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  Pulmonary Hypertension

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Articles published in Am J Physiol Heart Circ Physiol

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Single Articles


    July 2021
  1. SAHOO S, Li Y, de Jesus D, Sembrat JC, et al
    Notch2 Suppression Mimicking Changes in Human Pulmonary Hypertension Modulates Notch1 and Promotes Endothelial Cell Proliferation.
    Am J Physiol Heart Circ Physiol. 2021 Jul 23. doi: 10.1152/ajpheart.00125.2021.
    PubMed     Abstract available


    June 2021
  2. VU LD, Saravia J, Jaligama S, Baboeram Panday RV, et al
    Deficiency of ST2 signaling ameliorates RSV-associated pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2021 Jun 25. doi: 10.1152/ajpheart.00018.2021.
    PubMed     Abstract available


  3. FERGUSON BS, Wennersten SA, Demos-Davies KM, Rubino M, et al
    DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy.
    Am J Physiol Heart Circ Physiol. 2021 Jun 18. doi: 10.1152/ajpheart.00115.2021.
    PubMed     Abstract available


  4. COLEBANK MJ, Qureshi MU, Rajagopal S, Krasuski RA, et al
    A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2021 Jun 18. doi: 10.1152/ajpheart.00086.2021.
    PubMed     Abstract available


  5. SCHAFER M, Ivy DD, Nguyen K, Boncella KL, et al
    Metalloproteinases and Their Inhibitors Are Associated with Pulmonary Arterial Stiffness and Ventricular Function in Pediatric Pulmonary Hypertension.
    Am J Physiol Heart Circ Physiol. 2021 Jun 4. doi: 10.1152/ajpheart.00750.2020.
    PubMed     Abstract available


    February 2021
  6. FRIED ND, Morris TM, Whitehead A, Lazartigues E, et al
    Angiotensin-II type 1 receptor mediates pulmonary hypertension and right ventricular remodeling induced by inhaled nicotine.
    Am J Physiol Heart Circ Physiol. 2021 Feb 12. doi: 10.1152/ajpheart.00883.2020.
    PubMed     Abstract available


    January 2021
  7. INAGAKI T, Pearson JT, Tsuchimochi H, Schwenke DO, et al
    Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
    Am J Physiol Heart Circ Physiol. 2021 Jan 22. doi: 10.1152/ajpheart.00327.2020.
    PubMed     Abstract available


  8. MUNDO W, Wolfson G, Moore LG, Houck JA, et al
    Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2021 Jan 8. doi: 10.1152/ajpheart.00520.2020.
    PubMed     Abstract available


    October 2020
  9. FUKUMITSU M, Westerhof BE, Ruigrok D, Braams NJ, et al
    Early return of reflected waves increases right ventricular wall stress in chronic thromboembolic pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2020 Oct 9. doi: 10.1152/ajpheart.00442.2020.
    PubMed     Abstract available


    September 2020
  10. YAMANAKA R, Hoshino A, Fukai K, Urata R, et al
    TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2020 Sep 18. doi: 10.1152/ajpheart.00314.2020.
    PubMed     Abstract available


    August 2020
  11. LEI S, Peng F, Li ML, Duan WB, et al
    LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension.
    Am J Physiol Heart Circ Physiol. 2020;319:H377-H391.
    PubMed     Abstract available


    May 2020
  12. HANSEN T, Galougahi KK, Besnier M, Genetzakis E, et al
    The Novel P2X7 Receptor PKT100 Improves Right Ventricular Function and Survival in Pulmonary Hypertension.
    Am J Physiol Heart Circ Physiol. 2020 May 29. doi: 10.1152/ajpheart.00580.2019.
    PubMed     Abstract available


    April 2020
  13. KANG Y, Zhang G, Huang EC, Huang J, et al
    Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension.
    Am J Physiol Heart Circ Physiol. 2020;318:H853-H866.
    PubMed     Abstract available


    February 2020
  14. FRANK BS, Schafer M, Douwes JM, Ivy DD, et al
    Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension.
    Am J Physiol Heart Circ Physiol. 2020;318:H401-H412.
    PubMed     Abstract available


    December 2019
  15. ALENEZI F, Rajagopal S, Kutty S
    Assessing Right Atrial Function in Pulmonary Hypertension -a Window to the Soul of the Right Heart?
    Am J Physiol Heart Circ Physiol. 2019 Dec 20. doi: 10.1152/ajpheart.00739.2019.
    PubMed    


    November 2019
  16. TELLO K, Dalmer A, Vanderpool RR, Ghofrani HA, et al
    Right ventricular function correlates of right atrial strain in pulmonary hypertension: a combined cardiac magnetic resonance and conductance catheter study.
    Am J Physiol Heart Circ Physiol. 2019 Nov 22. doi: 10.1152/ajpheart.00485.2019.
    PubMed     Abstract available


  17. FINSBERG HNT, Sundnes JS, Xi C, Lee LC, et al
    Computational quantification of patient specific changes in ventricular dynamics associated with pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2019 Nov 1. doi: 10.1152/ajpheart.00094.2019.
    PubMed     Abstract available


    September 2019
  18. SU J, Hughes AD, Simonsen U, Nielsen-Kudsk JE, et al
    Impact of pulmonary endarterectomy on pulmonary arterial wave propagation and reservoir function.
    Am J Physiol Heart Circ Physiol. 2019;317:H505-H516.
    PubMed     Abstract available


    August 2019
  19. CAI Z, van Duin RWB, Stam K, Uitterdijk A, et al
    Right Ventricular Oxygen Delivery as a Determinant of Right Ventricular Functional Reserve during Exercise in Juvenile Swine with Chronic Pulmonary Hypertension.
    Am J Physiol Heart Circ Physiol. 2019 Aug 9. doi: 10.1152/ajpheart.00130.2019.
    PubMed     Abstract available


    May 2019
  20. SCHMUCK EG, Hacker TA, Schreier DA, Chesler NC, et al
    Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats.
    Am J Physiol Heart Circ Physiol. 2019;316:H1005-H1013.
    PubMed     Abstract available


  21. SCHAFER M, Ivy DD, Abman SH, Stenmark K, et al
    Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies.
    Am J Physiol Heart Circ Physiol. 2019;316:H1091-H1104.
    PubMed     Abstract available


  22. PHILIP JL, Murphy TM, Schreier DA, Stevens S, et al
    Pulmonary vascular mechanical consequences of ischemic heart failure and implications for right ventricular function.
    Am J Physiol Heart Circ Physiol. 2019;316:H1167-H1177.
    PubMed     Abstract available


  23. VANDEN EYNDEN F, El-Oumeiri B, Bove T, Van Nooten G, et al
    Proximal pressure reducing effect of wave reflection in the pulmonary circulation disappear in obstructive disease: insight from a rabbit model.
    Am J Physiol Heart Circ Physiol. 2019;316:H992-H1004.
    PubMed     Abstract available


    March 2019
  24. OMURA J, Bonnet S, Kutty S
    Right Ventricular and Pulmonary Vascular Changes in Pulmonary Hypertension Associated with Left Heart Disease.
    Am J Physiol Heart Circ Physiol. 2019 Mar 15. doi: 10.1152/ajpheart.00159.2019.
    PubMed    


    June 2018
  25. KIMURA D, Saravia J, Jaligama S, McNamara I, et al
    New mouse model of pulmonary hypertension induced by respiratory syncytial virus bronchiolitis.
    Am J Physiol Heart Circ Physiol. 2018 Jun 15. doi: 10.1152/ajpheart.00627.2017.
    PubMed     Abstract available


  26. SU J, Logan CC, Hughes AD, Parker KH, et al
    Impact of chronic hypoxia on proximal pulmonary artery wave propagation and mechanical properties in rats.
    Am J Physiol Heart Circ Physiol. 2018;314:H1264-H1278.
    PubMed     Abstract available


    May 2018
  27. WEISE-CROSS L, Sands MA, Sheak JR, Broughton BRS, et al
    Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia.
    Am J Physiol Heart Circ Physiol. 2018;314:H1011-H1021.
    PubMed     Abstract available


  28. YAOITA N, Shimokawa H
    Effect of heart rate reduction in pulmonary arterial hypertension.
    Am J Physiol Heart Circ Physiol. 2018;314:H889-H891.
    PubMed    


    March 2018
  29. DE WIJS-MEIJLER DPM, van Duin RWB, Duncker DJ, Scherrer U, et al
    Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period: a new swine model of pulmonary vascular disease.
    Am J Physiol Heart Circ Physiol. 2018;314:H603-H615.
    PubMed     Abstract available


    January 2018
  30. TANAKA S, Shiroto T, Godo S, Saito H, et al
    Important role of endothelium-dependent hyperpolarization in pulmonary microcirculation in male mice -Implications for hypoxia-induced pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2018 Jan 5. doi: 10.1152/ajpheart.00487.2017.
    PubMed     Abstract available


    November 2017
  31. STAM K, van Duin RWB, Uitterdijk A, Cai Z, et al
    Exercise Facilitates Early Recognition of Cardiac and Vascular Remodeling in Chronic Thrombo-Embolic Pulmonary Hypertension in a Novel CTEPH Swine Model.
    Am J Physiol Heart Circ Physiol. 2017 Nov 22:ajpheart.00380.2017.
    PubMed     Abstract available


  32. GOMEZ O, Okumura K, Honjo O, Sun M, et al
    HEART RATE REDUCTION IMPROVES BIVENTRICULAR FUNCTION AND INTERACTIONS IN EXPERIMENTAL PULMONARY HYPERTENSION.
    Am J Physiol Heart Circ Physiol. 2017 Nov 16:ajpheart.00493.2017.
    PubMed     Abstract available


    October 2017
  33. VAN DUIN RWB, Houweling B, Uitterdijk A, Duncker DJ, et al
    Pulmonary vasodilation by phosphodiesterase 5-inhibition is enhanced and nitric oxide-independent in early pulmonary hypertension after myocardial infarction.
    Am J Physiol Heart Circ Physiol. 2017 Oct 6:ajpheart.00370.2017.
    PubMed     Abstract available


    June 2017
  34. FULOP GA, Yabluchanskiy A
    Cyp2c44-mediated decrease of 15-HETE exacerbates pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2017 Jun 16:ajpheart.00320.2017.
    PubMed     Abstract available


    May 2017
  35. HASHIMOTO R, Joshi SR, Jiang H, Capdevila JH, et al
    Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: Implication in chronic hypoxia-induced pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2017 May 26:ajpheart.00785.2016.
    PubMed     Abstract available


    April 2017
  36. PALAU-CABALLERO G, Walmsley J, Van Empel V, Lumens J, et al
    Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model.
    Am J Physiol Heart Circ Physiol. 2017;312:H691-H700.
    PubMed     Abstract available


    July 2016
  37. ALAA M, Abdellatif M, Tavares-Silva M, Oliveira-Pinto J, et al
    Right ventricular end-diastolic stiffness heralds right ventricular failure in monocrotaline-induced pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2016 Jul 29:ajpheart.00202.2016.
    PubMed     Abstract available


    May 2016
  38. VISOVATTI SH, Hyman MC, Goonewardena SN, Anyanwu AC, et al
    Purinergic dysregulation in pulmonary hypertension.
    Am J Physiol Heart Circ Physiol. 2016 May 20:ajpheart.00572.2015.
    PubMed     Abstract available


    April 2016
  39. FUKUMITSU M, Kawada T, Shimizu S, Turner MJ, et al
    Development of a servo pump system for in vivo loading of pathological pulmonary artery impedance on the right ventricle of normal rats.
    Am J Physiol Heart Circ Physiol. 2016;310:H973-83.
    PubMed     Abstract available


  40. QUAIL MA, Segers P, Muthurangu V
    Reply to: "Letter to the editor: Comparing pace and speed in the pulmonary circulation?".
    Am J Physiol Heart Circ Physiol. 2016;310:H950.
    PubMed    


  41. WEIR-MCCALL JR, Struthers AD, Lipworth BJ, Houston JG, et al
    Letter to the editor: Comparing pace and speed in the pulmonary circulation?
    Am J Physiol Heart Circ Physiol. 2016;310:H949.
    PubMed    


    September 2015
  42. FENSTER BE, Browning J, Schroeder JD, Schafer M, et al
    Vorticity is a marker of right ventricular diastolic dysfunction.
    Am J Physiol Heart Circ Physiol. 2015;309:H1087-93.
    PubMed     Abstract available


    August 2015
  43. NATALI AJ, Fowler ED, Calaghan SC, White E, et al
    Voluntary exercise delays heart failure onset in rats with pulmonary artery hypertension.
    Am J Physiol Heart Circ Physiol. 2015;309:H421-4.
    PubMed     Abstract available


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