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Articles published in Eur J Pharmacol

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    July 2021
  1. YANG F, Zou YQ, Li M, Luo WJ, et al
    Intervertebral foramen injection of plerixafor attenuates neuropathic pain after chronic compression of the dorsal root ganglion: Possible involvement of the down-regulation of Nav1.8 and Nav1.9.
    Eur J Pharmacol. 2021;908:174322.
    PubMed     Abstract available


    June 2021
  2. GUO ZB, Tang L, Wang LP, Wu HH, et al
    The analgesic effects of ulinastatin either as a single agent or in combination with sufentanil: A novel therapeutic potential for postoperative pain.
    Eur J Pharmacol. 2021;907:174267.
    PubMed     Abstract available


    May 2021
  3. SPRING DE ALMEIDA A, de Barros Bernardes L, Trevisan G
    TRP Channels in Cancer Pain.
    Eur J Pharmacol. 2021 May 17:174185. doi: 10.1016/j.ejphar.2021.174185.
    PubMed     Abstract available


  4. YAO L, Zhang TY, Diao XT, Ma JJ, et al
    Functional expression of glycine receptors in DRG neurons of mice.
    Eur J Pharmacol. 2021;899:174034.
    PubMed     Abstract available


  5. MUCHHALA KH, Jacob JC, Dewey WL, Akbarali HI, et al
    Role of beta-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia.
    Eur J Pharmacol. 2021;899:174007.
    PubMed     Abstract available


    April 2021
  6. ZHANG T, Zhang R, Xu B, Zhang M, et al
    Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor.
    Eur J Pharmacol. 2021;903:174139.
    PubMed     Abstract available


  7. DIAS QUINTAO JL, Reis Gonzaga AC, Galdino G, Lima Romero TR, et al
    TNF-alpha, CXCL-1 and IL-1 beta as activators of the opioid system involved in peripheral analgesic control in mice.
    Eur J Pharmacol. 2021;896:173900.
    PubMed     Abstract available


  8. GONCALVES WA, Ferreira RCM, Rezende BM, Mahecha GAB, et al
    Endogenous opioid and cannabinoid systems modulate the muscle pain: a pharmacological study into the peripheral site.
    Eur J Pharmacol. 2021 Apr 4:174089. doi: 10.1016/j.ejphar.2021.174089.
    PubMed     Abstract available


    March 2021
  9. XU Q, Sun L, Zhang W, Wu H, et al
    A novel visceral pain model of uterine cervix inflammation in rat.
    Eur J Pharmacol. 2021;900:174080.
    PubMed     Abstract available


  10. SHEIKHOLESLAMI MA, Ghafghazi S, Parvardeh S, Koohsari S, et al
    Analgesic effects of cuminic alcohol (4-isopropylbenzyl alcohol), a monocyclic terpenoid, in animal models of nociceptive and neuropathic pain: Role of opioid receptors, L-arginine/NO/cGMP pathway, and inflammatory cytokines.
    Eur J Pharmacol. 2021;900:174075.
    PubMed     Abstract available


  11. KAWASAKI S, Soga M, Sakurai Y, Nanchi I, et al
    Selective blockade of transient receptor potential vanilloid 4 reduces cyclophosphamide-induced bladder pain in mice.
    Eur J Pharmacol. 2021 Mar 15:174040. doi: 10.1016/j.ejphar.2021.174040.
    PubMed     Abstract available


  12. DAI G, Li B, Xu Y, Li Z, et al
    Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice.
    Eur J Pharmacol. 2021;895:173869.
    PubMed     Abstract available


  13. RYU SW, Kim YO, Kim HB, Oh SB, et al
    Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain.
    Eur J Pharmacol. 2021;899:174029.
    PubMed     Abstract available


  14. LIMCHAROEN T, Muangnoi C, Dasuni Wasana PW, Hasriadi, et al
    Improved antiallodynic, antihyperalgesic and anti-inflammatory response achieved through potential prodrug of curcumin, curcumin diethyl diglutarate in a mouse model of neuropathic pain.
    Eur J Pharmacol. 2021 Mar 8:174008. doi: 10.1016/j.ejphar.2021.174008.
    PubMed     Abstract available


    February 2021
  15. XING Y, Liu Y, Deng M, Wang HP, et al
    The synergistic effects of Opioid and neuropeptide B/W in rat acute inflammatory and neuropathic pain models.
    Eur J Pharmacol. 2021 Feb 24:173979. doi: 10.1016/j.ejphar.2021.173979.
    PubMed     Abstract available


  16. MENA-VALDES LC, Blanco-Hernandez Y, Espinosa-Juarez JV, Lopez-Munoz FJ, et al
    Haloperidol potentiates antinociceptive effects of morphine and disrupt opioid tolerance.
    Eur J Pharmacol. 2021;893:173825.
    PubMed     Abstract available


  17. ALIJANPOUR S, Jafaripour S, Ghasemzadeh Z, Khakpai F, et al
    Harmaline potentiates morphine-induced antinociception via affecting the ventral hippocampal GABA-A receptors in mice.
    Eur J Pharmacol. 2021;893:173806.
    PubMed     Abstract available


  18. WANG X, Liu Y, Zhang H, Jin J, et al
    Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway.
    Eur J Pharmacol. 2021 Feb 14:173945. doi: 10.1016/j.ejphar.2021.173945.
    PubMed     Abstract available


    January 2021
  19. BRUSCO I, Justino AB, Silva CR, Scussel R, et al
    Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice.
    Eur J Pharmacol. 2021 Jan 18:173870. doi: 10.1016/j.ejphar.2021.173870.
    PubMed     Abstract available


  20. RICARDO CARVALHO VP, Figueira da Silva J, Buzelin MA, Antonio da Silva Junior C, et al
    Calcium channels blockers toxins attenuate abdominal hyperalgesia and inflammatory response associated with the cerulein-induced acute pancreatitis in rats.
    Eur J Pharmacol. 2021;891:173672.
    PubMed     Abstract available


  21. DECIGA-CAMPOS M, Villafan-Gutierrez R, Espinosa-Juarez JV, Jaramillo-Morales OA, et al
    Synergistic interaction between haloperidol and gabapentin in a model of neuropathic nociception in rat.
    Eur J Pharmacol. 2021;891:173702.
    PubMed     Abstract available


  22. CAMARGO LL, Denadai-Souza A, Yshii LM, Lima C, et al
    The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis.
    Eur J Pharmacol. 2021;890:173636.
    PubMed     Abstract available


    December 2020
  23. TSUBOTA M, Matsui K, Nakano M, Kajitani R, et al
    Corrigendum to "Essential role of Cav3.2 T-type calcium channels in butyrate-induced colonic pain and nociceptor hypersensitivity in mice" [Eur. J. Pharmacol. 887 (2020) 173576].
    Eur J Pharmacol. 2020 Dec 22:173795. doi: 10.1016/j.ejphar.2020.173795.
    PubMed    


  24. NYMAN J, Guo N, Sandstrom A, Hallberg M, et al
    The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain.
    Eur J Pharmacol. 2020;892:173820.
    PubMed     Abstract available


    November 2020
  25. LI T, Wang T, Wang L, Liu R, et al
    Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats.
    Eur J Pharmacol. 2020 Nov 5:173693. doi: 10.1016/j.ejphar.2020.173693.
    PubMed     Abstract available


    October 2020
  26. ZHANG X, Xia L, Xie A, Liao O, et al
    Low concentration of Bupivacaine ameliorates painful diabetic neuropathy by mediating miR-23a/PDE4B axis in microglia.
    Eur J Pharmacol. 2020 Oct 31:173719. doi: 10.1016/j.ejphar.2020.173719.
    PubMed     Abstract available


  27. ZHANG Z, Yao Z, Wu K, Zhang T, et al
    Resveratrol rescued the pain related hypersensitivity for Cntnap2-deficient mice.
    Eur J Pharmacol. 2020 Oct 31:173704. doi: 10.1016/j.ejphar.2020.173704.
    PubMed     Abstract available


  28. SHAW S, Uniyal A, Gadepalli A, Tiwari V, et al
    Adenosine receptor signalling: Probing the potential pathways for the ministration of neuropathic pain.
    Eur J Pharmacol. 2020;889:173619.
    PubMed     Abstract available


    September 2020
  29. TOMITA S, Sekiguchi F, Kasanami Y, Naoe K, et al
    Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain.
    Eur J Pharmacol. 2020 Sep 21:173587. doi: 10.1016/j.ejphar.2020.173587.
    PubMed     Abstract available


  30. TSUBOTA M, Matsui K, Nakano M, Kajitani R, et al
    Essential role of Cav3.2 T-type calcium channels in butyrate-induced colonic pain and nociceptor hypersensitivity in mice.
    Eur J Pharmacol. 2020 Sep 16:173576. doi: 10.1016/j.ejphar.2020.173576.
    PubMed     Abstract available


  31. NOZU T, Miyagishi S, Ishioh M, Takakusaki K, et al
    Imipramine improves visceral sensation and gut barrier in rat models of irritable bowel syndrome.
    Eur J Pharmacol. 2020;887:173565.
    PubMed     Abstract available


  32. KUBACKA M, Rapacz A, Salat K, Filipek B, et al
    KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies.
    Eur J Pharmacol. 2020 Sep 4:173540. doi: 10.1016/j.ejphar.2020.173540.
    PubMed     Abstract available


    August 2020
  33. ECKERT WA 3RD, Wiener JJM, Cai H, Ameriks MK, et al
    Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
    Eur J Pharmacol. 2020;880:173171.
    PubMed     Abstract available


  34. MINAMI T, Takeda M, Sata M, Kato H, et al
    Thrombomodulin alfa prevents oxaliplatin-induced neuropathic symptoms through activation of thrombin-activatable fibrinolysis inhibitor and protein C without affecting anti-tumor activity.
    Eur J Pharmacol. 2020;880:173196.
    PubMed     Abstract available


  35. ZHANG R, Xu B, Zhang Q, Chen D, et al
    Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
    Eur J Pharmacol. 2020;880:173169.
    PubMed     Abstract available


    July 2020
  36. YIN Q, Wang JF, Xu XH, Xie H, et al
    Effect of lycopene on pain facilitation and the SIRT1/mTOR pathway in the dorsal horn of burn injury rats.
    Eur J Pharmacol. 2020 Jul 23:173365. doi: 10.1016/j.ejphar.2020.173365.
    PubMed     Abstract available


  37. ALMEIDA MOREIRA LEAL LK, Lima LA, Alexandre de Aquino PE, Costa de Sousa JA, et al
    Vitamin D (VD3) antioxidative and anti-inflammatory activities: Peripheral and central effects.
    Eur J Pharmacol. 2020;879:173099.
    PubMed     Abstract available


    June 2020
  38. GUO J, Li G, Yang L
    Role of H2S in pain: Growing evidences of mystification.
    Eur J Pharmacol. 2020 Jun 30:173322. doi: 10.1016/j.ejphar.2020.173322.
    PubMed     Abstract available


  39. HUANG J, Chen D, Yan F, Wu S, et al
    JTC-801 alleviates mechanical allodynia in paclitaxel-induced neuropathic pain through the PI3K/Akt pathway.
    Eur J Pharmacol. 2020 Jun 27:173306. doi: 10.1016/j.ejphar.2020.173306.
    PubMed     Abstract available


  40. WANG R, Qiu Z, Wang G, Hu Q, et al
    Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db/db mice.
    Eur J Pharmacol. 2020;882:173266.
    PubMed     Abstract available


  41. TETREAULT P, Besserer-Offroy E, Brouillette RL, Rene A, et al
    Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.
    Eur J Pharmacol. 2020 Jun 10:173174. doi: 10.1016/j.ejphar.2020.173174.
    PubMed     Abstract available


  42. MATERA C, Flammini L, Riefolo F, Domenichini G, et al
    Novel analgesic agents obtained by molecular hybridization of orthosteric and allosteric ligands.
    Eur J Pharmacol. 2020;876:173061.
    PubMed     Abstract available


    May 2020
  43. KISO T, Watabiki T, Sekizawa T
    ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain.
    Eur J Pharmacol. 2020 May 20:173194. doi: 10.1016/j.ejphar.2020.173194.
    PubMed     Abstract available


  44. YU C, Zhang Y, Gao KX, Sun HT, et al
    Serotonergically dependent antihyperalgesic and antiallodynic effects of isoliquiritin in a mouse model of neuropathic pain.
    Eur J Pharmacol. 2020 May 14:173184. doi: 10.1016/j.ejphar.2020.173184.
    PubMed     Abstract available


  45. SANNA MD, Manassero G, Vercelli A, Herdegen T, et al
    The isoform-specific functions of the c-Jun N-terminal kinase (JNK) in a mouse model of antiretroviral-induced painful peripheral neuropathy.
    Eur J Pharmacol. 2020;880:173161.
    PubMed     Abstract available


  46. BOGACKA J, Popiolek-Barczyk K, Pawlik K, Ciechanowska A, et al
    CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain.
    Eur J Pharmacol. 2020 May 11:173166. doi: 10.1016/j.ejphar.2020.173166.
    PubMed     Abstract available


    April 2020
  47. NEMOTO W, Yamagata R, Nakagawasai O, Nakagawa K, et al
    Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice.
    Eur J Pharmacol. 2020;872:172950.
    PubMed     Abstract available


    March 2020
  48. MAO XF, Ahsan MZ, Apryani E, Tang XQ, et al
    Dual mu-opioid receptor and norepinephrine reuptake mechanisms contribute to dezocine- and tapentadol-induced mechanical antiallodynia in cancer pain.
    Eur J Pharmacol. 2020 Mar 12:173062. doi: 10.1016/j.ejphar.2020.173062.
    PubMed     Abstract available


    February 2020
  49. MORAES TR, Elisei LS, Malta IH, Galdino G, et al
    Participation of CXCL1 in the glial cells during neuropathic pain.
    Eur J Pharmacol. 2020 Feb 28:173039. doi: 10.1016/j.ejphar.2020.173039.
    PubMed     Abstract available


  50. MATSUURA W, Nakamoto K, Tokuyama S
    Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice.
    Eur J Pharmacol. 2020;874:173029.
    PubMed     Abstract available


  51. ZHOU J, Qi F, Hu Z, Zhang L, et al
    Dezocine attenuates the remifentanil-induced postoperative hyperalgesia by inhibition of phosphorylation of CaMKalpha.
    Eur J Pharmacol. 2020;869:172882.
    PubMed     Abstract available


    January 2020
  52. AKBAR S, Subhan F, Shahid M, Wadood A, et al
    6-Methoxyflavanone abate cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study.
    Eur J Pharmacol. 2020 Jan 29:172972. doi: 10.1016/j.ejphar.2020.172972.
    PubMed     Abstract available


  53. HARA K, Haranishi Y, Terada T
    Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.
    Eur J Pharmacol. 2020 Jan 25:172949. doi: 10.1016/j.ejphar.2020.172949.
    PubMed     Abstract available


    December 2019
  54. RAPACZ A, Rybka S, Obniska J, Jodlowska A, et al
    Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain.
    Eur J Pharmacol. 2019;869:172890.
    PubMed     Abstract available


  55. COUTENS B, Derreumaux C, Labaste F, Minville V, et al
    Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
    Eur J Pharmacol. 2019 Dec 20:172884. doi: 10.1016/j.ejphar.2019.172884.
    PubMed     Abstract available


  56. PANG H, Ren Y, Li H, Chen C, et al
    LncRNAs linc00311 and AK141205 are identified as new regulators in STAT3-mediated neuropathic pain in bCCI rats.
    Eur J Pharmacol. 2019;868:172880.
    PubMed     Abstract available


  57. SANNA MD, Borgonetti V, Masini E, Galeotti N, et al
    Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway.
    Eur J Pharmacol. 2019;868:172859.
    PubMed     Abstract available


    October 2019
  58. NAGAKURA Y, Miwa M, Yoshida M, Miura R, et al
    Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
    Eur J Pharmacol. 2019 Oct 4:172716. doi: 10.1016/j.ejphar.2019.172716.
    PubMed     Abstract available


    September 2019
  59. SALAGA M, Binienda A, Tichkule RB, Thakur GA, et al
    Corrigendum to "The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome" [Eur. J. Pharmacol. (2018),
    Eur J Pharmacol. 2019 Sep 10:172656. doi: 10.1016/j.ejphar.2019.172656.
    PubMed    


    August 2019
  60. GARCIA G, Noriega-Navarro R, Martinez-Rojas VA, Gutierrez-Lara EJ, et al
    Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.
    Eur J Pharmacol. 2019;862:172631.
    PubMed     Abstract available


    July 2019
  61. DE PRA SDT, David Antoniazzi CT, Ferro PR, Kudsi SQ, et al
    Nociceptive mechanisms involved in the acute and chronic phases of a complex regional pain syndrome type 1 model in mice.
    Eur J Pharmacol. 2019 Jul 18:172555. doi: 10.1016/j.ejphar.2019.172555.
    PubMed     Abstract available


  62. RIGO FK, Bochi GV, Pereira AL, Adamante G, et al
    TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice.
    Eur J Pharmacol. 2019;855:65-74.
    PubMed     Abstract available


    June 2019
  63. AUGUSTO PSA, Braga AV, Rodrigues FF, Morais MI, et al
    Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
    Eur J Pharmacol. 2019;858:172497.
    PubMed     Abstract available


  64. GE MM, Chen SP, Zhou YQ, Li Z, et al
    The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain.
    Eur J Pharmacol. 2019 Jun 19:172475. doi: 10.1016/j.ejphar.2019.172475.
    PubMed     Abstract available


  65. SALIMI S, Tamaddonfard E
    Microinjection of histamine and its H3 receptor agonist and antagonist into the agranular insular cortex influence sensory and affective components of neuropathic pain in rats.
    Eur J Pharmacol. 2019;857:172450.
    PubMed     Abstract available


  66. DE LA LUZ-CUELLAR YE, Rodriguez-Palma EJ, Franco-Enzastiga U, Salinas-Abarca AB, et al
    Blockade of spinal alpha5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats.
    Eur J Pharmacol. 2019 Jun 7:172443. doi: 10.1016/j.ejphar.2019.172443.
    PubMed     Abstract available


  67. MADANRAJ AS, Khan FU, Naveed M, Ali U, et al
    Interventions to chronic prostatitis/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?
    Eur J Pharmacol. 2019 Jun 3:172429. doi: 10.1016/j.ejphar.2019.172429.
    PubMed     Abstract available


    May 2019
  68. MELO ISF, Rodrigues FF, Costa SOAM, Braga AV, et al
    4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-alpha and CXCL1 production and exhibits activity in models of pain and inflammation.
    Eur J Pharmacol. 2019;856:172404.
    PubMed     Abstract available


  69. BECK TC, Reichel CM, Helke KL, Bhadsavle SS, et al
    Non-addictive orally-active kappa opioid agonists for the treatment of peripheral pain in rats.
    Eur J Pharmacol. 2019 May 16. pii: S0014-2999(19)30335.
    PubMed     Abstract available


  70. SHARMA J, Kulshrestha R, Singh N, Jaggi AS, et al
    Dual role of D-amino acid oxidase in experimental pain models.
    Eur J Pharmacol. 2019 May 3. pii: S0014-2999(19)30305.
    PubMed     Abstract available


    April 2019
  71. GARCIA MM, Goicoechea C, Avellanal M, Traseira S, et al
    Comparison of the antinociceptive profiles of morphine and oxycodone in two models of inflammatory and osteoarthritic pain in rat.
    Eur J Pharmacol. 2019 Apr 9. pii: S0014-2999(19)30239.
    PubMed     Abstract available


  72. GAO T, Shi T, Wiesenfeld-Hallin Z, Li T, et al
    Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
    Eur J Pharmacol. 2019;854:101-108.
    PubMed     Abstract available


  73. HE YT, Duan XL, Guo Z, Li HL, et al
    A synthetic peptide disturbing GluN2A/SHP1 interaction in dorsal root ganglion attenuated pathological pain.
    Eur J Pharmacol. 2019 Apr 2. pii: S0014-2999(19)30221.
    PubMed     Abstract available


    March 2019
  74. NOZU T, Miyagishi S, Nozu R, Takakusaki K, et al
    Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.
    Eur J Pharmacol. 2019;852:198-206.
    PubMed     Abstract available


  75. MERCADO-REYES J, Almanza A, Segura-Chama P, Pellicer F, et al
    D2-like receptor agonist synergizes the mu-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat.
    Eur J Pharmacol. 2019 Mar 12. pii: S0014-2999(19)30175.
    PubMed     Abstract available


    February 2019
  76. CORNELISSEN JC, Steele FF, Tenney RD, Obeng S, et al
    Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys.
    Eur J Pharmacol. 2019;844:175-182.
    PubMed     Abstract available


    January 2019
  77. PASQUINUCCI L, Turnaturi R, Montenegro L, Caraci F, et al
    Simultaneous targeting of MOR/DOR: a useful strategy for inflammatory pain modulation.
    Eur J Pharmacol. 2019 Jan 25. pii: S0014-2999(19)30052.
    PubMed     Abstract available


  78. GAZZO G, Girard P, Kamoun N, Verleye M, et al
    Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.
    Eur J Pharmacol. 2019;843:316-322.
    PubMed     Abstract available


    December 2018
  79. FALK S, Appel CK, Bennedbaek HB, Al-Dihaissy T, et al
    Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain.
    Eur J Pharmacol. 2018 Dec 21. pii: S0014-2999(18)30750.
    PubMed     Abstract available


  80. LANDA-JUAREZ AY, Perez-Severiano F, Castaneda-Hernandez G, Ortiz MI, et al
    The antihyperalgesic effect of docosahexaenoic acid in streptozotocin-induced neuropathic pain in the rat involves the opioidergic system.
    Eur J Pharmacol. 2018 Dec 21. pii: S0014-2999(18)30751.
    PubMed     Abstract available


  81. ASANO T, Hattori T, Tanaka KI, Yamakawa N, et al
    Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain.
    Eur J Pharmacol. 2018 Dec 6. pii: S0014-2999(18)30704.
    PubMed     Abstract available


    October 2018
  82. SRIKANTH M, Chew WS, Hind T, Lim SM, et al
    Lysophosphatidic acid and its receptor LPA1 mediate carrageenan induced inflammatory pain in mice.
    Eur J Pharmacol. 2018 Oct 12. pii: S0014-2999(18)30582.
    PubMed     Abstract available


    September 2018
  83. ROJEWSKA E, Piotrowska A, Jurga A, Makuch W, et al
    Zaprinast diminished pain and enhanced opioid analgesia in a rat neuropathic pain model.
    Eur J Pharmacol. 2018 Sep 10. pii: S0014-2999(18)30518.
    PubMed     Abstract available


    August 2018
  84. LI N, Han ZL, Xu B, Zhang MN, et al
    Systemic administration of the bifunctional opioid/neuropeptide FF receptors agonist BN-9 produced peripheral antinociception in preclinical mouse models of pain.
    Eur J Pharmacol. 2018;837:53-63.
    PubMed     Abstract available


  85. SALAGA M, Binienda A, Tichkule RB, Thakur GA, et al
    The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
    Eur J Pharmacol. 2018 Aug 16. pii: S0014-2999(18)30473.
    PubMed     Abstract available


    July 2018
  86. MARTIKAINEN IK, Hagelberg N, Jaaskelainen SK, Hietala J, et al
    Dopaminergic and serotonergic mechanisms in the modulation of pain: In vivo studies in human brain.
    Eur J Pharmacol. 2018 Jul 20. pii: S0014-2999(18)30412.
    PubMed     Abstract available


    June 2018
  87. MERLOS M, Portillo-Salido E, Brenchat A, Aubel B, et al
    Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.
    Eur J Pharmacol. 2018 Jun 19. pii: S0014-2999(18)30353.
    PubMed     Abstract available


  88. FUJITA M, Tamano R, Yoneda S, Omachi S, et al
    Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: different inhibitory mechanism on spinal microglia from minocycline and propentofylline.
    Eur J Pharmacol. 2018 Jun 7. pii: S0014-2999(18)30336.
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  89. SHINOHARA A, Andoh T, Saiki I, Kuraishi Y, et al
    Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice.
    Eur J Pharmacol. 2018 Jun 7. pii: S0014-2999(18)30337.
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    May 2018
  90. GUI Y, Chen L, Duan S, Li G, et al
    Methyl cinnamate alleviated CCI-induced upregualtion of spinal AMPA receptors and pain hypersensitivity by targeting AMPK.
    Eur J Pharmacol. 2018 May 23. pii: S0014-2999(18)30297.
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  91. SCHIENE K, Schroder W, Linz K, Frosch S, et al
    Nociceptin/orphanin FQ opioid peptide (NOP) receptor and micro-opioid peptide (MOP) receptors both contribute to the anti-hypersensitive effect of cebranopadol in a rat model of arthritic pain.
    Eur J Pharmacol. 2018 May 9. pii: S0014-2999(18)30261.
    PubMed     Abstract available


    March 2018
  92. BARAKAT A, Hamdy MM, Elbadr MM
    Uses of fluoxetine in nociceptive pain management: a literature overview.
    Eur J Pharmacol. 2018 Mar 30. pii: S0014-2999(18)30209.
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  93. HEWEDY WA
    Linagliptin attenuates chronic post-ischemia pain: possible anti-inflammatory and anti-oxidant mechanisms.
    Eur J Pharmacol. 2018 Mar 29. pii: S0014-2999(18)30198.
    PubMed     Abstract available


  94. ZHAO JY, Yang L, Bai HH, Liu JP, et al
    Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain.
    Eur J Pharmacol. 2018 Mar 8. pii: S0014-2999(18)30148.
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  95. RUTTEN K, Schroder W, Christoph T, Koch T, et al
    Selectivity profiling of NOP, MOP, DOP and KOP receptor antagonists in the rat spinal nerve ligation model of mononeuropathic pain.
    Eur J Pharmacol. 2018 Mar 7. pii: S0014-2999(18)30144.
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  96. NEMUTLU SAMUR D, Arslan R, Aydin S, Bektas N, et al
    Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms.
    Eur J Pharmacol. 2018 Mar 6. pii: S0014-2999(18)30142.
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    February 2018
  97. SANNA MD, Galeotti N
    The HDAC1/c-JUN complex is essential in the promotion of nerve injury-induced neuropathic pain through JNK signalling.
    Eur J Pharmacol. 2018 Feb 22. pii: S0014-2999(18)30119.
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  98. OU Y, Su M, Ling Y, Wei Q, et al
    Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain.
    Eur J Pharmacol. 2018;823:105-109.
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    January 2018
  99. LIANG X, Yu G, Su R
    Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain.
    Eur J Pharmacol. 2018;823:27-34.
    PubMed     Abstract available


  100. BRITO AMS, Godin AM, Augusto PSA, Menezes RR, et al
    Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-alpha and CXCL-1.
    Eur J Pharmacol. 2018;818:17-25.
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    December 2017
  101. RAPACZ A, Obniska J, Koczurkiewicz P, Wojcik-Pszczola K, et al
    Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice.
    Eur J Pharmacol. 2017 Dec 17. pii: S0014-2999(17)30831.
    PubMed     Abstract available


    November 2017
  102. XU S, Qin B, Shi A, Zhao J, et al
    Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats.
    Eur J Pharmacol. 2017 Nov 18. pii: S0014-2999(17)30752.
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  103. YAO W, Han Q, Wang L, Niu Z, et al
    Ropivacaine relieves pain and prevents chondrocyte degradation probably through Calcineurin/NFAT1 signaling pathway in osteoarthritis rats.
    Eur J Pharmacol. 2017 Nov 17. pii: S0014-2999(17)30763.
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  104. AHLAWAT A, Sharma S
    A new promising simultaneous approach for attenuating type II diabetes mellitus induced neuropathic pain in rats: iNOS inhibition and neuroregeneration.
    Eur J Pharmacol. 2017;818:419-428.
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    October 2017
  105. KOPRUSZINSKI CM, Dos Reis RC, Gambeta E, Acco A, et al
    Blockade of endothelin receptors reduces tumor-induced ongoing pain and evoked hypersensitivity in a rat model of facial carcinoma induced pain.
    Eur J Pharmacol. 2017;818:132-140.
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    September 2017
  106. TAMADDONFARD E, Erfanparast A, Abbas Farshid A, Delkhosh-Kasmaie F, et al
    Role of ventrolateral orbital cortex muscarinic and nicotinic receptors in modulation of capsaicin-induced orofacial pain-related behaviors in rats.
    Eur J Pharmacol. 2017 Sep 29. pii: S0014-2999(17)30635.
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  107. SUDO RT, do Amaral RV, Monteiro CEDS, Pitta IDR, et al
    Antinociception induced by a novel alpha2A adrenergic receptor agonist in rodents acute and chronic pain models.
    Eur J Pharmacol. 2017 Sep 19. pii: S0014-2999(17)30604.
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    August 2017
  108. AHMAD N, Subhan F, Islam N, Shahid M, et al
    Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model.
    Eur J Pharmacol. 2017 Aug 30. pii: S0014-2999(17)30548.
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    July 2017
  109. ZHANG R, Xu B, Zhang MN, Zhang T, et al
    Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model.
    Eur J Pharmacol. 2017 Jul 27. pii: S0014-2999(17)30499.
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  110. SALIMI A, Sabetkasaei M, Raisi H, Labibi F, et al
    Carbamazepine effects on pain management and serum IL-6, IL-10 evaluation in addicted patients undergoing surgery.
    Eur J Pharmacol. 2017 Jul 8. pii: S0014-2999(17)30455.
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    June 2017
  111. LIN Y, Liu L, Jiang H, Zhou J, et al
    Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis.
    Eur J Pharmacol. 2017 Jun 26. pii: S0014-2999(17)30438.
    PubMed     Abstract available


  112. DI CESARE MANNELLI L, Ghelardini C, Micheli L, Del Bello F, et al
    Synergic stimulation of serotonin 5-HT1A receptor and alpha2-adrenoceptors for neuropathic pain relief: preclinical effects of 2-substituted imidazoline derivatives.
    Eur J Pharmacol. 2017 Jun 17. pii: S0014-2999(17)30431.
    PubMed     Abstract available


  113. KAUR M, Singh A, Kumar B, Singh SK, et al
    Protective effect of co-administration of curcumin and sildenafil in alcohol induced neuropathy in rats.
    Eur J Pharmacol. 2017;805:58-66.
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    April 2017
  114. BENADE V, Nirogi R, Bhyrapuneni G, Daripelli S, et al
    Mechanistic evaluation of Tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats.
    Eur J Pharmacol. 2017 Apr 12. pii: S0014-2999(17)30263.
    PubMed     Abstract available


    March 2017
  115. SPINDOLA HM, Grando R, Figueiredo MC, Basting R, et al
    Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice.
    Eur J Pharmacol. 2017 Mar 16. pii: S0014-2999(17)30203.
    PubMed     Abstract available


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