: The AMEDEO Literature Guide

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Sepsis

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Articles published in Crit Care Med
Retrieve available abstracts of 594 articles:
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August 2021

HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
Serum Agmatine Levels Were Negatively Correlated With the Severity of Sepsis: Beware of Potential Confounders!
Crit Care Med. 2021;49:e810-e811.
PubMed

PLOPPER GE, Sciarretta KL, Buchman TG
Disparities in Sepsis Outcomes May Be Attributable to Access to Care.
Crit Care Med. 2021;49:1358-1360.
PubMed

PREST J, Sathananthan M, Jeganathan N
Current Trends in Sepsis-Related Mortality in the United States.
Crit Care Med. 2021;49:1276-1284.
PubMed Abstract available

July 2021

VAZQUEZ GUILLAMET MC, Dodda S, Liu L, Kollef MH, et al
Race Does Not Impact Sepsis Outcomes When Considering Socioeconomic Factors in Multilevel Modeling.
Crit Care Med. 2021 Jul 13. pii: 00003246-900000000-95151.
PubMed Abstract available

SHAPPELL CN, Klompas M, Rhee C
Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond.
Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95161.
PubMed

KARAKIKE E, Giamarellos-Bourboulis EJ, Kyprianou M, Fleischmann-Struzek C, et al
Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.
Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95156.
PubMed Abstract available

Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis: Erratum.
Crit Care Med. 2021;49:e740.
PubMed

HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
Higher Levels of S-100beta-a Biomarker of Astrocyte and Glial Activation Were Associated With a Greater Delirium Duration in Sepsis and Traumatic Brain Injury Patients: Beware of Some Confounders!
Crit Care Med. 2021;49:e736-e737.
PubMed

HONORE PM, Redant S, Preseau T, Kaefer K, et al
Heparin-Binding Protein Performs Better for Detecting Sepsis Among Patients Presenting With Signs of Systemic Infection Compared With Procalcitonin, C-Reactive Protein, and Lactate Level, and Heparin-Binding Protein Is Sufficient for Both Ruling in an
Crit Care Med. 2021;49:e733-e734.
PubMed

STAUNTON O, Staunton C
We Are Not Waiting for a Cure for Sepsis-We Are Waiting for Leadership.
Crit Care Med. 2021;49:1192-1193.
PubMed

SHAH AD, MacCallum NS, Harris S, Brealey DA, et al
Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative.
Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005169.
PubMed Abstract available

HOLDER AL, Shashikumar SP, Wardi G, Buchman TG, et al
A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU.
Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005175.
PubMed Abstract available

June 2021

HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis and Septic Shock: Beware of Some Confounders!
Crit Care Med. 2021;49:e659.
PubMed

OXMAN DA
Less Lumping and More Splitting: Why We Should Not Call COVID Sepsis.
Crit Care Med. 2021;49:e656-e657.
PubMed

May 2021

DE ROQUETAILLADE C, Mansouri S, Brumpt C, Neuwirth M, et al
Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis.
Crit Care Med. 2021 May 18. pii: 00003246-900000000-95220.
PubMed Abstract available

GOETZ G, Hawlik K, Wild C
Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis: An Update Systematic Review of Comparative Efficacy and Safety.
Crit Care Med. 2021 May 3. pii: 00003246-900000000-95226.
PubMed Abstract available

ABRAHAM E
Moving Forward With Refinement of Definitions for Sepsis.
Crit Care Med. 2021;49:861-863.
PubMed

RHEE C, Heil EL
Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis.
Crit Care Med. 2021;49:858-860.
PubMed

April 2021

MOLINARI L, Heskia F, Peerapornratana S, Ronco C, et al
Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
Crit Care Med. 2021 Apr 30. pii: 00003246-900000000-95233.
PubMed Abstract available

TAN K, Harazim M, Simpson A, Tan YC, et al
Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes-The Beta-Blockers in European and Australian/American Septic Patients (BEAST) Study.
Crit Care Med. 2021 Apr 28. doi: 10.1097/CCM.0000000000005034.
PubMed Abstract available

DE CARVALHO LRP, Abreu SC, de Castro LL, Andrade da Silva LH, et al
Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis.
Crit Care Med. 2021 Apr 19. pii: 00003246-900000000-95254.
PubMed Abstract available

OH TK, Park HY, Song IA
Depression and Long-Term Survival Among South Korean Sepsis Survivors: A Nationwide Cohort Study From 2011 to 2014.
Crit Care Med. 2021 Apr 8. pii: 00003246-900000000-95275.
PubMed Abstract available

LAT I, Coopersmith CM, De Backer D
The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
Crit Care Med. 2021;49:623-635.
PubMed Abstract available

CARR AC
Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
Crit Care Med. 2021;49:e477-e478.
PubMed

March 2021

REN X
Potential Endotype Transition for Coronavirus Disease 2019-Related Sepsis With Longitudinal Transcriptome Profiling.
Crit Care Med. 2021 Mar 16. pii: 00003246-900000000-95304.
PubMed

February 2021

BORN S, Dame C, Matthaus-Kramer C, Schlapbach LJ, et al
Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016.
Crit Care Med. 2021 Feb 23. doi: 10.1097/CCM.0000000000004919.
PubMed Abstract available

WANG HE, Kabeto MM, Gray M, Wadley VG, et al
Trajectory of Cognitive Decline After Sepsis.
Crit Care Med. 2021 Feb 18. doi: 10.1097/CCM.0000000000004897.
PubMed Abstract available

TAYLOR SP, Anderson WE, Beam K, Taylor B, et al
The Association Between Antibiotic Delay Intervals and Hospital Mortality Among Patients Treated in the Emergency Department for Suspected Sepsis.
Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95342.
PubMed Abstract available

DEMERLE KM, Angus DC, Baillie JK, Brant E, et al
Sepsis Subclasses: A Framework for Development and Interpretation.
Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95341.
PubMed Abstract available

YU SC, Betthauser KD, Gupta A, Lyons PG, et al
Comparison of Sepsis Definitions as Automated Criteria.
Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95354.
PubMed Abstract available

COOPERSMITH CM, Antonelli M, Bauer SR, Deutschman CS, et al
Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.
Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95348.
PubMed Abstract available

BEESLEY SJ, Sorensen J, Walkey AJ, Tonna JE, et al
Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis.
Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95347.
PubMed Abstract available

JACQUEMET PL, Schweizer R, Ruste M, Pozzi M, et al
Venoarterial Extracorporeal Membranous Oxygenation Should Be Considered as an Appropriate Rescue Therapy for Sepsis-Induced Refractory Cardiogenic Shock.
Crit Care Med. 2021;49:e210-e211.
PubMed

MUNROE E, Prescott HC
Late Mortality From Sepsis: What We Know and What It Means.
Crit Care Med. 2021;49:353-355.
PubMed

ROURKE EM, Kuttab HI, Lykins JD, Hughes MD, et al
Fluid Resuscitation in Septic Patients With Comorbid Heart Failure.
Crit Care Med. 2021;49:e201-e204.
PubMed

TRIPATHI S, Kumar S, Kaushik S
The Practice and Complications of Midline Catheters: A Systematic Review.
Crit Care Med. 2021;49:e140-e150.
PubMed Abstract available

January 2021

ALHAZZANI W, Evans L, Alshamsi F, Moller MH, et al
Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
Crit Care Med. 2021 Jan 28. doi: 10.1097/CCM.0000000000004899.
PubMed Abstract available

KELLUM JA, Artigas A, Gunnerson KJ, Honore PM, et al
Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.
Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004845.
PubMed Abstract available

LIZZA BD, Betthauser KD, Juang PH, Hampton NB, et al
Racial Disparities in Readmissions Following Initial Hospitalization for Sepsis.
Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004809.
PubMed Abstract available

BONAZZETTI C, Morena V, Giacomelli A, Oreni L, et al
Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study.
Crit Care Med. 2021;49:e31-e40.
PubMed Abstract available

HANSON SJ, Patel N, Petersen TL, Feng M, et al
The authors reply.
Crit Care Med. 2021;49:e111-e112.
PubMed

ARCOVERDE DE SOUSA D, Spessoto AB
Peripherally Inserted Central Catheter Versus Central Venous Catheter: It Is Time to Use Different Approaches and Metrics for a More Useful Comparison.
Crit Care Med. 2021;49:e109-e110.
PubMed

BARANOWSKY A, Appelt J, Kleber C, Lange T, et al
Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor.
Crit Care Med. 2021;49:e41-e52.
PubMed Abstract available

VERBOOM DM, van de Groep K, Boel CHE, Haas PJA, et al
The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients.
Crit Care Med. 2021;49:60-69.
PubMed Abstract available

WONG HR, Hart KW, Lindsell CJ, Sweeney TE, et al
External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients.
Crit Care Med. 2021;49:e98-e101.
PubMed Abstract available

SEVRANSKY JE, Agarwal A, Jabaley CS, Rochwerg B, et al
Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients.
Crit Care Med. 2021;49:151-155.
PubMed

December 2020

FARRAH K, McIntyre L, Doig CJ, Talarico R, et al
Sepsis-Associated Mortality, Resource Use, and Healthcare Costs: A Propensity-Matched Cohort Study.
Crit Care Med. 2020 Dec 17. doi: 10.1097/CCM.0000000000004777.
PubMed Abstract available

PLATA-MENCHACA EP, Ferrer R
Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis.
Crit Care Med. 2020 Dec 8. doi: 10.1097/CCM.0000000000004776.
PubMed

ROWE S, Alcheikh A
Harm or Benefit of High-Dose Vitamin C in Adult Patients With Sepsis and Glucose-6-Phosphate Dehydrogenase Deficiency?
Crit Care Med. 2020;48:e1356.
PubMed

KADRI SS
The Sepsis Proxy Pageant: Seeking Beauty in Imperfection.
Crit Care Med. 2020;48:1917-1919.
PubMed

November 2020

LANKADEVA YR, Peiris RM, Okazaki N, Birchall IE, et al
Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
Crit Care Med. 2020 Nov 25. doi: 10.1097/CCM.0000000000004770.
PubMed Abstract available

SWEENEY TE, Liesenfeld O, Wacker J, He YD, et al
Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019.
Crit Care Med. 2020 Nov 17. doi: 10.1097/CCM.0000000000004786.
PubMed Abstract available

WU YL, Yo CH, Hsu WT, Qian F, et al
Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis.
Crit Care Med. 2020 Nov 16. doi: 10.1097/CCM.0000000000004738.
PubMed Abstract available

BANIASADI A, Rezaeirad S, Zare H, Ghassemi MM, et al
Two-Step Imputation and AdaBoost-Based Classification for Early Prediction of Sepsis on Imbalanced Clinical Data.
Crit Care Med. 2020 Nov 5. doi: 10.1097/CCM.0000000000004705.
PubMed Abstract available

October 2020

NESARAGI N, Patidar S
Early Prediction of Sepsis From Clinical Data Using Ratio and Power-Based Features.
Crit Care Med. 2020 Oct 13. doi: 10.1097/CCM.0000000000004691.
PubMed Abstract available

HE Z, Du L, Zhang P, Zhao R, et al
Early Sepsis Prediction Using Ensemble Learning With Deep Features and Artificial Features Extracted From Clinical Electronic Health Records.
Crit Care Med. 2020 Oct 12. doi: 10.1097/CCM.0000000000004644.
PubMed Abstract available

KEMPKER JA, Rudd KE, Wang HE, Martin GS, et al
Sepsis Epidemiology Across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, Chasm-A Direct Application of the Institute for Health Metrics and Evaluation Case Definition to Hospital
Crit Care Med. 2020 Oct 2. doi: 10.1097/CCM.0000000000004577.
PubMed Abstract available

SCOTT HF, Brilli RJ, Paul R, Macias CG, et al
Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement.
Crit Care Med. 2020;48:e916-e926.
PubMed Abstract available

LI X, Xu X, Xie F, Xu X, et al
A Time-Phased Machine Learning Model for Real-Time Prediction of Sepsis in Critical Care.
Crit Care Med. 2020;48:e884-e888.
PubMed Abstract available

PARK S, Jeon K, Oh DK, Choi EY, et al
Normothermia in Patients With Sepsis Who Present to Emergency Departments Is Associated With Low Compliance With Sepsis Bundles and Increased In-Hospital Mortality Rate.
Crit Care Med. 2020;48:1462-1470.
PubMed Abstract available

BOURNE DS, Davis BS, Gigli KH, Chang CH, et al
Economic Analysis of Mandated Protocolized Sepsis Care in New York Hospitals.
Crit Care Med. 2020;48:1411-1418.
PubMed Abstract available

SCHLAPBACH LJ, Watson RS
Adapting Pediatric Sepsis Criteria for Benchmarking and Quality Control - The Search for the Holy Grail Continues.
Crit Care Med. 2020;48:1549-1551.
PubMed

WALLEY KR, Boyd JH
Lipoprotein Biology in Sepsis.
Crit Care Med. 2020;48:1547-1549.
PubMed

NOEL C, Schorr C
Normothermia in Sepsis Warrants More Than a Lukewarm Response.
Crit Care Med. 2020;48:1538-1540.
PubMed

September 2020

BHAVANI SV, Wolfe KS, Hrusch CL, Greenberg JA, et al
Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.
Crit Care Med. 2020 Sep 17. doi: 10.1097/CCM.0000000000004610.
PubMed Abstract available

August 2020

SHAPPELL CN, Klompas M, Rhee C
Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?
Crit Care Med. 2020 Aug 24. doi: 10.1097/CCM.0000000000004601.
PubMed

BELTRAN-GARCIA J, Osca-Verdegal R, Pallardo FV, Ferreres J, et al
Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches.
Crit Care Med. 2020 Aug 18. doi: 10.1097/CCM.0000000000004625.
PubMed Abstract available

YANG M, Liu C, Wang X, Li Y, et al
An Explainable Artificial Intelligence Predictor for Early Detection of Sepsis.
Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004550.
PubMed Abstract available

MAVES RC
Procalcitonin Is Not an Adequate Tool for Antimicrobial De-Escalation in Sepsis.
Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004547.
PubMed

MORRILL JH, Kormilitzin A, Nevado-Holgado AJ, Swaminathan S, et al
Utilization of the Signature Method to Identify the Early Onset of Sepsis From Multivariate Physiological Time Series in Critical Care Monitoring.
Crit Care Med. 2020 Aug 3. doi: 10.1097/CCM.0000000000004510.
PubMed Abstract available

SATO R, Kuriyama A
Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
Crit Care Med. 2020;48:e722-e729.
PubMed Abstract available

DEUTSCHMAN CS, Hellman J, Ferrer Roca R, De Backer D, et al
The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities.
Crit Care Med. 2020;48:1217-1232.
PubMed Abstract available

GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
Crit Care Med. 2020;48:1175-1179.
PubMed Abstract available

LEVI M, Vincent JL, Tanaka K, Radford AH, et al
Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
Crit Care Med. 2020;48:1140-1147.
PubMed Abstract available

July 2020

BUSCH LM, Sun J, Eichacker PQ, Torabi-Parizi P, et al
Inhibitory Immune Checkpoint Molecule Expression in Clinical Sepsis Studies: A Systematic Review.
Crit Care Med. 2020 Jul 20. doi: 10.1097/CCM.0000000000004496.
PubMed Abstract available

ZHOU Y, Xu W, Shao A
Application Prospect of Mesenchymal Stem Cells in the Treatment of Sepsis.
Crit Care Med. 2020;48:e634.
PubMed

SCHINKEL M, Boerman AW, Nanayakkara PWB
A Different Perspective on the Use of Sepsis Alert.
Crit Care Med. 2020;48:e632-e633.
PubMed

BARBASH IJ
Disparities in Sepsis Outcomes: A Problem in Need of Solutions.
Crit Care Med. 2020;48:1079-1080.
PubMed

June 2020

JAGAN N, Morrow LE, Walters RW, Plambeck RW, et al
Sepsis and the Obesity Paradox: Size Matters in More Than One Way.
Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004459.
PubMed Abstract available

EGUIA E, Bunn C, Kulshrestha S, Markossian T, et al
Trends, Cost, and Mortality From Sepsis After Trauma in the United States: An Evaluation of the National Inpatient Sample of Hospitalizations, 2012-2016.
Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004451.
PubMed Abstract available

ENGOREN M, Seelhammer T, Freundlich RE, Maile MD, et al
A Comparison of Sepsis-2 (Systemic Inflammatory Response Syndrome Based) to Sepsis-3 (Sequential Organ Failure Assessment Based) Definitions-A Multicenter Retrospective Study.
Crit Care Med. 2020 Jun 22. doi: 10.1097/CCM.0000000000004449.
PubMed Abstract available

GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004430.
PubMed Abstract available

LEVI M, Vincent JL, Tanaka K, Radford AH, et al
Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004426.
PubMed Abstract available

CAWCUTT KA, Beachy M, Peitz GJ
Antibiotic Delivery in Sepsis: How Do We Improve?
Crit Care Med. 2020;48:e540-e541.
PubMed

COOKSLEY T, Haji-Michael P
Oncologic Sepsis on the ICU: Two Decades of Improving Outcomes.
Crit Care Med. 2020;48:925-926.
PubMed

SEE H, Slonim AD
Evaluating the Effect of Policy Changes on Sepsis Outcomes.
Crit Care Med. 2020;48:919-920.
PubMed

RHEE C, Strich JR, Klompas M, Yealy DM, et al
SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care...But Now Is the Time to Improve SEP-1.
Crit Care Med. 2020;48:779-782.
PubMed

May 2020

EHLER J, Petzold A, Sharshar T, Ely EW, et al
Biomarker Panel to Differentiate Brain Injury From Brain Dysfunction in Patients With Sepsis-Associated Encephalopathy.
Crit Care Med. 2020;48:e436-e437.
PubMed

April 2020

RUSH B, Danziger J, Walley KR, Kumar A, et al
Treatment in Disproportionately Minority Hospitals Is Associated With Increased Risk of Mortality in Sepsis: A National Analysis.
Crit Care Med. 2020 Apr 28. doi: 10.1097/CCM.0000000000004375.
PubMed Abstract available

OSBORN TM
Sepsis Mandates Help Clinicians and Patients.
Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004342.
PubMed

LEMIALE V, Pons S, Mirouse A, Tudesq JJ, et al
Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique Study.
Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004322.
PubMed Abstract available

LINDELL RB, Nishisaki A, Weiss SL, Traynor DM, et al
Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock.
Crit Care Med. 2020 Apr 14. doi: 10.1097/CCM.0000000000004329.
PubMed Abstract available

CHINAI B, Gaughan J, Schorr C
Implementation of the Affordable Care Act: A Comparison of Outcomes in Patients With Severe Sepsis and Septic Shock Using the National Inpatient Sample.
Crit Care Med. 2020 Apr 9. doi: 10.1097/CCM.0000000000004310.
PubMed Abstract available

GALIATSATOS P, Follin A, Alghanim F, Sherry M, et al
The Association Between Neighborhood Socioeconomic Disadvantage and Readmissions for Patients Hospitalized With Sepsis.
Crit Care Med. 2020 Apr 8. doi: 10.1097/CCM.0000000000004307.
PubMed Abstract available

STRICH JR, Wang J, Eichacker PQ
Sepsis Bundles That Focus on Clinician Judgment and Proven Interventions Are Needed to Increase Bundle Compliance and Effectiveness.
Crit Care Med. 2020;48:602-605.
PubMed

ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
Crit Care Med. 2020;48:484-490.
PubMed Abstract available

MATSUDA W
Should We Restrict ICU Admission for Frail Septic Patients?
Crit Care Med. 2020;48:e342-e343.
PubMed

CARLTON EF, Prescott HC
The authors reply.
Crit Care Med. 2020;48:e334-e335.
PubMed

PATEL S, Katanga JA, Burman S, Said H, et al
Making Sense of Readmissions.
Crit Care Med. 2020;48:e333-e334.
PubMed

SWEENEY DA, Kalil AC
Be Quick But Don't Hurry: Septic Shock, Staphylococcus aureus Bacteremia, and the Timing of Appropriate Antibiotics.
Crit Care Med. 2020;48:608-609.
PubMed

SILVA AYO, Amorim EA, Barbosa-Silva MC, Lima MN, et al
Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice.
Crit Care Med. 2020;48:e290-e298.
PubMed Abstract available

CORL KA, Zeba F, Caffrey AR, Hermenau M, et al
Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus aureus Bacteremia.
Crit Care Med. 2020;48:525-532.
PubMed Abstract available

LACHMANN G, Knaak C, Vorderwulbecke G, La Rosee P, et al
Hyperferritinemia in Critically Ill Patients.
Crit Care Med. 2020;48:459-465.
PubMed Abstract available

March 2020

ALHAZZANI W, Moller MH, Arabi YM, Loeb M, et al
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).
Crit Care Med. 2020 Mar 27. doi: 10.1097/CCM.0000000000004363.
PubMed Abstract available

HENDRICKSON CM, Matthay MA
Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults.
Crit Care Med. 2020;48:428-430.
PubMed

BUSCH LM, Kalil AC, Kadri SS
Predicting Sepsis Mortality and Costs Using Medicare Claims: A Method to the Madness.
Crit Care Med. 2020;48:424-426.
PubMed

LEVY MM
Identifying the Burden of Sepsis With Big Data.
Crit Care Med. 2020;48:422-423.
PubMed

RHEE C, Klompas M
The Eye-Popping Costs Associated With Sepsis Diagnoses Among Medicare Beneficiaries.
Crit Care Med. 2020;48:420-422.
PubMed

WHITNEY JE, Zhang B, Koterba N, Chen F, et al
Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.
Crit Care Med. 2020;48:344-352.
PubMed Abstract available

BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018.
Crit Care Med. 2020;48:302-318.
PubMed Abstract available

BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018.
Crit Care Med. 2020;48:289-301.
PubMed Abstract available

BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018.
Crit Care Med. 2020;48:276-288.
PubMed Abstract available

KUTTAB HI, Ward MA
The authors reply.
Crit Care Med. 2020;48:e260-e261.
PubMed

JONES TW, Finder S, Newsome AS, Smith SE, et al
Getting to the Heart of the Matter: What We Know About Fluid Resuscitation in Septic Heart Failure Patients.
Crit Care Med. 2020;48:e259-e260.
PubMed

LAW AC, Stevens JP, Walkey AJ
The authors reply.
Crit Care Med. 2020;48:e249-e250.
PubMed

OUD L
Trends of Time to Hospital Mortality Versus Timing of Death Among Patients With Septic Shock in Administrative Data.
Crit Care Med. 2020;48:e249.
PubMed

MARRARO GA, Spada C, Zeng Y
Administrative Database and Empiric Therapy Are Always Useful for Appropriate Treatment of Pediatric Patients?
Crit Care Med. 2020;48:438-440.
PubMed

JILANI SM, Giroir BP
Septic Shock in Children: When Should Prevention Start and Treatment End?
Crit Care Med. 2020;48:426-428.
PubMed

ZADOR Z, Landry A, Balas M, Marshall JC, et al
Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness.
Crit Care Med. 2020;48:338-343.
PubMed Abstract available

ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
Crit Care Med. 2020;48:329-337.
PubMed Abstract available

ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
Crit Care Med. 2020;48:319-328.
PubMed Abstract available

BELLETTI A, Nagy A, Sartorelli M, Mucchetti M, et al
Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials.
Crit Care Med. 2020;48:398-405.
PubMed Abstract available

February 2020

CARLTON EF, Donnelly JP, Hensley MK, Cornell TT, et al
New Medical Device Acquisition During Pediatric Severe Sepsis Hospitalizations.
Crit Care Med. 2020 Feb 27. doi: 10.1097/CCM.0000000000004272.
PubMed Abstract available

BINNIE A, Tsang JLY, Hu P, Carrasqueiro G, et al
Epigenetics of Sepsis.
Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004247.
PubMed Abstract available

KWON MY, Ghanta S, Ng J, Tsoyi K, et al
Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004244.
PubMed Abstract available

ISHII J, Ohshimo S, Shime N
Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program.
Crit Care Med. 2020;48:e161-e162.
PubMed

BUCHMAN TG, Zehnbauer BA
Exploring the Epigenetics of Severe Sepsis: First Step in a Long Journey.
Crit Care Med. 2020;48:254-255.
PubMed

REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
Crit Care Med. 2020;48:210-217.
PubMed Abstract available

PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
Crit Care Med. 2020;48:200-209.
PubMed Abstract available

BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
Crit Care Med. 2020;48:142-150.
PubMed Abstract available

SARIA S, Henry KE
Too Many Definitions of Sepsis: Can Machine Learning Leverage the Electronic Health Record to Increase Accuracy and Bring Consensus?
Crit Care Med. 2020;48:137-141.
PubMed

AFSHAR M, Markossian T, Joyce C
The authors reply.
Crit Care Med. 2020;48:e162-e163.
PubMed

January 2020

ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
Crit Care Med. 2020 Jan 13. doi: 10.1097/CCM.0000000000004179.
PubMed Abstract available

LEMASLE L, Blet A, Geven C, Cherifa M, et al
Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
Crit Care Med. 2020;48:49-55.
PubMed Abstract available

December 2019

REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
Crit Care Med. 2019 Dec 17. doi: 10.1097/CCM.0000000000004145.
PubMed Abstract available

BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
Crit Care Med. 2019 Dec 11. doi: 10.1097/CCM.0000000000004097.
PubMed Abstract available

XIE J, Wang H, Kang Y, Zhou L, et al
The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey.
Crit Care Med. 2019 Dec 5. doi: 10.1097/CCM.0000000000004155.
PubMed Abstract available

OUD L
The Impact of Atrial Fibrillation on Short-Term Mortality and Resource Utilization in Sepsis.
Crit Care Med. 2019;47:e1032.
PubMed

November 2019

PROUT AJ, Talisa VB, Carcillo JA, Decker BK, et al
Bacterial and Fungal Etiology of Sepsis in Children in the United States: Reconsidering Empiric Therapy.
Crit Care Med. 2019 Nov 27. doi: 10.1097/CCM.0000000000004140.
PubMed Abstract available

SHUBIN NJ, Navalkar K, Sampson D, Yager TD, et al
Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
Crit Care Med. 2019 Nov 8. doi: 10.1097/CCM.0000000000004083.
PubMed Abstract available

OSUCHOWSKI MF, Rosengart MR
Change Is the Only Constant: How to Adopt the New Trends in Sepsis Modeling?
Crit Care Med. 2019;47:1673-1675.
PubMed

HOPKINS RO
Acquired Brain Injury Following Sepsis.
Crit Care Med. 2019;47:1658-1659.
PubMed

SIMPSON SQ
Sepsis Biomarkers and Physician Judgment in the Emergency Room.
Crit Care Med. 2019;47:1656-1657.
PubMed

October 2019

SHIMADA T, Topchiy E, Leung AKK, Kong HJ, et al
Very Low Density Lipoprotein Receptor Sequesters Lipopolysaccharide Into Adipose Tissue During Sepsis.
Crit Care Med. 2019 Oct 23. doi: 10.1097/CCM.0000000000004064.
PubMed Abstract available

LI X, Zhu J, Tian L, Ma X, et al
Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-kappaB Signaling Pathway.
Crit Care Med. 2019 Oct 21. doi: 10.1097/CCM.0000000000004065.
PubMed Abstract available

YAN X, Tu H, Liu Y, Chen T, et al
Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis.
Crit Care Med. 2019 Oct 17. doi: 10.1097/CCM.0000000000004070.
PubMed Abstract available

NUSSHAG C, Rupp C, Schmitt F, Krautkramer E, et al
Cell Cycle Biomarkers and Soluble Urokinase-Type Plasminogen Activator Receptor for the Prediction of Sepsis-Induced Acute Kidney Injury Requiring Renal Replacement Therapy: A Prospective, Exploratory Study.
Crit Care Med. 2019 Oct 4. doi: 10.1097/CCM.0000000000004042.
PubMed Abstract available

PELTAN ID, Liu VX
More Than We Bargained For: The "Dominating" Cost Effectiveness of Sepsis Quality Improvement?
Crit Care Med. 2019;47:1464-1467.
PubMed

PARKER RI
Cancer and Sepsis: Adding Insult to Injury-As if Either Alone Were Not Enough?
Crit Care Med. 2019;47:1452-1453.
PubMed

LEVY MM
Implementation of Sepsis Bundles: Just Do It!!
Crit Care Med. 2019;47:1450-1451.
PubMed

September 2019

OH SY, Cho S, Kim GH, Jang EJ, et al
Incidence and Outcomes of Sepsis in Korea: A Nationwide Cohort Study From 2007 to 2016.
Crit Care Med. 2019 Sep 30. doi: 10.1097/CCM.0000000000004041.
PubMed Abstract available

GOULDEN R
Alternative Explanations for the Obesity Paradox in Sepsis.
Crit Care Med. 2019;47:e790.
PubMed

PITTA MR, Campos FM
Comment on "Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients".
Crit Care Med. 2019;47:e789-e790.
PubMed

SURESH K, D'Alessio F
Immune Checkpoint Inhibitor Use in Sepsis: Monitoring Immune Checkpoint Inhibitor Toxicity.
Crit Care Med. 2019;47:e788.
PubMed

OUD L
Reporting Epidemiologic Studies in Sepsis Combining the International Classification of Diseases, 9th Edition and International Classification of Diseases, 10th Edition Codes.
Crit Care Med. 2019;47:e785.
PubMed

August 2019

KUTTAB HI, Lykins JD, Hughes MD, Wroblewski K, et al
Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock.
Crit Care Med. 2019 Aug 7. doi: 10.1097/CCM.0000000000003960.
PubMed Abstract available

STORTZ JA, Hollen MK, Nacionales DC, Horiguchi H, et al
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003926.
PubMed Abstract available

GIANNINI HM, Ginestra JC, Chivers C, Draugelis M, et al
A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice.
Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003891.
PubMed Abstract available

EHLENBACH WJ, Sonnen JA, Montine TJ, Larson EB, et al
Association Between Sepsis and Microvascular Brain Injury.
Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003924.
PubMed Abstract available

WEISS SL, Zhang D, Bush J, Graham K, et al
Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis.
Crit Care Med. 2019 Aug 2. doi: 10.1097/CCM.0000000000003931.
PubMed Abstract available

SAMUELS DC, Hulgan T, Fessel JP, Billings FT 4th, et al
Mitochondrial DNA Haplogroups and Delirium During Sepsis.
Crit Care Med. 2019;47:1065-1071.
PubMed Abstract available

GAZMURI RJ, Anez de Gomez CI, Siddiqui M, Schechtman J, et al
Severe Sepsis and Septic Shock Early Management Bundle Risks Aiding Vasopressor Misuse.
Crit Care Med. 2019;47:e717.
PubMed

LEE JT, Mikkelsen ME
Risk Stratification Tools in Sepsis: From Acute Physiology and Chronic Health Evaluation to Quick Sequential Organ Failure Assessment.
Crit Care Med. 2019;47:1159-1161.
PubMed

PARKER RI
Sepsis: From Little Findings Big Ideas Grow.
Crit Care Med. 2019;47:1152-1153.
PubMed

July 2019

MIAO H, Shi J, Wang C, Lu G, et al
Continuous Renal Replacement Therapy in Pediatric Severe Sepsis: A Propensity Score-Matched Prospective Multicenter Cohort Study in the PICU.
Crit Care Med. 2019 Jul 31. doi: 10.1097/CCM.0000000000003901.
PubMed Abstract available

PEPPER DJ, Sun J, Cui X, Welsh J, et al
Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).
Crit Care Med. 2019 Jul 31. doi: 10.1097/CCM.0000000000003892.
PubMed Abstract available

HENSLEY MK, Donnelly JP, Carlton EF, Prescott HC, et al
Epidemiology and Outcomes of Cancer-Related Versus Non-Cancer-Related Sepsis Hospitalizations.
Crit Care Med. 2019 Jul 25. doi: 10.1097/CCM.0000000000003896.
PubMed Abstract available

PARK CHL, de Almeida JP, de Oliveira GQ, Rizk SI, et al
Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial.
Crit Care Med. 2019 Jul 25. doi: 10.1097/CCM.0000000000003900.
PubMed Abstract available

KASHIOURIS MG, Zemore Z, Kimball Z, Stefanou C, et al
Supply Chain Delays in Antimicrobial Administration After the Initial Clinician Order and Mortality in Patients With Sepsis.
Crit Care Med. 2019 Jul 24. doi: 10.1097/CCM.0000000000003921.
PubMed Abstract available

AFSHAR M, Arain E, Ye C, Gilbert E, et al
Patient Outcomes and Cost-Effectiveness of a Sepsis Care Quality Improvement Program in a Health System.
Crit Care Med. 2019 Jul 15. doi: 10.1097/CCM.0000000000003919.
PubMed Abstract available

BEALE R
Enough Is As Good As a Feast.
Crit Care Med. 2019;47:1004-1006.
PubMed

MUTHUMALAIAPPAN K
Efficacy of Mesenchymal Stem/Stromal Cell Infusion in Septic Patients Is a Puzzle Worthy of Attention.
Crit Care Med. 2019;47:1001-1002.
PubMed

TAPIA P, Gatica S, Cortes-Rivera C, Otero C, et al
Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.
Crit Care Med. 2019;47:942-950.
PubMed Abstract available

SCHLOSSER K, Wang JP, Dos Santos C, Walley KR, et al
Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.
Crit Care Med. 2019;47:918-925.
PubMed Abstract available

June 2019

ANTCLIFFE DB, Gordon AC
Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock?
Crit Care Med. 2019 Jun 3. doi: 10.1097/CCM.0000000000003833.
PubMed

DORNAS W
Damaging Effects of Oxygen in Induced Sepsis-Like Condition.
Crit Care Med. 2019;47:e535-e536.
PubMed

JOFFE AR, deCaen A
Not Enough Evidence to Use Plasma Exchange for Sepsis or Thrombocytopenia-Associated Multiple Organ Failure in Children.
Crit Care Med. 2019;47:e533-e534.
PubMed

BERG RMG, Asghar MS
Luxury Perfusion in Patients With Sepsis?
Crit Care Med. 2019;47:e533.
PubMed

LI S, Wang S, Priyanka P, Kellum JA, et al
Acute Kidney Injury in Critically Ill Patients After Noncardiac Major Surgery: Early Versus Late Onset.
Crit Care Med. 2019;47:e437-e444.
PubMed Abstract available

May 2019

RHEE C, Wang R, Zhang Z, Fram D, et al
Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data.
Crit Care Med. 2019 May 24. doi: 10.1097/CCM.0000000000003817.
PubMed Abstract available

GINESTRA JC, Giannini HM, Schweickert WD, Meadows L, et al
Clinician Perception of a Machine Learning-Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock.
Crit Care Med. 2019 May 24. doi: 10.1097/CCM.0000000000003803.
PubMed Abstract available

CROUSER ED, Parrillo JE, Seymour CW, Angus DC, et al
Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients.
Crit Care Med. 2019 May 17. doi: 10.1097/CCM.0000000000003799.
PubMed Abstract available

DESAI R, Hanna B, Singh S, Omar A, et al
Trends and Outcomes in Sepsis Hospitalizations With and Without Atrial Fibrillation: A Nationwide Inpatient Analysis.
Crit Care Med. 2019 May 13. doi: 10.1097/CCM.0000000000003806.
PubMed Abstract available

SIMPSON SQ
Sepsis Epidemiology From Administrative Data: Going, Going....
Crit Care Med. 2019;47:739-740.
PubMed

CROUSER ED, Caldwell CC, Hotchkiss RS
What Is the Skinny on Obesity During Sepsis?
Crit Care Med. 2019;47:735-736.
PubMed

CAWCUTT KA, Kalil AC
Saved From Sepsis: Can Immunotherapy Improve Acute and Postacute Outcomes?
Crit Care Med. 2019;47:733-735.
PubMed

WOOLUM JA, Flannery AH
The authors reply.
Crit Care Med. 2019;47:e435-e436.
PubMed

PATEL JJ, Bergl P
Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.
Crit Care Med. 2019;47:e434-e435.
PubMed

MORELLI A, Sanfilippo F, Rehberg S, Ertmer C, et al
The authors reply.
Crit Care Med. 2019;47:e432-e433.
PubMed

PETITJEANS F, Leroy S, Geloen A, Pichot C, et al
On the Right Track, Finally?
Crit Care Med. 2019;47:e431-e432.
PubMed

ROSSAINT J, Zarbock A
A Novel Approach for the Targeted Inhibition of Platelet Activation-Separating the Good From the Bad.
Crit Care Med. 2019;47:741-743.
PubMed

GRUMAZ S, Grumaz C, Vainshtein Y, Stevens P, et al
Enhanced Performance of Next-Generation Sequencing Diagnostics Compared With Standard of Care Microbiological Diagnostics in Patients Suffering From Septic Shock.
Crit Care Med. 2019;47:e394-e402.
PubMed Abstract available

April 2019

CORL KA, Prodromou M, Merchant RC, Gareen I, et al
The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study.
Crit Care Med. 2019 Apr 12. doi: 10.1097/CCM.0000000000003779.
PubMed Abstract available

HIGGINS AM, Peake SL, Bellomo R, Cooper DJ, et al
Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.
Crit Care Med. 2019 Apr 8. doi: 10.1097/CCM.0000000000003762.
PubMed Abstract available

WIEDERMANN CJ
Hypoalbuminemia and the Risk of Acute Kidney Injury in Sepsis.
Crit Care Med. 2019;47:e377-e378.
PubMed

ARGENT AC
Readmission After Hospitalization for Pediatric Severe Sepsis-Data From a U.S. Database.
Crit Care Med. 2019;47:612-613.
PubMed

BAUER PR
The Sicker Are Sicker: A Tale of Late Outcome After Sepsis.
Crit Care Med. 2019;47:610-611.
PubMed

HURST SD, Coopersmith CM
Can We Compare Sepsis Outcomes on a Hospital Level If Documentation Is Variable (or Inaccurate)?
Crit Care Med. 2019;47:599-600.
PubMed

FISHER J, Linder A, Caironi P, Russell JA, et al
The authors reply.
Crit Care Med. 2019;47:e378-e379.
PubMed

MENARD CE, Kumar A, Houston DS, Turgeon AF, et al
Evolution and Impact of Thrombocytopenia in Septic Shock: A Retrospective Cohort Study.
Crit Care Med. 2019;47:558-565.
PubMed Abstract available

LEIJTE GP, Kiers D, van der Heijden W, Jansen A, et al
Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
Crit Care Med. 2019;47:508-516.
PubMed Abstract available

March 2019

KOHOUTOVA M, Horak J, Jarkovska D, Martinkova V, et al
Vagus Nerve Stimulation Attenuates Multiple Organ Dysfunction in Resuscitated Porcine Progressive Sepsis.
Crit Care Med. 2019 Mar 25. doi: 10.1097/CCM.0000000000003714.
PubMed Abstract available

BOURCIER S, Hindlet P, Guidet B, Dechartres A, et al
Reporting of Organ Support Outcomes in Septic Shock Randomized Controlled Trials: A Methodologic Review-The Sepsis Organ Support Study.
Crit Care Med. 2019 Mar 19. doi: 10.1097/CCM.0000000000003746.
PubMed Abstract available

CHANG EY, Stevens ES, Bakinde N
Sepsis in Non-ICU Patients: A Call for Guideline Reassessment.
Crit Care Med. 2019;47:e266.
PubMed

SKLAR MC, Dos Santos CC, Lawler PR
Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Survival in Sepsis: Causal Inference Through Human Genetics.
Crit Care Med. 2019;47:489-491.
PubMed

SIMPSON SQ
Surveillance for Adult Sepsis Events: An Idea Whose Time Has Come.
Crit Care Med. 2019;47:467-468.
PubMed

RHEE C, Zhang Z, Kadri SS, Murphy DJ, et al
Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria.
Crit Care Med. 2019;47:307-314.
PubMed Abstract available

KELLY BJ, Lautenbach E, Han JH
The authors reply.
Crit Care Med. 2019;47:e275-e276.
PubMed

PATNAIK R, Gurjar M
Is Combined Biomarkers a Future Tool for Early Prediction of Mortality Among Septic Patients?
Crit Care Med. 2019;47:e275.
PubMed

REDFERN OC, Smith GB, Prytherch DR, Meredith P, et al
The authors reply.
Crit Care Med. 2019;47:e266-e267.
PubMed

February 2019

PEPPER DJ, Demirkale CY, Sun J, Rhee C, et al
Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients.
Crit Care Med. 2019 Feb 14. doi: 10.1097/CCM.0000000000003692.
PubMed Abstract available

KUSHIMOTO S, Abe T, Ogura H, Shiraishi A, et al
Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsi
Crit Care Med. 2019 Feb 14. doi: 10.1097/CCM.0000000000003688.
PubMed Abstract available

HOTCHKISS RS, Colston E, Yende S, Angus DC, et al
Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 (BMS-936559).
Crit Care Med. 2019 Feb 8. doi: 10.1097/CCM.0000000000003685.
PubMed Abstract available

ILKO SA, Vakkalanka JP, Ahmed A, Harland KK, et al
Central Venous Access Capability and Critical Care Telemedicine Decreases Inter-Hospital Transfer Among Severe Sepsis Patients: A Mixed Methods Design.
Crit Care Med. 2019 Feb 5. doi: 10.1097/CCM.0000000000003686.
PubMed Abstract available

GRANJA T, Korner A, Gluck C, Hohmann JD, et al
Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study.
Crit Care Med. 2019 Feb 5. doi: 10.1097/CCM.0000000000003682.
PubMed Abstract available

KRAFT BD, Chen L, Suliman HB, Piantadosi CA, et al
Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.
Crit Care Med. 2019 Feb 5. doi: 10.1097/CCM.0000000000003681.
PubMed Abstract available

BOSCH NA, Cohen DM, Walkey AJ
Risk Factors for New-Onset Atrial Fibrillation in Patients With Sepsis: A Systematic Review and Meta-Analysis.
Crit Care Med. 2019;47:280-287.
PubMed Abstract available

DE GROOTH HJ, Girbes AR
Corticosteroids in Sepsis: Clouded by Heterogeneity.
Crit Care Med. 2019;47:e163-e164.
PubMed

SCHURR JW, McLaughlin KC, Szumita PM
Defining the Role of Corticosteroids in Sepsis: Adjunctive Therapy for Shock Reversal.
Crit Care Med. 2019;47:e157-e158.
PubMed

MARTIN B, Bennett TD
Sepsis Computable Phenotypes in the Service of Observational Research.
Crit Care Med. 2019;47:303-305.
PubMed

OCZKOWSKI SJ, Rochwerg B, Alhazzani W, Siemieniuk RAC, et al
The authors reply.
Crit Care Med. 2019;47:e158-e159.
PubMed

WOOLUM JA, Flannery AH
The authors reply.
Crit Care Med. 2019;47:e154.
PubMed

OLANIPEKUN TO, Bakinde N, Effoe VS, Snyder R, et al
Further Considerations on the Benefits of Thiamine Administration in Patients With Septic Shock.
Crit Care Med. 2019;47:e153-e154.
PubMed

MORELLI A, Sanfilippo F, Arnemann P, Hessler M, et al
The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.
Crit Care Med. 2019;47:e89-e95.
PubMed Abstract available

January 2019

KIM J, Kim YA, Hwangbo B, Kim MJ, et al
Effect of Antihypertensive Medications on Sepsis-Related Outcomes: A Population-Based Cohort Study.
Crit Care Med. 2019 Jan 24. doi: 10.1097/CCM.0000000000003654.
PubMed Abstract available

CARLTON EF, Kohne JG, Shankar-Hari M, Prescott HC, et al
Readmission Diagnoses After Pediatric Severe Sepsis Hospitalization.
Crit Care Med. 2019 Jan 22. doi: 10.1097/CCM.0000000000003646.
PubMed Abstract available

GARDNER AK, Ghita GL, Wang Z, Ozrazgat-Baslanti T, et al
The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
Crit Care Med. 2019 Jan 18. doi: 10.1097/CCM.0000000000003655.
PubMed Abstract available

DAHABA AA
Can We Improve Long-Term Survival of Patients With Severe Sepsis at ICU Admission?
Crit Care Med. 2019;47:e71.
PubMed

WALKEY AJ
Exploring the Pathways Revealed by International Sepsis Benchmarking.
Crit Care Med. 2019;47:135-137.
PubMed

LANKADEVA YR, Kosaka J, Iguchi N, Evans RG, et al
Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury.
Crit Care Med. 2019;47:e36-e43.
PubMed Abstract available

LU C, Liu Q, Yuan H, Wang L, et al
Implementation of the Smart Use of Antibiotics Program to Reduce Unnecessary Antibiotic Use in a Neonatal ICU: A Prospective Interrupted Time-Series Study in a Developing Country.
Crit Care Med. 2019;47:e1-e7.
PubMed Abstract available

December 2018

BARBASH IJ, Davis B, Kahn JM
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
Crit Care Med. 2018 Dec 21. doi: 10.1097/CCM.0000000000003613.
PubMed Abstract available

KLOMPAS M, Rhee C
Current Sepsis Mandates Are Overly Prescriptive, and Some Aspects May Be Harmful.
Crit Care Med. 2018 Dec 4. doi: 10.1097/CCM.0000000000003579.
PubMed

VARGAS M, Servillo G
The End of Corticosteroid in Sepsis: Fragile Results From Fragile Trials.
Crit Care Med. 2018;46:e1228.
PubMed

GOODWIN AJ
Can Serial Quick Sequential (Sepsis-Related) Organ Failure Assessment Measurement Aid in Sepsis Identification and Triage Decisions?
Crit Care Med. 2018;46:2046-2048.
PubMed

KEMPKER JA, Martin GS
Severity and Timing of Onset Drive Economic Costs and Clinical Outcomes With Sepsis.
Crit Care Med. 2018;46:2043-2044.
PubMed

November 2018

RHEE C, Jentzsch MS, Kadri SS, Seymour CW, et al
Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons.
Crit Care Med. 2018 Nov 13. doi: 10.1097/CCM.0000000000003554.
PubMed Abstract available

MEHTA NM
Nutritional Status and Outcomes in Pediatric Severe Sepsis-Size Matters.
Crit Care Med. 2018;46:1886-1887.
PubMed

CARLTON EF, Prescott HC
Variation in Sepsis-Related Mortality; Implications for Performance Improvement.
Crit Care Med. 2018;46:1871-1873.
PubMed

WALLEY KR, Boyd JH, Kong HJ, Russell JA, et al
Low Low-Density Lipoprotein Levels Are Associated With, But Do Not Causally Contribute to, Increased Mortality in Sepsis.
Crit Care Med. 2018 Nov 1. doi: 10.1097/CCM.0000000000003551.
PubMed Abstract available

October 2018

LINDELL RB, Nishisaki A, Weiss SL, Balamuth F, et al
Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database.
Crit Care Med. 2018 Oct 31. doi: 10.1097/CCM.0000000000003541.
PubMed Abstract available

CHUNG KP, Chen GY, Chuang TY, Huang YT, et al
Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study.
Crit Care Med. 2018 Oct 30. doi: 10.1097/CCM.0000000000003517.
PubMed Abstract available

LAI CC, Wang YH, Wang CY, Wang HC, et al
Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers.
Crit Care Med. 2018 Oct 9. doi: 10.1097/CCM.0000000000003475.
PubMed Abstract available

SRINIVASAN V
Probiotics in Pediatric Severe Sepsis: The Time Has Come to Trust Our 'Gut'!
Crit Care Med. 2018;46:1707-1708.
PubMed

MARIK PE, Farkas JD
The Changing Paradigm of Sepsis: Early Diagnosis, Early Antibiotics, Early Pressors, and Early Adjuvant Treatment.
Crit Care Med. 2018;46:1690-1692.
PubMed

KANJILAL S, Kalil AC, Klompas M
What Is the Best Treatment for Vancomycin-Resistant Enterococcal Bloodstream Infections?
Crit Care Med. 2018;46:1700-1703.
PubMed

September 2018

RANZANI OT, Shankar-Hari M, Harrison DA, Rabello LS, et al
A Comparison of Mortality From Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis-Specific Patient Characteristics.
Crit Care Med. 2018 Sep 20. doi: 10.1097/CCM.0000000000003438.
PubMed Abstract available

HASSLACHER J, Joannidis M
Secretoneurin in Sepsis: Is It the Brain?
Crit Care Med. 2018;46:e959.
PubMed

CLAXTON AJ, Thompson-Leduc P, Kirson NY, Rice B, et al
Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis: Author Correction.
Crit Care Med. 2018;46:1560.
PubMed

EVANS LE
Progress Toward "Ruling Out" Sepsis.
Crit Care Med. 2018;46:1553-1554.
PubMed

LEWIS AJ, Lee JS, Rosengart MR
Translational Sepsis Research: Spanning the Divide.
Crit Care Med. 2018;46:1497-1505.
PubMed Abstract available

August 2018

REDFERN OC, Smith GB, Prytherch DR, Meredith P, et al
A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection.
Crit Care Med. 2018 Aug 20. doi: 10.1097/CCM.0000000000003359.
PubMed Abstract available

KIEVLAN DR, Zhang LA, Chang CH, Angus DC, et al
Evaluation of Repeated Quick Sepsis-Related Organ Failure Assessment Measurements Among Patients With Suspected Infection.
Crit Care Med. 2018 Aug 20. doi: 10.1097/CCM.0000000000003360.
PubMed Abstract available

KIDSON KM, Henderson WR, Hutcheon JA
Case Fatality and Adverse Outcomes Are Reduced in Pregnant Women With Severe Sepsis or Septic Shock Compared With Age-Matched Comorbid-Matched Nonpregnant Women.
Crit Care Med. 2018 Aug 9. doi: 10.1097/CCM.0000000000003348.
PubMed Abstract available

IRVING SY, Daly B, Verger J, Typpo KV, et al
The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study.
Crit Care Med. 2018 Aug 7. doi: 10.1097/CCM.0000000000003351.
PubMed Abstract available

HANIFFA R, Beane A, Dondorp AM
Is the Tail Wagging the Dog in Sepsis?
Crit Care Med. 2018;46:e818.
PubMed

PANNU S, Crouser ED
Blue Light Illuminates a Novel Sepsis Treatment.
Crit Care Med. 2018;46:1381-1382.
PubMed

SIMPSON SQ
Sepsis-The "Gift" That Keeps on Giving, Regardless of Age.
Crit Care Med. 2018;46:1378-1380.
PubMed

GAUGHAN J
Sepsis Redefined...Again.
Crit Care Med. 2018;46:1378.
PubMed

July 2018

PAOLI CJ, Reynolds MA, Sinha M, Gitlin M, et al
Epidemiology and Costs of Sepsis in the United States-An Analysis Based on Timing of Diagnosis and Severity Level.
Crit Care Med. 2018 Jul 25. doi: 10.1097/CCM.0000000000003342.
PubMed Abstract available

HATFIELD KM, Dantes RB, Baggs J, Sapiano MRP, et al
Assessing Variability in Hospital-Level Mortality Among U.S. Medicare Beneficiaries With Hospitalizations for Severe Sepsis and Septic Shock.
Crit Care Med. 2018 Jul 17. doi: 10.1097/CCM.0000000000003324.
PubMed Abstract available

WU J, Han B, Fanelli V, Wen X, et al
Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome.
Crit Care Med. 2018 Jul 2. doi: 10.1097/CCM.0000000000003265.
PubMed Abstract available

ROCHWERG B, Oczkowski SJ, Siemieniuk RAC, Agoritsas T, et al
Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis.
Crit Care Med. 2018 Jul 2. doi: 10.1097/CCM.0000000000003262.
PubMed Abstract available

THAMM K, Schrimpf C, Retzlaff J, Idowu TO, et al
Molecular Regulation of Acute Tie2 Suppression in Sepsis.
Crit Care Med. 2018 Jul 2. doi: 10.1097/CCM.0000000000003269.
PubMed Abstract available

AKYOL BEYOGLU C, Koksal GM, Esquinas AM
Association Between PaCO2 and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department-Is PaCO2 a Predictive Parameter for Hospital Discharge?
Crit Care Med. 2018;46:e718.
PubMed

GERLACH AT
Sepsis Biomarkers...The Long and Winding Road.
Crit Care Med. 2018;46:1194-1195.
PubMed

KELLY BJ, Lautenbach E, Nachamkin I, Coffin SE, et al
Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis.
Crit Care Med. 2018;46:1106-1113.
PubMed Abstract available

June 2018

RHEE C, Filbin MR, Massaro AF, Bulger AL, et al
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Crit Care Med. 2018 Jun 28. doi: 10.1097/CCM.0000000000003261.
PubMed Abstract available

COOPERSMITH CM, De Backer D, Deutschman CS, Ferrer R, et al
Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock.
Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003225.
PubMed Abstract available

ANGURANA SK, Bansal A, Singhi S, Aggarwal R, et al
Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial.
Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003279.
PubMed Abstract available

CHUANG YC, Lin HY, Chen PY, Lin CY, et al
Survival of Patients With Vancomycin-Resistant Enterococcus faecium Bacteremia Treated With Conventional or High Doses of Daptomycin or Linezolid Is Associated With the Rate of Bacterial Clearance.
Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003264.
PubMed Abstract available

LEVY MM, Evans LE, Rhodes A
The Surviving Sepsis Campaign Bundle: 2018 Update.
Crit Care Med. 2018;46:997-1000.
PubMed

JACOBS MC, Wiersinga WJ
Interleukin-34: A New Player in the Sepsis Arena.
Crit Care Med. 2018;46:1032-1033.
PubMed

PROWLE JR
Renal Blood Flow Measurement in Early Clinical Sepsis-Can You Catch a Shadow?
Crit Care Med. 2018;46:1028-1030.
PubMed

SHANKAR-HARI M, Rubenfeld GD
Race, Ethnicity, and Sepsis: Beyond Adjusted Odds Ratios.
Crit Care Med. 2018;46:1009-1010.
PubMed

HENSLEY MK, Prescott HC
Bad Brains, Bad Outcomes: Acute Neurologic Dysfunction and Late Death After Sepsis.
Crit Care Med. 2018;46:1001-1002.
PubMed

May 2018

MCHALE TM, Garciarena CD, Fagan RP, Smith SGJ, et al
Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis.
Crit Care Med. 2018 May 18. doi: 10.1097/CCM.0000000000003219.
PubMed Abstract available

LIMA A, van Rooij T, Ergin B, Sorelli M, et al
Dynamic Contrast-Enhanced Ultrasound Identifies Microcirculatory Alterations in Sepsis-Induced Acute Kidney Injury.
Crit Care Med. 2018 May 15. doi: 10.1097/CCM.0000000000003209.
PubMed Abstract available

ESTENSSORO E, Kanoore Edul VS, Loudet CI, Osatnik J, et al
Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina.
Crit Care Med. 2018 May 8. doi: 10.1097/CCM.0000000000003208.
PubMed Abstract available

MEARELLI F, Fiotti N, Giansante C, Casarsa C, et al
Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study.
Crit Care Med. 2018 May 7. doi: 10.1097/CCM.0000000000003206.
PubMed Abstract available

ABU-KAF H, Mizrakli Y, Novack V, Dreiher J, et al
Long-Term Survival of Young Patients Surviving ICU Admission With Severe Sepsis.
Crit Care Med. 2018 May 7. doi: 10.1097/CCM.0000000000003205.
PubMed Abstract available

LEWIS AJ, Zhang X, Griepentrog JE, Yuan D, et al
Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis.
Crit Care Med. 2018 May 4. doi: 10.1097/CCM.0000000000003190.
PubMed Abstract available

KALIL AC, Van Schooneveld TC
Is Procalcitonin-Guided Therapy Associated With Beneficial Outcomes in Critically Ill Patients With Sepsis?
Crit Care Med. 2018;46:811-812.
PubMed

STAUNTON O, Staunton C
The Urgency of Now: Attacking the Sepsis Crisis.
Crit Care Med. 2018;46:809-810.
PubMed

April 2018

MATHIEU C, Desrois M, Kober F, Lalevee N, et al
Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study.
Crit Care Med. 2018 Apr 7. doi: 10.1097/CCM.0000000000003146.
PubMed Abstract available

MASSE MH, Richard MA, D'Aragon F, St-Arnaud C, et al
Early Evidence of Sepsis-Associated Hyperperfusion-A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects.
Crit Care Med. 2018 Apr 6. doi: 10.1097/CCM.0000000000003147.
PubMed Abstract available

YOON J, Kym D, Hur J, Kim Y, et al
Comparative Usefulness of Sepsis-3, Burn Sepsis, and Conventional Sepsis Criteria in Patients With Major Burns.
Crit Care Med. 2018 Apr 3. doi: 10.1097/CCM.0000000000003144.
PubMed Abstract available

CROUSER ED
Sepsis-Induced Renal Failure: Ischemia or Toxemia?
Crit Care Med. 2018;46:658-660.
PubMed

KLOMPAS M, Rhee C
Missed Opportunities for Better Sepsis Care or Misplaced Blame? Deconstructing Patients' Encounters in the Week Before Sepsis Hospitalizations.
Crit Care Med. 2018;46:644-645.
PubMed

NATHANSON BH
First, Most, and Best: The Implications of Delays in Implementing Surviving Sepsis Campaign Guidelines.
Crit Care Med. 2018;46:642-643.
PubMed

SAVEL RH, Shiloh AL, Simon RJ, Kupfer Y, et al
Using Big Data to See the Big Picture in Sepsis.
Crit Care Med. 2018;46:640-641.
PubMed

March 2018

SKORUP P, Maudsdotter L, Tano E, Lipcsey M, et al
Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model.
Crit Care Med. 2018 Mar 27. doi: 10.1097/CCM.0000000000003139.
PubMed Abstract available

SWEENEY TE, Azad TD, Donato M, Haynes WA, et al
Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.
Crit Care Med. 2018 Mar 13. doi: 10.1097/CCM.0000000000003084.
PubMed Abstract available

LEE SH, Hsu TC, Lee MG, Chao CC, et al
Nationwide Trend of Sepsis: A Comparison Among Octogenarians, Elderly, and Young Adults.
Crit Care Med. 2018 Mar 10. doi: 10.1097/CCM.0000000000003085.
PubMed Abstract available

SCHEER CS, Kuhn SO, Rehberg S
Sepsis-3 Is a Positive Evolution in Discrimination Between Septic and Nonseptic Patients As Well As Sepsis Entities, Not a Step Backward.
Crit Care Med. 2018;46:e273.
PubMed

MACHADO FR, Azevedo LCP
Sepsis: A Threat That Needs a Global Solution.
Crit Care Med. 2018;46:454-459.
PubMed

MEYER N, Harhay MO, Small DS, Prescott HC, et al
Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis.
Crit Care Med. 2018;46:354-360.
PubMed Abstract available

February 2018

ROSJO H, Masson S, Caironi P, Stridsberg M, et al
Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.
Crit Care Med. 2018 Feb 23. doi: 10.1097/CCM.0000000000003050.
PubMed Abstract available

CHAUDHARY NS, Donnelly JP, Wang HE
Racial Differences in Sepsis Mortality at U.S. Academic Medical Center-Affiliated Hospitals.
Crit Care Med. 2018 Feb 12. doi: 10.1097/CCM.0000000000003020.
PubMed Abstract available

SCHULER A, Wulf DA, Lu Y, Iwashyna TJ, et al
The Impact of Acute Organ Dysfunction on Long-Term Survival in Sepsis.
Crit Care Med. 2018 Feb 9. doi: 10.1097/CCM.0000000000003023.
PubMed Abstract available

RYOO SM, Lee J, Lee YS, Lee JH, et al
Lactate Level Versus Lactate Clearance for Predicting Mortality in Patients With Septic Shock Defined by Sepsis-3.
Crit Care Med. 2018 Feb 9. doi: 10.1097/CCM.0000000000003030.
PubMed Abstract available

PRESCOTT HC, Cope TM, Gesten FC, Ledneva TA, et al
Reporting of Sepsis Cases for Performance Measurement Versus for Reimbursement in New York State.
Crit Care Med. 2018 Feb 5. doi: 10.1097/CCM.0000000000003005.
PubMed Abstract available

MORLEY PT
Early Fluid Management in Sepsis: Yes.
Crit Care Med. 2018;46:327-328.
PubMed

January 2018

LIN X, Luo H, Yan X, Song Z, et al
Interleukin-34 Ameliorates Survival and Bacterial Clearance in Polymicrobial Sepsis.
Crit Care Med. 2018 Jan 30. doi: 10.1097/CCM.0000000000003017.
PubMed Abstract available

CHERRUAULT M, Le Goff M, Tamburini J, Pene F, et al
Urgent Chemotherapy in Sepsis-Like Shock Related to Hematologic Malignancies.
Crit Care Med. 2018 Jan 25. doi: 10.1097/CCM.0000000000002990.
PubMed Abstract available

LYONS PG, Micek ST, Hampton N, Kollef MH, et al
Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality.
Crit Care Med. 2018 Jan 25. doi: 10.1097/CCM.0000000000002997.
PubMed Abstract available

FAISAL M, Scally A, Richardson D, Beatson K, et al
Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient's First Electronically Recorded Vital Signs and Blood Test Results.
Crit Care Med. 2018 Jan 24. doi: 10.1097/CCM.0000000000002967.
PubMed Abstract available

LEWIS AJ, Griepentrog JE, Zhang X, Angus DC, et al
Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis: A Murine Trial.
Crit Care Med. 2018 Jan 23. doi: 10.1097/CCM.0000000000003004.
PubMed Abstract available

LIU VX, Escobar GJ, Chaudhary R, Prescott HC, et al
Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization.
Crit Care Med. 2018 Jan 5. doi: 10.1097/CCM.0000000000002960.
PubMed Abstract available

KURODA K, Wake H, Mori S, Hinotsu S, et al
Decrease in Histidine-Rich Glycoprotein as a Novel Biomarker to Predict Sepsis Among Systemic Inflammatory Response Syndrome.
Crit Care Med. 2018 Jan 4. doi: 10.1097/CCM.0000000000002947.
PubMed Abstract available

JOHNSON AEW, Aboab J, Raffa JD, Pollard TJ, et al
A Comparative Analysis of Sepsis Identification Methods in an Electronic Database.
Crit Care Med. 2018 Jan 4. doi: 10.1097/CCM.0000000000002965.
PubMed Abstract available

PRUINELLI L, Westra BL, Yadav P, Hoff A, et al
Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock.
Crit Care Med. 2018 Jan 2. doi: 10.1097/CCM.0000000000002949.
PubMed Abstract available

DOTSON B
Calcium Channel Blockers and Sepsis Outcomes.
Crit Care Med. 2018;46:e97-e98.
PubMed

DELMAS B, Jabot J, Chanareille P, Ferdynus C, et al
Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions.
Crit Care Med. 2018;46:93-99.
PubMed Abstract available

LANKADEVA YR, Kosaka J, Evans RG, Bellomo R, et al
Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic Acute Kidney Injury.
Crit Care Med. 2018;46:e41-e48.
PubMed Abstract available

TYLER PD, Stone DJ, Geisler BP, McLennan S, et al
Racial and Geographic Disparities in Interhospital ICU Transfers.
Crit Care Med. 2018;46:e76-e80.
PubMed Abstract available

MIANO TA, Lam S
The Healthy User Effect in Studies of Statins in the Critically Ill.
Crit Care Med. 2018;46:e95.
PubMed

KRAMER AA
A Self-Fulfilling Hypothesis.
Crit Care Med. 2018;46:158-159.
PubMed

December 2017

NEMATI S, Holder A, Razmi F, Stanley MD, et al
An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU.
Crit Care Med. 2017 Dec 26. doi: 10.1097/CCM.0000000000002936.
PubMed Abstract available

IANKOVA I, Thompson-Leduc P, Kirson NY, Rice B, et al
Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis.
Crit Care Med. 2017 Dec 21. doi: 10.1097/CCM.0000000000002928.
PubMed Abstract available

SEMERARO F, Colucci M, Caironi P, Masson S, et al
Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis.
Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002919.
PubMed Abstract available

ROBERTS BW, Mohr NM, Ablordeppey E, Drewry AM, et al
Association Between Partial Pressure of Arterial Carbon Dioxide and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department.
Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002918.
PubMed Abstract available

VALLEY TS, Nallamothu BK, Heung M, Iwashyna TJ, et al
Hospital Variation in Renal Replacement Therapy for Sepsis in the United States.
Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002878.
PubMed Abstract available

PHILLIPS GS, Osborn TM, Terry KM, Gesten F, et al
The New York Sepsis Severity Score: Development of a Risk-Adjusted Severity Model for Sepsis.
Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002824.
PubMed Abstract available

KIKUTANI K, Ohshimo S, Shime N
Potential Confounders of Procalcitonin-Guided Antibiotic Therapy for Sepsis.
Crit Care Med. 2017;45:e1310-e1311.
PubMed

KRAMER AH
Is A Hemoglobin Concentration As Low As 7 g/dL Adequate For All Critically Ill Patients With Sepsis? Legitimate Doubts Remain!
Crit Care Med. 2017;45:2101-2102.
PubMed

ERWIN BL, Denaburg MA, Barker AB, McArdle PJ, et al
Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors.
Crit Care Med. 2017;45:e1226-e1232.
PubMed Abstract available

DU W, Liu D, Long Y, Wang X, et al
The beta-Blocker Esmolol Restores the Vascular Waterfall Phenomenon After Acute Endotoxemia.
Crit Care Med. 2017;45:e1247-e1253.
PubMed Abstract available

JAMME M, Daviaud F, Charpentier J, Marin N, et al
Time Course of Septic Shock in Immunocompromised and Nonimmunocompromised Patients.
Crit Care Med. 2017;45:2031-2039.
PubMed Abstract available

DUPUIS C, Garrouste-Orgeas M, Bailly S, Adrie C, et al
Effect of Transfusion on Mortality and Other Adverse Events Among Critically Ill Septic Patients: An Observational Study Using a Marginal Structural Cox Model.
Crit Care Med. 2017;45:1972-1980.
PubMed Abstract available

November 2017

LEISMAN DE, Doerfler ME, Schneider SM, Masick KD, et al
Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock.
Crit Care Med. 2017 Nov 3. doi: 10.1097/CCM.0000000000002834.
PubMed Abstract available

CASEY JD, Semler MW, Bastarache JA
Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?
Crit Care Med. 2017;45:1959-1960.
PubMed

JAWA RS, Kew RR
Sepsis in the Critically Ill-Does Gender Matter?
Crit Care Med. 2017;45:1957-1959.
PubMed

SPOLARICS Z
Victims or Culprits, B Cells May Serve as Markers for Mortality Risk and Targeted Therapy in Sepsis.
Crit Care Med. 2017;45:1951-1952.
PubMed

LIU VX, Walkey AJ
Machine Learning and Sepsis: On the Road to Revolution.
Crit Care Med. 2017;45:1946-1947.
PubMed

COQUEREL D, Chagnon F, Sainsily X, Dumont L, et al
ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.
Crit Care Med. 2017;45:e1139-e1148.
PubMed Abstract available

MOSKOWITZ A, Patel PV, Grossestreuer AV, Chase M, et al
Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection.
Crit Care Med. 2017;45:1813-1819.
PubMed Abstract available

October 2017

STEELAND S, Van Ryckeghem S, Vandewalle J, Ballegeer M, et al
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
Crit Care Med. 2017 Oct 31. doi: 10.1097/CCM.0000000000002813.
PubMed Abstract available

RUSH B, Tyler PD, Stone DJ, Geisler BP, et al
Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis.
Crit Care Med. 2017 Oct 24. doi: 10.1097/CCM.0000000000002777.
PubMed Abstract available

YEHYA N, Wong HR
Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome.
Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002754.
PubMed Abstract available

PUTHUCHEARY ZA, Sun Y, Zeng K, Vu LH, et al
Sepsis Reduces Bone Strength Before Morphologic Changes Are Identifiable.
Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002732.
PubMed Abstract available

WONG HR, Sweeney TE, Hart KW, Khatri P, et al
Pediatric Sepsis Endotypes Among Adults With Sepsis.
Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002733.
PubMed Abstract available

EHLENBACH WJ, Gilmore-Bykovskyi A, Repplinger MD, Westergaard RP, et al
Sepsis Survivors Admitted to Skilled Nursing Facilities: Cognitive Impairment, Activities of Daily Living Dependence, and Survival.
Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002755.
PubMed Abstract available

MEYER NJ, Reilly JP, Anderson BJ, Palakshappa JA, et al
Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration.
Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002749.
PubMed Abstract available

VITORIO D, Nassar AP Jr, Caruso P
Procalcitonin Clearance and Prognosis in Sepsis: Are There Really an Optimal Cutoff and Time Interval?
Crit Care Med. 2017;45:e1097-e1098.
PubMed

PFORTMUELLER CA, Meisel C, Schefold JC
Interpreting Immune Mediator Dysbalance in Sepsis.
Crit Care Med. 2017;45:e1094-e1095.
PubMed

RIMAWI RH
Bad Response or Bad Luck? A New Versus Recrudescent Sepsis Readmission.
Crit Care Med. 2017;45:1788-1789.
PubMed

LANSPA MJ, Morris AH
The Importance of Clinical Context on Assessing Outcomes in Sepsis.
Crit Care Med. 2017;45:1783-1785.
PubMed

NUGENT KL, Coopersmith CM
Fluid Management in Sepsis-Is There a Golden Hour (or Two)?
Crit Care Med. 2017;45:1773-1775.
PubMed

GRASSELLI G, Scaravilli V, Di Bella S, Biffi S, et al
Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impact on Patients' Outcome.
Crit Care Med. 2017;45:1726-1733.
PubMed Abstract available

September 2017

ANNANE D, Pastores SM, Rochwerg B, Arlt W, et al
Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.
Crit Care Med. 2017 Sep 21. doi: 10.1097/CCM.0000000000002737.
PubMed Abstract available

JONES JM, Fingar KR, Miller MA, Coffey R, et al
Racial Disparities in Sepsis-Related In-Hospital Mortality: Using a Broad Case Capture Method and Multivariate Controls for Clinical and Hospital Variables, 2004-2013.
Crit Care Med. 2017 Sep 12. doi: 10.1097/CCM.0000000000002699.
PubMed Abstract available

WANG HE, Jones AR, Donnelly JP
Revised National Estimates of Emergency Department Visits for Sepsis in the United States.
Crit Care Med. 2017;45:1443-1449.
PubMed Abstract available

AGAROSSI A, Pintaudi G
Antimicrobials and Progression to Septic Shock in Severe Sepsis Patients: Is Delay the Only Thing That Matters?
Crit Care Med. 2017;45:e988-e989.
PubMed

MARSHALL JC
Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis.
Crit Care Med. 2017;45:1582-1583.
PubMed

GAUDILLIERE B, Angst MS, Hotchkiss RS
Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!
Crit Care Med. 2017;45:1577-1578.
PubMed

RHEE C, Klompas M
What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition.
Crit Care Med. 2017;45:1569-1571.
PubMed

DEUTSCHMAN CS
Sepsis-3: Seeing the Entire Picture.
Crit Care Med. 2017;45:1567-1569.
PubMed

SPRUNG CL, Trahtemberg U
What Definition Should We Use for Sepsis and Septic Shock?
Crit Care Med. 2017;45:1564-1567.
PubMed

FADEL F, Andre-Gregoire G, Gravez B, Bauvois B, et al
Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock.
Crit Care Med. 2017;45:e954-e962.
PubMed Abstract available

August 2017

VAN VUGHT LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, et al
Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.
Crit Care Med. 2017 Aug 11. doi: 10.1097/CCM.0000000000002649.
PubMed Abstract available

ZHAI Q, Lai D, Cui P, Zhou R, et al
Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway.
Crit Care Med. 2017 Aug 10. doi: 10.1097/CCM.0000000000002646.
PubMed Abstract available

TRAUER J, Muhi S, McBryde ES, Al Harbi SA, et al
Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
Crit Care Med. 2017 Aug 9. doi: 10.1097/CCM.0000000000002654.
PubMed Abstract available

KALIL AC, Kellum JA
Is Early Goal-Directed Therapy Harmful to Patients With Sepsis and High Disease Severity?
Crit Care Med. 2017;45:1265-1267.
PubMed

July 2017

SHANKAR-HARI M, Singer M, Spencer J
Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?
Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002627.
PubMed Abstract available

DEMERLE KM, Royer SC, Mikkelsen ME, Prescott HC, et al
Readmissions for Recurrent Sepsis: New or Relapsed Infection?
Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002626.
PubMed Abstract available

VAN VUGHT LA, Holman R, de Jonge E, de Keizer NF, et al
Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis.
Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002590.
PubMed Abstract available

CHURPEK MM, Snyder A, Sokol S, Pettit NN, et al
Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores.
Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002648.
PubMed Abstract available

MACHADO FR, Ferreira EM, Sousa JL, Silva C, et al
Quality Improvement Initiatives in Sepsis in an Emerging Country: Does the Institution's Main Source of Income Influence the Results? An Analysis of 21,103 Patients.
Crit Care Med. 2017 Jul 6. doi: 10.1097/CCM.0000000000002585.
PubMed Abstract available

NI CHEALLAIGH C, Sheedy FJ
Shields Up-Systemic Protection Provided by microRNA-21 During Sepsis?
Crit Care Med. 2017;45:1261-1263.
PubMed

MARRARO GA, Genovese U, Spada C, Piga MA, et al
Can the Treatment Approach of Sepsis With Balanced Crystalloid Fluids Translate Into Therapy for Acute Respiratory Distress Syndrome if Considered as "Lung-Limited Sepsis"?
Crit Care Med. 2017;45:1246-1248.
PubMed

PRESCOTT HC, Donnelly JP
Penalizing Readmissions After Sepsis Could Do More Harm Than Good.
Crit Care Med. 2017;45:1243-1244.
PubMed

June 2017

LEISMAN DE, Goldman C, Doerfler ME, Masick KD, et al
Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort.
Crit Care Med. 2017 Jun 30. doi: 10.1097/CCM.0000000000002574.
PubMed Abstract available

LEE CC, Lee MG, Lee WC, Lai CC, et al
Preadmission Use of Calcium Channel Blocking Agents Is Associated With Improved Outcomes in Patients With Sepsis: A Population-Based Propensity Score-Matched Cohort Study.
Crit Care Med. 2017 Jun 27. doi: 10.1097/CCM.0000000000002550.
PubMed Abstract available

HE X, Su F, Xie K, Taccone FS, et al
Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis.
Crit Care Med. 2017 Jun 14. doi: 10.1097/CCM.0000000000002524.
PubMed Abstract available

LEISMAN DE, Sethna CB
Renin-Angiotensin-Aldosterone System Blockade Use in Sepsis Patients: Did It Impact Renal Outcomes?
Crit Care Med. 2017;45:e624.
PubMed

GAINES S, Alverdy JC
Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.
Crit Care Med. 2017;45:1106-1107.
PubMed

FRAIMOW HS
Safe at First, But Not Reaching Second: Implications of Delayed Second Doses of Antimicrobials in Patients Presenting to Emergency Departments With Sepsis.
Crit Care Med. 2017;45:1097-1098.
PubMed

DAVIS AL, Carcillo JA, Aneja RK, Deymann AJ, et al
American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock.
Crit Care Med. 2017;45:1061-1093.
PubMed Abstract available

PELTAN ID, Mitchell KH, Rudd KE, Mann BA, et al
Physician Variation in Time to Antimicrobial Treatment for Septic Patients Presenting to the Emergency Department.
Crit Care Med. 2017;45:1011-1018.
PubMed Abstract available

HENNING DJ, Carey JR, Oedorf K, Day DE, et al
The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock.
Crit Care Med. 2017;45:e575-e582.
PubMed Abstract available

RUSSELL JA, Lee T, Singer J, Boyd JH, et al
The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.
Crit Care Med. 2017;45:940-948.
PubMed Abstract available

TERRASINI N, Lionetti V
Exosomes in Critical Illness.
Crit Care Med. 2017;45:1054-1060.
PubMed Abstract available

May 2017

STERLING SA, Puskarich MA, Glass AF, Guirgis F, et al
The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
Crit Care Med. 2017 May 24. doi: 10.1097/CCM.0000000000002512.
PubMed Abstract available

STANA F, Vujovic M, Mayaki D, Leduc-Gaudet JP, et al
Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.
Crit Care Med. 2017 May 22. doi: 10.1097/CCM.0000000000002520.
PubMed Abstract available

DEUTSCHMAN CS
"Defining" Sepsis: Moving Toward Measuring the "Dysregulated Host Response".
Crit Care Med. 2017;45:927-930.
PubMed

MARIK PE
Glucocorticosteroids as Adjunctive Therapy for Acute Respiratory Distress Syndrome and Sepsis? Yes, But Not as Monotherapy.
Crit Care Med. 2017;45:910-911.
PubMed

LEVY MM
Antibiotics in Sepsis: The New Frontier.
Crit Care Med. 2017;45:907-908.
PubMed

JUNG B, Mahul M, Breilh D, Legeron R, et al
Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under- and Overdosing.
Crit Care Med. 2017;45:e470-e478.
PubMed Abstract available

BERGAMIN FS, Almeida JP, Landoni G, Galas FRBG, et al
Liberal Versus Restrictive Transfusion Strategy in Critically Ill Oncologic Patients: The Transfusion Requirements in Critically Ill Oncologic Patients Randomized Controlled Trial.
Crit Care Med. 2017;45:766-773.
PubMed Abstract available

DREWRY AM, Ablordeppey EA, Murray ET, Stoll CRT, et al
Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis.
Crit Care Med. 2017;45:806-813.
PubMed Abstract available

April 2017

NORMAN BC, Cooke CR, Ely EW, Graves JA, et al
Sepsis-Associated 30-Day Risk-Standardized Readmissions: Analysis of a Nationwide Medicare Sample.
Crit Care Med. 2017 Apr 29. doi: 10.1097/CCM.0000000000002476.
PubMed Abstract available

CHANG T, Tu YK, Lee CT, Chao A, et al
Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis.
Crit Care Med. 2017 Apr 25. doi: 10.1097/CCM.0000000000002362.
PubMed Abstract available

JIA P, Wu X, Dai Y, Teng J, et al
MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis.
Crit Care Med. 2017 Apr 21. doi: 10.1097/CCM.0000000000002363.
PubMed Abstract available

EMRATH ET, Fortenberry JD, Travers C, McCracken CE, et al
Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis.
Crit Care Med. 2017 Apr 21. doi: 10.1097/CCM.0000000000002365.
PubMed Abstract available

ARULKUMARAN N, Sixma ML, Jentho E, Ceravola E, et al
Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery.
Crit Care Med. 2017 Apr 20. doi: 10.1097/CCM.0000000000002381.
PubMed Abstract available

ZHOU J, Tian H, Du X, Xi X, et al
Population-Based Epidemiology of Sepsis in a Subdistrict of Beijing.
Crit Care Med. 2017 Apr 18. doi: 10.1097/CCM.0000000000002414.
PubMed Abstract available

PINTO BB, Dyson A, Umbrello M, Carre JE, et al
Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand.
Crit Care Med. 2017 Apr 13. doi: 10.1097/CCM.0000000000002448.
PubMed Abstract available

SCICLUNA BP, van der Poll T
Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.
Crit Care Med. 2017;45:e457.
PubMed

WALLEY KR
New Approaches to Modifying Inotropy in Sepsis-Induced Myocardial Dysfunction.
Crit Care Med. 2017;45:754-756.
PubMed

SIMPSON SQ
Surviving Transfer for Sepsis: Size Matters-Or Does It?
Crit Care Med. 2017;45:749-750.
PubMed

LAUPLAND KB, Niven DJ
The Normal Abnormal Vital Sign of Sepsis.
Crit Care Med. 2017;45:747-748.
PubMed

DEUTSCHMAN CS
Sepsis-3: Of Love and Bliss.
Crit Care Med. 2017;45:739-740.
PubMed

ALDER MN, Opoka AM, Lahni P, Hildeman DA, et al
Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.
Crit Care Med. 2017;45:e426-e432.
PubMed Abstract available

ARVANITI K, Lathyris D, Blot S, Apostolidou-Kiouti F, et al
Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis.
Crit Care Med. 2017;45:e437-e448.
PubMed Abstract available

March 2017

FAWZY A, Walkey AJ
Association Between Hospital Case Volume of Sepsis, Adherence to Evidence-Based Processes of Care and Patient Outcomes.
Crit Care Med. 2017 Mar 27. doi: 10.1097/CCM.0000000000002409.
PubMed Abstract available

LEISMAN D, Huang V, Zhou Q, Gribben J, et al
Delayed Second Dose Antibiotics for Patients Admitted From the Emergency Department With Sepsis: Prevalence, Risk Factors, and Outcomes.
Crit Care Med. 2017 Mar 21. doi: 10.1097/CCM.0000000000002377.
PubMed Abstract available

SHANKAR-HARI M, Fear D, Lavender P, Mare T, et al
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis.
Crit Care Med. 2017 Mar 14. doi: 10.1097/CCM.0000000000002380.
PubMed Abstract available

MOSS TJ, Calland JF, Enfield KB, Gomez-Manjarres DC, et al
New-Onset Atrial Fibrillation in the Critically Ill.
Crit Care Med. 2017 Mar 14. doi: 10.1097/CCM.0000000000002325.
PubMed Abstract available

MCKOWN AC, McGuinn EM, Ware LB, Wang L, et al
Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis.
Crit Care Med. 2017 Mar 2. doi: 10.1097/CCM.0000000000002286.
PubMed Abstract available

SCHUETZ P, Birkhahn R, Sherwin R, Jones AE, et al
Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
Crit Care Med. 2017 Mar 2. doi: 10.1097/CCM.0000000000002321.
PubMed Abstract available

FRENCKEN JF, van Vught LA, Peelen LM, Ong DS, et al
An Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study.
Crit Care Med. 2017 Mar 2. doi: 10.1097/CCM.0000000000002292.
PubMed Abstract available

PEPPER DJ
Adipose Tissue Measurements in Patients With Sepsis.
Crit Care Med. 2017;45:e331.
PubMed

KUHN SO, Meissner K, Rehberg S
Fluid Resuscitation in Sepsis: "Get the Balance Right".
Crit Care Med. 2017;45:555-556.
PubMed

MOROWITZ MJ, Di Caro V, Pang D, Cummings J, et al
Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.
Crit Care Med. 2017 Mar 1. doi: 10.1097/CCM.0000000000002291.
PubMed Abstract available

KELLUM JA, Pike F, Yealy DM, Huang DT, et al
Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study.
Crit Care Med. 2017;45:438-445.
PubMed Abstract available

MYATRA SN, Prabu NR, Divatia JV, Monnet X, et al
The Changes in Pulse Pressure Variation or Stroke Volume Variation After a "Tidal Volume Challenge" Reliably Predict Fluid Responsiveness During Low Tidal Volume Ventilation.
Crit Care Med. 2017;45:415-421.
PubMed Abstract available

February 2017

HOOGENDIJK AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, et al
Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-kappaB in Multiple Cell Types.
Crit Care Med. 2017 Feb 24. doi: 10.1097/CCM.0000000000002294.
PubMed Abstract available

SEYMOUR CW, Kahn JM, Martin-Gill C, Callaway CW, et al
Delays From First Medical Contact to Antibiotic Administration for Sepsis.
Crit Care Med. 2017 Feb 23. doi: 10.1097/CCM.0000000000002264.
PubMed Abstract available

WHILES BB, Deis AS, Simpson SQ
Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients.
Crit Care Med. 2017 Feb 6. doi: 10.1097/CCM.0000000000002262.
PubMed Abstract available

BRENT AJ
Meta-Analysis of Time to Antimicrobial Therapy in Sepsis: Confounding as Well as Bias.
Crit Care Med. 2017;45:e242-e243.
PubMed

BRIASSOULIS G, Ilia S
Vitamin D Deficiency in Sepsis: "Body Humors" Imbalance or Sepsis "Epiphenomenon"?
Crit Care Med. 2017;45:376-377.
PubMed

BHARDWAJ A, Mikkelsen ME
Sepsis Quality Improvement Initiatives: Prepare for the Marathon, Not the Sprint.
Crit Care Med. 2017;45:374-375.
PubMed

ALVERDY JC, Krezalek MA
Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.
Crit Care Med. 2017;45:337-347.
PubMed Abstract available

VON BAHR V, Hultman J, Eksborg S, Frenckner B, et al
Long-Term Survival in Adults Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure and Sepsis.
Crit Care Med. 2017;45:164-170.
PubMed Abstract available

OFOMA UR, Dahdah J, Kethireddy S, Maeng D, et al
Case Volume-Outcomes Associations Among Patients With Severe Sepsis Who Underwent Interhospital Transfer.
Crit Care Med. 2017 Feb 1. doi: 10.1097/CCM.0000000000002254.
PubMed Abstract available

HUET O, Pickering RJ, Tikellis C, Latouche C, et al
Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock.
Crit Care Med. 2017;45:e184-e194.
PubMed Abstract available

January 2017

SUNDEN-CULLBERG J, Rylance R, Svefors J, Norrby-Teglund A, et al
Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU.
Crit Care Med. 2017 Jan 30. doi: 10.1097/CCM.0000000000002249.
PubMed Abstract available

DELLINGER RP, Schorr CA, Levy MM
A Users' Guide to the 2016 Surviving Sepsis Guidelines.
Crit Care Med. 2017 Jan 17. doi: 10.1097/CCM.0000000000002257.
PubMed

COZ YATACO A, Jaehne AK, Rivers EP
Protocolized Early Sepsis Care Is Not Only Helpful for Patients: It Prevents Medical Errors.
Crit Care Med. 2017 Jan 17. doi: 10.1097/CCM.0000000000002237.
PubMed

RHODES A, Evans LE, Alhazzani W, Levy MM, et al
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.
Crit Care Med. 2017 Jan 17. doi: 10.1097/CCM.0000000000002255.
PubMed Abstract available

WIEWEL MA, van Vught LA, Scicluna BP, Hoogendijk AJ, et al
Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis; a Prospective Observational Study.
Crit Care Med. 2017 Jan 10. doi: 10.1097/CCM.0000000000002236.
PubMed Abstract available

MATKOVICH SJ, Al Khiami B, Efimov IR, Evans S, et al
Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.
Crit Care Med. 2017 Jan 6. doi: 10.1097/CCM.0000000000002207.
PubMed Abstract available

KALIL AC, Johnson DW, Lisco SJ, Sun J, et al
Early Goal-Directed Therapy for Sepsis: A Novel Solution for Discordant Survival Outcomes in Clinical Trials.
Crit Care Med. 2017 Jan 6. doi: 10.1097/CCM.0000000000002235.
PubMed Abstract available

CROUSER ED, Hotchkiss RS
Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.
Crit Care Med. 2017;45:145-147.
PubMed

RIE M
Rural Sepsis Mortality: Patient Emergency Care Preference Impacts Resuscitation Outcome Value.
Crit Care Med. 2017;45:138-139.
PubMed

OPAL SM
Source Control in Sepsis Urgent or Not So Fast?
Crit Care Med. 2017;45:130-132.
PubMed

MIRA JC, Moldawer LL
Sepsis Diagnostics: From Discovery to Application.
Crit Care Med. 2017;45:129-130.
PubMed

BAILLY DK, Reeder RW, Zabrocki LA, Hubbard AM, et al
Development and Validation of a Score to Predict Mortality in Children Undergoing Extracorporeal Membrane Oxygenation for Respiratory Failure: Pediatric Pulmonary Rescue With Extracorporeal Membrane Oxygenation Prediction Score.
Crit Care Med. 2017;45:e58-e66.
PubMed Abstract available

December 2016

LEISMAN DE, Doerfler ME, Ward MF, Masick KD, et al
Survival Benefit and Cost Savings From Compliance With a Simplified 3-Hour Sepsis Bundle in a Series of Prospective, Multisite, Observational Cohorts.
Crit Care Med. 2016.
PubMed Abstract available

SAKR Y, Rubatto Birri PN, Kotfis K, Nanchal R, et al
Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit.
Crit Care Med. 2016.
PubMed Abstract available

KRISHNAN S, Shah K, Dhillon G, Presberg K, et al
1995: FATAL PURPURA FULMINANS AND FULMINANT PSEUDOMONAL SEPSIS.
Crit Care Med. 2016;44.
PubMed

SOLVERSON K, Doig C
1990: A FATAL CASE OF OVERWHELMING PNEUMOCOCCAL SEPSIS IN A SPLENECTOMISED PATIENT.
Crit Care Med. 2016;44.
PubMed

SHANBHAG A, Llanos Ulloa O, Meena N
1988: PNEUMOCOCCAL SEPSIS IN ITP POST-SPLENECTOMY AND VACCINATION DUE TO COEXISTING CVID.
Crit Care Med. 2016;44.
PubMed

LIU C, Crnkovic A, Dalfino J, Barlin J, et al
1830: WHETHER TO PROCEED WITH DEEP BRAIN STIMULATOR BATTERY CHANGE IN A PATIENT WITH POTENTIAL SEPSIS.
Crit Care Med. 2016;44.
PubMed

HITOSUGI-LEVESQUE M, Devendra G
1780: A FATAL CASE OF VIBRIO VULNIFICUS SEPSIS WITH HEMORRHAGIC BULLAE.
Crit Care Med. 2016;44.
PubMed

MEDEPALLI K, Benninger L, Lebeck-Lee C, Elwing J, et al
1741: CHEMOTHERAPY: A THERAPEUTIC OPTION IN SEPSIS?
Crit Care Med. 2016;44.
PubMed

GUTIERREZ J, Andavolu R, Ursell P
1650: MYOCARDIAL CALCIFICATION IN PEDIATRIC VIRAL SEPSIS.
Crit Care Med. 2016;44.
PubMed

MALHOTRA I, Desoky H, Shenoy MA, Shankar S, et al
1619: SEPSIS-INDUCED ISOLATED RIGHT VENTRICULAR STRESS CARDIOMYOPATHY MASQUERADING AS PULMONARY EMBOLISM.
Crit Care Med. 2016;44.
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ROBERTSON J, Criss C, Hsieh L, Gish J, et al
1500: STEROID USE FOR REFRACTORY HYPOTENSION IN CONGENITAL DIAPHRAGMATIC HERNIA INCREASES SEPSIS RISK.
Crit Care Med. 2016;44.
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JUNE A, Bhutta A, Holloway A, Bagdure D, et al
1493: OUTCOMES OF PATIENTS WITH SEPSIS RELATED TO STAPHALOCOCCUS AUREUS MANAGED WITH ECMO.
Crit Care Med. 2016;44.
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KYO M, Ohshimo S, Kida Y, Shime N, et al
1492: THE VALIDATION OF QSOFA CRITERIA FOR SEPSIS.
Crit Care Med. 2016;44.
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SAITO N, Kawasaki A, Akizuki N, Namiki M, et al
1491: ANTITHROMBIN III DEFICIENCY RELATES TO MORTALITY IN SEPSIS.
Crit Care Med. 2016;44.
PubMed

BLAU S, Spector R
1487: SEPSIS CARE IN NEW YORK STATE: SERVING TWO MASTERS.
Crit Care Med. 2016;44.
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DICK-PEREZ R, Mohr N, Harland K, Ahmed A, et al
1479: ED CHARGES PREDICT SEVERITY OF ILLNESS AND MORTALITY IN PATIENTS WITH SEVERE SEPSIS/SEPTIC SHOCK.
Crit Care Med. 2016;44.
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EL QADDOUMI H, Roy A, Davis J, Katsikeris F, et al
1478: PRESENTATION AND COURSE OF PRENATAL SEPSIS IN AN ACADEMIC MEDICAL CENTER.
Crit Care Med. 2016;44.
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GRAHAM J, Krall B, Presente A, Saucier J, et al
1477: SOFA SCORES IN PATIENTS TRIGGERING AN EMR-BASED SEPSIS ALERT.
Crit Care Med. 2016;44.
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NAZER L, Abusara A, Hawari F
1476: ASSESSING THE 3RD INTERNATIONAL CONSENSUS DEFINITION FOR SEPTIC SHOCK (SEPSIS-3) IN CANCER PATIENTS.
Crit Care Med. 2016;44.
PubMed

DELUCA P, Ali S, Fryckberg A, Vyas N, et al
1475: ASSESSMENT OF NONCOMPLIANCE WITH BUNDLE THERAPY FOR THE TREATMENT OF SEPSIS ON THE INPATIENT FLOOR.
Crit Care Med. 2016;44.
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HARTKOPP B, Fletcher S, Ekengren F, Berg G, et al
1473: TERTIARY HOSPITAL SEPSIS CHAMPION: EDUCATION REVEALS NEEDS AND INCREASES TRANSFERS.
Crit Care Med. 2016;44.
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JIM F, Li J, Peng Z
1472: ACTIVATION OF THE CHOLINERGIC ANTIINFLAMMATORY PATHWAY IMPROVES SEPSIS-INDUCED HYPERGLYCEMIA.
Crit Care Med. 2016;44.
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JAIMES F, Castano P, Plaza M, Molina F, et al
1470: ANTIBIOTICS PRESCRIPTION IS NOT ASSOCIATED WITH PROGNOSIS IN SEPSIS: A PROSPECTIVE COHORT STUDY.
Crit Care Med. 2016;44.
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LIMA K, Caynak R, Lara F, Tran N, et al
1469: LACTATE MONITORING FOR SEVERE SEPSIS AND SEPTIC SHOCK: ARE ALL LACTATE MEASUREMENTS THE SAME?
Crit Care Med. 2016;44.
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WEISS S, Balamuth F, Fitzgerald J, Hensley J, et al
1468: EPIDEMIOLOGY OF DEATH FOLLOWING PEDIATRIC SEPSIS: WHEN, WHY, AND HOW SEPTIC KIDS DIE.
Crit Care Med. 2016;44.
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FRENCKEN J, Donker D, Horn J, Van Der Poll T, et al
1462: MYOCARDIAL INJURY DURING SEPSIS: INCIDENCE AND ASSOCIATION WITH MORTALITY.
Crit Care Med. 2016;44.
PubMed

BREUER R, Hassinger A
1461: THE PEDIATRIC PROVIDER EXPERIENCE WITH SEPSIS AND SEPTIC SHOCK (PRESS) STUDY.
Crit Care Med. 2016;44.
PubMed

ZILBERBERG M, Shorr A, Micek S, Williams M, et al
1460: EPIDEMIOLOGY AND OUTCOMES OF SEPSIS-ASSOCIATED COAGULOPATHY IN SEVERE SEPSIS AND SEPTIC SHOCK.
Crit Care Med. 2016;44.
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TAKAUJI S, Hayakawa M, Ono K, Fujita S, et al
1459: VENOARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION FOR SEVERE SEPSIS AND SEPTIC SHOCK IN 3,195 ADULTS.
Crit Care Med. 2016;44.
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NOURIEL J, Millis S, Ottolini J, Wilburn J, et al
1457: THE RELATIONSHIP BETWEEN BLOOD PRESSURE VARIABILITY AND LACTATE IN EARLY SEPSIS RESUSCITATION.
Crit Care Med. 2016;44.
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GUIRGIS F, Sterling S, Smotherman C, Moore F, et al
1456: A COMPARISON OF SOFA USING SPO2/FIO2 RATIO TO SOFA, SIRS, AND QSOFA FOR SEPSIS MORTALITY.
Crit Care Med. 2016;44.
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YUNE H, Kim K, Jo YH, Kim J, et al
1453: INFUSION OF METHYLENE BLUE IN SEVERE SEPSIS AND SEPTIC SHOCK: A RANDOMIZED CONTROLLED TRIAL.
Crit Care Med. 2016;44.
PubMed

JAIMES F, Londono J, Nino C, Valencia M, et al
1452: NO IMPROVEMENT WITH EGDT OR ANTIBIOTICS IN PATIENTS WITH SEPSIS: AN INSTRUMENTAL VARIABLE ANALYSIS.
Crit Care Med. 2016;44.
PubMed

HARTOG C, Matt B, Kortgen A, Konig C, et al
1446: WHAT MATTERS MOST TO SURVIVORS OF SEPSIS? DEVELOPMENT OF PATIENT-REPORTED QUALITY-OF-LIFE DOMAINS.
Crit Care Med. 2016;44.
PubMed

SAKHUJA A, Kumar G, Vallabhajosyula S, Kashyap R, et al
1445: WHO CAN BE CALLED "ELDERLY" FOR SEVERE SEPSIS MORTALITY?
Crit Care Med. 2016;44.
PubMed

LEVY E, Zinter M, Madden K, Randolph A, et al
1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Crit Care Med. 2016;44.
PubMed

HANDY B, Jones P, Ostlund R Jr, Schuetz P, et al
1440: VALIDATION OF THE ELECSYS BRAHMS PROCALCITONIN ASSAY IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK.
Crit Care Med. 2016;44.
PubMed

MILZMAN D, Paik M, Shuster K, Floyd R, et al
1438: EARLY DETERMINATION OF OUTCOMES FOR SIRS VS QSOFA IN ED SEPSIS PATIENTS.
Crit Care Med. 2016;44.
PubMed

WALKER J, Peters M, Nadel S, Pathan N, et al
1436: THE ABILITY OF SEPSIS CRITERIA TO PREDICT SERIOUS BACTERIAL INFECTION IN CRITICALLY ILL CHILDREN.
Crit Care Med. 2016;44.
PubMed

MORESCO B, Root K, Cuellar C, Harkins L, et al
1435: EVALUATION OF EARLY MANAGEMENT OF SEPSIS AND COMPLIANCE WITH SEPSIS GUIDELINES.
Crit Care Med. 2016;44.
PubMed

WISKAR K, Boyd J, Rush B
1434: ASSOCIATION BETWEEN HOSPITAL CHARACTERISTICS AND MORTALITY IN SEPSIS.
Crit Care Med. 2016;44.
PubMed

TAYLOR S, Gandy T, Karvestski C, Templin M, et al
1428: INCIDENCE, PREDICTORS, AND ALTERNATE DIAGNOSES OF PATIENTS WITH FALSE-POSITIVE SEVERE SEPSIS.
Crit Care Med. 2016;44.
PubMed

FERREIRA J, Adams C, Tucker C, Allen B, et al
1427: EFFICACY OF NON-WEIGHT-BASED VASOPRESSOR DOSING IN CRITICALLY ILL PATIENTS WITH SEVERE SEPSIS.
Crit Care Med. 2016;44.
PubMed

LEISMAN D, D'Amore J, Gribben J, Ward M, et al
1426: BUNDLE COMPLIANCE EFFECT GREATER IN HEMODYNAMICALLY STABLE SEPSIS PATIENTS WITH INTERMEDIATE LACTATE.
Crit Care Med. 2016;44.
PubMed

SPECTOR R, Blau S
1425: SEPSIS MANAGEMENT: THE EFFECT OF PROTOCOL INITIATION ON PATIENT OUTCOME.
Crit Care Med. 2016;44.
PubMed

PARK JR, Kim Y, Park T, Oh WY, et al
1423: MICROCIRCULATORY ALTERATIONS IN HEMORRHAGIC SHOCK AND SEPSIS WITH OPTICAL COHERENCE TOMOGRAPHY.
Crit Care Med. 2016;44.
PubMed

PEARSON D, Benson A, Blanset J, Lovett K, et al
1422: COMMON REASONS CORE MEASURES ARE NOT MET IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK.
Crit Care Med. 2016;44.
PubMed

PELTAN I, Mitchell K, Rudd K, Mann B, et al
1421: PREHOSPITAL LEVEL OF CARE, PREHOSPITAL IV ACCESS, AND TIMING OF ANTIBIOTICS IN SEPSIS.
Crit Care Med. 2016;44.
PubMed

IBARRA F, Rowden A, Dzintars K, Lindsley J, et al
1418: UTILITY OF A SEVERE SEPSIS ORDER SET IN A MEDICAL INTENSIVE CARE UNIT.
Crit Care Med. 2016;44.
PubMed

WOZNIAK J, Dargin J
1416: THE EFFECT OF PROVIDING CLINICAL PERFORMANCE FEEDBACK ON COMPLIANCE WITH SEPSIS TREATMENT BUNDLES.
Crit Care Med. 2016;44.
PubMed

WOZNIAK J, Dargin J
1415: THE EFFECT OF PROVIDING CLINICAL PERFORMANCE FEEDBACK ON COMPLIANCE WITH SEPSIS TREATMENT BUNDLES.
Crit Care Med. 2016;44.
PubMed

HUANG C, Daniels R, Lembo A, Heymann T, et al
1413: MENTAL, PHYSIOLOGIC, AND FUNCTIONAL DISABILITIES IN POST-SEPSIS SYNDROME: AN INTERNATIONAL SURVEY.
Crit Care Med. 2016;44.
PubMed

NGUYEN T, Marini J, Lam F, Cohen D, et al
1411: PORCINE MODEL OF STAPHYLOCOCCUS AUREUS SEPSIS-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION.
Crit Care Med. 2016;44.
PubMed

STEGER A, Pedersen A, Shears E, Hurst L, et al
1409: A NURSE-LED APPROACH TO IMPROVE EARLY SEPSIS CARE IN THE EMERGENCY DEPARTMENT.
Crit Care Med. 2016;44.
PubMed

SHAH T, Rech M, Sterk E
1406: IMPACT OF THE EMERGENCY DEPARTMENT SEPSIS SCREENING TOOL ON OUTCOMES IN PATIENTS WITH SEPSIS.
Crit Care Med. 2016;44.
PubMed

SAKHUJA A, Kumar G, Vallabhajosyula S, Kashani K, et al
1405: SEASONAL VARIATIONS IN SEVERE SEPSIS HOSPITALIZATIONS.
Crit Care Med. 2016;44.
PubMed

TAYLOR S, Roohollahi A, Karvetski C, Templin M, et al
1403: DOES CIRRHOSIS AFFECT THE PROGNOSTIC UTILITY OF LACTATE FOR SEVERE SEPSIS?
Crit Care Med. 2016;44.
PubMed

ATEELI H, Jaffer F, Goel K, Low SW, et al
1402: CURB-65 SCORE CORRELATES WITH ICU ADMISSION AND IN-HOSPITAL MORTALITY IN PATIENTS WITH SEPSIS.
Crit Care Med. 2016;44.
PubMed

CUSTER J, Bhutta A, Bagdure D, Holloway A, et al
1399: OUTCOMES OF PEDIATRIC PATIENTS WITH SEPSIS MANAGED ON EXTRACORPOREAL MEMBRANE OXYGENATION.
Crit Care Med. 2016;44.
PubMed

HOSHINO K, Kawano Y, Maruyama J, Mizunuma M, et al
1398: PLASMINOGEN ACTIVATOR INHIBITOR-1 IS THE MOST PREDICTIVE MARKER OF MORTALITY IN SEPSIS.
Crit Care Med. 2016;44.
PubMed

HUANG C, Daniels R, Lembo A, Heymann T, et al
1397: SEPSIS SURVIVORS' SATISFACTION WITH SUPPORT SERVICES DURING AND AFTER THEIR HOSPITALIZATION.
Crit Care Med. 2016;44.
PubMed

LEISMAN D, Huang V, Zhou Q, Gribben J, et al
1396: DELAYED 2ND-DOSE ANTIBIOTICS FOR ED SEPSIS PATIENTS: PREVALENCE, RISK FACTORS, & ASSOCIATED OUTCOMES.
Crit Care Med. 2016;44.
PubMed

TANNEHILL D, O'Brien J, Kasal J, Subramanian S, et al
1395: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS AND SEPTIC SHOCK PATIENTS.
Crit Care Med. 2016;44.
PubMed

MCHUGH W, McDonough K, Carlton E, Kidwell K, et al
1394: PERSONALIZED IMMUNOMODULATION IN HIGH-RISK SEPSIS PATIENTS IN A PEDIATRIC CRITICAL CARE UNIT.
Crit Care Med. 2016;44.
PubMed

MAHAPATRA S, Ying L, Steinman L, Cornfield D, et al
1393: AN AMYLOIDOGENIC HEXAPEPTIDE, AMYLIN, ATTENUATES INFLAMMATION AND ACUTE LUNG INJURY IN MURINE SEPSIS.
Crit Care Med. 2016;44.
PubMed

FUKUDA S, Randolph A, Ihara K, Cox R, et al
1390: PEROXYNITRITE DECOMPOSITION CATALYST REDUCES NOREPINEPHRINE REQUIREMENT DURING SEPSIS IN OVINE MODEL.
Crit Care Med. 2016;44.
PubMed

MOORE C, Ainsworth J, Wang Y, Barnes L, et al
1389: OPTIMIZED PREDICTIVE MONITORING OF NON-INTENSIVE CARE UNIT PATIENTS AT RISK FOR SEPSIS.
Crit Care Med. 2016;44.
PubMed

RUSH B, Wiskar K, Boyd J
1388: ASSOCIATION OF WEEKEND ADMISSION WITH SEPSIS MORTALITY IN THE UNITED STATES.
Crit Care Med. 2016;44.
PubMed

KWAK S
1387: FLECAINIDE ATTENUATES SEPSIS-INDUCED ACUTE LUNG INJURY BY CONTROLLING INFLAMMATORY RESPONSE.
Crit Care Med. 2016;44.
PubMed

TRAN N, Lima K, Caynak R, Scobino C, et al
1385: EVALUATION OF PROCALCITONIN-DIRECTED TREATMENT OF SEPSIS IN PEDIATRIC INTENSIVE CARE PATIENTS.
Crit Care Med. 2016;44.
PubMed

STILL M, Carpenter D, Holder C, Murphy D, et al
1384: SUCCESS WITH IMPLEMENTATION OF A SYSTEM-BASED SEPSIS MANAGEMENT PROGRAM.
Crit Care Med. 2016;44.
PubMed

RINATO K, Pretto-Sparkuhl A, Mauch H, Viti L, et al
1383: IMPACT OF AN ENHANCED "CODE SEPSIS" PROGRAM ON MORTALITY OF ED PATIENTS PRESENTING WITH SEPSIS.
Crit Care Med. 2016;44.
PubMed

AAKRE C, Kitson J, Herasevich V
1380: TIME-MOTION ANALYSIS AND ECONOMIC IMPACT OF SOFA SCORE INTEGRATION INTO THE NEW SEPSIS-3 DEFINITION.
Crit Care Med. 2016;44.
PubMed

LEWIS A, Yuan D, Zhang X, Collage R, et al
1379: BLUE LIGHT THERAPY MODULATES THE SYSTEMIC RESPONSE TO SEPSIS IN MICE AND HUMANS.
Crit Care Med. 2016;44.
PubMed

SATO R, Kuriyama A, Takada T, Nasu M, et al
1377: PREVALENCE AND RISK FACTORS OF SEPSIS-INDUCED CARDIOMYOPATHY: A RETROSPECTIVE COHORT STUDY.
Crit Care Med. 2016;44.
PubMed

GELVEZ J, Olarte JL, Williams L, Darnell C, et al
1376: THE EFFECT OF EMERGENCY ROOM FLUID RESUSCITATION ON PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK.
Crit Care Med. 2016;44.
PubMed

HUDCOVA J, Poutsiaka D, Khan M, Waqas A, et al
1374: UTILITY OF PRESEPSIN IN DISTINGUISHING SEPSIS FROM SYSTEMIC INFLAMMATORY RESPONSE SYNDROME.
Crit Care Med. 2016;44.
PubMed

LIMA L, McCracken C, Fortenberry J, Hebbar K, et al
1373: UTILITY OF PLASMA EXCHANGE IN PEDIATRIC SEVERE SEPSIS.
Crit Care Med. 2016;44.
PubMed

MIKACENIC C, Price B, Harju-Baker S, Katz R, et al
1372: DEVELOPMENT OF A ROBUST BIOMARKER PREDICTIVE MODEL FOR DEATH IN ICU PATIENTS WITH SIRS AND SEPSIS.
Crit Care Med. 2016;44.
PubMed

SCOTT H, Brou L, Deakyne S, Bajaj L, et al
1371: USING LACTATE AND BLOOD PRESSURE TO CLASSIFY SHOCK IN PEDIATRIC SEPSIS: AN EHR-BASED APPROACH.
Crit Care Med. 2016;44.
PubMed

TAYLOR B, Gunn E, Templin M, Karvestski C, et al
1370: VOLUME ADMINISTRATION AND OUTCOMES IN OBESE PATIENTS WITH SEPSIS IN THE ERA OF PROTOCOLIZED CARE.
Crit Care Med. 2016;44.
PubMed

LI X, Guo L, Yuan Y, Zhan CG, et al
1368: SYNTHETIC HDL AS AN EFFECTIVE THERAPY FOR SEPSIS.
Crit Care Med. 2016;44.
PubMed

CHUNG KS, Kim CY, Lee SH, Kim SK, et al
1366: CLINICAL IMPLICATIONS OF THE PLASMA EPHA2 RECEPTOR LEVEL IN PATIENTS WITH SEPSIS.
Crit Care Med. 2016;44.
PubMed

TANNEHILL D, Sharpe B, Miller M, Saifo A, et al
1365: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS PATIENTS TREATED OUTSIDE THE ICU.
Crit Care Med. 2016;44.
PubMed

GASPERINO J, Gabriel-Jocson E, Perez E, Levy R, et al
1364: COMPARISON OF THE QSOFA SCORE AND SIRS CRITERIA IN PATIENTS WITH KNOWN OR SUSPECTED SEPSIS.
Crit Care Med. 2016;44.
PubMed

ZHAI X, Jiang L, Yang Z, Yu T, et al
1363: EFFECT OF ULINASTATIN ON MICROCIRCULATION DURING SEPSIS IN A RAT CECAL LIGATION AND PUNCTURE MODEL.
Crit Care Med. 2016;44.
PubMed

VALLABHAJOSYULA S, Jentzer J, Geske J, Kashani K, et al
1362: LONG-TERM NEW-ONSET HEART FAILURE IN PATIENTS WITH MYOCARDIAL DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK.
Crit Care Med. 2016;44.
PubMed

WALSH M, Hobbs B, Giancarelli A, Bhullar I, et al
1357: THE EFFECT OF OBESITY ON MORTALITY IN TRAUMA PATIENTS WITH SEPSIS.
Crit Care Med. 2016;44.
PubMed

TAYLOR B, Alexander M, Karvestski C, Templin M, et al
1354: AN AGGRESSIVE SEPSIS IDENTIFICATION INITIATIVE INCREASES FALSE-POSITIVE DIAGNOSES.
Crit Care Med. 2016;44.
PubMed

LANTRY J, April M
1353: SEPSIS CLINICAL CRITERIA IN ED PATIENTS ADMITTED TO AN ICU: AN EXTERNAL VALIDATION STUDY OF QSOFA.
Crit Care Med. 2016;44.
PubMed

HAILESELASSIE B, Su E, Nino D, Liu H, et al
1352: IMPACT OF MITOCHONDRIAL ROS SCAVENGERS ON CARDIAC MECHANICS IN A MURINE MODEL OF SEPSIS.
Crit Care Med. 2016;44.
PubMed

KAWANO Y, Hoshino K, Irie Y, Izutani Y, et al
1347: USEFULNESS OF SEPSIS BIOMARKERS ACCORDING TO THE NEW DEFINITIONS OF SEPSIS.
Crit Care Med. 2016;44.
PubMed

REILLY J, Shashaty M, Anderson B, Palakshappa J, et al
1344: PLASMA RIP3, A REGULATOR OF NECROPTOSIS, IS ASSOCIATED WITH MORTALITY & ORGAN DYSFUNCTION IN SEPSIS.
Crit Care Med. 2016;44.
PubMed

WEST A, Mangubat PM, Giles K, Guynn A, et al
1343: ANALYZING ACCURACY AND EARLY DETERMINANTS OF SEVERE SEPSIS USING REAL-TIME EMR INTEGRATED ALGORITHM.
Crit Care Med. 2016;44.
PubMed

TYLER P, Celi LA, Rush B
1342: INTERHOSPITAL TRANSFER OF PATIENTS WITH SEPSIS ACROSS THE UNITED STATES.
Crit Care Med. 2016;44.
PubMed

MARIK P, Bittner E, Hansell D, Sahatjian J, et al
1341: FLUID ADMINISTRATION IN SEPSIS/SEPTIC SHOCK, PATTERNS AND OUTCOMES: LARGE NATIONAL DATABASE ANALYSIS.
Crit Care Med. 2016;44.
PubMed

AMES S, Davis B, Carcillo J, Angus D, et al
1338: HOSPITAL-LEVEL VARIATION IN RISK-ADJUSTED MORTALITY FOR PEDIATRIC SEPSIS.
Crit Care Med. 2016;44.
PubMed

MAYR F, Balakumar V, Talisa V, Fine M, et al
1336: UNDERSTANDING THE BURDEN OF UNPLANNED SEPSIS READMISSIONS.
Crit Care Med. 2016;44.
PubMed

SALOMON J, Serrao K, Guardiola J, Bonura A, et al
1335: EARLY DETECTION OF PEDIATRIC SEPSIS USING AN ELECTRONIC MEDICAL RECORD-BASED SCREENING TOOL.
Crit Care Med. 2016;44.
PubMed

LU M, Chen E
1334: MMF PROTECTS AGAINST LIVER INJURY DURING SEPSIS VIA REGULATION OF MAPK AND NF-KappaB PATHWAYS.
Crit Care Med. 2016;44.
PubMed

PROUT A, Talisa V, Mayr F, Yende S, et al
1333: PEDIATRIC SEPSIS AND SEPTIC SHOCK: RISK FACTORS AND COMORBID CONDITIONS.
Crit Care Med. 2016;44.
PubMed

KASAL J, Stoll B, Katyal A, Tannehill D, et al
1331: ASSESSMENT OF QSOFA AND OTHER CRITERIA IN SEPSIS WITH NORMAL BLOOD PRESSURE AND INTERMEDIATE LACTATE.
Crit Care Med. 2016;44.
PubMed

ZHANG LA, Parker R, Banerjee I, Clermont G, et al
1330: SEPSIS ENDOTYPES AND THEIR PHYSIOLOGIC CHARACTERIZATION USING VITAL SIGNS.
Crit Care Med. 2016;44.
PubMed

FAY K, Klingensmith N, Lyons J, Ramonell K, et al
1329: CD43 SIGNALING CONTROLS SURVIVAL, TH2 SKEWING, AND MEMORY T CELL APOPTOSIS DURING SEPSIS.
Crit Care Med. 2016;44.
PubMed

KILLIEN E, Farris R, Watson R, Flanagin M, et al
1328: DETERIORATION IN HEALTH-RELATED QUALITY OF LIFE IS COMMON AMONG CHILDREN SURVIVING SEPSIS.
Crit Care Med. 2016;44.
PubMed

MENG X, Zhai Y, Ao L, Hui H, et al
1326: AGING ELEVATES MYOCARDIAL TLR2 LEVELS TO AUGMENT CARDIAC DYSFUNCTION AND MORTALITY DURING SEPSIS.
Crit Care Med. 2016;44.
PubMed

SUZUKI K, Okada H, Takada C, Oda K, et al
1325: HYDROCORTISONE THERAPY WITH CAR PEPTIDE PROTECTS THE INJURED ENDOTHELIAL GLYCOCALYX IN SEPSIS.
Crit Care Med. 2016;44.
PubMed

FOUNTAIN S, Perry J 3rd, Stoffer B, Raschke R, et al
1278: DESIGN OF AN ELECTRONIC MEDICAL RECORD-BASED ALERT SYSTEM TO DETECT THE ONSET OF SEVERE SEPSIS.
Crit Care Med. 2016;44.
PubMed

PENOYER D, Snyder J, Inderwiesen P, Geddie P, et al
1229: SEPSIS CORE MEASURES AND BLOOD CULTURE DOCUMENTATION: TIMING IS EVERYTHING!
Crit Care Med. 2016;44.
PubMed

BORGES N, Bavare A, Cruz A, Patel B, et al
1204: RAPID RESPONSE TO PEDIATRIC SEPSIS IN A TERTIARY CHILDREN'S HOSPITAL: BATTLING COMPLEXITY.
Crit Care Med. 2016;44.
PubMed

BALDAWI M, Al-Jubouri M, Watson J, Kathrin Jaehne A, et al
1104: THE POTENTIAL FINANCIAL CONSEQUENCE OF THE NEW SEPSIS-3 SEPSIS DEFINITIONS.
Crit Care Med. 2016;44.
PubMed

BLAHA K, Diaz F, Quilodran J, Medina T, et al
934: SAFETY AND EFFICACY OF A PREVENTIVE STRATEGY FOR FLUID OVERLOAD IN CHILDREN WITH SEPSIS AND PARDS.
Crit Care Med. 2016;44.
PubMed

PANG D, Wu Y, Cummings J, Panigrahy A, et al
721: MICROGLIAL ACTIVATION CORRELATES WITH CYTOTOXIC EDEMA IN A MURINE MODEL OF SEPSIS.
Crit Care Med. 2016;44.
PubMed

SADAKA F, Korobey M, Dumm A, Wegener G, et al
692: PRACTICE PATTERNS FOR ANTIBIOTIC DE-ESCALATION IN MRSA CULTURE-NEGATIVE SEPSIS.
Crit Care Med. 2016;44.
PubMed

ZILBERBERG M, Nathanson B, Sulham K, Fan W, et al
645: HOSPITAL RESOURCE USE ASSOCIATED WITH TREATMENT OF ACINETOBACTER BAUMANNII PNEUMONIA AND SEPSIS.
Crit Care Med. 2016;44.
PubMed

ALCAMO A, Alessi L, Noona Vehovic S, Pang D, et al
626: MULTIDRUG-RESISTANT ORGANISM SEPSIS IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS: A BURGEONING PROBLEM.
Crit Care Med. 2016;44.
PubMed

GUL F, Kemal Arslantas M, Bilgili B, Besir A, et al
482: SERUM VITAMIN D LEVEL VARIATION IN SIRS, SEPSIS, AND SEPTIC SHOCK.
Crit Care Med. 2016;44.
PubMed

HASSINGER A, Breuer R
434: SEPSIS DRILLS: A MULTIDISCIPLINARY SEPSIS EDUCATIONAL PROGRAM IN A PEDIATRIC HOSPITAL.
Crit Care Med. 2016;44.
PubMed

VILLAR J, Lighthall G
333: SERUM LACTATE LEVEL PREDICTS 3-DAY, 30-DAY, AND 1-YEAR MORTALITY IN PATIENTS WITH AND WITHOUT SEPSIS.
Crit Care Med. 2016;44.
PubMed

MORGAN R, Sutton R, Kilbaugh T, Lautz A, et al
287: PULMONARY VASODILATOR THERAPY IN A SWINE MODEL OF PEDIATRIC SEPSIS-ASSOCIATED CARDIAC ARREST.
Crit Care Med. 2016;44.
PubMed

VALLABHAJOSYULA S, Kashyap R, Geske J, Sakhuja A, et al
185: DOPPLER-DEFINED ACUTE PULMONARY HYPERTENSION IN SEPSIS AND SEPTIC SHOCK.
Crit Care Med. 2016;44.
PubMed

HIRATA JI, Ohya M
107: OXIDANT/ANTIOXIDANT TREATMENT INFLUENCES PULMONARY DNA VIA MTH1 MODIFICATIONS IN SEPSIS-INDUCED ALI.
Crit Care Med. 2016;44.
PubMed

VALLABHAJOSYULA S, Kashyap R, Geske J, Kumar M, et al
28: RIGHT VENTRICULAR DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK: AN EIGHT-YEAR ANALYSIS.
Crit Care Med. 2016;44.
PubMed

VALLABHAJOSYULA S, Jentzer J, Geske J, Sakhuja A, et al
23: CARDIORENAL SYNDROME IN SEPSIS AND SEPTIC SHOCK: THE MAYO CLINIC EXPERIENCE.
Crit Care Med. 2016;44.
PubMed

KATSIOS C, Doumouras A, Shaefi S, Novack V, et al
22: CONSERVATIVE FLUID STRATEGIES DECREASE MORTALITY IN SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Crit Care Med. 2016;44.
PubMed

HIRANO Y, Aziz M, Weng-Lang Y, Ochani M, et al
21: THE ROLE OF JUNCTIONAL ADHESION MOLECULE C IN THE AGING PHENOTYPE OF NEUTROPHILS DURING SEPSIS.
Crit Care Med. 2016;44.
PubMed

JOHNSON A, Celi LA, Raffa J, Pollard T, et al
18: EXTERNAL VALIDATION OF THE SEPSIS-3 GUIDELINES.
Crit Care Med. 2016;44.
PubMed

ENKHBAATAR P
Cellular Therapy for Sepsis: A New Hope?
Crit Care Med. 2016;44:2296-2298.
PubMed

KEMPKER JA, Martin GS
Does Sepsis Case Mix Heterogeneity Prevent Outcome Comparisons?
Crit Care Med. 2016;44:2288-2289.
PubMed

TOWNSEND SR
Collaborating for Success in Sepsis Quality Improvement.
Crit Care Med. 2016;44:2275-2277.
PubMed

November 2016

ZHANG Z, Li Q
Identifying Sepsis in Clinical Database With Sepsis-3 Definition.
Crit Care Med. 2016;44:e1145-e1146.
PubMed

ZIMMERMAN JJ, Davis R
Imprecise (Sepsis) Medicine Can Become Precise.
Crit Care Med. 2016;44:e1143-e1144.
PubMed

SAVEL RH, Simon RJ, Kupfer Y
Unraveling the Mysterious Relationship Between Obesity and Outcomes in Patients With Sepsis.
Crit Care Med. 2016;44:2104-2105.
PubMed

COHEN M, Falcone P, Kusnezov D, Paragas J, et al
Sepsis and Presidential Initiatives.
Crit Care Med. 2016;44:1963-1965.
PubMed

October 2016

JAEHNE AK, Rivers EP
Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly.
Crit Care Med. 2016.
PubMed

YOUKEE D, Hulme W, Roberts T, Daniels R, et al
Time Matters: Antibiotic Timing in Sepsis and Septic Shock.
Crit Care Med. 2016;44:e1016-e1017.
PubMed

SHIRAKURA Y, Kuriyama A
Timing of Antibiotic Administration in Sepsis and Septic Shock: The Impact That a Meta-Analysis Does Not Depict.
Crit Care Med. 2016;44:e1004.
PubMed

MARRARO GA, Genovese U
The Treatment of Severe Sepsis in the Pediatric Age: Long-Awaited Prospects and New Challenges Are Looming.
Crit Care Med. 2016;44:1960-1962.
PubMed

September 2016

PREAU S, Bortolotti P, Colling D, Dewavrin F, et al
Diagnostic Accuracy of the Inferior Vena Cava Collapsibility to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis and Acute Circulatory Failure.
Crit Care Med. 2016.
PubMed Abstract available

SWEENEY TE, Khatri P
Benchmarking Sepsis Gene Expression Diagnostics Using Public Data.
Crit Care Med. 2016.
PubMed Abstract available

SCHEER CS, Fuchs C, Kuhn SO, Vollmer M, et al
Quality Improvement Initiative for Severe Sepsis and Septic Shock Reduces 90-Day Mortality: A 7.5-Year Observational Study.
Crit Care Med. 2016.
PubMed Abstract available

ZIMMERMAN JJ, Sullivan E, Yager TD, Cheng C, et al
Diagnostic Accuracy of a Host Gene Expression Signature That Discriminates Clinical Severe Sepsis Syndrome and Infection-Negative Systemic Inflammation Among Critically Ill Children.
Crit Care Med. 2016.
PubMed Abstract available

SEPULVEDA M, Gonano LA, Viotti M, Morell M, et al
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
Crit Care Med. 2016.
PubMed Abstract available

MIRA JC, Gentile LF, Mathias BJ, Efron PA, et al
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Crit Care Med. 2016.
PubMed Abstract available

DALLI J, Colas RA, Quintana C, Barragan-Bradford D, et al
Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.
Crit Care Med. 2016.
PubMed Abstract available

MELLA JR, Chiswick E, Stepien D, Moitra R, et al
Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.
Crit Care Med. 2016.
PubMed Abstract available

PAREKH D, Patel JM, Scott A, Lax S, et al
Vitamin D Deficiency in Human and Murine Sepsis.
Crit Care Med. 2016.
PubMed Abstract available

AARVOLD AB, Ryan HM, Magee LA, von Dadelszen P, et al
Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients.
Crit Care Med. 2016.
PubMed Abstract available

OAMI T, Watanabe E, Hatano M, Sunahara S, et al
Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model.
Crit Care Med. 2016.
PubMed Abstract available

BEESLEY SJ, Wilson EL, Lanspa MJ, Grissom CK, et al
Relative Bradycardia in Patients With Septic Shock Requiring Vasopressor Therapy.
Crit Care Med. 2016.
PubMed Abstract available

MOHR NM, Harland KK, Shane DM, Ahmed A, et al
Rural Patients With Severe Sepsis or Septic Shock who Bypass Rural Hospitals Have Increased Mortality: An Instrumental Variables Approach.
Crit Care Med. 2016.
PubMed Abstract available

MARTINEZ ML, Ferrer R, Torrents E, Guillamat-Prats R, et al
Impact of Source Control in Patients With Severe Sepsis and Septic Shock.
Crit Care Med. 2016.
PubMed Abstract available

April 2016

RHEE C
Cytokine Imbalance Predicts Poor Outcomes in Staphylococcus aureus Bacteremia--But What Can We Do About It?
Crit Care Med. 2016;44:846-7.
PubMed

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