Home The Word Brain My Amedeo FAQ Privacy About Flying Publisher   


COVID-19: Daily Top 10 Papers


  Vaccines

  Free Subscription


31.05.2021

4 Ann Intern Med
2 BMC Pediatr
8 BMJ
3 Clin Infect Dis
1 Indian Pediatr
1 J Immunol
1 J Infect
4 JAMA
5 Lancet
2 MMWR Morb Mortal Wkly Rep
2 N Engl J Med
4 Nat Med
1 Pediatr Infect Dis J
1 Pediatrics
1 PLoS Med
6 PLoS One
1 Science
43 Vaccine


   Retrieve available abstracts of this week’s articles:
HTML format
 
 
Single Articles


    Ann Intern Med

  1. GREGORY JM, Moore DJ
    The Dual Burden of Type 1 Diabetes and COVID-19.
    Ann Intern Med. 2021 Jan 26. doi: 10.7326/M21-0367.
    PubMed        

  2. CONNOLLY CM, Boyarsky BJ, Ruddy JA, Werbel WA, et al
    Absence of Humoral Response After Two-Dose SARS-CoV-2 Messenger RNA Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: A Case Series.
    Ann Intern Med. 2021 May 25. doi: 10.7326/M21-1451.
    PubMed        

  3. MARION O, Del Bello A, Abravanel F, Couat C, et al
    Safety and Immunogenicity of Anti-SARS-CoV-2 Messenger RNA Vaccines in Recipients of Solid Organ Transplants.
    Ann Intern Med. 2021 May 25. doi: 10.7326/M21-1341.
    PubMed        

  4. ARNOLD DT, Milne A, Samms E, Stadon L, et al
    Symptoms After COVID-19 Vaccination in Patients With Persistent Symptoms After Acute Infection: A Case Series.
    Ann Intern Med. 2021 May 25. doi: 10.7326/M21-1976.
    PubMed        


    BMC Pediatr

  5. LIN JJ, Liu XH, Xia L, Feng YL, et al
    A Niemann-pick C1 disease child with BCG-itis: a case report and analysis.
    BMC Pediatr. 2021;21:218.
    PubMed         Abstract available

  6. HIRADE T, Harada A, Koike D, Abe Y, et al
    Subcutaneous abscess caused by Streptococcus pneumoniae serotype 28F in an infant: a case report.
    BMC Pediatr. 2021;21:8.
    PubMed         Abstract available


    BMJ

  7. IACOBUCCI G
    Covid-19: Local councils initiate surge vaccination to tackle B.1.617.2 variant.
    BMJ. 2021;373:n1361.
    PubMed        

  8. CARTWRIGHT AC, Tompkins M, Boncey J, Hastie C, et al
    Patient information on covid-19 vaccines-a vaccine centre lottery.
    BMJ. 2021;373:n1310.
    PubMed        

  9. IACOBUCCI G
    Covid-19: Are high rates of B.1.617.2 linked to vaccine hesitancy?
    BMJ. 2021;373:n1345.
    PubMed        

  10. IACOBUCCI G
    Covid-19: Single vaccine dose is 33% effective against variant from India, data show.
    BMJ. 2021;373:n1346.
    PubMed        


  11. Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study.
    BMJ. 2021;373:n1334.
    PubMed        

  12. THACKER PD
    Covid-19: How independent were the US and British vaccine advisory committees?
    BMJ. 2021;373:n1283.
    PubMed        

  13. DYER O
    Covid-19: Variants are spreading in countries with low vaccination rates.
    BMJ. 2021;373:n1359.
    PubMed        

  14. TORJESEN I
    Covid-19: Pfizer-BioNTech vaccine is "likely" responsible for deaths of some elderly patients, Norwegian review finds.
    BMJ. 2021;373:n1372.
    PubMed        


    Clin Infect Dis

  15. YADAV PD, Sapkal GN, Abraham P, Deshpande G, et al
    Neutralization potential of Covishield vaccinated individuals sera against B.1.617.1.
    Clin Infect Dis. 2021 May 24. pii: 6283706. doi: 10.1093.
    PubMed        

  16. NEWALL AT, Leong RN, Reyes JF, Curns AT, et al
    Rotavirus vaccination likely to be cost saving to society in the United States.
    Clin Infect Dis. 2021 May 26. pii: 6285405. doi: 10.1093.
    PubMed         Abstract available

  17. GOWER CM, Stowe J, Andrews NJ, Dunning J, et al
    Sustained declines in age group-specific rotavirus infection and acute gastroenteritis in vaccinated and unvaccinated individuals during the five years since Rotavirus vaccine introduction in England.
    Clin Infect Dis. 2021 May 27. pii: 6287118. doi: 10.1093.
    PubMed         Abstract available


    Indian Pediatr

  18. KASI SG, Dhir SK, Shivananda S, Marathe S, et al
    Breastfeeding and Coronavirus Disease 2019 (COVID-19) Vaccination: Position Statement of the Indian Academy of Pediatrics/Advisory Committee on Vaccination and Immunization Practices.
    Indian Pediatr. 2021 May 28. pii: S097475591600336.
    PubMed         Abstract available


    J Immunol

  19. SANDOR AM, Sturdivant MS, Ting JPY
    Influenza Virus and SARS-CoV-2 Vaccines.
    J Immunol. 2021;206:2509-2520.
    PubMed         Abstract available


    J Infect

  20. J BP, Jolly B, John N, Bhoyar RC, et al
    Genomic survey of SARS-CoV-2 vaccine breakthrough infections in healthcare workers from Kerala, India.
    J Infect. 2021 May 24. pii: S0163-4453(21)00260.
    PubMed        


    JAMA

  21. DALY M, Jones A, Robinson E
    Public Trust and Willingness to Vaccinate Against COVID-19 in the US From October 14, 2020, to March 29, 2021.
    JAMA. 2021 May 24. pii: 2780519. doi: 10.1001/jama.2021.8246.
    PubMed        

  22. RUBIN R
    Allergic Reactions to mRNA Vaccines.
    JAMA. 2021;325:2038.
    PubMed        

  23. AL KAABI N, Zhang Y, Xia S, Yang Y, et al
    Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial.
    JAMA. 2021 May 26. pii: 2780562. doi: 10.1001/jama.2021.8565.
    PubMed         Abstract available

  24. HOTEZ PJ, Narayan KMV
    Restoring Vaccine Diplomacy.
    JAMA. 2021 May 28. pii: 2780640. doi: 10.1001/jama.2021.7439.
    PubMed        


    Lancet

  25. THE LANCET
    Improving prisoner health for stronger public health.
    Lancet. 2021;397:555.
    PubMed        

  26. LOGUNOV DY, Dolzhikova IV, Shcheblyakov DV
    Data discrepancies and substandard reporting of interim data of Sputnik V phase 3 trial - Authors' reply.
    Lancet. 2021 May 12. pii: S0140-6736(21)00894.
    PubMed        

  27. GENC K
    COVID-19 in Turkey: a nation on edge.
    Lancet. 2021;397:1794-1796.
    PubMed        

  28. ZAROCOSTAS J
    What next for a COVID-19 intellectual property waiver?
    Lancet. 2021;397:1871-1872.
    PubMed        

  29. JAWAD NK, Taweeleh LA, Elharake JA, Khamis N, et al
    Refugee access to COVID-19 vaccines in Lebanon.
    Lancet. 2021;397:1884.
    PubMed        


    MMWR Morb Mortal Wkly Rep


  30. COVID-19 Vaccine Breakthrough Infections Reported to CDC - United States, January 1-April 30, 2021.
    MMWR Morb Mortal Wkly Rep. 2021;70:792-793.
    PubMed         Abstract available


  31. QuickStats: Percentage* of Adults Aged 18-26 Years Who Ever Received a Human Papillomavirus Vaccine,(dagger) by Race and Hispanic Origin( section sign) and Sex - National Health Interview Survey, United States, 2019( paragraph sign).
    MMWR Morb Mortal Wkly Rep. 2021;70:797.
    PubMed        


    N Engl J Med

  32. VOLPP KG, Cannuscio CC
    Incentives for Immunity - Strategies for Increasing Covid-19 Vaccine Uptake.
    N Engl J Med. 2021 May 26. doi: 10.1056/NEJMp2107719.
    PubMed        

  33. FRENCK RW JR, Klein NP, Kitchin N, Gurtman A, et al
    Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents.
    N Engl J Med. 2021 May 27. doi: 10.1056/NEJMoa2107456.
    PubMed         Abstract available


    Nat Med

  34. AU L, Fendler A, Shepherd STC, Rzeniewicz K, et al
    Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.
    Nat Med. 2021 May 26. pii: 10.1038/s41591-021-01387.
    PubMed         Abstract available

  35. EWER KJ, Barrett JR, Belij-Rammerstorfer S, Sharpe H, et al
    Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.
    Nat Med. 2021 May 21. pii: 10.1038/s41591-021-01363.
    PubMed        

  36. OTU A, Agogo E, Ebenso B
    Africa needs more genome sequencing to tackle new variants of SARS-CoV-2.
    Nat Med. 2021;27:744-745.
    PubMed        

  37. PLANAS D, Bruel T, Grzelak L, Guivel-Benhassine F, et al
    Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.
    Nat Med. 2021 Mar 26. pii: 10.1038/s41591-021-01318.
    PubMed         Abstract available


    Pediatr Infect Dis J

  38. ZIMMERMANN P, Jones CE
    Factors That Influence Infant Immunity and Vaccine Responses.
    Pediatr Infect Dis J. 2021;40.
    PubMed         Abstract available


    Pediatrics

  39. WALL DJ, Patel MM, Chung JR, Lee B, et al
    Antibody Response and Protection After Receipt of Inactivated Influenza Vaccine: A Systematic Review.
    Pediatrics. 2021 May 26. pii: peds.2020-019901. doi: 10.1542/peds.2020-019901.
    PubMed         Abstract available


    PLoS Med

  40. GOLDMAN M, Hermans C
    Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity.
    PLoS Med. 2021;18:e1003648.
    PubMed         Abstract available


    PLoS One

  41. NIKOLOVSKI J, Koldijk M, Weverling GJ, Spertus J, et al
    Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. adults.
    PLoS One. 2021;16:e0251963.
    PubMed         Abstract available

  42. CAINI S, Paget J, Spreeuwenberg P, Korevaar JC, et al
    Impact of influenza vaccination in the Netherlands, 2007-2016: Vaccinees consult their general practitioner for clinically diagnosed influenza, acute respiratory infections, and pneumonia more often than non-vaccinees.
    PLoS One. 2021;16:e0249883.
    PubMed         Abstract available

  43. EZAJ MMA, Haque MS, Syed SB, Khan MSA, et al
    Comparative proteomic analysis to annotate the structural and functional association of the hypothetical proteins of S. maltophilia k279a and predict potential T and B cell targets for vaccination.
    PLoS One. 2021;16:e0252295.
    PubMed         Abstract available

  44. ZEIGLER DF, Gage E, Clegg CH
    Epitope-targeting platform for broadly protective influenza vaccines.
    PLoS One. 2021;16:e0252170.
    PubMed         Abstract available

  45. KITONSA J, Kamacooko O, Bahemuka UM, Kibengo F, et al
    Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda.
    PLoS One. 2021;16:e0251992.
    PubMed         Abstract available

  46. CHE X, Liu Y, Wang J, Xu Y, et al
    Booster immunization of meningococcal meningitis vaccine among children in Hangzhou, China, 2014-2019.
    PLoS One. 2021;16:e0251567.
    PubMed         Abstract available


    Science

  47. KARRON RA
    Preventing respiratory syncytial virus (RSV) disease in children.
    Science. 2021;372:686-687.
    PubMed        


    Vaccine

  48. VREMAN S, Rebel JMJ, McCaffrey J, Ledl K, et al
    Early immune responses in skin and lymph node after skin delivery of Toll-like receptor agonists in neonatal and adult pigs.
    Vaccine. 2021;39:1857-1869.
    PubMed         Abstract available

  49. LAMPONEN T, Hetemaki I, Niemi HJ, Jarva H, et al
    Heterologous boosting of nonrelated toxoid immunity during acute Puumala hantavirus infection.
    Vaccine. 2021;39:1818-1825.
    PubMed         Abstract available

  50. BRANDILEONE MC, Almeida SCG, Bokermann S, Minamisava R, et al
    Dynamics of antimicrobial resistance of Streptococcus pneumoniae following PCV10 introduction in Brazil: Nationwide surveillance from 2007 to 2019.
    Vaccine. 2021;39:3207-3215.
    PubMed         Abstract available

  51. MINTA AA, Silva MWT, Shrestha A, de Quiroz-Castro M, et al
    Hepatitis B surface antigen seroprevalence among children in the Philippines, 2018.
    Vaccine. 2021 Mar 9. pii: S0264-410X(21)00222.
    PubMed         Abstract available

  52. QUAN DH, Counoupas C, Nagalingam G, Pinto R, et al
    Advax adjuvant formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity.
    Vaccine. 2021;39:1990-1996.
    PubMed         Abstract available

  53. AMIN-CHOWDHURY Z, Groves N, Sheppard CL, Litt D, et al
    Invasive pneumococcal disease due to 22F and 33F in England: A tail of two serotypes.
    Vaccine. 2021;39:1997-2004.
    PubMed         Abstract available

  54. CROWCROFT NS, Bolotin S, Li Y, Campbell H, et al
    Infant pertussis and maternal immunity: The curious case of Canada.
    Vaccine. 2021;39:1977-1981.
    PubMed         Abstract available

  55. ZHANG Z, Pan J, Chen M, Zhang T, et al
    Seroepidemiology of pertussis in China: A population-based, cross-sectional study.
    Vaccine. 2021;39:1687-1692.
    PubMed         Abstract available

  56. RANE MS, Page LC, McVeigh E, Miller K, et al
    Improving adolescent human papillomavirus (HPV) immunization uptake in school-based health centers through awareness campaigns.
    Vaccine. 2021;39:1765-1772.
    PubMed         Abstract available

  57. CEYHAN M, Karadag-Oncel E, Hascelik G, Ustundag G, et al
    Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged less than five years.
    Vaccine. 2021;39:2041-2047.
    PubMed         Abstract available

  58. THANAWASTIEN A, Joyce KE, Cartee RT, Haines LA, et al
    Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid.
    Vaccine. 2021;39:1652-1660.
    PubMed         Abstract available

  59. MACIAS AE, McElhaney JE, Chaves SS, Nealon J, et al
    The disease burden of influenza beyond respiratory illness.
    Vaccine. 2020 Oct 8. pii: S0264-410X(20)31209.
    PubMed         Abstract available

  60. NET P, Colrat F, Nascimento Costa M, Bianic F, et al
    Estimating public health and economic benefits along 10 years of Fluzone(R) High Dose in the United States.
    Vaccine. 2021;39 Suppl 1:A56-A69.
    PubMed         Abstract available

  61. KHETSURIANI N, Zaika O, Chitadze N, Slobodianyk L, et al
    Seroprevalence of hepatitis B virus infection markers among children in Ukraine, 2017.
    Vaccine. 2021 Feb 11. pii: S0264-410X(21)00133.
    PubMed         Abstract available

  62. SERAZIN NA, Edem B, Williams SR, Ortiz JR, et al
    Acute respiratory distress syndrome (ARDS) as an adverse event following immunization: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.
    Vaccine. 2021;39:3028-3036.
    PubMed         Abstract available

  63. KHANNA M, Rady H, Dai G, Ramsay AJ, et al
    Intranasal boosting with MVA encoding secreted mycobacterial proteins Ag85A and ESAT-6 generates strong pulmonary immune responses and protection against M. tuberculosis in mice given BCG as neonates.
    Vaccine. 2021;39:1780-1787.
    PubMed         Abstract available

  64. VOGEL TP, Top KA, Karatzios C, Hilmers DC, et al
    Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.
    Vaccine. 2021;39:3037-3049.
    PubMed         Abstract available

  65. GUZMAN-HOLST A, Luna-Casas G, Cervantes-Apolinar MY, Huerta-Garcia GC, et al
    Pertussis infant morbidity and mortality trends after universal maternal immunisation in Mexico: An ecological database study with time-series analysis.
    Vaccine. 2021;39:2311-2318.
    PubMed         Abstract available

  66. SMITH TG, Fooks AR, Moore SM, Freuling CM, et al
    Negligible risk of rabies importation in dogs thirty days after demonstration of adequate serum antibody titer.
    Vaccine. 2021 Apr 4. pii: S0264-410X(21)00368.
    PubMed        

  67. EYAL N, Gerhard T, Strom BL
    Strengthening and accelerating SARS-CoV-2 vaccine safety surveillance through registered pre-approval rollout after challenge tests.
    Vaccine. 2021 Apr 30. pii: S0264-410X(21)00526.
    PubMed        

  68. SON HJ, Lee E, Park SY, Lee S, et al
    Promotion of healthcare personnel vaccinations among newly employed doctors and nurses: Evidence-guided strategy.
    Vaccine. 2021 May 20. pii: S0264-410X(21)00589.
    PubMed         Abstract available

  69. OKORONKWO C, Taiwo LA, Asolo JA, Baptiste AEJ, et al
    Leveraging on the 2017/2018 measles vaccination campaign to improve health workers knowledge and practice on injection safety: A case study of north-central states, Nigeria.
    Vaccine. 2021 May 20. pii: S0264-410X(21)00565.
    PubMed         Abstract available

  70. TUFAIL S, Shah MA, Zafar M, Asif TA, et al
    Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family.
    Vaccine. 2021 May 21. pii: S0264-410X(21)00585.
    PubMed         Abstract available

  71. HIRST A, Hyer RN, Janssen RS
    Comparative cost-effectiveness of a 2-dose versus 3-dose vaccine for hepatitis B prevention in selected adult populations.
    Vaccine. 2021 May 21. pii: S0264-410X(21)00582.
    PubMed         Abstract available

  72. NADARZYNSKI T, Frost M, Miller D, Wheldon CW, et al
    Vaccine acceptability, uptake and completion amongst men who have sex with men: A systematic review, meta-analysis and theoretical framework.
    Vaccine. 2021 May 22. pii: S0264-410X(21)00564.
    PubMed         Abstract available

  73. LUK TT, Zhao S, Wu Y, Wong JY, et al
    Prevalence and determinants of SARS-CoV-2 vaccine hesitancy in Hong Kong: A population-based survey.
    Vaccine. 2021 May 18. pii: S0264-410X(21)00608.
    PubMed         Abstract available

  74. NAG K, Chandra Baray J, Rahman Khan M, Mahmud A, et al
    An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single dose.
    Vaccine. 2021 May 18. pii: S0264-410X(21)00607.
    PubMed         Abstract available

  75. COX SN, Wedlock PT, Pallas SW, Mitgang EA, et al
    A systems map of the economic considerations for vaccination: Application to hard-to-reach populations.
    Vaccine. 2021 May 24. pii: S0264-410X(21)00605.
    PubMed         Abstract available

  76. WOOD RM, Murch BJ, Moss SJ, Tyler JMB, et al
    Operational research for the safe and effective design of COVID-19 mass vaccination centres.
    Vaccine. 2021 May 14. pii: S0264-410X(21)00588.
    PubMed        

  77. NICHOLLS LAB, Gallant AJ, Cogan N, Rasmussen S, et al
    Older adults' vaccine hesitancy: Psychosocial factors associated with influenza, pneumococcal, and shingles vaccine uptake.
    Vaccine. 2021 May 19. pii: S0264-410X(21)00544.
    PubMed         Abstract available

  78. BLANCHARD-ROHNER G, Enriquez N, Lemaitre B, Cadau G, et al
    Pneumococcal immunity and PCV13 vaccine response in SOT-candidates and recipients.
    Vaccine. 2021 May 20. pii: S0264-410X(21)00594.
    PubMed         Abstract available

  79. AFIFI TO, Salmon S, Taillieu T, Stewart-Tufescu A, et al
    Older adolescents and young adults willingness to receive the COVID-19 vaccine: Implications for informing public health strategies.
    Vaccine. 2021 May 12. pii: S0264-410X(21)00590.
    PubMed         Abstract available

  80. MANCA TA, Graham JE, MacDonald NE, Top KA, et al
    Healthcare providers' interpretations of product labelling information developed through a consensus stakeholder approach.
    Vaccine. 2021;39:2652-2659.
    PubMed         Abstract available

  81. SATOH C, Toizumi M, Nguyen HAT, Hara M, et al
    Prevalence and characteristics of children with otitis media with effusion in Vietnam.
    Vaccine. 2021;39:2613-2619.
    PubMed         Abstract available

  82. MENKIR TF, Jbaily A, Verguet S
    Incorporating equity in infectious disease modeling: Case study of a distributional impact framework for measles transmission.
    Vaccine. 2021;39:2894-2900.
    PubMed         Abstract available

  83. BIANCHI FP, Larocca AMV, Bozzi A, Spinelli G, et al
    Long-term persistence of poliovirus neutralizing antibodies in the era of polio elimination: An Italian retrospective cohort study.
    Vaccine. 2021;39:2989-2994.
    PubMed         Abstract available

  84. ARDURA-GARCIA C, Kreis C, Rakic M, Jaboyedoff M, et al
    Rotavirus disease and health care utilisation among children under 5 years of age in highly developed countries: A systematic review and meta-analysis.
    Vaccine. 2021;39:2917-2928.
    PubMed         Abstract available

  85. SULLIVAN E, Lecollinet S, Kerviel A, Hue E, et al
    Entry-competent-replication-abortive African horse sickness virus strains elicit robust immunity in ponies against all serotypes.
    Vaccine. 2021;39:3161-3168.
    PubMed         Abstract available

  86. TAMANDJOU TCHUEM CR, Andersson MI, Wiysonge CS, Mufenda J, et al
    Prevention of hepatitis B mother-to-child transmission in Namibia: A cost-effectiveness analysis.
    Vaccine. 2021 May 4. pii: S0264-410X(21)00498.
    PubMed         Abstract available

  87. PASTORINO R, Villani L, La Milia DI, Ieraci R, et al
    Influenza and pneumococcal vaccinations are not associated to COVID-19 outcomes among patients admitted to a university hospital.
    Vaccine. 2021 May 9. pii: S0264-410X(21)00566.
    PubMed         Abstract available

  88. SOMIYA M, Mine S, Yasukawa K, Ikeda S, et al
    Sex differences in the incidence of anaphylaxis to LNP-mRNA COVID-19 vaccines.
    Vaccine. 2021 May 6. pii: S0264-410X(21)00548.
    PubMed        

  89. DANG JHT, Stewart SL, Blumberg DA, Rodriguez HP, et al
    Patient and clinician factors associated with uptake of the human papillomavirus (HPV) vaccine among adolescent patients of a primary care network.
    Vaccine. 2021 May 19. pii: S0264-410X(21)00525.
    PubMed         Abstract available

  90. WATESKA AR, Nowalk MP, Jalal H, Lin CJ, et al
    Is further research on adult pneumococcal vaccine uptake improvement programs worthwhile? Alpha value of information analysis.
    Vaccine. 2021 May 24. pii: S0264-410X(21)00609.
    PubMed         Abstract available


Thank you for your interest in scientific medicine.


AMEDEO Vaccines is free of charge.
This policy is made possible thanks to a media sponsorship by Boehringer Ingelheim.

Design: