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Articles published in Proc Natl Acad Sci U S A

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    June 2021
  1. ZHANG S, Liu YQ, Jia C, Lim YJ, et al
    Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  2. REBELO D, Oliveira F, Abrunhosa A, Januario C, et al
    A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  3. APICCO DJ, Shlevkov E, Nezich CL, Tran DT, et al
    The Parkinson's disease-associated gene ITPKB protects against alpha-synuclein aggregation by regulating ER-to-mitochondria calcium release.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  4. VRIJSEN S, Besora-Casals L, van Veen S, Zielich J, et al
    ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
    Proc Natl Acad Sci U S A. 2020;117:31198-31207.
    PubMed     Abstract available


    October 2020
  5. BREKK OR, Honey JR, Lee S, Hallett PJ, et al
    Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.
    Proc Natl Acad Sci U S A. 2020 Oct 15. pii: 2003021117.
    PubMed     Abstract available


  6. MOR DE, Sohrabi S, Kaletsky R, Keyes W, et al
    Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria.
    Proc Natl Acad Sci U S A. 2020 Oct 6. pii: 2009838117.
    PubMed     Abstract available


    September 2020
  7. AHN EH, Kang SS, Qi Q, Liu X, et al
    Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 14. pii: 2004087117.
    PubMed     Abstract available


    August 2020
  8. DEAN DN, Lee JC
    Defining an amyloid link Between Parkinson's disease and melanoma.
    Proc Natl Acad Sci U S A. 2020 Aug 31. pii: 2009702117.
    PubMed     Abstract available


    July 2020
  9. ZHAO K, Lim YJ, Liu Z, Long H, et al
    Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
    Proc Natl Acad Sci U S A. 2020 Jul 31. pii: 1922741117.
    PubMed     Abstract available


  10. MIZRAHI-KLIGER AD, Kaplan A, Israel Z, Deffains M, et al
    Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia.
    Proc Natl Acad Sci U S A. 2020 Jul 7. pii: 2001560117.
    PubMed     Abstract available


  11. NGUYEN APT, Tsika E, Kelly K, Levine N, et al
    Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
    Proc Natl Acad Sci U S A. 2020 Jul 6. pii: 1922184117.
    PubMed     Abstract available


    June 2020
  12. HANNESTAD JK, Rocha S, Agnarsson B, Zhdanov VP, et al
    Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric alpha-synuclein.
    Proc Natl Acad Sci U S A. 2020;117:14178-14186.
    PubMed     Abstract available


    May 2020
  13. ZHANG Q, Xu Y, Lee J, Jarnik M, et al
    A myosin-7B-dependent endocytosis pathway mediates cellular entry of alpha-synuclein fibrils and polycation-bearing cargos.
    Proc Natl Acad Sci U S A. 2020;117:10865-10875.
    PubMed     Abstract available


  14. CAO M, Park D, Wu Y, De Camilli P, et al
    Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.
    Proc Natl Acad Sci U S A. 2020 May 18. pii: 2004335117.
    PubMed     Abstract available


  15. FAVA VM, Cobat A, Gzara C, Alcais A, et al
    Reply to Zhang et al.: The differential role of LRRK2 variants in nested leprosy phenotypes.
    Proc Natl Acad Sci U S A. 2020;117:10124-10125.
    PubMed    


    April 2020
  16. ZHANG DF, Wang D, Li YY, Yao YG, et al
    Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?
    Proc Natl Acad Sci U S A. 2020 Apr 28. pii: 2000533117.
    PubMed    


  17. LUAN Y, Tang D, Wu H, Gu W, et al
    Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice.
    Proc Natl Acad Sci U S A. 2020 Apr 20. pii: 1916263117.
    PubMed     Abstract available


    March 2020

  18. Correction for Cristopher Bragg et al., Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1.
    Proc Natl Acad Sci U S A. 2020 Mar 9. pii: 2003190117.
    PubMed    


  19. MAHUL-MELLIER AL, Burtscher J, Maharjan N, Weerens L, et al
    The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is one of the major drivers of neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:4971-4982.
    PubMed     Abstract available


    February 2020
  20. HAM SJ, Lee D, Yoo H, Jun K, et al
    Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
    Proc Natl Acad Sci U S A. 2020;117:4281-4291.
    PubMed     Abstract available


  21. BOYER DR, Li B, Sun C, Fan W, et al
    The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
    Proc Natl Acad Sci U S A. 2020;117:3592-3602.
    PubMed     Abstract available


    January 2020
  22. EARLS RH, Menees KB, Chung J, Gutekunst CA, et al
    NK cells clear alpha-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of alpha-synucleinopathy.
    Proc Natl Acad Sci U S A. 2020;117:1762-1771.
    PubMed     Abstract available


    December 2019
  23. VITEK JL, Johnson LA
    Understanding Parkinson's disease and deep brain stimulation: Role of monkey models.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1902300116.
    PubMed     Abstract available


    November 2019
  24. AGGARWAL A, Reichert H, VijayRaghavan K
    A locomotor assay reveals deficits in heterozygous Parkinson's disease model and proprioceptive mutants in adult Drosophila.
    Proc Natl Acad Sci U S A. 2019 Nov 20. pii: 1807456116.
    PubMed     Abstract available


  25. CHOPEK JW, Hultborn H, Brownstone RM
    Multistable properties of human subthalamic nucleus neurons in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 1912128116.
    PubMed     Abstract available


    September 2019
  26. MORI A, Hatano T, Inoshita T, Shiba-Fukushima K, et al
    Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and alpha-synuclein stability through membrane remodeling.
    Proc Natl Acad Sci U S A. 2019 Sep 23. pii: 1902958116.
    PubMed     Abstract available


    August 2019
  27. BECK G, Singh A, Zhang J, Potts LF, et al
    Role of striatal DeltaFosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.
    Proc Natl Acad Sci U S A. 2019 Aug 27. pii: 1907810116.
    PubMed     Abstract available


  28. ARAKI K, Yagi N, Aoyama K, Choong CJ, et al
    Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of alpha-synuclein.
    Proc Natl Acad Sci U S A. 2019 Aug 19. pii: 1906124116.
    PubMed     Abstract available


  29. DOCTROW B
    Profile of Claire L. Parkinson.
    Proc Natl Acad Sci U S A. 2019 Aug 5. pii: 1912448116.
    PubMed    


  30. LEE J, Pinares-Garcia P, Loke H, Ham S, et al
    Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson's disease.
    Proc Natl Acad Sci U S A. 2019 Aug 1. pii: 1900406116.
    PubMed     Abstract available


    July 2019
  31. CAGNAN H, Mallet N, Moll CKE, Gulberti A, et al
    Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network.
    Proc Natl Acad Sci U S A. 2019 Jul 24. pii: 1819975116.
    PubMed     Abstract available


  32. FAVA VM, Xu YZ, Lettre G, Van Thuc N, et al
    Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2019 Jul 15. pii: 1901805116.
    PubMed     Abstract available


  33. PASLAWSKI W, Zareba-Paslawska J, Zhang X, Holzl K, et al
    alpha-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.
    Proc Natl Acad Sci U S A. 2019 Jul 3. pii: 1821409116.
    PubMed     Abstract available


    June 2019
  34. CZANIECKI C, Ryan T, Stykel MG, Drolet J, et al
    Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.
    Proc Natl Acad Sci U S A. 2019 Jun 24. pii: 1900576116.
    PubMed     Abstract available


    March 2019
  35. HOLLENBACH JA, Norman PJ, Creary LE, Damotte V, et al
    A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2019 Mar 25. pii: 1821778116.
    PubMed     Abstract available


  36. SHEN HH
    Core Concept: Can deep brain stimulation find success beyond Parkinson's disease?
    Proc Natl Acad Sci U S A. 2019;116:4764-4766.
    PubMed    


  37. CHEN X, Kordich JK, Williams ET, Levine N, et al
    Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
    Proc Natl Acad Sci U S A. 2019 Mar 6. pii: 1814909116.
    PubMed     Abstract available


    January 2019
  38. ZHANG P, Fan Y, Ru H, Wang L, et al
    Crystal structure of the WD40 domain dimer of LRRK2.
    Proc Natl Acad Sci U S A. 2019;116:1579-1584.
    PubMed     Abstract available


  39. LEVINE PM, Galesic A, Balana AT, Mahul-Mellier AL, et al
    alpha-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2019 Jan 16. pii: 1808845116.
    PubMed     Abstract available


    December 2018
  40. YAN R, Zhang J, Park HJ, Park ES, et al
    Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.
    Proc Natl Acad Sci U S A. 2018 Dec 3. pii: 1813365115.
    PubMed     Abstract available


    November 2018
  41. BRESKA A, Ivry RB
    Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 Nov 13. pii: 1810596115.
    PubMed     Abstract available


    October 2018
  42. GUO JF, Zhang L, Li K, Mei JP, et al
    Coding mutations in NUS1 contribute to Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 Oct 22. pii: 1809969115.
    PubMed     Abstract available


  43. PUJOLS J, Pena-Diaz S, Lazaro DF, Peccati F, et al
    Small molecule inhibits alpha-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
    Proc Natl Acad Sci U S A. 2018;115:10481-10486.
    PubMed     Abstract available


    September 2018
  44. LEE KS, Huh S, Lee S, Wu Z, et al
    Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models.
    Proc Natl Acad Sci U S A. 2018;115:E8844-E8853.
    PubMed     Abstract available


    August 2018
  45. TELKES I, Viswanathan A, Jimenez-Shahed J, Abosch A, et al
    Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 Aug 21. pii: 1810589115.
    PubMed     Abstract available


    July 2018
  46. RUGGERI FS, Benedetti F, Knowles TPJ, Lashuel HA, et al
    Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid alpha-synuclein fibrils.
    Proc Natl Acad Sci U S A. 2018;115:7230-7235.
    PubMed     Abstract available


    May 2018
  47. BORLONGAN CV
    Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 30. pii: 1807276115.
    PubMed    


  48. KIM KS, Marcogliese PC, Yang J, Callaghan SM, et al
    Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 14. pii: 1718946115.
    PubMed     Abstract available


  49. NGUYEN M, Krainc D
    LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 7. pii: 1717590115.
    PubMed     Abstract available


  50. REN Q, Ma M, Yang J, Nonaka R, et al
    Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 7. pii: 1802179115.
    PubMed     Abstract available


    March 2018
  51. KUMAR J, Erana H, Lopez-Martinez E, Claes N, et al
    Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.
    Proc Natl Acad Sci U S A. 2018 Mar 12. pii: 1721690115.
    PubMed     Abstract available


    February 2018
  52. GRASSI D, Howard S, Zhou M, Diaz-Perez N, et al
    Identification of a highly neurotoxic alpha-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 Feb 27. pii: 1713849115.
    PubMed     Abstract available


    January 2018
  53. KIM S, Yun SP, Lee S, Umanah GE, et al
    GBA1 deficiency negatively affects physiological alpha-synuclein tetramers and related multimers.
    Proc Natl Acad Sci U S A. 2018;115:798-803.
    PubMed     Abstract available


    December 2017
  54. WOERMAN AL, Kazmi SA, Patel S, Aoyagi A, et al
    Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
    Proc Natl Acad Sci U S A. 2017 Dec 26. pii: 1719369115.
    PubMed     Abstract available


  55. BRAGG DC, Mangkalaphiban K, Vaine CA, Kulkarni NJ, et al
    Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1.
    Proc Natl Acad Sci U S A. 2017 Dec 11. pii: 1712526114.
    PubMed     Abstract available


    September 2017
  56. KANG SS, Zhang Z, Liu X, Manfredsson FP, et al
    TrkB neurotrophic activities are blocked by alpha-synuclein, triggering dopaminergic cell death in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Sep 18. pii: 201713969.
    PubMed     Abstract available


  57. THAKUR P, Breger LS, Lundblad M, Wan OW, et al
    Modeling Parkinson's disease pathology by combination of fibril seeds and alpha-synuclein overexpression in the rat brain.
    Proc Natl Acad Sci U S A. 2017 Sep 12. pii: 201710442.
    PubMed     Abstract available


    June 2017
  58. TURRIANI E, Lazaro DF, Ryazanov S, Leonov A, et al
    Treatment with diphenyl-pyrazole compound anle138b/c reveals that alpha-synuclein protects melanoma cells from autophagic cell death.
    Proc Natl Acad Sci U S A. 2017 Jun 5. pii: 201700200.
    PubMed     Abstract available


    April 2017
  59. KOUROUPI G, Taoufik E, Vlachos IS, Tsioras K, et al
    Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Apr 17. pii: 201617259.
    PubMed     Abstract available



  60. Editorial Expression of Concern: Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.
    Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201704295.
    PubMed    


    March 2017
  61. KIM KS
    Toward neuroprotective treatments of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 30. pii: 201703362.
    PubMed    


  62. SPATHIS AD, Asvos X, Ziavra D, Karampelas T, et al
    Nurr1:RXRalpha heterodimer activation as monotherapy for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 27. pii: 201616874.
    PubMed     Abstract available


  63. MOLLENHAUER B, Weintraub D
    The depressed brain in Parkinson's disease: Implications for an inflammatory biomarker.
    Proc Natl Acad Sci U S A. 2017 Mar 10. pii: 201700737.
    PubMed    


    February 2017
  64. DUNN AR, Stout KA, Ozawa M, Lohr KM, et al
    Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
    Proc Natl Acad Sci U S A. 2017 Feb 28. pii: 201616892.
    PubMed     Abstract available


    January 2017
  65. GREEN H, Zhang X, Tiklova K, Volakakis N, et al
    Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201621218.
    PubMed     Abstract available


  66. PARK Y, Hoang QQ
    Combating Parkinson's disease-associated toxicity by modulating proteostasis.
    Proc Natl Acad Sci U S A. 2017 Jan 17. pii: 201620082.
    PubMed    


    October 2016
  67. HORVATH I, Wittung-Stafshede P
    Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Oct 17. pii: 201610371.
    PubMed     Abstract available


    April 2016
  68. PINOTSI D, Michel CH, Buell AK, Laine RF, et al
    Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
    Proc Natl Acad Sci U S A. 2016;113:3815-9.
    PubMed     Abstract available


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