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Articles published in J Clin Invest

Retrieve available abstracts of 64 articles:
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Single Articles


    September 2025
  1. PARK SH, Cheon DH, Kim YM, Choi Y, et al
    NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models.
    J Clin Invest. 2025;135:e183093.
    PubMed     Abstract available


  2. JI L, Yan J, Losurdo NA, Wang H, et al
    Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.
    J Clin Invest. 2025;135:e186119.
    PubMed     Abstract available


  3. YANG J, Jiang Z, Fitzgerald DC, Ma C, et al
    Retraction of Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.
    J Clin Invest. 2025;135:e198608.
    PubMed    


  4. DENG Z, Law CS, Kurra S, Simchoni N, et al
    Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity.
    J Clin Invest. 2025;135:e180252.
    PubMed     Abstract available


  5. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Corrigendum to Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2025;135:e198274.
    PubMed    


    August 2025
  6. XU T, Heon-Roberts R, Moore T, Dubot P, et al
    Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.
    J Clin Invest. 2025;135:e177430.
    PubMed     Abstract available


    July 2025
  7. SAKA S, Lu Z, Wang Y, Liu P, et al
    Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice.
    J Clin Invest. 2025 Jul 29:e188140. doi: 10.1172/JCI188140.
    PubMed     Abstract available


  8. SHAO JS, Lai AC, Huang WC, Wu KC, et al
    Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s.
    J Clin Invest. 2025 Jul 17:e187372. doi: 10.1172/JCI187372.
    PubMed     Abstract available


  9. SINGH AK, Bernabucci M, Dvorak NM, Haghighijoo Z, et al
    Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.
    J Clin Invest. 2025;135:e183749.
    PubMed     Abstract available


  10. HUGHES EP, Syage AR, Mirzaei Mehrabad E, Lane TE, et al
    OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.
    J Clin Invest. 2025;135:e187862.
    PubMed     Abstract available


    June 2025
  11. TOMISHIMA SA, Kim DD, Porter N, Guha I, et al
    The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice.
    J Clin Invest. 2025 Jun 26:e180913. doi: 10.1172/JCI180913.
    PubMed     Abstract available


    May 2025
  12. D'ADDIO F, Amabile G, Assi E, Maestroni A, et al
    TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.
    J Clin Invest. 2025;135:e185783.
    PubMed     Abstract available


  13. SCHLEGEL N
    Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial stem cell defects in inflammatory bowel disease.
    J Clin Invest. 2025;135:e192640.
    PubMed     Abstract available


  14. HUANG Y, Xie X, Liu M, Zhang Y, et al
    Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.
    J Clin Invest. 2025;135:e183607.
    PubMed     Abstract available


    April 2025
  15. GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al
    Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes.
    J Clin Invest. 2025;135:e183513.
    PubMed     Abstract available


  16. GAO C, Dai Y, Spezza PA, Boasiako P, et al
    Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation.
    J Clin Invest. 2025;135:e189801.
    PubMed     Abstract available


  17. KANG M, Choi J, Han J, Araki T, et al
    Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.
    J Clin Invest. 2025;135:e176631.
    PubMed     Abstract available


    March 2025
  18. DELAFONTAINE S, Meyts I
    Oncostatin M silence and neopeptide: the value of exploring patients with rare inherited bone marrow failure.
    J Clin Invest. 2025;135:e190955.
    PubMed     Abstract available


    February 2025
  19. LI H, Liu P, Xu S, Li Y, et al
    FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
    J Clin Invest. 2025;135:e191424.
    PubMed    


  20. WEI W, Gao X, Qian J, Li L, et al
    Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival.
    J Clin Invest. 2025;135:e177375.
    PubMed     Abstract available


    January 2025
  21. HAMAMOTO K, Zhu G, Lai Q, Lesperance J, et al
    HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.
    J Clin Invest. 2025;135:e184743.
    PubMed     Abstract available


  22. CUI X, Hou L, Yan B, Liu J, et al
    Sex dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling.
    J Clin Invest. 2025 Jan 21:e182125. doi: 10.1172/JCI182125.
    PubMed     Abstract available


  23. GRIFFITH JW, Luster AD
    No bones about it: regulatory T cells promote fracture healing.
    J Clin Invest. 2025;135:e188368.
    PubMed     Abstract available


  24. LI J, Bai J, Pham VT, Hashimoto M, et al
    Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells.
    J Clin Invest. 2025 Jan 9:e184069. doi: 10.1172/JCI184069.
    PubMed     Abstract available


  25. CHEN S, Huang C, Li K, Cheng M, et al
    Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice.
    J Clin Invest. 2025;135:e180893.
    PubMed     Abstract available


  26. CHEN YT, Jiang MM, Leynes C, Adeyeye M, et al
    ATRX silences Cartpt expression in osteoblastic cells during skeletal development.
    J Clin Invest. 2025;135:e163587.
    PubMed     Abstract available


  27. CAMPBELL K, Li Q
    Clonal hematopoiesis JAKs up plaque formation.
    J Clin Invest. 2025;135:e187529.
    PubMed     Abstract available


  28. WANG BZ, Morsink MA, Kim SW, Luo LJ, et al
    Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
    J Clin Invest. 2025;135:e181630.
    PubMed     Abstract available


    December 2024
  29. SAARELA D, Lis P, Gomes S, Nirujogi RS, et al
    Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.
    J Clin Invest. 2024;135:e183592.
    PubMed     Abstract available


  30. DEFAMIE V, Aliar K, Sarkar S, Vyas F, et al
    Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury.
    J Clin Invest. 2024;135:e164997.
    PubMed     Abstract available


  31. KIM Y, Kim SW, Saul D, Neyazi M, et al
    Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
    J Clin Invest. 2024;135:e183353.
    PubMed     Abstract available


  32. WU Q, Yu C, Yu F, Guo Y, et al
    Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells.
    J Clin Invest. 2024;134:e173403.
    PubMed     Abstract available


  33. PEACH T, Quattrocelli M
    The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals.
    J Clin Invest. 2024;134:e185054.
    PubMed     Abstract available


  34. WANG Q, Hu T, Zhang Q, Zhang Y, et al
    Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells.
    J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595.
    PubMed     Abstract available


    November 2024
  35. NAYAK RC, Emberesh S, Trump LR, Wellendorf AM, et al
    G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates.
    J Clin Invest. 2024;135:e177342.
    PubMed     Abstract available


  36. WANG S, Huang T, Wu Q, Yuan H, et al
    Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation.
    J Clin Invest. 2024;134:e176851.
    PubMed     Abstract available


  37. ANCEL S, Michaud J, Migliavacca E, Jomard C, et al
    Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
    J Clin Invest. 2024 Nov 12:e163648. doi: 10.1172/JCI163648.
    PubMed     Abstract available


  38. PALLAVICINI G, Moccia A, Iegiani G, Parolisi R, et al
    Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity.
    J Clin Invest. 2024;134:e175435.
    PubMed     Abstract available


    October 2024
  39. LIU Q, Huang J, Ding H, Tao Y, et al
    Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity.
    J Clin Invest. 2024;134:e177077.
    PubMed     Abstract available


  40. SINHA S, Callow BW, Farfel AP, Roy S, et al
    Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels.
    J Clin Invest. 2024;134:e170953.
    PubMed     Abstract available


  41. GHOTBI E, Tchegnon E, Chen Z, Li S, et al
    Transcription factor KROX20 marks epithelial stem cells for hair follicle formation.
    J Clin Invest. 2024 Oct 3:e180160. doi: 10.1172/JCI180160.
    PubMed     Abstract available


  42. CHEN CL, Tsukamoto H, Liu JC, Kashiwabara C, et al
    Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
    J Clin Invest. 2024;134:e186923.
    PubMed    


    September 2024
  43. YANG H, Ping X, Zhou J, Ailifeire H, et al
    Reversible cold-induced lens opacity in a hibernator reveals a molecular target for treating cataracts.
    J Clin Invest. 2024;134:e169666.
    PubMed     Abstract available


  44. LIU H, Zhao XF, Lu YN, Hayes LR, et al
    CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA.
    J Clin Invest. 2024;134:e179016.
    PubMed     Abstract available


  45. DESCHAMPS P, Wacheux M, Gosseye A, Morabito M, et al
    CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia.
    J Clin Invest. 2024;134:e180738.
    PubMed     Abstract available


  46. XING W, Feng H, Jiang B, Gao B, et al
    Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing.
    J Clin Invest. 2024;134:e176528.
    PubMed     Abstract available


    August 2024
  47. BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al
    Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single cell analyses.
    J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331.
    PubMed     Abstract available


  48. WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al
    MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.
    J Clin Invest. 2024;134:e168393.
    PubMed     Abstract available


  49. SRIDHAR A, DeSantiago J, Chen H, Pavel MA, et al
    Modulation of NOX2 causes obesity-mediated atrial fibrillation.
    J Clin Invest. 2024;134:e175447.
    PubMed     Abstract available


  50. SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al
    CHIP: a clonal odyssey of the bone marrow niche.
    J Clin Invest. 2024;134:e180068.
    PubMed     Abstract available


    July 2024
  51. WU K, Zhang Y, Yin-DeClue H, Sun K, et al
    A correctable immune niche for epithelial stem-cell reprogramming and post-viral lung diseases.
    J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092.
    PubMed     Abstract available


    June 2024
  52. MAROM R, Song IW, Busse EC, Washington ME, et al
    The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.
    J Clin Invest. 2024;134:e170369.
    PubMed     Abstract available


    May 2024
  53. SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al
    Susceptibility to innate immune activation in genetically mediated myocarditis.
    J Clin Invest. 2024;134:e180254.
    PubMed     Abstract available


  54. SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al
    Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
    J Clin Invest. 2024;134:e179834.
    PubMed     Abstract available


  55. LEOW DM, Ng YK, Wang LC, Koh HW, et al
    Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy.
    J Clin Invest. 2024;134:e173702.
    PubMed     Abstract available


  56. LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al
    Generation of allogenic and xenogeneic functional muscle stem cells for intramuscular transplantation.
    J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998.
    PubMed     Abstract available


    April 2024
  57. MOE A, Rayasam A, Sauber G, Shah RK, et al
    Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease.
    J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205.
    PubMed     Abstract available


  58. SONG X, Tiek D, Miki S, Huang T, et al
    RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.
    J Clin Invest. 2024;134:e173789.
    PubMed     Abstract available


  59. KEAN LS, Blazar BR
    Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation.
    J Clin Invest. 2024;134:e179944.
    PubMed    


  60. NORTH D, Chakraverty R
    The road to refractory graft-versus-host disease is paved with good intentions.
    J Clin Invest. 2024;134:e177728.
    PubMed     Abstract available


  61. ZHANG P, Fleming P, Andoniou CE, Waltner OG, et al
    IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.
    J Clin Invest. 2024;134:e174184.
    PubMed     Abstract available


    March 2024
  62. MA H, Lu C, Ziegler J, Liu A, et al
    Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.
    J Clin Invest. 2024;134:e180350.
    PubMed    


  63. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2024;134:e167369.
    PubMed     Abstract available


    January 2024
  64. LUO M, Bao L, Xue Y, Zhu M, et al
    ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.
    J Clin Invest. 2024;134:e171166.
    PubMed     Abstract available


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