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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 31 articles:
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Single Articles


    May 2026
  1. PARK SK, Lee J, Park SJ, Kim YN, et al
    Functional dissection of SPOP at the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis.
    Proc Natl Acad Sci U S A. 2026;123:e2523210123.
    PubMed     Abstract available


  2. LI X, Wang S, Wei Y, Xie C, et al
    AR-targeted therapies sensitize prostate cancer to cuproptosis by transcriptionally activating FDX1.
    Proc Natl Acad Sci U S A. 2026;123:e2534978123.
    PubMed     Abstract available


    April 2026
  3. LI J, Yang F, Zhang X, Xu L, et al
    Loss of UFL1 drives chromosome instability and tumorigenesis of prostate cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2523965123.
    PubMed     Abstract available


    March 2026
  4. ABT ER, Wang L, Varuzhanyan G, Freeland J, et al
    Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade.
    Proc Natl Acad Sci U S A. 2026;123:e2532814123.
    PubMed     Abstract available


    February 2026
  5. TENDLER S, De Gregorio R, Balderes P, Michel AL, et al
    Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers.
    Proc Natl Acad Sci U S A. 2026;123:e2505785123.
    PubMed     Abstract available


  6. TRAPHAGEN NA, Wheeler E, Li R, Akhshi T, et al
    Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2515790122.
    PubMed     Abstract available


    January 2026
  7. LIN Y, Wang R, Li F, Lu Z, et al
    Circular RNA-based therapy targeting metabolic vulnerability of fatty acid synthesis overcomes castration-resistant prostate cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2504904123.
    PubMed     Abstract available


    December 2025
  8. ZHANG Y, Ren H, Ma C, Shi C, et al
    A PSAT1 buff of YBX1 transcriptionally sustains HLA-E-mediated evasion of NK immunity.
    Proc Natl Acad Sci U S A. 2025;122:e2505658122.
    PubMed     Abstract available


  9. ERSOY-FAZLIOGLU B, Lingadahalli S, Altintas UB, Cingoz A, et al
    Distinct transcription factor interactions drive HOXB13 activity in different stages of prostate cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2500327122.
    PubMed     Abstract available


    November 2025
  10. ZHANG X, Yang Y, Zou H, Cai D, et al
    Circadian regulator REV-ERBalpha is a master regulator of tumor lineage plasticity and an effective therapeutic target.
    Proc Natl Acad Sci U S A. 2025;122:e2513468122.
    PubMed     Abstract available


    October 2025
  11. YUAN S, Ming DJ, He J, Liu MY, et al
    A PHF19-YTHDC1 condensate switches EZH2-mediated gene suppression to activation for prostate cancer progression.
    Proc Natl Acad Sci U S A. 2025;122:e2510386122.
    PubMed     Abstract available


  12. XIE J, Shen K, Liang W, Kuang Z, et al
    Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.
    Proc Natl Acad Sci U S A. 2025;122:e2509222122.
    PubMed     Abstract available


    September 2025
  13. CHOWDHURY SR, Parikh CN, Kaur AN, DeMarco KD, et al
    PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
    Proc Natl Acad Sci U S A. 2025;122:e2514948122.
    PubMed     Abstract available


  14. CHO H, Zhang Y, Tien JC, Mannan R, et al
    Cellular cartography reveals mouse prostate organization and determinants of castration resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2427116122.
    PubMed     Abstract available


    July 2025

  15. Retraction for Kundu et al., Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-gamma.
    Proc Natl Acad Sci U S A. 2025;122:e2516531122.
    PubMed    


  16. HE D, Zhang L, Yu L, Zhang Y, et al
    Fine structural design of 3betaHSD1 inhibitors for prostate cancer therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2422267122.
    PubMed     Abstract available


  17. SUSHENTSEV N, Hamm G, Manavaki R, McLean MA, et al
    Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2502423122.
    PubMed     Abstract available


    June 2025
  18. PAPPAS K, Ferrari M, Smith P, Nandakumar S, et al
    BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex function.
    Proc Natl Acad Sci U S A. 2025;122:e2426743122.
    PubMed     Abstract available


    April 2025

  19. Correction for Pitzen et al., Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2504762122.
    PubMed    


    March 2025
  20. LEE J, Park J, Hur Y, Um D, et al
    ETV5 reduces androgen receptor expression and induces neural stem-like properties during neuroendocrine prostate cancer development.
    Proc Natl Acad Sci U S A. 2025;122:e2420313122.
    PubMed     Abstract available


    February 2025
  21. PITZEN SP, Rudenick AN, Qiu Y, Zhang W, et al
    Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2415308122.
    PubMed     Abstract available


    December 2024
  22. VARUZHANYAN G, Chen CC, Freeland J, He T, et al
    PGC-1alpha drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
    Proc Natl Acad Sci U S A. 2024;121:e2416882121.
    PubMed     Abstract available


    November 2024
  23. KOHRT SE, Novak EJ, Tapadar S, Wu B, et al
    Small-molecule disruption of androgen receptor-dependent chromatin clusters.
    Proc Natl Acad Sci U S A. 2024;121:e2406239121.
    PubMed     Abstract available


    October 2024
  24. WANG Z, Yu H, Bao W, Qu M, et al
    Proteomic and phosphoproteomic landscape of localized prostate cancer unveils distinct molecular subtypes and insights into precision therapeutics.
    Proc Natl Acad Sci U S A. 2024;121:e2402741121.
    PubMed     Abstract available


    September 2024
  25. SU XA, Stopsack KH, Schmidt DR, Ma D, et al
    RAD21 promotes oncogenesis and lethal progression of prostate cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2405543121.
    PubMed     Abstract available


    August 2024
  26. YU G, Corn PG, Mak CSL, Liang X, et al
    Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization.
    Proc Natl Acad Sci U S A. 2024;121:e2402903121.
    PubMed     Abstract available


    July 2024
  27. PORNOUR M, Jeon HY, Ryu H, Khadka S, et al
    USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.
    Proc Natl Acad Sci U S A. 2024;121:e2403331121.
    PubMed     Abstract available


  28. ZAIDI S, Park J, Chan JM, Roudier MP, et al
    Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen-targeted therapies.
    Proc Natl Acad Sci U S A. 2024;121:e2322203121.
    PubMed     Abstract available


    April 2024
  29. HE T, Cheng C, Qiao Y, Cho H, et al
    Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2322563121.
    PubMed     Abstract available


    December 2023
  30. SUSHENTSEV N, Hamm G, Richings J, McLean MA, et al
    Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence.
    Proc Natl Acad Sci U S A. 2023;120:e2312261120.
    PubMed     Abstract available


    November 2023
  31. MAJI S, Pradhan AK, Kumar A, Bhoopathi P, et al
    MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis.
    Proc Natl Acad Sci U S A. 2023;120:e2307094120.
    PubMed     Abstract available


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