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  Stroke

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Articles published in Ann Intern Med

Retrieve available abstracts of 85 articles:
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Single Articles


    April 2024
  1. DRAKE T, Landsteiner A, Langsetmo L, MacDonald R, et al
    Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Systematic Review and Network Meta-analysis for the American College of Physicians.
    Ann Intern Med. 2024 Apr 19. doi: 10.7326/M23-1490.
    PubMed     Abstract available


  2. QASEEM A, Obley AJ, Shamliyan T, Hicks LA, et al
    Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Clinical Guideline From the American College of Physicians.
    Ann Intern Med. 2024 Apr 19. doi: 10.7326/M23-2788.
    PubMed     Abstract available


  3. AJZENBERG H, Binhashr MAN, Hewitt MK, Unger M, et al
    Critical Care: What You May Have Missed in 2023.
    Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0565.
    PubMed     Abstract available


    March 2024
  4. SHADRIN IY, Newby LK
    In subclinical AF, apixaban reduced stroke or systemic embolism but increased major bleeding vs. aspirin at 3.5 y.
    Ann Intern Med. 2024;177:JC26.
    PubMed     Abstract available


    February 2024
  5. KANJEE Z, Dearborn-Tomazos JL, Kumar S, Reynolds EE, et al
    How Would You Prevent Subsequent Strokes in This Patient? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
    Ann Intern Med. 2024 Feb 13. doi: 10.7326/M23-3136.
    PubMed     Abstract available


    January 2024
  6. FU EL, Carrero JJ, Sang Y, Evans M, et al
    Association of Low Glomerular Filtration Rate With Adverse Outcomes at Older Age in a Large Population With Routinely Measured Cystatin C.
    Ann Intern Med. 2024 Jan 30. doi: 10.7326/M23-1138.
    PubMed     Abstract available


  7. HILL MD
    After EVT for ischemic stroke, intensive vs. conventional BP management reduced functional independence at 3 mo.
    Ann Intern Med. 2024 Jan 2. doi: 10.7326/J23-0106.
    PubMed     Abstract available


    December 2023
  8. SUD M, Sivaswamy A, Austin PC, Anderson TJ, et al
    Development and Validation of the CANHEART Population-Based Laboratory Prediction Models for Atherosclerotic Cardiovascular Disease.
    Ann Intern Med. 2023 Dec 12. doi: 10.7326/M23-1345.
    PubMed     Abstract available


  9. AGARWAL R, Tu W, Farjat AE, Farag YMK, et al
    Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis.
    Ann Intern Med. 2023 Dec 5. doi: 10.7326/M23-1023.
    PubMed     Abstract available


  10. WEITZ HH, Merli GJ, Benesch C
    Annals Consult Guys - Surgery After Thromboembolic Stroke.
    Ann Intern Med. 2023;176:eW220025.
    PubMed    


    November 2023
  11. TANG M, Nakamoto CH, Stern AD, Zubizarreta JR, et al
    Effects of Remote Patient Monitoring Use on Care Outcomes Among Medicare Patients With Hypertension : An Observational Study.
    Ann Intern Med. 2023 Nov 7. doi: 10.7326/M23-1182.
    PubMed     Abstract available


  12. CRUZ-FLORES S
    In healthy older adults, low-dose aspirin did not differ from placebo for ischemic stroke but increased intracranial bleeding.
    Ann Intern Med. 2023 Nov 7. doi: 10.7326/J23-0092.
    PubMed     Abstract available


  13. TANNU M, Newby LK
    In CAD, P2Y12 inhibitor vs. aspirin monotherapy reduces a composite CV outcome without increasing major bleeding.
    Ann Intern Med. 2023;176:JC123.
    PubMed     Abstract available


    October 2023
  14. EASTIN C
    In minor, nondisabling, acute ischemic stroke, DAPT was noninferior to IV alteplase for excellent functional outcome at 90 d.
    Ann Intern Med. 2023 Oct 3. doi: 10.7326/J23-0072.
    PubMed     Abstract available


  15. ALBERTS MJ
    In ischemic stroke without large or medium vessel occlusion, tirofiban increased likelihood of an excellent outcome.
    Ann Intern Med. 2023 Oct 3. doi: 10.7326/J23-0074.
    PubMed     Abstract available


    September 2023
  16. RIETZ H, Pennlert J, Nordstrom P, Brunstrom M, et al
    Blood Pressure Level in Late Adolescence and Risk for Cardiovascular Events : A Cohort Study.
    Ann Intern Med. 2023 Sep 26. doi: 10.7326/M23-0112.
    PubMed     Abstract available


  17. KIM DH, Lee SB, Park CM, Levin R, et al
    Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
    Ann Intern Med. 2023 Sep 5. doi: 10.7326/M22-3021.
    PubMed     Abstract available


  18. BANNOW BTS
    In adults with cancer and VTE, DOACs were noninferior to LMWH for recurrent, nonfatal VTE at 6 mo.
    Ann Intern Med. 2023;176:JC104.
    PubMed     Abstract available


    August 2023
  19. CARLIN S, Douketis J
    In AF, the effects of DOACs vs. warfarin on death and stroke/systemic embolism vary by baseline CrCl level.
    Ann Intern Med. 2023 Aug 1. doi: 10.7326/J23-0054.
    PubMed     Abstract available


  20. BAHREINI M, Lang E
    In ischemic stroke, EVT improved 90-d function more than usual care across admission SBP levels.
    Ann Intern Med. 2023 Aug 1. doi: 10.7326/J23-0055.
    PubMed     Abstract available


  21. KIRSCHNER JM, Hunter BR
    SAEM issued 4 strong recommendations (high-certainty evidence) for determining cause of acute vestibular syndrome in the ED.
    Ann Intern Med. 2023;176:JC86.
    PubMed     Abstract available


    July 2023
  22. MCCORMICK N, Yokose C, Wei J, Lu N, et al
    Comparative Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations : A General Population Cohort Study.
    Ann Intern Med. 2023 Jul 25. doi: 10.7326/M23-0724.
    PubMed     Abstract available


  23. ESKIN B
    In ischemic stroke, adding EVT to usual care at 6 to 24 h improved functional status at 90 d.
    Ann Intern Med. 2023 Jul 4. doi: 10.7326/J23-0050.
    PubMed     Abstract available


  24. AL-KHATIB SM
    Atrial Fibrillation.
    Ann Intern Med. 2023;176:ITC97-ITC112.
    PubMed     Abstract available


    June 2023
  25. FERGUSON E, Lang E
    In large acute ischemic stroke, adding endovascular thrombectomy to medical therapy improved function at 90 d.
    Ann Intern Med. 2023 Jun 6. doi: 10.7326/J23-0033.
    PubMed     Abstract available


  26. ALBERTS MJ
    After ICH, starting long-term therapeutic oral anticoagulation in patients with AF reduces MACE at 1 to 3 y.
    Ann Intern Med. 2023;176:JC71.
    PubMed     Abstract available


    May 2023
  27. RAY WA, Chung CP, Stein CM, Smalley W, et al
    Risk for Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients With Atrial Fibrillation : A Retrospective Cohort Study.
    Ann Intern Med. 2023 May 23. doi: 10.7326/M22-3238.
    PubMed     Abstract available


  28. RICHARDSON TL JR, Halvorson AE, Hackstadt AJ, Hung AM, et al
    Primary Occurrence of Cardiovascular Events After Adding Sodium-Glucose Cotransporter-2 Inhibitors or Glucagon-like Peptide-1 Receptor Agonists Compared With Dipeptidyl Peptidase-4 Inhibitors: A Cohort Study in Veterans With Diabetes.
    Ann Intern Med. 2023 May 9. doi: 10.7326/M22-2751.
    PubMed     Abstract available


  29. ZHU J, Kamel H, Gupta A, Mushlin AI, et al
    Prioritizing Quality Measures in Acute Stroke Care : A Cost-Effectiveness Analysis.
    Ann Intern Med. 2023 May 2. doi: 10.7326/M22-3186.
    PubMed     Abstract available


  30. GRIFFIN M, Lip GYH
    In limb or pelvic fracture, aspirin was noninferior to enoxaparin for reducing all-cause death.
    Ann Intern Med. 2023;176:JC56.
    PubMed     Abstract available


    April 2023
  31. MARCUCCI M, Painter TW, Conen D, Lomivorotov V, et al
    Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial.
    Ann Intern Med. 2023 Apr 25. doi: 10.7326/M22-3157.
    PubMed     Abstract available


  32. ADIE SK, Konerman MC
    Annals for Hospitalists Inpatient Notes - Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure With Preserved Ejection Fraction-What Hospitalists Need to Know.
    Ann Intern Med. 2023;176:eM230588.
    PubMed    


  33. LADER EW
    After PCI and 6 to 18 mo of DAPT, clopidogrel reduced a composite of clinical events vs. aspirin at 6 y.
    Ann Intern Med. 2023;176:JC38.
    PubMed     Abstract available


  34. PERISETTI A, Sharma P
    In older patients receiving aspirin, H pylori eradication reduced hospitalization or death due to peptic ulcer bleeding at 2.5 y.
    Ann Intern Med. 2023;176:JC45.
    PubMed     Abstract available


    March 2023
  35. FORD ND, DeSisto CL, Galang RR, Kuklina EV, et al
    Cardiac Arrest During Delivery Hospitalization : A Cohort Study.
    Ann Intern Med. 2023 Mar 14. doi: 10.7326/M22-2750.
    PubMed     Abstract available


  36. CHEW DS, Piccini JP
    Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation.
    Ann Intern Med. 2023;176:eL220517.
    PubMed    


  37. ANDERSON CE, Lieberman RA, Olshansky B
    Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation.
    Ann Intern Med. 2023;176:eL220516.
    PubMed    


  38. DUNN A
    In AF, underdosing of DOACs was not linked to reduced bleeding.
    Ann Intern Med. 2023;176:JC32.
    PubMed     Abstract available


    February 2023
  39. LO B
    In basilar-artery occlusion stroke, thrombectomy improved functional outcomes without increasing ICH.
    Ann Intern Med. 2023 Feb 7. doi: 10.7326/J22-0120.
    PubMed     Abstract available


  40. LO B
    In basilar-artery occlusion stroke, thrombectomy improved functional outcome at 90 d but increased ICH.
    Ann Intern Med. 2023 Feb 7. doi: 10.7326/J22-0119.
    PubMed     Abstract available


  41. SCHECTMAN JM
    In high-risk outpatients with COVID-19, neither colchicine nor aspirin reduced disease progression or death at 45 d.
    Ann Intern Med. 2023 Feb 7. doi: 10.7326/J22-0118.
    PubMed     Abstract available


    January 2023
  42. LADER EW
    In rheumatic heart disease-associated AF, rivaroxaban increased adverse vascular outcomes vs. VKA at 3 y.
    Ann Intern Med. 2023;176:JC2.
    PubMed     Abstract available


    December 2022
  43. MAHESHWARI A, Norby FL, Inciardi RM, Wang W, et al
    Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke : A Prospective Cohort Study.
    Ann Intern Med. 2022 Dec 20. doi: 10.7326/M22-1638.
    PubMed     Abstract available


  44. KO D, Benjamin EJ
    Atrial Cardiopathy and Cardioembolic Stroke.
    Ann Intern Med. 2022 Dec 20. doi: 10.7326/M22-3476.
    PubMed    


  45. GOEL A, Malik AH
    In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality.
    Ann Intern Med. 2022 Dec 6. doi: 10.7326/J22-0094.
    PubMed     Abstract available


    November 2022
  46. DONATO AA, Goswami V
    In acute ischemic stroke, thrombectomy was not noninferior to alteplase + thrombectomy for 90-d functional independence.
    Ann Intern Med. 2022 Nov 1. doi: 10.7326/J22-0088.
    PubMed     Abstract available


  47. LAU WCY, Torre CO, Man KKC, Stewart HM, et al
    Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study.
    Ann Intern Med. 2022 Nov 1. doi: 10.7326/M22-0511.
    PubMed     Abstract available


  48. WANG A, Xie X, Tian X, Johnston SC, et al
    Ticagrelor-Aspirin Versus Clopidogrel-Aspirin Among CYP2C19 Loss-of-Function Carriers With Minor Stroke or Transient Ischemic Attack in Relation to Renal Function: A Post Hoc Analysis of the CHANCE-2 Trial.
    Ann Intern Med. 2022 Nov 1. doi: 10.7326/M22-1667.
    PubMed     Abstract available


  49. FERGUSON E, Lang E
    In acute ischemic stroke, early IV tenecteplase was noninferior to alteplase for excellent functional outcome.
    Ann Intern Med. 2022 Nov 1. doi: 10.7326/J22-0090.
    PubMed     Abstract available


    October 2022
  50. DAWWAS GK, Cuker A, Barnes GD, Lewis JD, et al
    Apixaban Versus Rivaroxaban in Patients With Atrial Fibrillation and Valvular Heart Disease : A Population-Based Study.
    Ann Intern Med. 2022 Oct 18. doi: 10.7326/M22-0318.
    PubMed     Abstract available


  51. CHOI JG, Winn AN, Skandari MR, Franco MI, et al
    First-Line Therapy for Type 2 Diabetes With Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists : A Cost-Effectiveness Study.
    Ann Intern Med. 2022 Oct 4. doi: 10.7326/M21-2941.
    PubMed     Abstract available


    September 2022
  52. ESKIN B
    In ischemic stroke, IV alteplase within 3 h of onset improves functional outcome vs. control.
    Ann Intern Med. 2022 Sep 6. doi: 10.7326/J22-0069.
    PubMed     Abstract available


  53. KIM D, Yang PS, You SC, Jang E, et al
    Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients : A Nationwide Propensity Score-Weighted Study.
    Ann Intern Med. 2022 Sep 6. doi: 10.7326/M21-4798.
    PubMed     Abstract available


    August 2022
  54. INOUE-CHOI M, Ramirez Y, Cornelis MC, Berrington de Gonzalez A, et al
    Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank : A Prospective Cohort Study.
    Ann Intern Med. 2022 Aug 30. doi: 10.7326/M22-0041.
    PubMed     Abstract available


  55. BOTTON J, Jabagi MJ, Bertrand M, Baricault B, et al
    Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following COVID-19 Vaccines in Adults Younger Than 75 Years in France.
    Ann Intern Med. 2022 Aug 23. doi: 10.7326/M22-0988.
    PubMed     Abstract available


  56. CHEW DS, Zhou K, Pokorney SD, Matchar DB, et al
    Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation : A Decision Analysis.
    Ann Intern Med. 2022 Aug 16. doi: 10.7326/M21-4653.
    PubMed     Abstract available


  57. KANTHARIA BK
    Left Atrial Appendage Occlusion Versus Anticoagulation in Atrial Fibrillation: Equipoise When Bleeding Risk Is High.
    Ann Intern Med. 2022 Aug 16. doi: 10.7326/M22-2271.
    PubMed    



  58. Summary for Patients: Occlusion Devices Versus Blood Thinners for Atrial Fibrillation.
    Ann Intern Med. 2022 Aug 16. doi: 10.7326/P22-0015.
    PubMed    


    July 2022
  59. SIONTIS KC, Gersh BJ, Weston SA, Jiang R, et al
    Associations of Atrial Fibrillation After Noncardiac Surgery With Stroke, Subsequent Arrhythmia, and Death : A Cohort Study.
    Ann Intern Med. 2022 Jul 26. doi: 10.7326/M22-0434.
    PubMed     Abstract available


    June 2022
  60. LO BM, Carpenter CR
    In acute stroke with a large ischemic region, endovascular therapy improved functional status at 90 d.
    Ann Intern Med. 2022 Jun 7. doi: 10.7326/J22-0035.
    PubMed     Abstract available


    May 2022
  61. SHIN H, Schneeweiss S, Glynn RJ, Patorno E, et al
    Cardiovascular Outcomes in Patients Initiating First-Line Treatment of Type 2 Diabetes With Sodium-Glucose Cotransporter-2 Inhibitors Versus Metformin : A Cohort Study.
    Ann Intern Med. 2022 May 24. doi: 10.7326/M21-4012.
    PubMed     Abstract available


  62. KRYCHTIUK KA, Granger CB
    In older persons at risk for dementia, a multidomain approach reduced stroke and transient ischemic attack.
    Ann Intern Med. 2022 May 3. doi: 10.7326/J22-0030.
    PubMed     Abstract available


    April 2022
  63. HOLT A, Blanche P, Jensen AKG, Nouhravesh N, et al
    Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study.
    Ann Intern Med. 2022 Apr 19. doi: 10.7326/M21-3445.
    PubMed     Abstract available


  64. LIN K, Lang E
    In ischemic stroke upon wakening, IV thrombolysis or EVT improves functional outcome at 90 d.
    Ann Intern Med. 2022 Apr 5. doi: 10.7326/J22-0020.
    PubMed     Abstract available


  65. ESKIN B
    In acute ischemic stroke, EVT alone vs. IV alteplase plus EVT did not differ for functional outcome at 90 d.
    Ann Intern Med. 2022 Apr 5. doi: 10.7326/J22-0016.
    PubMed     Abstract available


    March 2022
  66. JOUNDI RA
    In patients with stroke or TIA and CYP2C19 loss-of-function alleles, ticagrelor vs. clopidogrel reduced 90-d stroke.
    Ann Intern Med. 2022;175:JC30.
    PubMed     Abstract available


    February 2022
  67. HUANG HK, Liu PP, Lin SM, Hsu JY, et al
    Diabetes-Related Complications and Mortality in Patients With Atrial Fibrillation Receiving Different Oral Anticoagulants : A Nationwide Analysis.
    Ann Intern Med. 2022 Feb 15. doi: 10.7326/M21-3498.
    PubMed     Abstract available


    January 2022
  68. SEE I, Lale A, Marquez P, Streiff MB, et al
    Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination-United States, December 2020 to August 2021.
    Ann Intern Med. 2022 Jan 18. doi: 10.7326/M21-4502.
    PubMed     Abstract available


  69. YOUSUFUDDIN M, Jahangir A
    In older patients at high risk for stroke, intensive AF screening with an implantable loop recorder did not reduce stroke.
    Ann Intern Med. 2022;175:JC8.
    PubMed     Abstract available


    December 2021
  70. YEAP BB, Marriott RJ, Antonio L, Raj S, et al
    Associations of Serum Testosterone and Sex Hormone-Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men.
    Ann Intern Med. 2021 Dec 28. doi: 10.7326/M21-0551.
    PubMed     Abstract available


  71. KANNER L, Glatt AE
    Patients with COVID-19 had increased risk for acute MI and ischemic stroke at 14 d vs. matched controls.
    Ann Intern Med. 2021 Dec 7. doi: 10.7326/ACPJ202112210.
    PubMed     Abstract available


    September 2021
  72. PATORNO E, Htoo PT, Glynn RJ, Schneeweiss S, et al
    Sodium-Glucose Cotransporter-2 Inhibitors Versus Glucagon-like Peptide-1 Receptor Agonists and the Risk for Cardiovascular Outcomes in Routine Care Patients With Diabetes Across Categories of Cardiovascular Disease.
    Ann Intern Med. 2021 Sep 28. doi: 10.7326/M21-0893.
    PubMed     Abstract available


    July 2021
  73. KIM DH, Pawar A, Gagne JJ, Bessette LG, et al
    Frailty and Clinical Outcomes of Direct Oral Anticoagulants Versus Warfarin in Older Adults With Atrial Fibrillation : A Cohort Study.
    Ann Intern Med. 2021 Jul 20. doi: 10.7326/M20-7141.
    PubMed     Abstract available


    April 2021
  74. HILL MD
    In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d.
    Ann Intern Med. 2021 Apr 6. doi: 10.7326/ACPJ202104200.
    PubMed     Abstract available


    March 2021
  75. DAWWAS GK, Dietrich E, Cuker A, Barnes GD, et al
    Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation : A Population-Based Cohort Study.
    Ann Intern Med. 2021 Mar 30. doi: 10.7326/M20-6194.
    PubMed     Abstract available


    January 2021
  76. STEINBERG DI
    In older patients with AF, low-dose edoxaban reduced stroke or systemic embolism without increasing major bleeding.
    Ann Intern Med. 2021;174:JC5.
    PubMed     Abstract available


    December 2020
  77. HILL MD
    In acute ischemic stroke or TIA, adding ticagrelor to aspirin reduced stroke or death and increased severe bleeding.
    Ann Intern Med. 2020;173:JC63.
    PubMed     Abstract available


  78. AGGARWAL G, Aggarwal S, Cohen M
    Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
    Ann Intern Med. 2020;173:945.
    PubMed    


  79. KUMAR P, Mojadidi MK, Tobis JM
    Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
    Ann Intern Med. 2020;173:944-945.
    PubMed    


  80. KARAGIANNI A, Eriksson P, Dellborg M
    Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
    Ann Intern Med. 2020;173:945-946.
    PubMed    


  81. DENG W, Yin S, McMullin D, Inglessis-Azuaje I, et al
    Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
    Ann Intern Med. 2020;173:946-947.
    PubMed    


    September 2020
  82. ELGENDY IY
    In established atherosclerosis, P2Y12 inhibitor vs. aspirin monotherapy reduces MI but not stroke or mortality.
    Ann Intern Med. 2020;173:JC26.
    PubMed     Abstract available


    June 2020
  83. KUSSMAUL WG 3RD
    Different Strokes.
    Ann Intern Med. 2020;172:761-762.
    PubMed    


  84. DENG W, Yin S, McMullin D, Inglessis-Azuaje I, et al
    Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence: A Prospective Cohort Study.
    Ann Intern Med. 2020;172:717-725.
    PubMed     Abstract available


    May 2020
  85. LAU WCY, Cheung CL, Man KKC, Chan EW, et al
    Association Between Treatment With Apixaban, Dabigatran, Rivaroxaban, or Warfarin and Risk for Osteoporotic Fractures Among Patients With Atrial Fibrillation.
    Ann Intern Med. 2020 May 19. doi: 10.7326/M19-3671.
    PubMed     Abstract available


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