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  Pain Management

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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 34 articles:
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Single Articles


    February 2024
  1. HUANG Z, Zhang Y, Wang S, Qi R, et al
    FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m(6)A-dependent stabilization of 5-HT3A mRNA in sensory neurons.
    Proc Natl Acad Sci U S A. 2024;121:e2312861121.
    PubMed     Abstract available


    December 2023
  2. YOUSUF MS, Sahn JJ, Yang H, David ET, et al
    Highly specific sigma(2)R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response.
    Proc Natl Acad Sci U S A. 2023;120:e2306090120.
    PubMed     Abstract available


  3. CHEN M, Shin M, Ware TB, Donvito G, et al
    Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling.
    Proc Natl Acad Sci U S A. 2023;120:e2304900120.
    PubMed     Abstract available


    November 2023
  4. GOMEZ K, Santiago U, Nelson TS, Allen HN, et al
    A peptidomimetic modulator of the Ca(V)2.2 N-type calcium channel for chronic pain.
    Proc Natl Acad Sci U S A. 2023;120:e2305215120.
    PubMed     Abstract available


    August 2023
  5. GOMEZ K, Stratton HJ, Duran P, Loya S, et al
    Identification and targeting of a unique Na(V)1.7 domain driving chronic pain.
    Proc Natl Acad Sci U S A. 2023;120:e2217800120.
    PubMed     Abstract available


    July 2023
  6. WALKER AA, Robinson SD, Merritt DJ, Cardoso FC, et al
    Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).
    Proc Natl Acad Sci U S A. 2023;120:e2305871120.
    PubMed     Abstract available


    June 2023
  7. ELLINGSEN DM, Isenburg K, Jung C, Lee J, et al
    Brain-to-brain mechanisms underlying pain empathy and social modulation of pain in the patient-clinician interaction.
    Proc Natl Acad Sci U S A. 2023;120:e2212910120.
    PubMed     Abstract available


    May 2023
  8. HEGRON A, Peach CJ, Tonello R, Seemann P, et al
    Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
    Proc Natl Acad Sci U S A. 2023;120:e2220979120.
    PubMed     Abstract available


    April 2023
  9. CAXARIA S, Bharde S, Fuller AM, Evans R, et al
    Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.
    Proc Natl Acad Sci U S A. 2023;120:e2211631120.
    PubMed     Abstract available


  10. WISEDCHAISRI G, Gamal El-Din TM, Zheng N, Catterall WA, et al
    Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na(V)1.7.
    Proc Natl Acad Sci U S A. 2023;120:e2219624120.
    PubMed     Abstract available


    February 2023
  11. ZHAO W, Zhao L, Chang X, Lu X, et al
    Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain.
    Proc Natl Acad Sci U S A. 2023;120:e2215192120.
    PubMed     Abstract available


    January 2023
  12. MULDERS D, Seymour B, Mouraux A, Mancini F, et al
    Confidence of probabilistic predictions modulates the cortical response to pain.
    Proc Natl Acad Sci U S A. 2023;120:e2212252120.
    PubMed     Abstract available


    November 2022
  13. NELSON TS, Sinha GP, Santos DFS, Jukkola P, et al
    Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain.
    Proc Natl Acad Sci U S A. 2022;119:e2204515119.
    PubMed     Abstract available


  14. TANIOKU T, Nishibata M, Tokinaga Y, Konno K, et al
    Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity.
    Proc Natl Acad Sci U S A. 2022;119:e2121989119.
    PubMed     Abstract available


    August 2022
  15. ZHAO L, Luo H, Ma Y, Zhu S, et al
    An analgesic peptide H-20 attenuates chronic pain via the PD-1 pathway with few adverse effects.
    Proc Natl Acad Sci U S A. 2022;119:e2204114119.
    PubMed     Abstract available


    July 2022
  16. BOUCHATTA O, Aby F, Sifeddine W, Bouali-Benazzouz R, et al
    Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder.
    Proc Natl Acad Sci U S A. 2022;119:e2114094119.
    PubMed     Abstract available


  17. KATO Y, Ohsugi K, Fukuno Y, Iwatsuki K, et al
    Vesicular nucleotide transporter is a molecular target of eicosapentaenoic acid for neuropathic and inflammatory pain treatment.
    Proc Natl Acad Sci U S A. 2022;119:e2122158119.
    PubMed     Abstract available



  18. Correction for Latorre et al., Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
    Proc Natl Acad Sci U S A. 2022;119:e2209800119.
    PubMed    


  19. LENZ M, Salzmann M, Ciotu CI, Kaun C, et al
    Pharmacologic modulation of intracellular Na(+) concentration with ranolazine impacts inflammatory response in humans and mice.
    Proc Natl Acad Sci U S A. 2022;119:e2207020119.
    PubMed     Abstract available


  20. CHOSHEN-HILLEL S, Sadras I, Gordon-Hecker T, Genzer S, et al
    Physicians prescribe fewer analgesics during night shifts than day shifts.
    Proc Natl Acad Sci U S A. 2022;119:e2200047119.
    PubMed     Abstract available


    June 2022
  21. COLL MP, Slimani H, Woo CW, Wager TD, et al
    The neural signature of the decision value of future pain.
    Proc Natl Acad Sci U S A. 2022;119:e2119931119.
    PubMed     Abstract available


    May 2022
  22. EL KHAMLICHI C, Reverchon F, Hervouet-Coste N, Robin E, et al
    Serodolin, a beta-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
    Proc Natl Acad Sci U S A. 2022;119:e2118847119.
    PubMed     Abstract available


  23. SUN L, Tong CK, Morgenstern TJ, Zhou H, et al
    Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain.
    Proc Natl Acad Sci U S A. 2022;119:e2118129119.
    PubMed     Abstract available


    April 2022
  24. QI R, Cao J, Sun Y, Li Y, et al
    Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels.
    Proc Natl Acad Sci U S A. 2022;119:e2117209119.
    PubMed     Abstract available


    February 2022
  25. LATORRE R, Hegron A, Peach CJ, Teng S, et al
    Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  26. FINOL-URDANETA RK, Ziegman R, Dekan Z, McArthur JR, et al
    Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    January 2022
  27. RAYMONDI SILVA J, Iftinca M, Fernandes Gomes FI, Segal JP, et al
    Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  28. NICKEL MM, Tiemann L, Hohn VD, May ES, et al
    Temporal-spectral signaling of sensory information and expectations in the cerebral processing of pain.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    July 2021
  29. WERCBERGER R, Braz JM, Weinrich JA, Basbaum AI, et al
    Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  30. BROCKINGTON G, Gomes Moreira AP, Buso MS, Gomes da Silva S, et al
    Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  31. WALKER AA, Robinson SD, Paluzzi JV, Merritt DJ, et al
    Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  32. KANDASAMY R, Hillhouse TM, Livingston KE, Kochan KE, et al
    Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  33. PRADO J, Westerink RHS, Popov-Celeketic J, Steen-Louws C, et al
    Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  34. SRINIVASAN SS, Gutierrez-Arango S, Teng AC, Israel E, et al
    Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


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