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Articles published in J Clin Invest

Retrieve available abstracts of 111 articles:
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Single Articles


    August 2026
  1. SHIRAI T, Kuzuya K, Kishi M, Ichikawa S, et al
    Migration-dependent extrafollicular programming of preplasmablast age-associated B cells drives lupus pathogenesis.
    J Clin Invest. 2026;136:e204095.
    PubMed     Abstract available


  2. LIN Y, Gu Q, Lu S, Pan Z, et al
    Second corrigendum to Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease.
    J Clin Invest. 2026;136:e210543.
    PubMed    


  3. HOLZMULLER V, Gawron J, Burk AC, Stell AV, et al
    Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.
    J Clin Invest. 2026 Aug 4:e205864. doi: 10.1172/JCI205864.
    PubMed     Abstract available


  4. WU W, Zhang P, Wang D, Wu X, et al
    Corrigendum to Cancer stem cells synthesize proline to attenuate oxidative stress.
    J Clin Invest. 2026;136:e210189.
    PubMed    


    July 2026
  5. RAMSEY AC, Tang XY, Macias MJ, Nano PR, et al
    TGF-beta signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration.
    J Clin Invest. 2026;136:e190035.
    PubMed     Abstract available


  6. ARABZADEH M, Tang YH, Colin-Leitzinger C, Marzban S, et al
    Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes.
    J Clin Invest. 2026;136:e204429.
    PubMed     Abstract available


    June 2026
  7. WEYAND CM, Goronzy JJ
    Immune responses in aging adults.
    J Clin Invest. 2026;136:e206227.
    PubMed     Abstract available


  8. ZHANG X, Liu X, Qiao Y, Rabata A, et al
    Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis.
    J Clin Invest. 2026;136:e198031.
    PubMed     Abstract available


  9. WU W, Zhang P, Wang D, Wu X, et al
    Cancer stem cells synthesize proline to attenuate oxidative stress.
    J Clin Invest. 2026;136:e200775.
    PubMed     Abstract available


    May 2026
  10. TANAKA M, Kim NC, Draper I, Littel HR, et al
    Deficiency of muscular dystrophy-related gene JAG2 causes NOTCH signaling dysfunction in muscle stem cells.
    J Clin Invest. 2026 May 19:e198639. doi: 10.1172/JCI198639.
    PubMed     Abstract available


  11. KIM TW, Piao J, Bocchi VD, Koo SY, et al
    Modulation of WNT and FGF18 enhances yield and subtype identity of hPSC-derived midbrain dopamine neurons.
    J Clin Invest. 2026;136:e190954.
    PubMed     Abstract available


  12. BASAKIS P, Shih LK, Li J, Brat DJ, et al
    Uncovering a feedback loop in glioblastoma that reinforces stemness and immunosuppression.
    J Clin Invest. 2026;136:e205841.
    PubMed     Abstract available


  13. ZHOU F, Pang L, Liu Y, Khan F, et al
    Symbiotic exclusivity between CLOCK and TFPI2 drives stemness and immunosuppression in glioblastoma models.
    J Clin Invest. 2026;136:e199056.
    PubMed     Abstract available


  14. GHERARDINI J, Samra T, Gomez-Gomez T, Akhundlu A, et al
    Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy.
    J Clin Invest. 2026;136:e174447.
    PubMed     Abstract available


  15. GU W, Wang X, Solmonson A, Cai L, et al
    l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.
    J Clin Invest. 2026;136:e197010.
    PubMed     Abstract available


    April 2026
  16. ZHANG S, Liu J, Li Y, Wang Y, et al
    Physiological MplW514L expression in hematopoietic stem cell causes an essential thrombocythemia and progressive myelofibrosis.
    J Clin Invest. 2026 Apr 23:e199690. doi: 10.1172/JCI199690.
    PubMed     Abstract available


  17. MA X, Nettleford SK, Tian Y, Dawany N, et al
    TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics.
    J Clin Invest. 2026;136:e186032.
    PubMed     Abstract available


  18. HOFBAUER LC, Rauner M
    Deconstructing senescence phenotypes in cells of the bone and bone marrow.
    J Clin Invest. 2026;136:e204645.
    PubMed     Abstract available


  19. DOOLITTLE ML, Froemming MN, Rowsey JL, Ruan M, et al
    Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.
    J Clin Invest. 2026;136:e195772.
    PubMed     Abstract available


    March 2026
  20. SHI H, Yao H, Liu Y, Fan M, et al
    BM-derived mesenchymal stem cell microvesicles protect enteric neural precursor cells and alleviate diabetes-associated enteric neuropathy.
    J Clin Invest. 2026;136:e192437.
    PubMed     Abstract available


  21. LIAN C, Peng W, Su P, Ye Y, et al
    Notch1 O-GlcNAcylation drives tumor stemness and mechanoadaptation to a stiff microenvironment and promotes chordoma recurrence.
    J Clin Invest. 2026;136:e194378.
    PubMed     Abstract available


  22. DE STEFANO MA, Ambrosio R, Luongo C, Porcelli T, et al
    Type 2 deiodinase-dependent surge in thyroid hormone controls muscle stem cell quiescence and self-renewal.
    J Clin Invest. 2026 Mar 5:e194925. doi: 10.1172/JCI194925.
    PubMed     Abstract available


  23. SONG P, Chen C, Franchini R, Duong B, et al
    N-acetyl-l-leucine lowers alpha-synuclein levels and improves synaptic function in Parkinson's disease models.
    J Clin Invest. 2026;136:e196137.
    PubMed     Abstract available


  24. SUN R, Gao C, Lu RO
    Tumor-intrinsic chromatin programs enforce immune evasion in glioblastoma.
    J Clin Invest. 2026;136:e203222.
    PubMed     Abstract available


  25. ZHU X, John AJ, Kim S, Wang L, et al
    Alcohol use disorder-associated gene FNDC4 alters glutamatergic and GABAergic neurogenesis in neural organoids.
    J Clin Invest. 2026;136:e193204.
    PubMed     Abstract available


    February 2026
  26. MARTENS MJ, Dutta D, Yu Y, Rein LE, et al
    The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers.
    J Clin Invest. 2026;136:e195228.
    PubMed     Abstract available


  27. KONISHI S, Enkhbayar K, Liu S, Miyashita N, et al
    TP53/TAU axis regulates microtubule bundling to control alveolar stem cell mediated regeneration.
    J Clin Invest. 2026 Feb 5:e194762. doi: 10.1172/JCI194762.
    PubMed     Abstract available


  28. CHEN S, Barajas S, Vemula S, Yang Y, et al
    Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.
    J Clin Invest. 2025;136:e184285.
    PubMed     Abstract available


    January 2026
  29. WU Z, Li N, Luo Z, Chen Z, et al
    Corrigendum to Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.
    J Clin Invest. 2026;136:e203674.
    PubMed    


  30. YUAN F, Wu X, Yuan H, Wang D, et al
    Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels.
    J Clin Invest. 2026;136:e192599.
    PubMed     Abstract available


  31. WU H, Zhong X, Ma N, He Z, et al
    Selective disruption of RORgammat-CBFbeta interaction by IMU-935 prevents RORgammat-dependent Th17 autoimmunity but not thymocyte development.
    J Clin Invest. 2026;136:e185942.
    PubMed     Abstract available


    December 2025
  32. CHEN HC, Bang MF, Wang HH, Shpargel KB, et al
    UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes.
    J Clin Invest. 2025 Dec 16:e196325. doi: 10.1172/JCI196325.
    PubMed     Abstract available


  33. LEUNG CON, Gurung S, Chung KPS, Leung RWH, et al
    Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver-induced hepatocellular carcinoma by driving ITGB1-mediated beta-catenin activation.
    J Clin Invest. 2025;135:e182322.
    PubMed     Abstract available


  34. ADACHI Y, Chen W, Zhang C, Wang T, et al
    Targeting kinesin family member 20A sensitizes stem-like triple-negative breast cancer cells to standard chemotherapy.
    J Clin Invest. 2025;135:e182394.
    PubMed     Abstract available


  35. GU H, Weng L, Chen C, Hao X, et al
    Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche.
    J Clin Invest. 2025;135:e189051.
    PubMed     Abstract available


  36. WU Z, Li N, Luo Z, Chen Z, et al
    Expression of Concern for Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.
    J Clin Invest. 2025;135:e202595.
    PubMed    


    November 2025
  37. KINCROSS H, Mo YA, Wang X, Chang L, et al
    Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1.
    J Clin Invest. 2025 Nov 25:e181943. doi: 10.1172/JCI181943.
    PubMed     Abstract available


  38. LIN Y, Gu Q, Lu S, Pan Z, et al
    Corrigendum to Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease.
    J Clin Invest. 2025;135:e200847.
    PubMed    


  39. TAMBRALLI A, Knight JS
    Neutrophils take center stage in VEXAS syndrome pathogenesis.
    J Clin Invest. 2025;135:e199299.
    PubMed     Abstract available


  40. DONG G, Liu J, Jin W, Zhou H, et al
    UBA1-depleted neutrophils disrupt immune homeostasis and induce VEXAS-like autoinflammatory disease in mice.
    J Clin Invest. 2025;135:e193011.
    PubMed     Abstract available


    October 2025
  41. SINGH B, Hossain MA, Liang XH, Fages J, et al
    Lnk Deficiency Enhances Translesion Synthesis to Alleviate Replication Stress and Promote Hematopoietic Stem Cell Fitness.
    J Clin Invest. 2025 Oct 30:e191713. doi: 10.1172/JCI191713.
    PubMed     Abstract available


  42. MULLIN C, Lin K, Choe E, Sha C, et al
    The hematopoietic stem cell MYB enhancer is essential and recurrently amplified during T-cell leukemogenesis.
    J Clin Invest. 2025 Oct 23:e187998. doi: 10.1172/JCI187998.
    PubMed     Abstract available


  43. MEI Y, Xu Y, Zhang X, Feng B, et al
    3D cultured human medium spiny neurons functionally integrate and rescue motor deficits in Huntington's disease mice.
    J Clin Invest. 2025;135:e187941.
    PubMed     Abstract available


  44. MO J, Anastasaki C, Chen Z, Shipman T, et al
    Corrigendum for Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.
    J Clin Invest. 2025;135:e199700.
    PubMed    


  45. WU Z, Li N, Luo Z, Chen Z, et al
    Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.
    J Clin Invest. 2025;135:e193014.
    PubMed     Abstract available


  46. DUVAL AJ, Seker-Polat F, Rogozinska M, Kinali M, et al
    SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer.
    J Clin Invest. 2025;135:e186467.
    PubMed     Abstract available


    September 2025
  47. PARK SH, Cheon DH, Kim YM, Choi Y, et al
    NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models.
    J Clin Invest. 2025;135:e183093.
    PubMed     Abstract available


  48. JI L, Yan J, Losurdo NA, Wang H, et al
    Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.
    J Clin Invest. 2025;135:e186119.
    PubMed     Abstract available


  49. YANG J, Jiang Z, Fitzgerald DC, Ma C, et al
    Retraction of Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.
    J Clin Invest. 2025;135:e198608.
    PubMed    


  50. VIRGILIO E, Tielens S, Bonfield G, Nian FS, et al
    Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome.
    J Clin Invest. 2025 Sep 9:e195756. doi: 10.1172/JCI195756.
    PubMed     Abstract available


  51. DENG Z, Law CS, Kurra S, Simchoni N, et al
    Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity.
    J Clin Invest. 2025;135:e180252.
    PubMed     Abstract available


  52. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Corrigendum to Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2025;135:e198274.
    PubMed    


    August 2025
  53. XU T, Heon-Roberts R, Moore T, Dubot P, et al
    Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.
    J Clin Invest. 2025;135:e177430.
    PubMed     Abstract available


    July 2025
  54. SAKA S, Lu Z, Wang Y, Liu P, et al
    Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice.
    J Clin Invest. 2025 Jul 29:e188140. doi: 10.1172/JCI188140.
    PubMed     Abstract available


  55. SHAO JS, Lai AC, Huang WC, Wu KC, et al
    Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s.
    J Clin Invest. 2025 Jul 17:e187372. doi: 10.1172/JCI187372.
    PubMed     Abstract available


  56. SINGH AK, Bernabucci M, Dvorak NM, Haghighijoo Z, et al
    Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.
    J Clin Invest. 2025;135:e183749.
    PubMed     Abstract available


  57. HUGHES EP, Syage AR, Mirzaei Mehrabad E, Lane TE, et al
    OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.
    J Clin Invest. 2025;135:e187862.
    PubMed     Abstract available


    June 2025
  58. TOMISHIMA SA, Kim DD, Porter N, Guha I, et al
    The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice.
    J Clin Invest. 2025 Jun 26:e180913. doi: 10.1172/JCI180913.
    PubMed     Abstract available


    May 2025
  59. D'ADDIO F, Amabile G, Assi E, Maestroni A, et al
    TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.
    J Clin Invest. 2025;135:e185783.
    PubMed     Abstract available


  60. SCHLEGEL N
    Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial stem cell defects in inflammatory bowel disease.
    J Clin Invest. 2025;135:e192640.
    PubMed     Abstract available


  61. HUANG Y, Xie X, Liu M, Zhang Y, et al
    Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.
    J Clin Invest. 2025;135:e183607.
    PubMed     Abstract available


    April 2025
  62. GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al
    Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes.
    J Clin Invest. 2025;135:e183513.
    PubMed     Abstract available


  63. GAO C, Dai Y, Spezza PA, Boasiako P, et al
    Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation.
    J Clin Invest. 2025;135:e189801.
    PubMed     Abstract available


  64. KANG M, Choi J, Han J, Araki T, et al
    Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.
    J Clin Invest. 2025;135:e176631.
    PubMed     Abstract available


    March 2025
  65. DELAFONTAINE S, Meyts I
    Oncostatin M silence and neopeptide: the value of exploring patients with rare inherited bone marrow failure.
    J Clin Invest. 2025;135:e190955.
    PubMed     Abstract available


    February 2025
  66. LI H, Liu P, Xu S, Li Y, et al
    FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
    J Clin Invest. 2025;135:e191424.
    PubMed    


  67. WEI W, Gao X, Qian J, Li L, et al
    Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival.
    J Clin Invest. 2025;135:e177375.
    PubMed     Abstract available


    January 2025
  68. HAMAMOTO K, Zhu G, Lai Q, Lesperance J, et al
    HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.
    J Clin Invest. 2025;135:e184743.
    PubMed     Abstract available


  69. CUI X, Hou L, Yan B, Liu J, et al
    Sex dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling.
    J Clin Invest. 2025 Jan 21:e182125. doi: 10.1172/JCI182125.
    PubMed     Abstract available


  70. GRIFFITH JW, Luster AD
    No bones about it: regulatory T cells promote fracture healing.
    J Clin Invest. 2025;135:e188368.
    PubMed     Abstract available


  71. LI J, Bai J, Pham VT, Hashimoto M, et al
    Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells.
    J Clin Invest. 2025 Jan 9:e184069. doi: 10.1172/JCI184069.
    PubMed     Abstract available


  72. CHEN S, Huang C, Li K, Cheng M, et al
    Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice.
    J Clin Invest. 2025;135:e180893.
    PubMed     Abstract available


  73. CHEN YT, Jiang MM, Leynes C, Adeyeye M, et al
    ATRX silences Cartpt expression in osteoblastic cells during skeletal development.
    J Clin Invest. 2025;135:e163587.
    PubMed     Abstract available


  74. CAMPBELL K, Li Q
    Clonal hematopoiesis JAKs up plaque formation.
    J Clin Invest. 2025;135:e187529.
    PubMed     Abstract available


  75. WANG BZ, Morsink MA, Kim SW, Luo LJ, et al
    Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
    J Clin Invest. 2025;135:e181630.
    PubMed     Abstract available


    December 2024
  76. SAARELA D, Lis P, Gomes S, Nirujogi RS, et al
    Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.
    J Clin Invest. 2024;135:e183592.
    PubMed     Abstract available


  77. DEFAMIE V, Aliar K, Sarkar S, Vyas F, et al
    Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury.
    J Clin Invest. 2024;135:e164997.
    PubMed     Abstract available


  78. KIM Y, Kim SW, Saul D, Neyazi M, et al
    Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
    J Clin Invest. 2024;135:e183353.
    PubMed     Abstract available


  79. WU Q, Yu C, Yu F, Guo Y, et al
    Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells.
    J Clin Invest. 2024;134:e173403.
    PubMed     Abstract available


  80. PEACH T, Quattrocelli M
    The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals.
    J Clin Invest. 2024;134:e185054.
    PubMed     Abstract available


  81. WANG Q, Hu T, Zhang Q, Zhang Y, et al
    Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells.
    J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595.
    PubMed     Abstract available


    November 2024
  82. NAYAK RC, Emberesh S, Trump LR, Wellendorf AM, et al
    G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates.
    J Clin Invest. 2024;135:e177342.
    PubMed     Abstract available


  83. WANG S, Huang T, Wu Q, Yuan H, et al
    Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation.
    J Clin Invest. 2024;134:e176851.
    PubMed     Abstract available


  84. ANCEL S, Michaud J, Migliavacca E, Jomard C, et al
    Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
    J Clin Invest. 2024 Nov 12:e163648. doi: 10.1172/JCI163648.
    PubMed     Abstract available


  85. PALLAVICINI G, Moccia A, Iegiani G, Parolisi R, et al
    Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity.
    J Clin Invest. 2024;134:e175435.
    PubMed     Abstract available


    October 2024
  86. LIU Q, Huang J, Ding H, Tao Y, et al
    Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity.
    J Clin Invest. 2024;134:e177077.
    PubMed     Abstract available


  87. SINHA S, Callow BW, Farfel AP, Roy S, et al
    Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels.
    J Clin Invest. 2024;134:e170953.
    PubMed     Abstract available


  88. GHOTBI E, Tchegnon E, Chen Z, Li S, et al
    Transcription factor KROX20 marks epithelial stem cells for hair follicle formation.
    J Clin Invest. 2024 Oct 3:e180160. doi: 10.1172/JCI180160.
    PubMed     Abstract available


  89. CHEN CL, Tsukamoto H, Liu JC, Kashiwabara C, et al
    Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
    J Clin Invest. 2024;134:e186923.
    PubMed    


    September 2024
  90. YANG H, Ping X, Zhou J, Ailifeire H, et al
    Reversible cold-induced lens opacity in a hibernator reveals a molecular target for treating cataracts.
    J Clin Invest. 2024;134:e169666.
    PubMed     Abstract available


  91. LIU H, Zhao XF, Lu YN, Hayes LR, et al
    CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA.
    J Clin Invest. 2024;134:e179016.
    PubMed     Abstract available


  92. DESCHAMPS P, Wacheux M, Gosseye A, Morabito M, et al
    CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia.
    J Clin Invest. 2024;134:e180738.
    PubMed     Abstract available


  93. XING W, Feng H, Jiang B, Gao B, et al
    Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing.
    J Clin Invest. 2024;134:e176528.
    PubMed     Abstract available


    August 2024
  94. BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al
    Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single cell analyses.
    J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331.
    PubMed     Abstract available


  95. WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al
    MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.
    J Clin Invest. 2024;134:e168393.
    PubMed     Abstract available


  96. SRIDHAR A, DeSantiago J, Chen H, Pavel MA, et al
    Modulation of NOX2 causes obesity-mediated atrial fibrillation.
    J Clin Invest. 2024;134:e175447.
    PubMed     Abstract available


  97. SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al
    CHIP: a clonal odyssey of the bone marrow niche.
    J Clin Invest. 2024;134:e180068.
    PubMed     Abstract available


    July 2024
  98. WU K, Zhang Y, Yin-DeClue H, Sun K, et al
    A correctable immune niche for epithelial stem-cell reprogramming and post-viral lung diseases.
    J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092.
    PubMed     Abstract available


    June 2024
  99. MAROM R, Song IW, Busse EC, Washington ME, et al
    The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.
    J Clin Invest. 2024;134:e170369.
    PubMed     Abstract available


    May 2024
  100. SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al
    Susceptibility to innate immune activation in genetically mediated myocarditis.
    J Clin Invest. 2024;134:e180254.
    PubMed     Abstract available


  101. SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al
    Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
    J Clin Invest. 2024;134:e179834.
    PubMed     Abstract available


  102. LEOW DM, Ng YK, Wang LC, Koh HW, et al
    Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy.
    J Clin Invest. 2024;134:e173702.
    PubMed     Abstract available


  103. LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al
    Generation of allogenic and xenogeneic functional muscle stem cells for intramuscular transplantation.
    J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998.
    PubMed     Abstract available


    April 2024
  104. MOE A, Rayasam A, Sauber G, Shah RK, et al
    Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease.
    J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205.
    PubMed     Abstract available


  105. SONG X, Tiek D, Miki S, Huang T, et al
    RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.
    J Clin Invest. 2024;134:e173789.
    PubMed     Abstract available


  106. KEAN LS, Blazar BR
    Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation.
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