGZHANINA AV, Kogan AE, Katrukha IA, Koshkina EV, et al
    Full-Size and Partially Truncated Cardiac Troponin Complexes in the Blood of Patients with Acute Myocardial Infarction.
    Clin Chem. 2019 Mar 11. pii: clinchem.2018.301127.
    PubMed     Abstract available


  42. HAAGENSEN K, Collinson P, Asberg A, Aakre KM, et al
    How Does the Analytical Quality of the High-Sensitivity Cardiac Troponin T Assay Affect the ESC Rule Out Algorithm for NSTEMI?
    Clin Chem. 2019;65:494-496.
    PubMed    


    February 2019
  43. VAN DEN BROEK I
    Proteins and Clinical Mass Spectrometry: A Fairy Tale?
    Clin Chem. 2019;65:220-221.
    PubMed    


    January 2019
  44. BOEDDINGHAUS J, Nestelberger T, Badertscher P, Twerenbold R, et al
    Predicting Acute Myocardial Infarction with a Single Blood Draw.
    Clin Chem. 2019 Jan 9. pii: clinchem.2018.294124.
    PubMed     Abstract available


  45. ANAND A, Shah ASV, Beshiri A, Jaffe AS, et al
    Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction.
    Clin Chem. 2019 Jan 9. pii: clinchem.2018.298059.
    PubMed     Abstract available


  46. MUELLER C, Twerenbold R, Reichlin T
    Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays.
    Clin Chem. 2019 Jan 7. pii: clinchem.2018.298638.
    PubMed    


    November 2018
  47. STEWART R
    Cardiovascular Disease and Frailty: What Are the Mechanistic Links?
    Clin Chem. 2018 Nov 30. pii: clinchem.2018.287318.
    PubMed     Abstract available


  48. JIN Z, Collier TS, Dai DLY, Chen V, et al
    Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease.
    Clin Chem. 2018 Nov 21. pii: clinchem.2018.291922.
    PubMed     Abstract available


    September 2018
  49. IBRAHIM NE, Gupta R, Lyass A, Li Y, et al
    Endothelin-1 Measurement in Patients Undergoing Diagnostic Coronary Angiography-Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study.
    Clin Chem. 2018 Sep 13. pii: clinchem.2017.286385.
    PubMed     Abstract available


    August 2018
  50. BECK HC, Jensen LO, Gils C, Ilondo AMM, et al
    Proteomic Discovery and Validation of the Confounding Effect of Heparin Administration on the Analysis of Candidate Cardiovascular Biomarkers.
    Clin Chem. 2018 Aug 16. pii: clinchem.2017.282665.
    PubMed     Abstract available


  51. MUELLER D, Puelacher C, Honegger U, Walter JE, et al
    Direct Comparison of Cardiac Troponin T and I Using a Uniform and a Sex-Specific Approach in the Detection of Functionally Relevant Coronary Artery Disease.
    Clin Chem. 2018 Aug 10. pii: clinchem.2018.286971.
    PubMed     Abstract available


    June 2018
  52. MYHRE PL, Omland T, Sarvari SI, Ukkonen H, et al
    Cardiac Troponin T Concentrations, Reversible Myocardial Ischemia, and Indices of Left Ventricular Remodeling in Patients with Suspected Stable Angina Pectoris: a DOPPLER-CIP Substudy.
    Clin Chem. 2018 Jun 29. pii: clinchem.2018.288894.
    PubMed     Abstract available


  53. BOEDDINGHAUS J, Twerenbold R, Nestelberger T, Badertscher P, et al
    Clinical Validation of a Novel High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction.
    Clin Chem. 2018 Jun 25. pii: clinchem.2018.286906.
    PubMed     Abstract available


    May 2018
  54. KIMENAI DM, Janssen EBNJ, Eggers KM, Lindahl B, et al
    Sex-Specific Versus Overall Clinical Decision Limits for Cardiac Troponin I and T for the Diagnosis of Acute Myocardial Infarction: A Systematic Review.
    Clin Chem. 2018 May 29. pii: clinchem.2018.286781.
    PubMed     Abstract available


  55. THAN MP, Aldous SJ, Troughton RW, Pemberton CJ, et al
    Detectable High-Sensitivity Cardiac Troponin within the Population Reference Interval Conveys High 5-Year Cardiovascular Risk: An Observational Study.
    Clin Chem. 2018 May 14. pii: clinchem.2017.285700.
    PubMed     Abstract available


    April 2018
  56. KATRUKHA IA, Kogan AE, Vylegzhanina AV, Kharitonov AV, et al
    Full-Size Cardiac Troponin I and Its Proteolytic Fragments in Blood of Patients with Acute Myocardial Infarction: Antibody Selection for Assay Development.
    Clin Chem. 2018 Apr 9. pii: clinchem.2017.286211.
    PubMed     Abstract available


    February 2018
  57. GREENSLADE J, Cho E, Van Hise C, Hawkins T, et al
    Evaluating Rapid Rule-out of Acute Myocardial Infarction by Use of a High-Sensitivity Cardiac Troponin I Assay at Presentation.
    Clin Chem. 2018 Feb 1. pii: clinchem.2017.283887.
    PubMed     Abstract available


    January 2018
  58. BADERTSCHER P, Boeddinghaus J, Nestelberger T, Twerenbold R, et al
    Effect of Acute Coronary Syndrome Probability on Diagnostic and Prognostic Performance of High-Sensitivity Cardiac Troponin.
    Clin Chem. 2018 Jan 17. pii: clinchem.2017.279513.
    PubMed     Abstract available


  59. WU AHB, Christenson RH, Greene DN, Jaffe AS, et al
    Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Mark
    Clin Chem. 2018 Jan 17. pii: clinchem.2017.277186.
    PubMed     Abstract available


    December 2017
  60. BHUPATHIRAJU SN, Stampfer MJ
    Menopausal Hormone Therapy and Cardiovascular Disease: Unraveling the Role of Age and Time Since Menopause Onset.
    Clin Chem. 2017 Dec 8. pii: clinchem.2017.272823.
    PubMed    


    October 2017
  61. WALTER JE, Honegger U, Puelacher C, Mueller D, et al
    Prospective Validation of a Biomarker-Based Rule Out Strategy for Functionally Relevant Coronary Artery Disease.
    Clin Chem. 2017 Oct 16. pii: clinchem.2017.277210.
    PubMed     Abstract available


  62. VARBO A, Freiberg JJ, Nordestgaard BG
    Remnant Cholesterol and Myocardial Infarction in Normal Weight, Overweight, and Obese Individuals from the Copenhagen General Population Study.
    Clin Chem. 2017 Oct 11. pii: clinchem.2017.279463.
    PubMed     Abstract available


  63. SILBERNAGEL G, Pagel P, Pfahlert V, Genser B, et al
    High-Density Lipoprotein Subclasses, Coronary Artery Disease, and Cardiovascular Mortality.
    Clin Chem. 2017 Oct 11. pii: clinchem.2017.275636.
    PubMed     Abstract available


  64. MARRA MP, Zaninotto M, Cacciavillani L, Iliceto S, et al
    Massive Troponin Release and Normal Coronary Arteries: Where Does the Truth Lie?
    Clin Chem. 2017;63:1570-1573.
    PubMed    


    September 2017
  65. KOENIG W
    C-Reactive Protein and Cardiovascular Risk: Will the Controversy End after CANTOS?
    Clin Chem. 2017 Sep 20. pii: clinchem.2017.273243.
    PubMed    


  66. CAO J, Steffen BT, Guan W, Budoff M, et al
    Evaluation of Lipoprotein(a) Electrophoretic and Immunoassay Methods in Discriminating Risk of Calcific Aortic Valve Disease and Incident Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis.
    Clin Chem. 2017 Sep 13. pii: clinchem.2016.270751.
    PubMed     Abstract available


  67. JAGODZINSKI A, Neumann JT, Ojeda F, Sorensen NA, et al
    Cardiovascular Biomarkers in Hypertensive Patients with Medical Treatment-Results from the Randomized TEAMSTA Protect I Trial.
    Clin Chem. 2017 Sep 13. pii: clinchem.2017.275289.
    PubMed     Abstract available


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