Retrieve available abstracts of 41 articles: HTML format
Single Articles
May 2025
Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein
accumulation and neuronal deficits in a transgenic mouse model linking
Alzheimer's disease and Parkinson's disease.
Proc Natl Acad Sci U S A. 2025;122:e2509530122. PubMed
April 2025
SONDERMANN P, Diercks CS, Rong C, Schultz PG, et al Targeted degradation of alpha-Synuclein using an evolved botulinum toxin protease.
Proc Natl Acad Sci U S A. 2025;122:e2426745122. PubMedAbstract available
February 2025
BAGNOLI E, Lin YE, Burel S, Jaimon E, et al Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis
pathway in the brain.
Proc Natl Acad Sci U S A. 2025;122:e2412029122. PubMedAbstract available
November 2024
GILBOA T, Ter-Ovanesyan D, Wang SC, Whiteman S, et al Measurement of alpha-synuclein as protein cargo in plasma extracellular vesicles.
Proc Natl Acad Sci U S A. 2024;121:e2408949121. PubMedAbstract available
October 2024
WILLIAMS D, Glasstetter LM, Jong TT, Chen T, et al High-throughput screening for small-molecule stabilizers of misfolded
glucocerebrosidase in Gaucher disease and Parkinson's disease.
Proc Natl Acad Sci U S A. 2024;121:e2406009121. PubMedAbstract available
COLEMAN CR, Pallos J, Arreola-Bustos A, Wang L, et al Natural variation in age-related dopamine neuron degeneration is glutathione
dependent and linked to life span.
Proc Natl Acad Sci U S A. 2024;121:e2403450121. PubMedAbstract available
September 2024
WANG X, Geng J, Rimal S, Sui Y, et al The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting
contact between lysosomes and the ER through STIM1.
Proc Natl Acad Sci U S A. 2024;121:e2400531121. PubMedAbstract available
Correction to Supporting Information for Woerman et al., Familial Parkinson's
point mutation abolishes multiple system atrophy prion replication.
Proc Natl Acad Sci U S A. 2024;121:e2417229121. PubMed
URIBE-CANO S, Kottmann AH The primary cilium of cholinergic neurons may be a linchpin in the progression of
Parkinson's Disease.
Proc Natl Acad Sci U S A. 2024;121:e2414226121. PubMed
KIM Y, McInnes J, Kim J, Liang YHW, et al Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in
alpha-Synuclein G51D knock-in mice.
Proc Natl Acad Sci U S A. 2024;121:e2406479121. PubMedAbstract available
Correction to Supporting Information for Chen et al., Parkinson's disease-linked
D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic
neurodegeneration.
Proc Natl Acad Sci U S A. 2024;121:e2416001121. PubMed
August 2024
LIU K, Tao Y, Zhao Q, Xia W, et al Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid
fibrils.
Proc Natl Acad Sci U S A. 2024;121:e2321633121. PubMedAbstract available
DEWISON KM, Rowlinson B, Machin JM, Crossley JA, et al Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and
lipid-independent pathways.
Proc Natl Acad Sci U S A. 2024;121:e2315006121. PubMedAbstract available
ROSENKRANTZ JL, Brandorff JE, Raghib S, Kapadia A, et al ZNF91 is an endogenous repressor of the molecular phenotype associated with
X-linked dystonia-parkinsonism (XDP).
Proc Natl Acad Sci U S A. 2024;121:e2401217121. PubMedAbstract available
KHAN SS, Jaimon E, Lin YE, Nikoloff J, et al Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven
and idiopathic Parkinson's disease.
Proc Natl Acad Sci U S A. 2024;121:e2402206121. PubMedAbstract available
CONNELLY EM, Rintala-Dempsey AC, Gundogdu M, Freeman EA, et al Capturing the catalytic intermediates of parkin ubiquitination.
Proc Natl Acad Sci U S A. 2024;121:e2403114121. PubMedAbstract available
July 2024
HOY CW, de Hemptinne C, Wang SS, Harmer CJ, et al Beta and theta oscillations track effort and previous reward in the human basal
ganglia and prefrontal cortex during decision making.
Proc Natl Acad Sci U S A. 2024;121:e2322869121. PubMedAbstract available
GUPTA S, Tielemans A, Guevara CA, Huntley GW, et al Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and
composition in striatum with cell-type and subunit specificity.
Proc Natl Acad Sci U S A. 2024;121:e2317833121. PubMedAbstract available
Correction for Ahuja et al., Bach1 derepression is neuroprotective in a mouse
model of Parkinson's disease.
Proc Natl Acad Sci U S A. 2024;121:e2411303121. PubMed
June 2024
Correction for Prusiner et al., Evidence for alpha-synuclein prions causing multiple
system atrophy in humans with parkinsonism.
Proc Natl Acad Sci U S A. 2024;121:e2408899121. PubMed
May 2024
CAI W, Young CB, Yuan R, Lee B, et al Subthalamic nucleus-language network connectivity predicts dopaminergic
modulation of speech function in Parkinson's disease.
Proc Natl Acad Sci U S A. 2024;121:e2316149121. PubMedAbstract available
April 2024
MOHD RAFIQ N, Fujise K, Rosenfeld MS, Xu P, et al Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in
iPSC-derived dopaminergic neurons.
Proc Natl Acad Sci U S A. 2024;121:e2318943121. PubMedAbstract available
February 2024
RILEY MJ, Mitchell CC, Ernst SE, Taylor EB, et al A model for stimulation of enzyme activity by a competitive inhibitor based on
the interaction of terazosin and phosphoglycerate kinase 1.
Proc Natl Acad Sci U S A. 2024;121:e2318956121. PubMedAbstract available
RONTGEN A, Toprakcioglu Z, Tomkins JE, Vendruscolo M, et al Modulation of alpha-synuclein in vitro aggregation kinetics by its alternative splice
isoforms.
Proc Natl Acad Sci U S A. 2024;121:e2313465121. PubMedAbstract available
January 2024
GILBOA T, Swank Z, Thakur R, Gould RA, et al Toward the quantification of alpha-synuclein aggregates with digital seed
amplification assays.
Proc Natl Acad Sci U S A. 2024;121:e2312031121. PubMedAbstract available
AUBREY LD, Ninkina N, Ulamec SM, Abramycheva NY, et al Substitution of Met-38 to Ile in gamma-synuclein found in two patients with
amyotrophic lateral sclerosis induces aggregation into amyloid.
Proc Natl Acad Sci U S A. 2024;121:e2309700120. PubMedAbstract available
TONG Y, Zhang P, Yang X, Liu X, et al Decreasing the intrinsically disordered protein alpha-synuclein levels by targeting
its structured mRNA with a ribonuclease-targeting chimera.
Proc Natl Acad Sci U S A. 2024;121:e2306682120. PubMedAbstract available
KAKUDA K, Ikenaka K, Kuma A, Doi J, et al Lysophagy protects against propagation of alpha-synuclein aggregation through
ruptured lysosomal vesicles.
Proc Natl Acad Sci U S A. 2024;121:e2312306120. PubMedAbstract available
December 2023
QI C, Verheijen BM, Kokubo Y, Shi Y, et al Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex
adopt the CTE fold.
Proc Natl Acad Sci U S A. 2023;120:e2306767120. PubMedAbstract available
November 2023
BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected
by DNA aptamer-attached portable graphene biosensor.
Proc Natl Acad Sci U S A. 2023;120:e2311565120. PubMedAbstract available
October 2023
YESHAW WM, Adhikari A, Chiang CY, Dhekne HS, et al Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2
kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
Proc Natl Acad Sci U S A. 2023;120:e2315171120. PubMedAbstract available
LAI Y, Zhao C, Tian Z, Wang C, et al Neutral lysophosphatidylcholine mediates alpha-synuclein-induced synaptic vesicle
clustering.
Proc Natl Acad Sci U S A. 2023;120:e2310174120. PubMedAbstract available
WANG X, Espadas J, Wu Y, Cai S, et al Membrane remodeling properties of the Parkinson's disease protein LRRK2.
Proc Natl Acad Sci U S A. 2023;120:e2309698120. PubMedAbstract available
September 2023
KIM DY, Shin JY, Lee JE, Kim HN, et al A selective ER-phagy exerts neuroprotective effects via modulation of alpha-synuclein
clearance in parkinsonian models.
Proc Natl Acad Sci U S A. 2023;120:e2221929120. PubMedAbstract available
LE GUEN Y, Luo G, Ambati A, Damotte V, et al Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases
uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
Proc Natl Acad Sci U S A. 2023;120:e2302720120. PubMedAbstract available
August 2023
YADAVALLI N, Ferguson SM LRRK2 suppresses lysosome degradative activity in macrophages and microglia
through MiT-TFE transcription factor inhibition.
Proc Natl Acad Sci U S A. 2023;120:e2303789120. PubMedAbstract available
July 2023
ZHANG S, Yi S, Wang L, Li S, et al Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1
in glia.
Proc Natl Acad Sci U S A. 2023;120:e2301002120. PubMedAbstract available
June 2023
MATSUI H, Ito S, Matsui H, Ito J, et al Phosphorylation of alpha-synuclein at T64 results in distinct oligomers and exerts
toxicity in models of Parkinson's disease.
Proc Natl Acad Sci U S A. 2023;120:e2214652120. PubMedAbstract available
April 2023
PENG JY, Qi ZX, Yan Q, Fan XJ, et al Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in
entopeduncular nucleus-thalamus circuitry.
Proc Natl Acad Sci U S A. 2023;120:e2216247120. PubMedAbstract available
SCHWARZ TC, Beier A, Ledolter K, Gossenreiter T, et al High-resolution structural information of membrane-bound alpha-synuclein provides
insight into the MoA of the anti-Parkinson drug UCB0599.
Proc Natl Acad Sci U S A. 2023;120:e2201910120. PubMedAbstract available
March 2023
CHEUNG THC, Ding Y, Zhuang X, Kang UJ, et al Learning critically drives parkinsonian motor deficits through imbalanced
striatal pathway recruitment.
Proc Natl Acad Sci U S A. 2023;120:e2213093120. PubMedAbstract available