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Articles published in Crit Care Med

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Single Articles


    August 2021
  1. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Serum Agmatine Levels Were Negatively Correlated With the Severity of Sepsis: Beware of Potential Confounders!
    Crit Care Med. 2021;49:e810-e811.
    PubMed    


  2. PLOPPER GE, Sciarretta KL, Buchman TG
    Disparities in Sepsis Outcomes May Be Attributable to Access to Care.
    Crit Care Med. 2021;49:1358-1360.
    PubMed    


  3. PREST J, Sathananthan M, Jeganathan N
    Current Trends in Sepsis-Related Mortality in the United States.
    Crit Care Med. 2021;49:1276-1284.
    PubMed     Abstract available


    July 2021
  4. VAZQUEZ GUILLAMET MC, Dodda S, Liu L, Kollef MH, et al
    Race Does Not Impact Sepsis Outcomes When Considering Socioeconomic Factors in Multilevel Modeling.
    Crit Care Med. 2021 Jul 13. pii: 00003246-900000000-95151.
    PubMed     Abstract available


  5. SHAPPELL CN, Klompas M, Rhee C
    Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond.
    Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95161.
    PubMed    


  6. KARAKIKE E, Giamarellos-Bourboulis EJ, Kyprianou M, Fleischmann-Struzek C, et al
    Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95156.
    PubMed     Abstract available



  7. Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis: Erratum.
    Crit Care Med. 2021;49:e740.
    PubMed    


  8. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Higher Levels of S-100beta-a Biomarker of Astrocyte and Glial Activation Were Associated With a Greater Delirium Duration in Sepsis and Traumatic Brain Injury Patients: Beware of Some Confounders!
    Crit Care Med. 2021;49:e736-e737.
    PubMed    


  9. HONORE PM, Redant S, Preseau T, Kaefer K, et al
    Heparin-Binding Protein Performs Better for Detecting Sepsis Among Patients Presenting With Signs of Systemic Infection Compared With Procalcitonin, C-Reactive Protein, and Lactate Level, and Heparin-Binding Protein Is Sufficient for Both Ruling in an
    Crit Care Med. 2021;49:e733-e734.
    PubMed    


  10. STAUNTON O, Staunton C
    We Are Not Waiting for a Cure for Sepsis-We Are Waiting for Leadership.
    Crit Care Med. 2021;49:1192-1193.
    PubMed    


  11. SHAH AD, MacCallum NS, Harris S, Brealey DA, et al
    Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative.
    Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005169.
    PubMed     Abstract available


  12. HOLDER AL, Shashikumar SP, Wardi G, Buchman TG, et al
    A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU.
    Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005175.
    PubMed     Abstract available


    June 2021
  13. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis and Septic Shock: Beware of Some Confounders!
    Crit Care Med. 2021;49:e659.
    PubMed    


  14. OXMAN DA
    Less Lumping and More Splitting: Why We Should Not Call COVID Sepsis.
    Crit Care Med. 2021;49:e656-e657.
    PubMed    


    May 2021
  15. DE ROQUETAILLADE C, Mansouri S, Brumpt C, Neuwirth M, et al
    Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis.
    Crit Care Med. 2021 May 18. pii: 00003246-900000000-95220.
    PubMed     Abstract available


  16. GOETZ G, Hawlik K, Wild C
    Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis: An Update Systematic Review of Comparative Efficacy and Safety.
    Crit Care Med. 2021 May 3. pii: 00003246-900000000-95226.
    PubMed     Abstract available


  17. ABRAHAM E
    Moving Forward With Refinement of Definitions for Sepsis.
    Crit Care Med. 2021;49:861-863.
    PubMed    


  18. RHEE C, Heil EL
    Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis.
    Crit Care Med. 2021;49:858-860.
    PubMed    


    April 2021
  19. MOLINARI L, Heskia F, Peerapornratana S, Ronco C, et al
    Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
    Crit Care Med. 2021 Apr 30. pii: 00003246-900000000-95233.
    PubMed     Abstract available


  20. TAN K, Harazim M, Simpson A, Tan YC, et al
    Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes-The Beta-Blockers in European and Australian/American Septic Patients (BEAST) Study.
    Crit Care Med. 2021 Apr 28. doi: 10.1097/CCM.0000000000005034.
    PubMed     Abstract available


  21. DE CARVALHO LRP, Abreu SC, de Castro LL, Andrade da Silva LH, et al
    Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis.
    Crit Care Med. 2021 Apr 19. pii: 00003246-900000000-95254.
    PubMed     Abstract available


  22. OH TK, Park HY, Song IA
    Depression and Long-Term Survival Among South Korean Sepsis Survivors: A Nationwide Cohort Study From 2011 to 2014.
    Crit Care Med. 2021 Apr 8. pii: 00003246-900000000-95275.
    PubMed     Abstract available


  23. LAT I, Coopersmith CM, De Backer D
    The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
    Crit Care Med. 2021;49:623-635.
    PubMed     Abstract available


  24. CARR AC
    Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
    Crit Care Med. 2021;49:e477-e478.
    PubMed    


    March 2021
  25. REN X
    Potential Endotype Transition for Coronavirus Disease 2019-Related Sepsis With Longitudinal Transcriptome Profiling.
    Crit Care Med. 2021 Mar 16. pii: 00003246-900000000-95304.
    PubMed    


    February 2021
  26. BORN S, Dame C, Matthaus-Kramer C, Schlapbach LJ, et al
    Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016.
    Crit Care Med. 2021 Feb 23. doi: 10.1097/CCM.0000000000004919.
    PubMed     Abstract available


  27. WANG HE, Kabeto MM, Gray M, Wadley VG, et al
    Trajectory of Cognitive Decline After Sepsis.
    Crit Care Med. 2021 Feb 18. doi: 10.1097/CCM.0000000000004897.
    PubMed     Abstract available


  28. TAYLOR SP, Anderson WE, Beam K, Taylor B, et al
    The Association Between Antibiotic Delay Intervals and Hospital Mortality Among Patients Treated in the Emergency Department for Suspected Sepsis.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95342.
    PubMed     Abstract available


  29. DEMERLE KM, Angus DC, Baillie JK, Brant E, et al
    Sepsis Subclasses: A Framework for Development and Interpretation.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95341.
    PubMed     Abstract available


  30. YU SC, Betthauser KD, Gupta A, Lyons PG, et al
    Comparison of Sepsis Definitions as Automated Criteria.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95354.
    PubMed     Abstract available


  31. COOPERSMITH CM, Antonelli M, Bauer SR, Deutschman CS, et al
    Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95348.
    PubMed     Abstract available


  32. BEESLEY SJ, Sorensen J, Walkey AJ, Tonna JE, et al
    Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95347.
    PubMed     Abstract available


  33. JACQUEMET PL, Schweizer R, Ruste M, Pozzi M, et al
    Venoarterial Extracorporeal Membranous Oxygenation Should Be Considered as an Appropriate Rescue Therapy for Sepsis-Induced Refractory Cardiogenic Shock.
    Crit Care Med. 2021;49:e210-e211.
    PubMed    


  34. MUNROE E, Prescott HC
    Late Mortality From Sepsis: What We Know and What It Means.
    Crit Care Med. 2021;49:353-355.
    PubMed    


  35. ROURKE EM, Kuttab HI, Lykins JD, Hughes MD, et al
    Fluid Resuscitation in Septic Patients With Comorbid Heart Failure.
    Crit Care Med. 2021;49:e201-e204.
    PubMed    


  36. TRIPATHI S, Kumar S, Kaushik S
    The Practice and Complications of Midline Catheters: A Systematic Review.
    Crit Care Med. 2021;49:e140-e150.
    PubMed     Abstract available


    January 2021
  37. ALHAZZANI W, Evans L, Alshamsi F, Moller MH, et al
    Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
    Crit Care Med. 2021 Jan 28. doi: 10.1097/CCM.0000000000004899.
    PubMed     Abstract available


  38. KELLUM JA, Artigas A, Gunnerson KJ, Honore PM, et al
    Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004845.
    PubMed     Abstract available


  39. LIZZA BD, Betthauser KD, Juang PH, Hampton NB, et al
    Racial Disparities in Readmissions Following Initial Hospitalization for Sepsis.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004809.
    PubMed     Abstract available


  40. BONAZZETTI C, Morena V, Giacomelli A, Oreni L, et al
    Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study.
    Crit Care Med. 2021;49:e31-e40.
    PubMed     Abstract available


  41. HANSON SJ, Patel N, Petersen TL, Feng M, et al
    The authors reply.
    Crit Care Med. 2021;49:e111-e112.
    PubMed    


  42. ARCOVERDE DE SOUSA D, Spessoto AB
    Peripherally Inserted Central Catheter Versus Central Venous Catheter: It Is Time to Use Different Approaches and Metrics for a More Useful Comparison.
    Crit Care Med. 2021;49:e109-e110.
    PubMed    


  43. BARANOWSKY A, Appelt J, Kleber C, Lange T, et al
    Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor.
    Crit Care Med. 2021;49:e41-e52.
    PubMed     Abstract available


  44. VERBOOM DM, van de Groep K, Boel CHE, Haas PJA, et al
    The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients.
    Crit Care Med. 2021;49:60-69.
    PubMed     Abstract available


  45. WONG HR, Hart KW, Lindsell CJ, Sweeney TE, et al
    External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients.
    Crit Care Med. 2021;49:e98-e101.
    PubMed     Abstract available


  46. SEVRANSKY JE, Agarwal A, Jabaley CS, Rochwerg B, et al
    Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients.
    Crit Care Med. 2021;49:151-155.
    PubMed    


    December 2020
  47. FARRAH K, McIntyre L, Doig CJ, Talarico R, et al
    Sepsis-Associated Mortality, Resource Use, and Healthcare Costs: A Propensity-Matched Cohort Study.
    Crit Care Med. 2020 Dec 17. doi: 10.1097/CCM.0000000000004777.
    PubMed     Abstract available


  48. PLATA-MENCHACA EP, Ferrer R
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis.
    Crit Care Med. 2020 Dec 8. doi: 10.1097/CCM.0000000000004776.
    PubMed    


  49. ROWE S, Alcheikh A
    Harm or Benefit of High-Dose Vitamin C in Adult Patients With Sepsis and Glucose-6-Phosphate Dehydrogenase Deficiency?
    Crit Care Med. 2020;48:e1356.
    PubMed    


  50. KADRI SS
    The Sepsis Proxy Pageant: Seeking Beauty in Imperfection.
    Crit Care Med. 2020;48:1917-1919.
    PubMed    


    November 2020
  51. LANKADEVA YR, Peiris RM, Okazaki N, Birchall IE, et al
    Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
    Crit Care Med. 2020 Nov 25. doi: 10.1097/CCM.0000000000004770.
    PubMed     Abstract available


  52. SWEENEY TE, Liesenfeld O, Wacker J, He YD, et al
    Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019.
    Crit Care Med. 2020 Nov 17. doi: 10.1097/CCM.0000000000004786.
    PubMed     Abstract available


  53. WU YL, Yo CH, Hsu WT, Qian F, et al
    Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2020 Nov 16. doi: 10.1097/CCM.0000000000004738.
    PubMed     Abstract available


  54. BANIASADI A, Rezaeirad S, Zare H, Ghassemi MM, et al
    Two-Step Imputation and AdaBoost-Based Classification for Early Prediction of Sepsis on Imbalanced Clinical Data.
    Crit Care Med. 2020 Nov 5. doi: 10.1097/CCM.0000000000004705.
    PubMed     Abstract available


    October 2020
  55. NESARAGI N, Patidar S
    Early Prediction of Sepsis From Clinical Data Using Ratio and Power-Based Features.
    Crit Care Med. 2020 Oct 13. doi: 10.1097/CCM.0000000000004691.
    PubMed     Abstract available


  56. HE Z, Du L, Zhang P, Zhao R, et al
    Early Sepsis Prediction Using Ensemble Learning With Deep Features and Artificial Features Extracted From Clinical Electronic Health Records.
    Crit Care Med. 2020 Oct 12. doi: 10.1097/CCM.0000000000004644.
    PubMed     Abstract available


  57. KEMPKER JA, Rudd KE, Wang HE, Martin GS, et al
    Sepsis Epidemiology Across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, Chasm-A Direct Application of the Institute for Health Metrics and Evaluation Case Definition to Hospital
    Crit Care Med. 2020 Oct 2. doi: 10.1097/CCM.0000000000004577.
    PubMed     Abstract available


  58. SCOTT HF, Brilli RJ, Paul R, Macias CG, et al
    Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement.
    Crit Care Med. 2020;48:e916-e926.
    PubMed     Abstract available


  59. LI X, Xu X, Xie F, Xu X, et al
    A Time-Phased Machine Learning Model for Real-Time Prediction of Sepsis in Critical Care.
    Crit Care Med. 2020;48:e884-e888.
    PubMed     Abstract available


  60. PARK S, Jeon K, Oh DK, Choi EY, et al
    Normothermia in Patients With Sepsis Who Present to Emergency Departments Is Associated With Low Compliance With Sepsis Bundles and Increased In-Hospital Mortality Rate.
    Crit Care Med. 2020;48:1462-1470.
    PubMed     Abstract available


  61. BOURNE DS, Davis BS, Gigli KH, Chang CH, et al
    Economic Analysis of Mandated Protocolized Sepsis Care in New York Hospitals.
    Crit Care Med. 2020;48:1411-1418.
    PubMed     Abstract available


  62. SCHLAPBACH LJ, Watson RS
    Adapting Pediatric Sepsis Criteria for Benchmarking and Quality Control - The Search for the Holy Grail Continues.
    Crit Care Med. 2020;48:1549-1551.
    PubMed    


  63. WALLEY KR, Boyd JH
    Lipoprotein Biology in Sepsis.
    Crit Care Med. 2020;48:1547-1549.
    PubMed    


  64. NOEL C, Schorr C
    Normothermia in Sepsis Warrants More Than a Lukewarm Response.
    Crit Care Med. 2020;48:1538-1540.
    PubMed    


    September 2020
  65. BHAVANI SV, Wolfe KS, Hrusch CL, Greenberg JA, et al
    Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.
    Crit Care Med. 2020 Sep 17. doi: 10.1097/CCM.0000000000004610.
    PubMed     Abstract available


    August 2020
  66. SHAPPELL CN, Klompas M, Rhee C
    Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?
    Crit Care Med. 2020 Aug 24. doi: 10.1097/CCM.0000000000004601.
    PubMed    


  67. BELTRAN-GARCIA J, Osca-Verdegal R, Pallardo FV, Ferreres J, et al
    Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches.
    Crit Care Med. 2020 Aug 18. doi: 10.1097/CCM.0000000000004625.
    PubMed     Abstract available


  68. YANG M, Liu C, Wang X, Li Y, et al
    An Explainable Artificial Intelligence Predictor for Early Detection of Sepsis.
    Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004550.
    PubMed     Abstract available


  69. MAVES RC
    Procalcitonin Is Not an Adequate Tool for Antimicrobial De-Escalation in Sepsis.
    Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004547.
    PubMed    


  70. MORRILL JH, Kormilitzin A, Nevado-Holgado AJ, Swaminathan S, et al
    Utilization of the Signature Method to Identify the Early Onset of Sepsis From Multivariate Physiological Time Series in Critical Care Monitoring.
    Crit Care Med. 2020 Aug 3. doi: 10.1097/CCM.0000000000004510.
    PubMed     Abstract available


  71. SATO R, Kuriyama A
    Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
    Crit Care Med. 2020;48:e722-e729.
    PubMed     Abstract available


  72. DEUTSCHMAN CS, Hellman J, Ferrer Roca R, De Backer D, et al
    The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities.
    Crit Care Med. 2020;48:1217-1232.
    PubMed     Abstract available


  73. GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
    Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
    Crit Care Med. 2020;48:1175-1179.
    PubMed     Abstract available


  74. LEVI M, Vincent JL, Tanaka K, Radford AH, et al
    Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
    Crit Care Med. 2020;48:1140-1147.
    PubMed     Abstract available


    July 2020
  75. BUSCH LM, Sun J, Eichacker PQ, Torabi-Parizi P, et al
    Inhibitory Immune Checkpoint Molecule Expression in Clinical Sepsis Studies: A Systematic Review.
    Crit Care Med. 2020 Jul 20. doi: 10.1097/CCM.0000000000004496.
    PubMed     Abstract available


  76. ZHOU Y, Xu W, Shao A
    Application Prospect of Mesenchymal Stem Cells in the Treatment of Sepsis.
    Crit Care Med. 2020;48:e634.
    PubMed    


  77. SCHINKEL M, Boerman AW, Nanayakkara PWB
    A Different Perspective on the Use of Sepsis Alert.
    Crit Care Med. 2020;48:e632-e633.
    PubMed    


  78. BARBASH IJ
    Disparities in Sepsis Outcomes: A Problem in Need of Solutions.
    Crit Care Med. 2020;48:1079-1080.
    PubMed    


    June 2020
  79. JAGAN N, Morrow LE, Walters RW, Plambeck RW, et al
    Sepsis and the Obesity Paradox: Size Matters in More Than One Way.
    Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004459.
    PubMed     Abstract available


  80. EGUIA E, Bunn C, Kulshrestha S, Markossian T, et al
    Trends, Cost, and Mortality From Sepsis After Trauma in the United States: An Evaluation of the National Inpatient Sample of Hospitalizations, 2012-2016.
    Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004451.
    PubMed     Abstract available


  81. ENGOREN M, Seelhammer T, Freundlich RE, Maile MD, et al
    A Comparison of Sepsis-2 (Systemic Inflammatory Response Syndrome Based) to Sepsis-3 (Sequential Organ Failure Assessment Based) Definitions-A Multicenter Retrospective Study.
    Crit Care Med. 2020 Jun 22. doi: 10.1097/CCM.0000000000004449.
    PubMed     Abstract available


  82. SATO R, Kuriyama A
    Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
    Crit Care Med. 2020 Jun 12. doi: 10.1097/CCM.0000000000004432.
    PubMed     Abstract available


  83. GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
    Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
    Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004430.
    PubMed     Abstract available


  84. LEVI M, Vincent JL, Tanaka K, Radford AH, et al
    Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
    Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004426.
    PubMed     Abstract available


  85. CAWCUTT KA, Beachy M, Peitz GJ
    Antibiotic Delivery in Sepsis: How Do We Improve?
    Crit Care Med. 2020;48:e540-e541.
    PubMed    


  86. COOKSLEY T, Haji-Michael P
    Oncologic Sepsis on the ICU: Two Decades of Improving Outcomes.
    Crit Care Med. 2020;48:925-926.
    PubMed    


  87. SEE H, Slonim AD
    Evaluating the Effect of Policy Changes on Sepsis Outcomes.
    Crit Care Med. 2020;48:919-920.
    PubMed    


  88. RHEE C, Strich JR, Klompas M, Yealy DM, et al
    SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care...But Now Is the Time to Improve SEP-1.
    Crit Care Med. 2020;48:779-782.
    PubMed    


    May 2020
  89. EHLER J, Petzold A, Sharshar T, Ely EW, et al
    Biomarker Panel to Differentiate Brain Injury From Brain Dysfunction in Patients With Sepsis-Associated Encephalopathy.
    Crit Care Med. 2020;48:e436-e437.
    PubMed    


    April 2020
  90. RUSH B, Danziger J, Walley KR, Kumar A, et al
    Treatment in Disproportionately Minority Hospitals Is Associated With Increased Risk of Mortality in Sepsis: A National Analysis.
    Crit Care Med. 2020 Apr 28. doi: 10.1097/CCM.0000000000004375.
    PubMed     Abstract available


  91. OSBORN TM
    Sepsis Mandates Help Clinicians and Patients.
    Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004342.
    PubMed    


  92. LEMIALE V, Pons S, Mirouse A, Tudesq JJ, et al
    Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique Study.
    Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004322.
    PubMed     Abstract available


  93. LINDELL RB, Nishisaki A, Weiss SL, Traynor DM, et al
    Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock.
    Crit Care Med. 2020 Apr 14. doi: 10.1097/CCM.0000000000004329.
    PubMed     Abstract available


  94. CHINAI B, Gaughan J, Schorr C
    Implementation of the Affordable Care Act: A Comparison of Outcomes in Patients With Severe Sepsis and Septic Shock Using the National Inpatient Sample.
    Crit Care Med. 2020 Apr 9. doi: 10.1097/CCM.0000000000004310.
    PubMed     Abstract available


  95. GALIATSATOS P, Follin A, Alghanim F, Sherry M, et al
    The Association Between Neighborhood Socioeconomic Disadvantage and Readmissions for Patients Hospitalized With Sepsis.
    Crit Care Med. 2020 Apr 8. doi: 10.1097/CCM.0000000000004307.
    PubMed     Abstract available


  96. STRICH JR, Wang J, Eichacker PQ
    Sepsis Bundles That Focus on Clinician Judgment and Proven Interventions Are Needed to Increase Bundle Compliance and Effectiveness.
    Crit Care Med. 2020;48:602-605.
    PubMed    


  97. ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
    Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
    Crit Care Med. 2020;48:484-490.
    PubMed     Abstract available


  98. MATSUDA W
    Should We Restrict ICU Admission for Frail Septic Patients?
    Crit Care Med. 2020;48:e342-e343.
    PubMed    


  99. CARLTON EF, Prescott HC
    The authors reply.
    Crit Care Med. 2020;48:e334-e335.
    PubMed    


  100. PATEL S, Katanga JA, Burman S, Said H, et al
    Making Sense of Readmissions.
    Crit Care Med. 2020;48:e333-e334.
    PubMed    


  101. SWEENEY DA, Kalil AC
    Be Quick But Don't Hurry: Septic Shock, Staphylococcus aureus Bacteremia, and the Timing of Appropriate Antibiotics.
    Crit Care Med. 2020;48:608-609.
    PubMed    


  102. SILVA AYO, Amorim EA, Barbosa-Silva MC, Lima MN, et al
    Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice.
    Crit Care Med. 2020;48:e290-e298.
    PubMed     Abstract available


  103. CORL KA, Zeba F, Caffrey AR, Hermenau M, et al
    Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus aureus Bacteremia.
    Crit Care Med. 2020;48:525-532.
    PubMed     Abstract available


  104. LACHMANN G, Knaak C, Vorderwulbecke G, La Rosee P, et al
    Hyperferritinemia in Critically Ill Patients.
    Crit Care Med. 2020;48:459-465.
    PubMed     Abstract available


    March 2020
  105. ALHAZZANI W, Moller MH, Arabi YM, Loeb M, et al
    Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).
    Crit Care Med. 2020 Mar 27. doi: 10.1097/CCM.0000000000004363.
    PubMed     Abstract available


  106. HENDRICKSON CM, Matthay MA
    Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults.
    Crit Care Med. 2020;48:428-430.
    PubMed    


  107. BUSCH LM, Kalil AC, Kadri SS
    Predicting Sepsis Mortality and Costs Using Medicare Claims: A Method to the Madness.
    Crit Care Med. 2020;48:424-426.
    PubMed    


  108. LEVY MM
    Identifying the Burden of Sepsis With Big Data.
    Crit Care Med. 2020;48:422-423.
    PubMed    


  109. RHEE C, Klompas M
    The Eye-Popping Costs Associated With Sepsis Diagnoses Among Medicare Beneficiaries.
    Crit Care Med. 2020;48:420-422.
    PubMed    


  110. WHITNEY JE, Zhang B, Koterba N, Chen F, et al
    Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.
    Crit Care Med. 2020;48:344-352.
    PubMed     Abstract available


  111. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:302-318.
    PubMed     Abstract available


  112. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:289-301.
    PubMed     Abstract available


  113. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:276-288.
    PubMed     Abstract available


  114. KUTTAB HI, Ward MA
    The authors reply.
    Crit Care Med. 2020;48:e260-e261.
    PubMed    


  115. JONES TW, Finder S, Newsome AS, Smith SE, et al
    Getting to the Heart of the Matter: What We Know About Fluid Resuscitation in Septic Heart Failure Patients.
    Crit Care Med. 2020;48:e259-e260.
    PubMed    


  116. LAW AC, Stevens JP, Walkey AJ
    The authors reply.
    Crit Care Med. 2020;48:e249-e250.
    PubMed    


  117. OUD L
    Trends of Time to Hospital Mortality Versus Timing of Death Among Patients With Septic Shock in Administrative Data.
    Crit Care Med. 2020;48:e249.
    PubMed    


  118. MARRARO GA, Spada C, Zeng Y
    Administrative Database and Empiric Therapy Are Always Useful for Appropriate Treatment of Pediatric Patients?
    Crit Care Med. 2020;48:438-440.
    PubMed    


  119. JILANI SM, Giroir BP
    Septic Shock in Children: When Should Prevention Start and Treatment End?
    Crit Care Med. 2020;48:426-428.
    PubMed    


  120. ZADOR Z, Landry A, Balas M, Marshall JC, et al
    Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness.
    Crit Care Med. 2020;48:338-343.
    PubMed     Abstract available


  121. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:329-337.
    PubMed     Abstract available


  122. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:319-328.
    PubMed     Abstract available


  123. BELLETTI A, Nagy A, Sartorelli M, Mucchetti M, et al
    Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials.
    Crit Care Med. 2020;48:398-405.
    PubMed     Abstract available


    February 2020
  124. CARLTON EF, Donnelly JP, Hensley MK, Cornell TT, et al
    New Medical Device Acquisition During Pediatric Severe Sepsis Hospitalizations.
    Crit Care Med. 2020 Feb 27. doi: 10.1097/CCM.0000000000004272.
    PubMed     Abstract available


  125. BINNIE A, Tsang JLY, Hu P, Carrasqueiro G, et al
    Epigenetics of Sepsis.
    Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004247.
    PubMed     Abstract available


  126. KWON MY, Ghanta S, Ng J, Tsoyi K, et al
    Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
    Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004244.
    PubMed     Abstract available


  127. ISHII J, Ohshimo S, Shime N
    Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program.
    Crit Care Med. 2020;48:e161-e162.
    PubMed    


  128. BUCHMAN TG, Zehnbauer BA
    Exploring the Epigenetics of Severe Sepsis: First Step in a Long Journey.
    Crit Care Med. 2020;48:254-255.
    PubMed    


  129. REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
    Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
    Crit Care Med. 2020;48:210-217.
    PubMed     Abstract available


  130. PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
    Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2020;48:200-209.
    PubMed     Abstract available


  131. BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
    Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
    Crit Care Med. 2020;48:142-150.
    PubMed     Abstract available


  132. SARIA S, Henry KE
    Too Many Definitions of Sepsis: Can Machine Learning Leverage the Electronic Health Record to Increase Accuracy and Bring Consensus?
    Crit Care Med. 2020;48:137-141.
    PubMed    


  133. AFSHAR M, Markossian T, Joyce C
    The authors reply.
    Crit Care Med. 2020;48:e162-e163.
    PubMed    


    January 2020
  134. ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
    Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
    Crit Care Med. 2020 Jan 13. doi: 10.1097/CCM.0000000000004179.
    PubMed     Abstract available


  135. LEMASLE L, Blet A, Geven C, Cherifa M, et al
    Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
    Crit Care Med. 2020;48:49-55.
    PubMed     Abstract available


    December 2019
  136. REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
    Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
    Crit Care Med. 2019 Dec 17. doi: 10.1097/CCM.0000000000004145.
    PubMed     Abstract available


  137. BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
    Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
    Crit Care Med. 2019 Dec 11. doi: 10.1097/CCM.0000000000004097.
    PubMed     Abstract available


  138. XIE J, Wang H, Kang Y, Zhou L, et al
    The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey.
    Crit Care Med. 2019 Dec 5. doi: 10.1097/CCM.0000000000004155.
    PubMed     Abstract available


  139. PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
    Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2019 Dec 3. doi: 10.1097/CCM.0000000000004132.
    PubMed     Abstract available


  140. OUD L
    The Impact of Atrial Fibrillation on Short-Term Mortality and Resource Utilization in Sepsis.
    Crit Care Med. 2019;47:e1032.
    PubMed    


    November 2019
  141. PROUT AJ, Talisa VB, Carcillo JA, Decker BK, et al
    Bacterial and Fungal Etiology of Sepsis in Children in the United States: Reconsidering Empiric Therapy.
    Crit Care Med. 2019 Nov 27. doi: 10.1097/CCM.0000000000004140.
    PubMed     Abstract available


  142. SHUBIN NJ, Navalkar K, Sampson D, Yager TD, et al
    Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
    Crit Care Med. 2019 Nov 8. doi: 10.1097/CCM.0000000000004083.
    PubMed     Abstract available


  143. OSUCHOWSKI MF, Rosengart MR
    Change Is the Only Constant: How to Adopt the New Trends in Sepsis Modeling?
    Crit Care Med. 2019;47:1673-1675.
    PubMed    


  144. HOPKINS RO
    Acquired Brain Injury Following Sepsis.
    Crit Care Med. 2019;47:1658-1659.
    PubMed    


  145. SIMPSON SQ
    Sepsis Biomarkers and Physician Judgment in the Emergency Room.
    Crit Care Med. 2019;47:1656-1657.
    PubMed    


    October 2019
  146. SHIMADA T, Topchiy E, Leung AKK, Kong HJ, et al
    Very Low Density Lipoprotein Receptor Sequesters Lipopolysaccharide Into Adipose Tissue During Sepsis.
    Crit Care Med. 2019 Oct 23. doi: 10.1097/CCM.0000000000004064.
    PubMed     Abstract available


  147. LI X, Zhu J, Tian L, Ma X, et al
    Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-kappaB Signaling Pathway.
    Crit Care Med. 2019 Oct 21. doi: 10.1097/CCM.0000000000004065.
    PubMed     Abstract available


  148. YAN X, Tu H, Liu Y, Chen T, et al
    Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis.
    Crit Care Med. 2019 Oct 17. doi: 10.1097/CCM.0000000000004070.
    PubMed     Abstract available


  149. NUSSHAG C, Rupp C, Schmitt F, Krautkramer E, et al
    Cell Cycle Biomarkers and Soluble Urokinase-Type Plasminogen Activator Receptor for the Prediction of Sepsis-Induced Acute Kidney Injury Requiring Renal Replacement Therapy: A Prospective, Exploratory Study.
    Crit Care Med. 2019 Oct 4. doi: 10.1097/CCM.0000000000004042.
    PubMed     Abstract available


  150. PELTAN ID, Liu VX
    More Than We Bargained For: The "Dominating" Cost Effectiveness of Sepsis Quality Improvement?
    Crit Care Med. 2019;47:1464-1467.
    PubMed    


  151. PARKER RI
    Cancer and Sepsis: Adding Insult to Injury-As if Either Alone Were Not Enough?
    Crit Care Med. 2019;47:1452-1453.
    PubMed    


  152. LEVY MM
    Implementation of Sepsis Bundles: Just Do It!!
    Crit Care Med. 2019;47:1450-1451.
    PubMed    


    September 2019
  153. OH SY, Cho S, Kim GH, Jang EJ, et al
    Incidence and Outcomes of Sepsis in Korea: A Nationwide Cohort Study From 2007 to 2016.
    Crit Care Med. 2019 Sep 30. doi: 10.1097/CCM.0000000000004041.
    PubMed     Abstract available


  154. GOULDEN R
    Alternative Explanations for the Obesity Paradox in Sepsis.
    Crit Care Med. 2019;47:e790.
    PubMed    


  155. PITTA MR, Campos FM
    Comment on "Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients".
    Crit Care Med. 2019;47:e789-e790.
    PubMed    


  156. SURESH K, D'Alessio F
    Immune Checkpoint Inhibitor Use in Sepsis: Monitoring Immune Checkpoint Inhibitor Toxicity.
    Crit Care Med. 2019;47:e788.
    PubMed    


  157. OUD L
    Reporting Epidemiologic Studies in Sepsis Combining the International Classification of Diseases, 9th Edition and International Classification of Diseases, 10th Edition Codes.
    Crit Care Med. 2019;47:e785.
    PubMed    


    August 2019
  158. KUTTAB HI, Lykins JD, Hughes MD, Wroblewski K, et al
    Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock.
    Crit Care Med. 2019 Aug 7. doi: 10.1097/CCM.0000000000003960.
    PubMed     Abstract available


  159. STORTZ JA, Hollen MK, Nacionales DC, Horiguchi H, et al
    Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
    Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003926.
    PubMed     Abstract available


  160. GIANNINI HM, Ginestra JC, Chivers C, Draugelis M, et al
    A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice.
    Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003891.
    PubMed     Abstract available


  161. EHLENBACH WJ, Sonnen JA, Montine TJ, Larson EB, et al
    Association Between Sepsis and Microvascular Brain Injury.
    Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003924.
    PubMed     Abstract available


  162. WEISS SL, Zhang D, Bush J, Graham K, et al
    Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis.
    Crit Care Med. 2019 Aug 2. doi: 10.1097/CCM.0000000000003931.
    PubMed     Abstract available


  163. SAMUELS DC, Hulgan T, Fessel JP, Billings FT 4th, et al
    Mitochondrial DNA Haplogroups and Delirium During Sepsis.
    Crit Care Med. 2019;47:1065-1071.
    PubMed     Abstract available


  164. GAZMURI RJ, Anez de Gomez CI, Siddiqui M, Schechtman J, et al
    Severe Sepsis and Septic Shock Early Management Bundle Risks Aiding Vasopressor Misuse.
    Crit Care Med. 2019;47:e717.
    PubMed    


  165. LEE JT, Mikkelsen ME
    Risk Stratification Tools in Sepsis: From Acute Physiology and Chronic Health Evaluation to Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2019;47:1159-1161.
    PubMed    


  166. PARKER RI
    Sepsis: From Little Findings Big Ideas Grow.
    Crit Care Med. 2019;47:1152-1153.
    PubMed    


    July 2019
  167. MIAO H, Shi J, Wang C, Lu G, et al
    Continuous Renal Replacement Therapy in Pediatric Severe Sepsis: A Propensity Score-Matched Prospective Multicenter Cohort Study in the PICU.
    Crit Care Med. 2019 Jul 31. doi: 10.1097/CCM.0000000000003901.
    PubMed     Abstract available


  168. PEPPER DJ, Sun J, Cui X, Welsh J, et al
    Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).
    Crit Care Med. 2019 Jul 31. doi: 10.1097/CCM.0000000000003892.
    PubMed     Abstract available


  169. HENSLEY MK, Donnelly JP, Carlton EF, Prescott HC, et al
    Epidemiology and Outcomes of Cancer-Related Versus Non-Cancer-Related Sepsis Hospitalizations.
    Crit Care Med. 2019 Jul 25. doi: 10.1097/CCM.0000000000003896.
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  170. PARK CHL, de Almeida JP, de Oliveira GQ, Rizk SI, et al
    Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial.
    Crit Care Med. 2019 Jul 25. doi: 10.1097/CCM.0000000000003900.
    PubMed     Abstract available


  171. KASHIOURIS MG, Zemore Z, Kimball Z, Stefanou C, et al
    Supply Chain Delays in Antimicrobial Administration After the Initial Clinician Order and Mortality in Patients With Sepsis.
    Crit Care Med. 2019 Jul 24. doi: 10.1097/CCM.0000000000003921.
    PubMed     Abstract available


  172. AFSHAR M, Arain E, Ye C, Gilbert E, et al
    Patient Outcomes and Cost-Effectiveness of a Sepsis Care Quality Improvement Program in a Health System.
    Crit Care Med. 2019 Jul 15. doi: 10.1097/CCM.0000000000003919.
    PubMed     Abstract available


  173. BEALE R
    Enough Is As Good As a Feast.
    Crit Care Med. 2019;47:1004-1006.
    PubMed    


  174. MUTHUMALAIAPPAN K
    Efficacy of Mesenchymal Stem/Stromal Cell Infusion in Septic Patients Is a Puzzle Worthy of Attention.
    Crit Care Med. 2019;47:1001-1002.
    PubMed    


  175. TAPIA P, Gatica S, Cortes-Rivera C, Otero C, et al
    Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.
    Crit Care Med. 2019;47:942-950.
    PubMed     Abstract available


  176. SCHLOSSER K, Wang JP, Dos Santos C, Walley KR, et al
    Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.
    Crit Care Med. 2019;47:918-925.
    PubMed     Abstract available


    June 2019
  177. ANTCLIFFE DB, Gordon AC
    Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock?
    Crit Care Med. 2019 Jun 3. doi: 10.1097/CCM.0000000000003833.
    PubMed    


  178. DORNAS W
    Damaging Effects of Oxygen in Induced Sepsis-Like Condition.
    Crit Care Med. 2019;47:e535-e536.
    PubMed    


  179. JOFFE AR, deCaen A
    Not Enough Evidence to Use Plasma Exchange for Sepsis or Thrombocytopenia-Associated Multiple Organ Failure in Children.
    Crit Care Med. 2019;47:e533-e534.
    PubMed    


  180. BERG RMG, Asghar MS
    Luxury Perfusion in Patients With Sepsis?
    Crit Care Med. 2019;47:e533.
    PubMed    


  181. LI S, Wang S, Priyanka P, Kellum JA, et al
    Acute Kidney Injury in Critically Ill Patients After Noncardiac Major Surgery: Early Versus Late Onset.
    Crit Care Med. 2019;47:e437-e444.
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    May 2019
  182. RHEE C, Wang R, Zhang Z, Fram D, et al
    Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data.
    Crit Care Med. 2019 May 24. doi: 10.1097/CCM.0000000000003817.
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  183. GINESTRA JC, Giannini HM, Schweickert WD, Meadows L, et al
    Clinician Perception of a Machine Learning-Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock.
    Crit Care Med. 2019 May 24. doi: 10.1097/CCM.0000000000003803.
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  184. CROUSER ED, Parrillo JE, Seymour CW, Angus DC, et al
    Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients.
    Crit Care Med. 2019 May 17. doi: 10.1097/CCM.0000000000003799.
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  185. DESAI R, Hanna B, Singh S, Omar A, et al
    Trends and Outcomes in Sepsis Hospitalizations With and Without Atrial Fibrillation: A Nationwide Inpatient Analysis.
    Crit Care Med. 2019 May 13. doi: 10.1097/CCM.0000000000003806.
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  186. SIMPSON SQ
    Sepsis Epidemiology From Administrative Data: Going, Going....
    Crit Care Med. 2019;47:739-740.
    PubMed    


  187. CROUSER ED, Caldwell CC, Hotchkiss RS
    What Is the Skinny on Obesity During Sepsis?
    Crit Care Med. 2019;47:735-736.
    PubMed    


  188. CAWCUTT KA, Kalil AC
    Saved From Sepsis: Can Immunotherapy Improve Acute and Postacute Outcomes?
    Crit Care Med. 2019;47:733-735.
    PubMed    


  189. WOOLUM JA, Flannery AH
    The authors reply.
    Crit Care Med. 2019;47:e435-e436.
    PubMed    


  190. PATEL JJ, Bergl P
    Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.
    Crit Care Med. 2019;47:e434-e435.
    PubMed    


  191. MORELLI A, Sanfilippo F, Rehberg S, Ertmer C, et al
    The authors reply.
    Crit Care Med. 2019;47:e432-e433.
    PubMed    


  192. PETITJEANS F, Leroy S, Geloen A, Pichot C, et al
    On the Right Track, Finally?
    Crit Care Med. 2019;47:e431-e432.
    PubMed    


  193. ROSSAINT J, Zarbock A
    A Novel Approach for the Targeted Inhibition of Platelet Activation-Separating the Good From the Bad.
    Crit Care Med. 2019;47:741-743.
    PubMed    


  194. GRUMAZ S, Grumaz C, Vainshtein Y, Stevens P, et al
    Enhanced Performance of Next-Generation Sequencing Diagnostics Compared With Standard of Care Microbiological Diagnostics in Patients Suffering From Septic Shock.
    Crit Care Med. 2019;47:e394-e402.
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    April 2019
  195. CORL KA, Prodromou M, Merchant RC, Gareen I, et al
    The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study.
    Crit Care Med. 2019 Apr 12. doi: 10.1097/CCM.0000000000003779.
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  196. HIGGINS AM, Peake SL, Bellomo R, Cooper DJ, et al
    Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.
    Crit Care Med. 2019 Apr 8. doi: 10.1097/CCM.0000000000003762.
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  197. WIEDERMANN CJ
    Hypoalbuminemia and the Risk of Acute Kidney Injury in Sepsis.
    Crit Care Med. 2019;47:e377-e378.
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  198. ARGENT AC
    Readmission After Hospitalization for Pediatric Severe Sepsis-Data From a U.S. Database.
    Crit Care Med. 2019;47:612-613.
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  199. BAUER PR
    The Sicker Are Sicker: A Tale of Late Outcome After Sepsis.
    Crit Care Med. 2019;47:610-611.
    PubMed    


  200. HURST SD, Coopersmith CM
    Can We Compare Sepsis Outcomes on a Hospital Level If Documentation Is Variable (or Inaccurate)?
    Crit Care Med. 2019;47:599-600.
    PubMed    


  201. FISHER J, Linder A, Caironi P, Russell JA, et al
    The authors reply.
    Crit Care Med. 2019;47:e378-e379.
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  202. MENARD CE, Kumar A, Houston DS, Turgeon AF, et al
    Evolution and Impact of Thrombocytopenia in Septic Shock: A Retrospective Cohort Study.
    Crit Care Med. 2019;47:558-565.
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  203. LEIJTE GP, Kiers D, van der Heijden W, Jansen A, et al
    Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
    Crit Care Med. 2019;47:508-516.
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    March 2019
  204. KOHOUTOVA M, Horak J, Jarkovska D, Martinkova V, et al
    Vagus Nerve Stimulation Attenuates Multiple Organ Dysfunction in Resuscitated Porcine Progressive Sepsis.
    Crit Care Med. 2019 Mar 25. doi: 10.1097/CCM.0000000000003714.
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  205. BOURCIER S, Hindlet P, Guidet B, Dechartres A, et al
    Reporting of Organ Support Outcomes in Septic Shock Randomized Controlled Trials: A Methodologic Review-The Sepsis Organ Support Study.
    Crit Care Med. 2019 Mar 19. doi: 10.1097/CCM.0000000000003746.
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  206. CHANG EY, Stevens ES, Bakinde N
    Sepsis in Non-ICU Patients: A Call for Guideline Reassessment.
    Crit Care Med. 2019;47:e266.
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  207. SKLAR MC, Dos Santos CC, Lawler PR
    Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Survival in Sepsis: Causal Inference Through Human Genetics.
    Crit Care Med. 2019;47:489-491.
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  208. SIMPSON SQ
    Surveillance for Adult Sepsis Events: An Idea Whose Time Has Come.
    Crit Care Med. 2019;47:467-468.
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  209. RHEE C, Zhang Z, Kadri SS, Murphy DJ, et al
    Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria.
    Crit Care Med. 2019;47:307-314.
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  210. KELLY BJ, Lautenbach E, Han JH
    The authors reply.
    Crit Care Med. 2019;47:e275-e276.
    PubMed    


  211. PATNAIK R, Gurjar M
    Is Combined Biomarkers a Future Tool for Early Prediction of Mortality Among Septic Patients?
    Crit Care Med. 2019;47:e275.
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  212. REDFERN OC, Smith GB, Prytherch DR, Meredith P, et al
    The authors reply.
    Crit Care Med. 2019;47:e266-e267.
    PubMed    


    February 2019
  213. PEPPER DJ, Demirkale CY, Sun J, Rhee C, et al
    Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients.
    Crit Care Med. 2019 Feb 14. doi: 10.1097/CCM.0000000000003692.
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    Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsi
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    Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 (BMS-936559).
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    Central Venous Access Capability and Critical Care Telemedicine Decreases Inter-Hospital Transfer Among Severe Sepsis Patients: A Mixed Methods Design.
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    Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study.
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    Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.
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    Risk Factors for New-Onset Atrial Fibrillation in Patients With Sepsis: A Systematic Review and Meta-Analysis.
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  220. DE GROOTH HJ, Girbes AR
    Corticosteroids in Sepsis: Clouded by Heterogeneity.
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    PubMed    


  221. SCHURR JW, McLaughlin KC, Szumita PM
    Defining the Role of Corticosteroids in Sepsis: Adjunctive Therapy for Shock Reversal.
    Crit Care Med. 2019;47:e157-e158.
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  222. MARTIN B, Bennett TD
    Sepsis Computable Phenotypes in the Service of Observational Research.
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  225. OLANIPEKUN TO, Bakinde N, Effoe VS, Snyder R, et al
    Further Considerations on the Benefits of Thiamine Administration in Patients With Septic Shock.
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    The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.
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    Effect of Antihypertensive Medications on Sepsis-Related Outcomes: A Population-Based Cohort Study.
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    Readmission Diagnoses After Pediatric Severe Sepsis Hospitalization.
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    The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
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  230. DAHABA AA
    Can We Improve Long-Term Survival of Patients With Severe Sepsis at ICU Admission?
    Crit Care Med. 2019;47:e71.
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  231. WALKEY AJ
    Exploring the Pathways Revealed by International Sepsis Benchmarking.
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  232. LANKADEVA YR, Kosaka J, Iguchi N, Evans RG, et al
    Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury.
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    Implementation of the Smart Use of Antibiotics Program to Reduce Unnecessary Antibiotic Use in a Neonatal ICU: A Prospective Interrupted Time-Series Study in a Developing Country.
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    December 2018
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    National Performance on the Medicare SEP-1 Sepsis Quality Measure.
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  235. KLOMPAS M, Rhee C
    Current Sepsis Mandates Are Overly Prescriptive, and Some Aspects May Be Harmful.
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  236. VARGAS M, Servillo G
    The End of Corticosteroid in Sepsis: Fragile Results From Fragile Trials.
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  237. GOODWIN AJ
    Can Serial Quick Sequential (Sepsis-Related) Organ Failure Assessment Measurement Aid in Sepsis Identification and Triage Decisions?
    Crit Care Med. 2018;46:2046-2048.
    PubMed    


  238. KEMPKER JA, Martin GS
    Severity and Timing of Onset Drive Economic Costs and Clinical Outcomes With Sepsis.
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    November 2018
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    Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons.
    Crit Care Med. 2018 Nov 13. doi: 10.1097/CCM.0000000000003554.
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  240. MEHTA NM
    Nutritional Status and Outcomes in Pediatric Severe Sepsis-Size Matters.
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  241. CARLTON EF, Prescott HC
    Variation in Sepsis-Related Mortality; Implications for Performance Improvement.
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    Low Low-Density Lipoprotein Levels Are Associated With, But Do Not Causally Contribute to, Increased Mortality in Sepsis.
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    October 2018
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    Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database.
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    Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study.
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    Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers.
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    Probiotics in Pediatric Severe Sepsis: The Time Has Come to Trust Our 'Gut'!
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  247. MARIK PE, Farkas JD
    The Changing Paradigm of Sepsis: Early Diagnosis, Early Antibiotics, Early Pressors, and Early Adjuvant Treatment.
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  248. KANJILAL S, Kalil AC, Klompas M
    What Is the Best Treatment for Vancomycin-Resistant Enterococcal Bloodstream Infections?
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    September 2018
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    A Comparison of Mortality From Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis-Specific Patient Characteristics.
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    Secretoneurin in Sepsis: Is It the Brain?
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    Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis: Author Correction.
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    Translational Sepsis Research: Spanning the Divide.
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    Case Fatality and Adverse Outcomes Are Reduced in Pregnant Women With Severe Sepsis or Septic Shock Compared With Age-Matched Comorbid-Matched Nonpregnant Women.
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    The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study.
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    Is the Tail Wagging the Dog in Sepsis?
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    Blue Light Illuminates a Novel Sepsis Treatment.
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    Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial.
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    Survival of Patients With Vancomycin-Resistant Enterococcus faecium Bacteremia Treated With Conventional or High Doses of Daptomycin or Linezolid Is Associated With the Rate of Bacterial Clearance.
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    The Surviving Sepsis Campaign Bundle: 2018 Update.
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    Renal Blood Flow Measurement in Early Clinical Sepsis-Can You Catch a Shadow?
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    Bad Brains, Bad Outcomes: Acute Neurologic Dysfunction and Late Death After Sepsis.
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    May 2018
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    Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis.
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    Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina.
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    Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study.
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    Is Procalcitonin-Guided Therapy Associated With Beneficial Outcomes in Critically Ill Patients With Sepsis?
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    Early Evidence of Sepsis-Associated Hyperperfusion-A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects.
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    Comparative Usefulness of Sepsis-3, Burn Sepsis, and Conventional Sepsis Criteria in Patients With Major Burns.
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    Sepsis-Induced Renal Failure: Ischemia or Toxemia?
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    First, Most, and Best: The Implications of Delays in Implementing Surviving Sepsis Campaign Guidelines.
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    Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.
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  318. TYLER PD, Stone DJ, Geisler BP, McLennan S, et al
    Racial and Geographic Disparities in Interhospital ICU Transfers.
    Crit Care Med. 2018;46:e76-e80.
    PubMed     Abstract available


  319. MIANO TA, Lam S
    The Healthy User Effect in Studies of Statins in the Critically Ill.
    Crit Care Med. 2018;46:e95.
    PubMed    


  320. KRAMER AA
    A Self-Fulfilling Hypothesis.
    Crit Care Med. 2018;46:158-159.
    PubMed    


    December 2017
  321. NEMATI S, Holder A, Razmi F, Stanley MD, et al
    An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU.
    Crit Care Med. 2017 Dec 26. doi: 10.1097/CCM.0000000000002936.
    PubMed     Abstract available


  322. IANKOVA I, Thompson-Leduc P, Kirson NY, Rice B, et al
    Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2017 Dec 21. doi: 10.1097/CCM.0000000000002928.
    PubMed     Abstract available


  323. SEMERARO F, Colucci M, Caironi P, Masson S, et al
    Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis.
    Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002919.
    PubMed     Abstract available


  324. ROBERTS BW, Mohr NM, Ablordeppey E, Drewry AM, et al
    Association Between Partial Pressure of Arterial Carbon Dioxide and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department.
    Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002918.
    PubMed     Abstract available


  325. VALLEY TS, Nallamothu BK, Heung M, Iwashyna TJ, et al
    Hospital Variation in Renal Replacement Therapy for Sepsis in the United States.
    Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002878.
    PubMed     Abstract available


  326. PHILLIPS GS, Osborn TM, Terry KM, Gesten F, et al
    The New York Sepsis Severity Score: Development of a Risk-Adjusted Severity Model for Sepsis.
    Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002824.
    PubMed     Abstract available


  327. KIKUTANI K, Ohshimo S, Shime N
    Potential Confounders of Procalcitonin-Guided Antibiotic Therapy for Sepsis.
    Crit Care Med. 2017;45:e1310-e1311.
    PubMed    


  328. KRAMER AH
    Is A Hemoglobin Concentration As Low As 7 g/dL Adequate For All Critically Ill Patients With Sepsis? Legitimate Doubts Remain!
    Crit Care Med. 2017;45:2101-2102.
    PubMed    


  329. ERWIN BL, Denaburg MA, Barker AB, McArdle PJ, et al
    Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors.
    Crit Care Med. 2017;45:e1226-e1232.
    PubMed     Abstract available


  330. DU W, Liu D, Long Y, Wang X, et al
    The beta-Blocker Esmolol Restores the Vascular Waterfall Phenomenon After Acute Endotoxemia.
    Crit Care Med. 2017;45:e1247-e1253.
    PubMed     Abstract available


  331. JAMME M, Daviaud F, Charpentier J, Marin N, et al
    Time Course of Septic Shock in Immunocompromised and Nonimmunocompromised Patients.
    Crit Care Med. 2017;45:2031-2039.
    PubMed     Abstract available


  332. DUPUIS C, Garrouste-Orgeas M, Bailly S, Adrie C, et al
    Effect of Transfusion on Mortality and Other Adverse Events Among Critically Ill Septic Patients: An Observational Study Using a Marginal Structural Cox Model.
    Crit Care Med. 2017;45:1972-1980.
    PubMed     Abstract available


    November 2017
  333. LEISMAN DE, Doerfler ME, Schneider SM, Masick KD, et al
    Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock.
    Crit Care Med. 2017 Nov 3. doi: 10.1097/CCM.0000000000002834.
    PubMed     Abstract available


  334. CASEY JD, Semler MW, Bastarache JA
    Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?
    Crit Care Med. 2017;45:1959-1960.
    PubMed    


  335. JAWA RS, Kew RR
    Sepsis in the Critically Ill-Does Gender Matter?
    Crit Care Med. 2017;45:1957-1959.
    PubMed    


  336. SPOLARICS Z
    Victims or Culprits, B Cells May Serve as Markers for Mortality Risk and Targeted Therapy in Sepsis.
    Crit Care Med. 2017;45:1951-1952.
    PubMed    


  337. LIU VX, Walkey AJ
    Machine Learning and Sepsis: On the Road to Revolution.
    Crit Care Med. 2017;45:1946-1947.
    PubMed    


  338. COQUEREL D, Chagnon F, Sainsily X, Dumont L, et al
    ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.
    Crit Care Med. 2017;45:e1139-e1148.
    PubMed     Abstract available


  339. MOSKOWITZ A, Patel PV, Grossestreuer AV, Chase M, et al
    Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection.
    Crit Care Med. 2017;45:1813-1819.
    PubMed     Abstract available


    October 2017
  340. STEELAND S, Van Ryckeghem S, Vandewalle J, Ballegeer M, et al
    Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
    Crit Care Med. 2017 Oct 31. doi: 10.1097/CCM.0000000000002813.
    PubMed     Abstract available


  341. RUSH B, Tyler PD, Stone DJ, Geisler BP, et al
    Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis.
    Crit Care Med. 2017 Oct 24. doi: 10.1097/CCM.0000000000002777.
    PubMed     Abstract available


  342. YEHYA N, Wong HR
    Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002754.
    PubMed     Abstract available


  343. PUTHUCHEARY ZA, Sun Y, Zeng K, Vu LH, et al
    Sepsis Reduces Bone Strength Before Morphologic Changes Are Identifiable.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002732.
    PubMed     Abstract available


  344. WONG HR, Sweeney TE, Hart KW, Khatri P, et al
    Pediatric Sepsis Endotypes Among Adults With Sepsis.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002733.
    PubMed     Abstract available


  345. EHLENBACH WJ, Gilmore-Bykovskyi A, Repplinger MD, Westergaard RP, et al
    Sepsis Survivors Admitted to Skilled Nursing Facilities: Cognitive Impairment, Activities of Daily Living Dependence, and Survival.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002755.
    PubMed     Abstract available


  346. MEYER NJ, Reilly JP, Anderson BJ, Palakshappa JA, et al
    Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002749.
    PubMed     Abstract available


  347. VITORIO D, Nassar AP Jr, Caruso P
    Procalcitonin Clearance and Prognosis in Sepsis: Are There Really an Optimal Cutoff and Time Interval?
    Crit Care Med. 2017;45:e1097-e1098.
    PubMed    


  348. PFORTMUELLER CA, Meisel C, Schefold JC
    Interpreting Immune Mediator Dysbalance in Sepsis.
    Crit Care Med. 2017;45:e1094-e1095.
    PubMed    


  349. RIMAWI RH
    Bad Response or Bad Luck? A New Versus Recrudescent Sepsis Readmission.
    Crit Care Med. 2017;45:1788-1789.
    PubMed    


  350. LANSPA MJ, Morris AH
    The Importance of Clinical Context on Assessing Outcomes in Sepsis.
    Crit Care Med. 2017;45:1783-1785.
    PubMed    


  351. NUGENT KL, Coopersmith CM
    Fluid Management in Sepsis-Is There a Golden Hour (or Two)?
    Crit Care Med. 2017;45:1773-1775.
    PubMed    


  352. GRASSELLI G, Scaravilli V, Di Bella S, Biffi S, et al
    Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impact on Patients' Outcome.
    Crit Care Med. 2017;45:1726-1733.
    PubMed     Abstract available


    September 2017
  353. ANNANE D, Pastores SM, Rochwerg B, Arlt W, et al
    Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.
    Crit Care Med. 2017 Sep 21. doi: 10.1097/CCM.0000000000002737.
    PubMed     Abstract available


  354. JONES JM, Fingar KR, Miller MA, Coffey R, et al
    Racial Disparities in Sepsis-Related In-Hospital Mortality: Using a Broad Case Capture Method and Multivariate Controls for Clinical and Hospital Variables, 2004-2013.
    Crit Care Med. 2017 Sep 12. doi: 10.1097/CCM.0000000000002699.
    PubMed     Abstract available


  355. WANG HE, Jones AR, Donnelly JP
    Revised National Estimates of Emergency Department Visits for Sepsis in the United States.
    Crit Care Med. 2017;45:1443-1449.
    PubMed     Abstract available


  356. AGAROSSI A, Pintaudi G
    Antimicrobials and Progression to Septic Shock in Severe Sepsis Patients: Is Delay the Only Thing That Matters?
    Crit Care Med. 2017;45:e988-e989.
    PubMed    


  357. MARSHALL JC
    Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis.
    Crit Care Med. 2017;45:1582-1583.
    PubMed    


  358. GAUDILLIERE B, Angst MS, Hotchkiss RS
    Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!
    Crit Care Med. 2017;45:1577-1578.
    PubMed    


  359. RHEE C, Klompas M
    What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition.
    Crit Care Med. 2017;45:1569-1571.
    PubMed    


  360. DEUTSCHMAN CS
    Sepsis-3: Seeing the Entire Picture.
    Crit Care Med. 2017;45:1567-1569.
    PubMed    


  361. SPRUNG CL, Trahtemberg U
    What Definition Should We Use for Sepsis and Septic Shock?
    Crit Care Med. 2017;45:1564-1567.
    PubMed    


  362. FADEL F, Andre-Gregoire G, Gravez B, Bauvois B, et al
    Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock.
    Crit Care Med. 2017;45:e954-e962.
    PubMed     Abstract available


    August 2017
  363. VAN VUGHT LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, et al
    Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.
    Crit Care Med. 2017 Aug 11. doi: 10.1097/CCM.0000000000002649.
    PubMed     Abstract available


  364. ZHAI Q, Lai D, Cui P, Zhou R, et al
    Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway.
    Crit Care Med. 2017 Aug 10. doi: 10.1097/CCM.0000000000002646.
    PubMed     Abstract available


  365. TRAUER J, Muhi S, McBryde ES, Al Harbi SA, et al
    Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
    Crit Care Med. 2017 Aug 9. doi: 10.1097/CCM.0000000000002654.
    PubMed     Abstract available


  366. KALIL AC, Kellum JA
    Is Early Goal-Directed Therapy Harmful to Patients With Sepsis and High Disease Severity?
    Crit Care Med. 2017;45:1265-1267.
    PubMed    


    July 2017
  367. SHANKAR-HARI M, Singer M, Spencer J
    Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?
    Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002627.
    PubMed     Abstract available


  368. DEMERLE KM, Royer SC, Mikkelsen ME, Prescott HC, et al
    Readmissions for Recurrent Sepsis: New or Relapsed Infection?
    Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002626.
    PubMed     Abstract available


  369. VAN VUGHT LA, Holman R, de Jonge E, de Keizer NF, et al
    Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis.
    Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002590.
    PubMed     Abstract available


  370. CHURPEK MM, Snyder A, Sokol S, Pettit NN, et al
    Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores.
    Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002648.
    PubMed     Abstract available


  371. MACHADO FR, Ferreira EM, Sousa JL, Silva C, et al
    Quality Improvement Initiatives in Sepsis in an Emerging Country: Does the Institution's Main Source of Income Influence the Results? An Analysis of 21,103 Patients.
    Crit Care Med. 2017 Jul 6. doi: 10.1097/CCM.0000000000002585.
    PubMed     Abstract available


  372. NI CHEALLAIGH C, Sheedy FJ
    Shields Up-Systemic Protection Provided by microRNA-21 During Sepsis?
    Crit Care Med. 2017;45:1261-1263.
    PubMed    


  373. MARRARO GA, Genovese U, Spada C, Piga MA, et al
    Can the Treatment Approach of Sepsis With Balanced Crystalloid Fluids Translate Into Therapy for Acute Respiratory Distress Syndrome if Considered as "Lung-Limited Sepsis"?
    Crit Care Med. 2017;45:1246-1248.
    PubMed    


  374. PRESCOTT HC, Donnelly JP
    Penalizing Readmissions After Sepsis Could Do More Harm Than Good.
    Crit Care Med. 2017;45:1243-1244.
    PubMed    


    June 2017
  375. LEISMAN DE, Goldman C, Doerfler ME, Masick KD, et al
    Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort.
    Crit Care Med. 2017 Jun 30. doi: 10.1097/CCM.0000000000002574.
    PubMed     Abstract available


  376. LEE CC, Lee MG, Lee WC, Lai CC, et al
    Preadmission Use of Calcium Channel Blocking Agents Is Associated With Improved Outcomes in Patients With Sepsis: A Population-Based Propensity Score-Matched Cohort Study.
    Crit Care Med. 2017 Jun 27. doi: 10.1097/CCM.0000000000002550.
    PubMed     Abstract available


  377. HE X, Su F, Xie K, Taccone FS, et al
    Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis.
    Crit Care Med. 2017 Jun 14. doi: 10.1097/CCM.0000000000002524.
    PubMed     Abstract available


  378. LEISMAN DE, Sethna CB
    Renin-Angiotensin-Aldosterone System Blockade Use in Sepsis Patients: Did It Impact Renal Outcomes?
    Crit Care Med. 2017;45:e624.
    PubMed    


  379. GAINES S, Alverdy JC
    Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.
    Crit Care Med. 2017;45:1106-1107.
    PubMed    


  380. FRAIMOW HS
    Safe at First, But Not Reaching Second: Implications of Delayed Second Doses of Antimicrobials in Patients Presenting to Emergency Departments With Sepsis.
    Crit Care Med. 2017;45:1097-1098.
    PubMed    


  381. DAVIS AL, Carcillo JA, Aneja RK, Deymann AJ, et al
    American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock.
    Crit Care Med. 2017;45:1061-1093.
    PubMed     Abstract available


  382. PELTAN ID, Mitchell KH, Rudd KE, Mann BA, et al
    Physician Variation in Time to Antimicrobial Treatment for Septic Patients Presenting to the Emergency Department.
    Crit Care Med. 2017;45:1011-1018.
    PubMed     Abstract available


  383. HENNING DJ, Carey JR, Oedorf K, Day DE, et al
    The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock.
    Crit Care Med. 2017;45:e575-e582.
    PubMed     Abstract available


  384. RUSSELL JA, Lee T, Singer J, Boyd JH, et al
    The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.
    Crit Care Med. 2017;45:940-948.
    PubMed     Abstract available


  385. TERRASINI N, Lionetti V
    Exosomes in Critical Illness.
    Crit Care Med. 2017;45:1054-1060.
    PubMed     Abstract available


    May 2017
  386. STERLING SA, Puskarich MA, Glass AF, Guirgis F, et al
    The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
    Crit Care Med. 2017 May 24. doi: 10.1097/CCM.0000000000002512.
    PubMed     Abstract available


  387. STANA F, Vujovic M, Mayaki D, Leduc-Gaudet JP, et al
    Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.
    Crit Care Med. 2017 May 22. doi: 10.1097/CCM.0000000000002520.
    PubMed     Abstract available


  388. DEUTSCHMAN CS
    "Defining" Sepsis: Moving Toward Measuring the "Dysregulated Host Response".
    Crit Care Med. 2017;45:927-930.
    PubMed    


  389. MARIK PE
    Glucocorticosteroids as Adjunctive Therapy for Acute Respiratory Distress Syndrome and Sepsis? Yes, But Not as Monotherapy.
    Crit Care Med. 2017;45:910-911.
    PubMed    


  390. LEVY MM
    Antibiotics in Sepsis: The New Frontier.
    Crit Care Med. 2017;45:907-908.
    PubMed    


  391. JUNG B, Mahul M, Breilh D, Legeron R, et al
    Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under- and Overdosing.
    Crit Care Med. 2017;45:e470-e478.
    PubMed     Abstract available


  392. BERGAMIN FS, Almeida JP, Landoni G, Galas FRBG, et al
    Liberal Versus Restrictive Transfusion Strategy in Critically Ill Oncologic Patients: The Transfusion Requirements in Critically Ill Oncologic Patients Randomized Controlled Trial.
    Crit Care Med. 2017;45:766-773.
    PubMed     Abstract available


  393. DREWRY AM, Ablordeppey EA, Murray ET, Stoll CRT, et al
    Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2017;45:806-813.
    PubMed     Abstract available


    April 2017
  394. NORMAN BC, Cooke CR, Ely EW, Graves JA, et al
    Sepsis-Associated 30-Day Risk-Standardized Readmissions: Analysis of a Nationwide Medicare Sample.
    Crit Care Med. 2017 Apr 29. doi: 10.1097/CCM.0000000000002476.
    PubMed     Abstract available


  395. CHANG T, Tu YK, Lee CT, Chao A, et al
    Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis.
    Crit Care Med. 2017 Apr 25. doi: 10.1097/CCM.0000000000002362.
    PubMed     Abstract available


  396. JIA P, Wu X, Dai Y, Teng J, et al
    MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis.
    Crit Care Med. 2017 Apr 21. doi: 10.1097/CCM.0000000000002363.
    PubMed     Abstract available


  397. EMRATH ET, Fortenberry JD, Travers C, McCracken CE, et al
    Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis.
    Crit Care Med. 2017 Apr 21. doi: 10.1097/CCM.0000000000002365.
    PubMed     Abstract available


  398. ARULKUMARAN N, Sixma ML, Jentho E, Ceravola E, et al
    Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery.
    Crit Care Med. 2017 Apr 20. doi: 10.1097/CCM.0000000000002381.
    PubMed     Abstract available


  399. ZHOU J, Tian H, Du X, Xi X, et al
    Population-Based Epidemiology of Sepsis in a Subdistrict of Beijing.
    Crit Care Med. 2017 Apr 18. doi: 10.1097/CCM.0000000000002414.
    PubMed     Abstract available


  400. PINTO BB, Dyson A, Umbrello M, Carre JE, et al
    Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand.
    Crit Care Med. 2017 Apr 13. doi: 10.1097/CCM.0000000000002448.
    PubMed     Abstract available


  401. SCICLUNA BP, van der Poll T
    Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.
    Crit Care Med. 2017;45:e457.
    PubMed    


  402. WALLEY KR
    New Approaches to Modifying Inotropy in Sepsis-Induced Myocardial Dysfunction.
    Crit Care Med. 2017;45:754-756.
    PubMed    


  403. SIMPSON SQ
    Surviving Transfer for Sepsis: Size Matters-Or Does It?
    Crit Care Med. 2017;45:749-750.
    PubMed    


  404. LAUPLAND KB, Niven DJ
    The Normal Abnormal Vital Sign of Sepsis.
    Crit Care Med. 2017;45:747-748.
    PubMed    


  405. DEUTSCHMAN CS
    Sepsis-3: Of Love and Bliss.
    Crit Care Med. 2017;45:739-740.
    PubMed    


  406. ALDER MN, Opoka AM, Lahni P, Hildeman DA, et al
    Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.
    Crit Care Med. 2017;45:e426-e432.
    PubMed     Abstract available


  407. ARVANITI K, Lathyris D, Blot S, Apostolidou-Kiouti F, et al
    Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis.
    Crit Care Med. 2017;45:e437-e448.
    PubMed     Abstract available


    March 2017
  408. FAWZY A, Walkey AJ
    Association Between Hospital Case Volume of Sepsis, Adherence to Evidence-Based Processes of Care and Patient Outcomes.
    Crit Care Med. 2017 Mar 27. doi: 10.1097/CCM.0000000000002409.
    PubMed     Abstract available


  409. LEISMAN D, Huang V, Zhou Q, Gribben J, et al
    Delayed Second Dose Antibiotics for Patients Admitted From the Emergency Department With Sepsis: Prevalence, Risk Factors, and Outcomes.
    Crit Care Med. 2017 Mar 21. doi: 10.1097/CCM.0000000000002377.
    PubMed     Abstract available


  410. SHANKAR-HARI M, Fear D, Lavender P, Mare T, et al
    Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis.
    Crit Care Med. 2017 Mar 14. doi: 10.1097/CCM.0000000000002380.
    PubMed     Abstract available


  411. MOSS TJ, Calland JF, Enfield KB, Gomez-Manjarres DC, et al
    New-Onset Atrial Fibrillation in the Critically Ill.
    Crit Care Med. 2017 Mar 14. doi: 10.1097/CCM.0000000000002325.
    PubMed     Abstract available


  412. MCKOWN AC, McGuinn EM, Ware LB, Wang L, et al
    Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis.
    Crit Care Med. 2017 Mar 2. doi: 10.1097/CCM.0000000000002286.
    PubMed     Abstract available


  413. SCHUETZ P, Birkhahn R, Sherwin R, Jones AE, et al
    Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
    Crit Care Med. 2017 Mar 2. doi: 10.1097/CCM.0000000000002321.
    PubMed     Abstract available


  414. FRENCKEN JF, van Vught LA, Peelen LM, Ong DS, et al
    An Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study.
    Crit Care Med. 2017 Mar 2. doi: 10.1097/CCM.0000000000002292.
    PubMed     Abstract available


  415. PEPPER DJ
    Adipose Tissue Measurements in Patients With Sepsis.
    Crit Care Med. 2017;45:e331.
    PubMed    


  416. KUHN SO, Meissner K, Rehberg S
    Fluid Resuscitation in Sepsis: "Get the Balance Right".
    Crit Care Med. 2017;45:555-556.
    PubMed    


  417. MOROWITZ MJ, Di Caro V, Pang D, Cummings J, et al
    Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.
    Crit Care Med. 2017 Mar 1. doi: 10.1097/CCM.0000000000002291.
    PubMed     Abstract available


  418. KELLUM JA, Pike F, Yealy DM, Huang DT, et al
    Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study.
    Crit Care Med. 2017;45:438-445.
    PubMed     Abstract available


  419. MYATRA SN, Prabu NR, Divatia JV, Monnet X, et al
    The Changes in Pulse Pressure Variation or Stroke Volume Variation After a "Tidal Volume Challenge" Reliably Predict Fluid Responsiveness During Low Tidal Volume Ventilation.
    Crit Care Med. 2017;45:415-421.
    PubMed     Abstract available


    February 2017
  420. HOOGENDIJK AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, et al
    Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-kappaB in Multiple Cell Types.
    Crit Care Med. 2017 Feb 24. doi: 10.1097/CCM.0000000000002294.
    PubMed     Abstract available


  421. SEYMOUR CW, Kahn JM, Martin-Gill C, Callaway CW, et al
    Delays From First Medical Contact to Antibiotic Administration for Sepsis.
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    Vitamin D Deficiency in Sepsis: "Body Humors" Imbalance or Sepsis "Epiphenomenon"?
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    Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.
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    Rural Sepsis Mortality: Patient Emergency Care Preference Impacts Resuscitation Outcome Value.
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    Source Control in Sepsis Urgent or Not So Fast?
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    Development and Validation of a Score to Predict Mortality in Children Undergoing Extracorporeal Membrane Oxygenation for Respiratory Failure: Pediatric Pulmonary Rescue With Extracorporeal Membrane Oxygenation Prediction Score.
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    1427: EFFICACY OF NON-WEIGHT-BASED VASOPRESSOR DOSING IN CRITICALLY ILL PATIENTS WITH SEVERE SEPSIS.
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  485. LEISMAN D, D'Amore J, Gribben J, Ward M, et al
    1426: BUNDLE COMPLIANCE EFFECT GREATER IN HEMODYNAMICALLY STABLE SEPSIS PATIENTS WITH INTERMEDIATE LACTATE.
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  486. SPECTOR R, Blau S
    1425: SEPSIS MANAGEMENT: THE EFFECT OF PROTOCOL INITIATION ON PATIENT OUTCOME.
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  487. PARK JR, Kim Y, Park T, Oh WY, et al
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  496. SHAH T, Rech M, Sterk E
    1406: IMPACT OF THE EMERGENCY DEPARTMENT SEPSIS SCREENING TOOL ON OUTCOMES IN PATIENTS WITH SEPSIS.
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    1403: DOES CIRRHOSIS AFFECT THE PROGNOSTIC UTILITY OF LACTATE FOR SEVERE SEPSIS?
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    1402: CURB-65 SCORE CORRELATES WITH ICU ADMISSION AND IN-HOSPITAL MORTALITY IN PATIENTS WITH SEPSIS.
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    1394: PERSONALIZED IMMUNOMODULATION IN HIGH-RISK SEPSIS PATIENTS IN A PEDIATRIC CRITICAL CARE UNIT.
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    1390: PEROXYNITRITE DECOMPOSITION CATALYST REDUCES NOREPINEPHRINE REQUIREMENT DURING SEPSIS IN OVINE MODEL.
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    1388: ASSOCIATION OF WEEKEND ADMISSION WITH SEPSIS MORTALITY IN THE UNITED STATES.
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    1387: FLECAINIDE ATTENUATES SEPSIS-INDUCED ACUTE LUNG INJURY BY CONTROLLING INFLAMMATORY RESPONSE.
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    1380: TIME-MOTION ANALYSIS AND ECONOMIC IMPACT OF SOFA SCORE INTEGRATION INTO THE NEW SEPSIS-3 DEFINITION.
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    1379: BLUE LIGHT THERAPY MODULATES THE SYSTEMIC RESPONSE TO SEPSIS IN MICE AND HUMANS.
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    PubMed    


  524. CHUNG KS, Kim CY, Lee SH, Kim SK, et al
    1366: CLINICAL IMPLICATIONS OF THE PLASMA EPHA2 RECEPTOR LEVEL IN PATIENTS WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  525. TANNEHILL D, Sharpe B, Miller M, Saifo A, et al
    1365: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS PATIENTS TREATED OUTSIDE THE ICU.
    Crit Care Med. 2016;44.
    PubMed    


  526. GASPERINO J, Gabriel-Jocson E, Perez E, Levy R, et al
    1364: COMPARISON OF THE QSOFA SCORE AND SIRS CRITERIA IN PATIENTS WITH KNOWN OR SUSPECTED SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  527. ZHAI X, Jiang L, Yang Z, Yu T, et al
    1363: EFFECT OF ULINASTATIN ON MICROCIRCULATION DURING SEPSIS IN A RAT CECAL LIGATION AND PUNCTURE MODEL.
    Crit Care Med. 2016;44.
    PubMed    


  528. VALLABHAJOSYULA S, Jentzer J, Geske J, Kashani K, et al
    1362: LONG-TERM NEW-ONSET HEART FAILURE IN PATIENTS WITH MYOCARDIAL DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  529. WALSH M, Hobbs B, Giancarelli A, Bhullar I, et al
    1357: THE EFFECT OF OBESITY ON MORTALITY IN TRAUMA PATIENTS WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  530. TAYLOR B, Alexander M, Karvestski C, Templin M, et al
    1354: AN AGGRESSIVE SEPSIS IDENTIFICATION INITIATIVE INCREASES FALSE-POSITIVE DIAGNOSES.
    Crit Care Med. 2016;44.
    PubMed    


  531. LANTRY J, April M
    1353: SEPSIS CLINICAL CRITERIA IN ED PATIENTS ADMITTED TO AN ICU: AN EXTERNAL VALIDATION STUDY OF QSOFA.
    Crit Care Med. 2016;44.
    PubMed    


  532. HAILESELASSIE B, Su E, Nino D, Liu H, et al
    1352: IMPACT OF MITOCHONDRIAL ROS SCAVENGERS ON CARDIAC MECHANICS IN A MURINE MODEL OF SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  533. KAWANO Y, Hoshino K, Irie Y, Izutani Y, et al
    1347: USEFULNESS OF SEPSIS BIOMARKERS ACCORDING TO THE NEW DEFINITIONS OF SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  534. REILLY J, Shashaty M, Anderson B, Palakshappa J, et al
    1344: PLASMA RIP3, A REGULATOR OF NECROPTOSIS, IS ASSOCIATED WITH MORTALITY & ORGAN DYSFUNCTION IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  535. WEST A, Mangubat PM, Giles K, Guynn A, et al
    1343: ANALYZING ACCURACY AND EARLY DETERMINANTS OF SEVERE SEPSIS USING REAL-TIME EMR INTEGRATED ALGORITHM.
    Crit Care Med. 2016;44.
    PubMed    


  536. TYLER P, Celi LA, Rush B
    1342: INTERHOSPITAL TRANSFER OF PATIENTS WITH SEPSIS ACROSS THE UNITED STATES.
    Crit Care Med. 2016;44.
    PubMed    


  537. MARIK P, Bittner E, Hansell D, Sahatjian J, et al
    1341: FLUID ADMINISTRATION IN SEPSIS/SEPTIC SHOCK, PATTERNS AND OUTCOMES: LARGE NATIONAL DATABASE ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  538. AMES S, Davis B, Carcillo J, Angus D, et al
    1338: HOSPITAL-LEVEL VARIATION IN RISK-ADJUSTED MORTALITY FOR PEDIATRIC SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  539. MAYR F, Balakumar V, Talisa V, Fine M, et al
    1336: UNDERSTANDING THE BURDEN OF UNPLANNED SEPSIS READMISSIONS.
    Crit Care Med. 2016;44.
    PubMed    


  540. SALOMON J, Serrao K, Guardiola J, Bonura A, et al
    1335: EARLY DETECTION OF PEDIATRIC SEPSIS USING AN ELECTRONIC MEDICAL RECORD-BASED SCREENING TOOL.
    Crit Care Med. 2016;44.
    PubMed    


  541. LU M, Chen E
    1334: MMF PROTECTS AGAINST LIVER INJURY DURING SEPSIS VIA REGULATION OF MAPK AND NF-KappaB PATHWAYS.
    Crit Care Med. 2016;44.
    PubMed    


  542. PROUT A, Talisa V, Mayr F, Yende S, et al
    1333: PEDIATRIC SEPSIS AND SEPTIC SHOCK: RISK FACTORS AND COMORBID CONDITIONS.
    Crit Care Med. 2016;44.
    PubMed    


  543. KASAL J, Stoll B, Katyal A, Tannehill D, et al
    1331: ASSESSMENT OF QSOFA AND OTHER CRITERIA IN SEPSIS WITH NORMAL BLOOD PRESSURE AND INTERMEDIATE LACTATE.
    Crit Care Med. 2016;44.
    PubMed    


  544. ZHANG LA, Parker R, Banerjee I, Clermont G, et al
    1330: SEPSIS ENDOTYPES AND THEIR PHYSIOLOGIC CHARACTERIZATION USING VITAL SIGNS.
    Crit Care Med. 2016;44.
    PubMed    


  545. FAY K, Klingensmith N, Lyons J, Ramonell K, et al
    1329: CD43 SIGNALING CONTROLS SURVIVAL, TH2 SKEWING, AND MEMORY T CELL APOPTOSIS DURING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  546. KILLIEN E, Farris R, Watson R, Flanagin M, et al
    1328: DETERIORATION IN HEALTH-RELATED QUALITY OF LIFE IS COMMON AMONG CHILDREN SURVIVING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  547. MENG X, Zhai Y, Ao L, Hui H, et al
    1326: AGING ELEVATES MYOCARDIAL TLR2 LEVELS TO AUGMENT CARDIAC DYSFUNCTION AND MORTALITY DURING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  548. SUZUKI K, Okada H, Takada C, Oda K, et al
    1325: HYDROCORTISONE THERAPY WITH CAR PEPTIDE PROTECTS THE INJURED ENDOTHELIAL GLYCOCALYX IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  549. FOUNTAIN S, Perry J 3rd, Stoffer B, Raschke R, et al
    1278: DESIGN OF AN ELECTRONIC MEDICAL RECORD-BASED ALERT SYSTEM TO DETECT THE ONSET OF SEVERE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  550. PENOYER D, Snyder J, Inderwiesen P, Geddie P, et al
    1229: SEPSIS CORE MEASURES AND BLOOD CULTURE DOCUMENTATION: TIMING IS EVERYTHING!
    Crit Care Med. 2016;44.
    PubMed    


  551. BORGES N, Bavare A, Cruz A, Patel B, et al
    1204: RAPID RESPONSE TO PEDIATRIC SEPSIS IN A TERTIARY CHILDREN'S HOSPITAL: BATTLING COMPLEXITY.
    Crit Care Med. 2016;44.
    PubMed    


  552. BALDAWI M, Al-Jubouri M, Watson J, Kathrin Jaehne A, et al
    1104: THE POTENTIAL FINANCIAL CONSEQUENCE OF THE NEW SEPSIS-3 SEPSIS DEFINITIONS.
    Crit Care Med. 2016;44.
    PubMed    


  553. BLAHA K, Diaz F, Quilodran J, Medina T, et al
    934: SAFETY AND EFFICACY OF A PREVENTIVE STRATEGY FOR FLUID OVERLOAD IN CHILDREN WITH SEPSIS AND PARDS.
    Crit Care Med. 2016;44.
    PubMed    


  554. PANG D, Wu Y, Cummings J, Panigrahy A, et al
    721: MICROGLIAL ACTIVATION CORRELATES WITH CYTOTOXIC EDEMA IN A MURINE MODEL OF SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  555. SADAKA F, Korobey M, Dumm A, Wegener G, et al
    692: PRACTICE PATTERNS FOR ANTIBIOTIC DE-ESCALATION IN MRSA CULTURE-NEGATIVE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  556. ZILBERBERG M, Nathanson B, Sulham K, Fan W, et al
    645: HOSPITAL RESOURCE USE ASSOCIATED WITH TREATMENT OF ACINETOBACTER BAUMANNII PNEUMONIA AND SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  557. ALCAMO A, Alessi L, Noona Vehovic S, Pang D, et al
    626: MULTIDRUG-RESISTANT ORGANISM SEPSIS IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS: A BURGEONING PROBLEM.
    Crit Care Med. 2016;44.
    PubMed    


  558. GUL F, Kemal Arslantas M, Bilgili B, Besir A, et al
    482: SERUM VITAMIN D LEVEL VARIATION IN SIRS, SEPSIS, AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  559. HASSINGER A, Breuer R
    434: SEPSIS DRILLS: A MULTIDISCIPLINARY SEPSIS EDUCATIONAL PROGRAM IN A PEDIATRIC HOSPITAL.
    Crit Care Med. 2016;44.
    PubMed    


  560. VILLAR J, Lighthall G
    333: SERUM LACTATE LEVEL PREDICTS 3-DAY, 30-DAY, AND 1-YEAR MORTALITY IN PATIENTS WITH AND WITHOUT SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  561. MORGAN R, Sutton R, Kilbaugh T, Lautz A, et al
    287: PULMONARY VASODILATOR THERAPY IN A SWINE MODEL OF PEDIATRIC SEPSIS-ASSOCIATED CARDIAC ARREST.
    Crit Care Med. 2016;44.
    PubMed    


  562. VALLABHAJOSYULA S, Kashyap R, Geske J, Sakhuja A, et al
    185: DOPPLER-DEFINED ACUTE PULMONARY HYPERTENSION IN SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  563. HIRATA JI, Ohya M
    107: OXIDANT/ANTIOXIDANT TREATMENT INFLUENCES PULMONARY DNA VIA MTH1 MODIFICATIONS IN SEPSIS-INDUCED ALI.
    Crit Care Med. 2016;44.
    PubMed    


  564. VALLABHAJOSYULA S, Kashyap R, Geske J, Kumar M, et al
    28: RIGHT VENTRICULAR DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK: AN EIGHT-YEAR ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  565. VALLABHAJOSYULA S, Jentzer J, Geske J, Sakhuja A, et al
    23: CARDIORENAL SYNDROME IN SEPSIS AND SEPTIC SHOCK: THE MAYO CLINIC EXPERIENCE.
    Crit Care Med. 2016;44.
    PubMed    


  566. KATSIOS C, Doumouras A, Shaefi S, Novack V, et al
    22: CONSERVATIVE FLUID STRATEGIES DECREASE MORTALITY IN SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  567. HIRANO Y, Aziz M, Weng-Lang Y, Ochani M, et al
    21: THE ROLE OF JUNCTIONAL ADHESION MOLECULE C IN THE AGING PHENOTYPE OF NEUTROPHILS DURING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  568. JOHNSON A, Celi LA, Raffa J, Pollard T, et al
    18: EXTERNAL VALIDATION OF THE SEPSIS-3 GUIDELINES.
    Crit Care Med. 2016;44.
    PubMed    


  569. ENKHBAATAR P
    Cellular Therapy for Sepsis: A New Hope?
    Crit Care Med. 2016;44:2296-2298.
    PubMed    


  570. KEMPKER JA, Martin GS
    Does Sepsis Case Mix Heterogeneity Prevent Outcome Comparisons?
    Crit Care Med. 2016;44:2288-2289.
    PubMed    


  571. TOWNSEND SR
    Collaborating for Success in Sepsis Quality Improvement.
    Crit Care Med. 2016;44:2275-2277.
    PubMed    


    November 2016
  572. ZHANG Z, Li Q
    Identifying Sepsis in Clinical Database With Sepsis-3 Definition.
    Crit Care Med. 2016;44:e1145-e1146.
    PubMed    


  573. ZIMMERMAN JJ, Davis R
    Imprecise (Sepsis) Medicine Can Become Precise.
    Crit Care Med. 2016;44:e1143-e1144.
    PubMed    


  574. SAVEL RH, Simon RJ, Kupfer Y
    Unraveling the Mysterious Relationship Between Obesity and Outcomes in Patients With Sepsis.
    Crit Care Med. 2016;44:2104-2105.
    PubMed    


  575. COHEN M, Falcone P, Kusnezov D, Paragas J, et al
    Sepsis and Presidential Initiatives.
    Crit Care Med. 2016;44:1963-1965.
    PubMed    


    October 2016
  576. JAEHNE AK, Rivers EP
    Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly.
    Crit Care Med. 2016.
    PubMed    


  577. YOUKEE D, Hulme W, Roberts T, Daniels R, et al
    Time Matters: Antibiotic Timing in Sepsis and Septic Shock.
    Crit Care Med. 2016;44:e1016-e1017.
    PubMed    


  578. SHIRAKURA Y, Kuriyama A
    Timing of Antibiotic Administration in Sepsis and Septic Shock: The Impact That a Meta-Analysis Does Not Depict.
    Crit Care Med. 2016;44:e1004.
    PubMed    


  579. MARRARO GA, Genovese U
    The Treatment of Severe Sepsis in the Pediatric Age: Long-Awaited Prospects and New Challenges Are Looming.
    Crit Care Med. 2016;44:1960-1962.
    PubMed    


    September 2016
  580. PREAU S, Bortolotti P, Colling D, Dewavrin F, et al
    Diagnostic Accuracy of the Inferior Vena Cava Collapsibility to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis and Acute Circulatory Failure.
    Crit Care Med. 2016.
    PubMed     Abstract available


  581. SWEENEY TE, Khatri P
    Benchmarking Sepsis Gene Expression Diagnostics Using Public Data.
    Crit Care Med. 2016.
    PubMed     Abstract available


  582. SCHEER CS, Fuchs C, Kuhn SO, Vollmer M, et al
    Quality Improvement Initiative for Severe Sepsis and Septic Shock Reduces 90-Day Mortality: A 7.5-Year Observational Study.
    Crit Care Med. 2016.
    PubMed     Abstract available


  583. ZIMMERMAN JJ, Sullivan E, Yager TD, Cheng C, et al
    Diagnostic Accuracy of a Host Gene Expression Signature That Discriminates Clinical Severe Sepsis Syndrome and Infection-Negative Systemic Inflammation Among Critically Ill Children.
    Crit Care Med. 2016.
    PubMed     Abstract available


  584. SEPULVEDA M, Gonano LA, Viotti M, Morell M, et al
    Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
    Crit Care Med. 2016.
    PubMed     Abstract available


  585. MIRA JC, Gentile LF, Mathias BJ, Efron PA, et al
    Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
    Crit Care Med. 2016.
    PubMed     Abstract available


  586. DALLI J, Colas RA, Quintana C, Barragan-Bradford D, et al
    Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.
    Crit Care Med. 2016.
    PubMed     Abstract available


  587. MELLA JR, Chiswick E, Stepien D, Moitra R, et al
    Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.
    Crit Care Med. 2016.
    PubMed     Abstract available


  588. PAREKH D, Patel JM, Scott A, Lax S, et al
    Vitamin D Deficiency in Human and Murine Sepsis.
    Crit Care Med. 2016.
    PubMed     Abstract available


  589. AARVOLD AB, Ryan HM, Magee LA, von Dadelszen P, et al
    Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients.
    Crit Care Med. 2016.
    PubMed     Abstract available


  590. OAMI T, Watanabe E, Hatano M, Sunahara S, et al
    Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model.
    Crit Care Med. 2016.
    PubMed     Abstract available


  591. BEESLEY SJ, Wilson EL, Lanspa MJ, Grissom CK, et al
    Relative Bradycardia in Patients With Septic Shock Requiring Vasopressor Therapy.
    Crit Care Med. 2016.
    PubMed     Abstract available


  592. MOHR NM, Harland KK, Shane DM, Ahmed A, et al
    Rural Patients With Severe Sepsis or Septic Shock who Bypass Rural Hospitals Have Increased Mortality: An Instrumental Variables Approach.
    Crit Care Med. 2016.
    PubMed     Abstract available


  593. MARTINEZ ML, Ferrer R, Torrents E, Guillamat-Prats R, et al
    Impact of Source Control in Patients With Severe Sepsis and Septic Shock.
    Crit Care Med. 2016.
    PubMed     Abstract available


    April 2016
  594. RHEE C
    Cytokine Imbalance Predicts Poor Outcomes in Staphylococcus aureus Bacteremia--But What Can We Do About It?
    Crit Care Med. 2016;44:846-7.
    PubMed    


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