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Articles published in Antimicrob Agents Chemother

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    October 2021
  1. VELASQUEZ AMA, Bartlett PJ, Linares IAP, Passalacqua TG, et al
    New insights into the mechanism of action of the cyclopalladated complex - CP2 in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction and Cell Death.
    Antimicrob Agents Chemother. 2021 Oct 11:AAC0076721. doi: 10.1128/AAC.00767.
    PubMed     Abstract available


  2. PALOQUE L, Coppee R, Stokes BH, Gnadig NF, et al
    Mutation in Plasmodium falciparum BTB/POZ domain of K13 protein confers artemisinin resistance.
    Antimicrob Agents Chemother. 2021 Oct 4:AAC0132021. doi: 10.1128/AAC.01320.
    PubMed     Abstract available


    September 2021
  3. MANH ND, Thanh NV, Quang HH, Van NTT, et al
    Pyronaridine-Artesunate (Pyramax(R)) for the Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam.
    Antimicrob Agents Chemother. 2021 Sep 27:AAC0027621. doi: 10.1128/AAC.00276.
    PubMed     Abstract available


  4. IMWONG M, Suwannasin K, Srisutham S, Vongpromek R, et al
    Evolution of multidrug resistance in Plasmodium falciparum: a longitudinal study of genetic resistance markers in the Greater Mekong Subregion.
    Antimicrob Agents Chemother. 2021 Sep 13:AAC0112121. doi: 10.1128/AAC.01121.
    PubMed     Abstract available


    August 2021
  5. ELLIS KM, Lucantoni L, Chavchich M, Abraham M, et al
    The novel bis-1,2,4-triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite.
    Antimicrob Agents Chemother. 2021 Aug 30:AAC0031121. doi: 10.1128/AAC.00311.
    PubMed     Abstract available


  6. ETXEBESTE-MITXELTORENA M, Plano D, Espuelas S, Moreno E, et al
    New phosphoramidates containing selenium as leishmanicidal agents.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0059021. doi: 10.1128/AAC.00590.
    PubMed     Abstract available


  7. KREUTZFELD O, Rasmussen SA, Ramanathan AA, Tumwebaze PK, et al
    Associations between varied susceptibilities of PfATP4 inhibitors and genotypes in Ugandan Plasmodium falciparum isolates.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0077121. doi: 10.1128/AAC.00771.
    PubMed     Abstract available


  8. TALAAM KK, Inaoka DK, Hatta T, Tsubokawa D, et al
    Mitochondria as a potential target for the development of prophylactic and therapeutic drugs against Schistosoma mansoni infection.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0041821. doi: 10.1128/AAC.00418.
    PubMed     Abstract available


  9. PAKOSZ Z, Lin TY, Michalczyk E, Nagano S, et al
    Inhibitory compounds targeting Plasmodium falciparum Gyrase B.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0026721. doi: 10.1128/AAC.00267.
    PubMed     Abstract available


    July 2021
  10. VAN LOON W, Bergmann C, Habarugira F, Tacoli C, et al
    Changing pattern of Plasmodium falciparum multi-drug resistance-1 gene polymorphisms in southern Rwanda.
    Antimicrob Agents Chemother. 2021 Jul 6:AAC0090121. doi: 10.1128/AAC.00901.
    PubMed     Abstract available


    June 2021
  11. TAN S, Mudeppa DG, Kokkonda S, White J 3rd, et al
    Properties of Plasmodium falciparum with a deleted apicoplast DNA gyrase.
    Antimicrob Agents Chemother. 2021 Jun 21:AAC0058621. doi: 10.1128/AAC.00586.
    PubMed     Abstract available


  12. TABASSUM W, Singh P, Suthram N, Bhattacharyya S, et al
    Elevated DNA damage sensitivity in malaria parasite induced by the synergistic action between PfHsp90 inhibitor and PfRad51 inhibitor.
    Antimicrob Agents Chemother. 2021 Jun 7:AAC0045721. doi: 10.1128/AAC.00457.
    PubMed     Abstract available


  13. BESHIR KB, Diallo N, Some FA, Sombie S, et al
    Persistent sub-microscopic Plasmodium falciparum parasitaemia 72 hours after treatment with artemether-lumefantrine predicts 42-day treatment failure in Mali and Burkina Faso.
    Antimicrob Agents Chemother. 2021 Jun 1:AAC0087321. doi: 10.1128/AAC.00873.
    PubMed     Abstract available


    April 2021
  14. GOMES-ALVES AG, Duarte M, Cruz T, Castro H, et al
    Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evaluation and mechanistic studies.
    Antimicrob Agents Chemother. 2021 Apr 26. pii: AAC.01513.
    PubMed     Abstract available


  15. FENG J, Xu D, Kong X, Lin K, et al
    Characterization of pfmdr1, pfcrt, pfK13, pfubp1, and pfap2mu in travelers returning from Africa with Plasmodium falciparum infections reported in China from 2014-2018.
    Antimicrob Agents Chemother. 2021 Apr 26. pii: AAC.02717.
    PubMed     Abstract available


  16. DICKIE EA, Ronin C, Sa M, Ciesielski F, et al
    Towards chemical validation of Leishmania infantum ribose 5-phosphate isomerase as a drug target.
    Antimicrob Agents Chemother. 2021 Apr 19. pii: AAC.01892.
    PubMed     Abstract available


  17. PERNAUTE-LAU L, Adegnika AA, Zhou Y, Zinsou JF, et al
    Pharmacogene sequencing of a Gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment.
    Antimicrob Agents Chemother. 2021 Apr 19. pii: AAC.00275.
    PubMed     Abstract available


    March 2021
  18. BURGERT L, Zaloumis S, Dini S, Marquart L, et al
    Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.
    Antimicrob Agents Chemother. 2021;65.
    PubMed     Abstract available


  19. CAO Y, Sun C, Wen H, Wang M, et al
    A yeast-based drug discovery platform to identify Plasmodium falciparum type II NADH dehydrogenase inhibitors.
    Antimicrob Agents Chemother. 2021 Mar 15. pii: AAC.02470.
    PubMed     Abstract available


  20. SI Y, Zeng W, Li N, Wang C, et al
    In Vitro Susceptibility of Plasmodium falciparum Isolates from the China-Myanmar Border Area to Piperaquine and Association with Candidate Markers.
    Antimicrob Agents Chemother. 2021 Mar 8. pii: AAC.02305.
    PubMed     Abstract available


  21. CHAN CF, Liu Z, Wong ILK, Zhao X, et al
    Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis.
    Antimicrob Agents Chemother. 2021 Mar 8. pii: AAC.02165.
    PubMed     Abstract available


  22. ZALOUMIS SG, Whyte JM, Tarning J, Krishna S, et al
    Development and validation of an in silico decision-tool to guide optimisation of intravenous artesunate dosing regimens for severe falciparum malaria patients.
    Antimicrob Agents Chemother. 2021 Mar 8. pii: AAC.02346.
    PubMed     Abstract available


  23. MARIN AA, Murillo O, Sussmann RA, Ortolan LS, et al
    Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria.
    Antimicrob Agents Chemother. 2021 Mar 1. pii: AAC.00004.
    PubMed     Abstract available


    February 2021
  24. ANDRADE-NETO VV, Rebello KM, Pereira TM, Torres-Santos EC, et al
    Effect of Itraconazole-Ezetimibe-Miltefosine Ternary Therapy in Murine Visceral Leishmaniasis.
    Antimicrob Agents Chemother. 2021 Feb 22. pii: AAC.02676.
    PubMed     Abstract available


  25. LI H, Abraham A, Gazzola D, Hu Y, et al
    Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans.
    Antimicrob Agents Chemother. 2021;65.
    PubMed     Abstract available


  26. QUANG HH, Chavchich M, Trinh NTM, Edgel KA, et al
    Multidrug-resistant Plasmodium falciparum parasites in the Central Highlands of Vietnam jeopardize malaria control and elimination strategies.
    Antimicrob Agents Chemother. 2021 Feb 1. pii: AAC.01639.
    PubMed     Abstract available


    January 2021
  27. RIBBISO KA, Heller LE, Taye A, Julian E, et al
    Artemisinin - Based Drugs Target the Plasmodium falciparum heme-detoxification pathway.
    Antimicrob Agents Chemother. 2021 Jan 25. pii: AAC.02137.
    PubMed     Abstract available


  28. TEWARI SG, Rajaram K, Swift RP, Reifman J, et al
    Metabolic survival adaptations of Plasmodium falciparum exposed to sub-lethal doses of fosmidomycin.
    Antimicrob Agents Chemother. 2021 Jan 25. pii: AAC.02392.
    PubMed     Abstract available


  29. WATTANAKUL T, Baker M, Mohrle J, McWhinney B, et al
    Semi-mechanistic pharmacokinetic and pharmacodynamic modelling of piperaquine in a volunteer infection study with Plasmodium falciparum blood-stage malaria.
    Antimicrob Agents Chemother. 2021 Jan 19. pii: AAC.01583.
    PubMed     Abstract available


    December 2020
  30. PAINTER HJ, Morrisey JM, Mather MW, Orchard LM, et al
    Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum.
    Antimicrob Agents Chemother. 2020 Dec 23. pii: AAC.02143.
    PubMed     Abstract available


  31. XU L, Liu Q, Zeng Q, Wu P, et al
    Radicicol, a Novel Lead Compound Against the Migratory-stage Schistosomula of Schistosoma japonicum.
    Antimicrob Agents Chemother. 2020 Dec 23. pii: AAC.01781.
    PubMed     Abstract available


  32. LIN JT, Waltmann A, Moser KA, Park Z, et al
    Selection of cytochrome b mutants is rare among Plasmodium falciparum patients failing treatment with atovaquone-proguanil in Cambodia.
    Antimicrob Agents Chemother. 2020 Dec 23. pii: AAC.01249.
    PubMed     Abstract available


    November 2020
  33. DEBBERT SL, Hintz MJ, Bell CJ, Earl KR, et al
    Activities of Quinoxaline, Nitroquinoxaline and [1,2,4]Triazolo[4,3-a]quinoxaline Analogs of MMV007204 against Schistosoma mansoni.
    Antimicrob Agents Chemother. 2020 Nov 30. pii: AAC.01370.
    PubMed     Abstract available


  34. MCCARTHY JS, Abd-Rahman AN, Collins KA, Marquart L, et al
    Defining the antimalarial activity of cipargamin in healthy volunteers experimentally infected with blood stage Plasmodium falciparum.
    Antimicrob Agents Chemother. 2020 Nov 16. pii: AAC.01423.
    PubMed     Abstract available


  35. WITMER K, Dahalan FA, Delves MJ, Yahiya S, et al
    Transmission of artemisinin-resistant malaria parasites to mosquitoes under antimalarial drug pressure.
    Antimicrob Agents Chemother. 2020 Nov 2. pii: AAC.00898.
    PubMed     Abstract available


    October 2020
  36. FERREIRA LT, Rodrigues J, Cassiano GC, Tavella TA, et al
    Correction for Ferreira et al., "Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax".
    Antimicrob Agents Chemother. 2020;64.
    PubMed    


  37. SEN U, Nayak A, Khurana J, Sharma D, et al
    Inhibition of PfMYST HAT activity blocks Plasmodium falciparum growth and survival.
    Antimicrob Agents Chemother. 2020 Oct 12. pii: AAC.00953.
    PubMed     Abstract available


  38. ETXEBESTE-MITXELTORENA M, Plano D, Espuelas S, Moreno E, et al
    New amides containing selenium as potent leishmanicidal agents targeting trypanothione reductase.
    Antimicrob Agents Chemother. 2020 Oct 12. pii: AAC.00524.
    PubMed     Abstract available


  39. MBYE H, Bojang F, Jawara AS, Njie B, et al
    Tolerance of Gambian Plasmodium falciparum to Dihydroartemisinin and Lumefantrine detected by Ex vivo Parasite Survival Rate Assay (PSRA).
    Antimicrob Agents Chemother. 2020 Oct 5. pii: AAC.00720.
    PubMed     Abstract available


  40. NAYEBARE P, Asua V, Conrad MD, Kajubi R, et al
    Associations between malaria preventive regimens and Plasmodium falciparum drug resistance mediating polymorphisms in Ugandan pregnant women.
    Antimicrob Agents Chemother. 2020 Oct 5. pii: AAC.01047.
    PubMed     Abstract available


    September 2020
  41. DE MORAES ALVES MM, Arcanjo DDR, Figueiredo KA, Oliveira JSSM, et al
    Gallic and Ellagic acids: Promising adjuvants to conventional amphotericin B for the treatment of cutaneous leishmaniasis.
    Antimicrob Agents Chemother. 2020 Sep 14. pii: AAC.00807.
    PubMed     Abstract available


  42. SANTOS CC, Zhang H, Batista MM, de Oliveira GM, et al
    In vitro and in vivo evaluation of an adamantyl-based phenyl sulfonyl acetamide against cutaneous leishmaniasis models of L. amazonensis.
    Antimicrob Agents Chemother. 2020 Sep 14. pii: AAC.01188.
    PubMed     Abstract available


    August 2020
  43. YAN H, Kong X, Zhang T, Xiao H, et al
    Prevalence of Plasmodium falciparum Kelch 13 (PfK13) and ubiquitin-specific protease 1 (pfubp1) gene polymorphisms in returning travellers from Africa reported in Eastern China.
    Antimicrob Agents Chemother. 2020 Aug 24. pii: AAC.00981.
    PubMed     Abstract available


  44. DE BRITO MG, Mengarda AC, Oliveira GL, Cirino ME, et al
    Therapeutic effect of diminazene aceturate on parasitic blood fluke Schistosoma mansoni infection.
    Antimicrob Agents Chemother. 2020 Aug 17. pii: AAC.01372.
    PubMed     Abstract available


    July 2020
  45. CUU G, Asua V, Tukwasibwe S, Nsobya S, et al
    Associations between aminoquinoline resistance genotypes and clinical presentations of Plasmodium falciparum infection in Uganda.
    Antimicrob Agents Chemother. 2020 Jul 13. pii: AAC.00721.
    PubMed     Abstract available


  46. BUSTINDUY AL, Kolamunnage-Dona R, Mirochnick MH, Capparelli EV, et al
    Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women infected with Schistosoma japonicum.
    Antimicrob Agents Chemother. 2020 Jul 6. pii: AAC.00566.
    PubMed     Abstract available


    June 2020
  47. FERREIRA LT, Rodrigues J, Cassiano GC, Tavella TA, et al
    Computational chemogenomics drug repositioning strategy enables the discovery of Epirubicin as a new repurposed hit for P. falciparum and P. vivax.
    Antimicrob Agents Chemother. 2020 Jun 29. pii: AAC.02041.
    PubMed     Abstract available


  48. ALVAREZ MG, Ramirez JC, Bertocchi G, Fernandez M, et al
    New scheme of intermittent benznidazole administration in patients chronically infected with Trypanosoma cruzi: Clinical, parasitological and serological assessment after three years of follow-up.
    Antimicrob Agents Chemother. 2020 Jun 22. pii: AAC.00439.
    PubMed     Abstract available


    May 2020
  49. YADAV S, Kuldeep J, Siddiqi MI, Goyal N, et al
    TCP1gamma subunit is indispensable for growth and infectivity of Leishmania donovani.
    Antimicrob Agents Chemother. 2020 May 26. pii: AAC.00669.
    PubMed     Abstract available


  50. FEHLING H, Choy SL, Ting F, Landschulze D, et al
    Anti-leishmanial effects of synthetic EhPIb analogs derived from the Entamoeba histolytica lipopeptidephosphoglycan.
    Antimicrob Agents Chemother. 2020 May 11. pii: AAC.00161.
    PubMed     Abstract available


  51. KASHIF M, Paladhi A, Singh R, Bhattacharyya S, et al
    Evaluation of leishmanicidal activity of an in silico screened novel inhibitor against ascorbate peroxidase of Leishmania donovani.
    Antimicrob Agents Chemother. 2020 May 4. pii: AAC.01766.
    PubMed     Abstract available


  52. VANHEER LN, Zhang H, Lin G, Kafsack BFC, et al
    Activity of epigenetic inhibitors against Plasmodium falciparum asexual and sexual blood stages.
    Antimicrob Agents Chemother. 2020 May 4. pii: AAC.02523.
    PubMed     Abstract available


    April 2020
  53. WATTANAKUL T, Ogutu B, Kabanywanyi AM, Asante KP, et al
    Cardiovascular safety and population pharmacokinetic properties of piperaquine in African patients with uncomplicated falciparum malaria - a pooled multicentre analysis.
    Antimicrob Agents Chemother. 2020 Apr 20. pii: AAC.01848.
    PubMed     Abstract available


  54. DOS SANTOS CCP, Ramos GS, De Paula RC, Faria KF, et al
    Therapeutic efficacy of a mixed formulation of conventional and PEGylated liposomes containing meglumine antimoniate, combined with allopurinol, in dogs naturally infected with Leishmania infantum.
    Antimicrob Agents Chemother. 2020 Apr 13. pii: AAC.00234.
    PubMed     Abstract available


    May 2019
  55. ROBERT MG, Foguim Tsombeng F, Gendrot M, Diawara S, et al
    Baseline Ex Vivo and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal.
    Antimicrob Agents Chemother. 2019;63.
    PubMed     Abstract available


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