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Articles published in Proc Natl Acad Sci U S A

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    July 2021

  1. Correction for Edwards et al., Exhaled aerosol increases with COVID-19 infection, age, and obesity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    February 2021
  2. EDWARDS DA, Ausiello D, Salzman J, Devlin T, et al
    Exhaled aerosol increases with COVID-19 infection, age, and obesity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  3. DING L, Zhang E, Yang Q, Jin L, et al
    Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  4. PRICE NL, Zhang X, Fernandez-Tussy P, Singh AK, et al
    Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  5. GAO Y, Chen X, He Q, Gimple RC, et al
    Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
    Proc Natl Acad Sci U S A. 2020;117:33295-33304.
    PubMed     Abstract available


  6. YUEH MF, He F, Chen C, Vu C, et al
    Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:31259-31266.
    PubMed     Abstract available


  7. JAIN S, Pydi SP, Toti KS, Robaye B, et al
    Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis.
    Proc Natl Acad Sci U S A. 2020;117:30763-30774.
    PubMed     Abstract available


    November 2020
  8. BARUCH A, Wong C, Chinn LW, Vaze A, et al
    Antibody-mediated activation of the FGFR1/Klothobeta complex corrects metabolic dysfunction and alters food preference in obese humans.
    Proc Natl Acad Sci U S A. 2020;117:28992-29000.
    PubMed     Abstract available


  9. GERA S, Sant D, Haider S, Korkmaz F, et al
    First-in-class humanized FSH blocking antibody targets bone and fat.
    Proc Natl Acad Sci U S A. 2020;117:28971-28979.
    PubMed     Abstract available


    October 2020
  10. RAPUANO KM, Laurent JS, Hagler DJ Jr, Hatton SN, et al
    Nucleus accumbens cytoarchitecture predicts weight gain in children.
    Proc Natl Acad Sci U S A. 2020;117:26977-26984.
    PubMed     Abstract available


  11. BONOMO RR, Cook TM, Gavini CK, White CR, et al
    Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice.
    Proc Natl Acad Sci U S A. 2020 Oct 5. pii: 2006065117.
    PubMed     Abstract available


    August 2020
  12. BIEGON A, Alia-Klein N, Alexoff DL, Fowler JS, et al
    Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women.
    Proc Natl Acad Sci U S A. 2020 Aug 31. pii: 2006117117.
    PubMed     Abstract available


  13. HAMER M, Gale CR, Kivimaki M, Batty GD, et al
    Overweight, obesity, and risk of hospitalization for COVID-19: A community-based cohort study of adults in the United Kingdom.
    Proc Natl Acad Sci U S A. 2020 Aug 11. pii: 2011086117.
    PubMed     Abstract available


  14. EWBANK SN, Campos CA, Chen JY, Bowen AJ, et al
    Chronic Gq signaling in AgRP neurons does not cause obesity.
    Proc Natl Acad Sci U S A. 2020 Aug 6. pii: 2004941117.
    PubMed     Abstract available


  15. ZHANG Y, Guan Y, Pan S, Yan L, et al
    Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.
    Proc Natl Acad Sci U S A. 2020 Aug 3. pii: 2004392117.
    PubMed     Abstract available


    July 2020
  16. YANG Y, Li X, Luan HH, Zhang B, et al
    OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
    Proc Natl Acad Sci U S A. 2020;117:16616-16625.
    PubMed     Abstract available


    June 2020

  17. Correction for Hwang et al., GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity.
    Proc Natl Acad Sci U S A. 2020 Jun 29. pii: 2011305117.
    PubMed    


  18. LI S, Peng J, Wang H, Zhang W, et al
    Hepsin enhances liver metabolism and inhibits adipocyte browning in mice.
    Proc Natl Acad Sci U S A. 2020;117:12359-12367.
    PubMed     Abstract available


    May 2020
  19. TAVALLAIE M, Voshtani R, Deng X, Qiao Y, et al
    Moderation of mitochondrial respiration mitigates metabolic syndrome of aging.
    Proc Natl Acad Sci U S A. 2020;117:9840-9850.
    PubMed     Abstract available


  20. JEDRYCHOWSKI MP, Lu GZ, Szpyt J, Mariotti M, et al
    Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
    Proc Natl Acad Sci U S A. 2020 May 1. pii: 2001387117.
    PubMed     Abstract available


    April 2020
  21. PEIRETTI F, Valero R, Govers R
    Is ionic choline and geranate (CAGE) liquid caging diet-derived fat, limiting its absorption?
    Proc Natl Acad Sci U S A. 2020;117:8247-8248.
    PubMed    


  22. NURUNNABI M, Ibsen KN, Tanner EEL, Mitragotri S, et al
    Reply to Peiretti et al.: Effect of CAGE on fat uptake and food intake.
    Proc Natl Acad Sci U S A. 2020;117:8249.
    PubMed    


    March 2020
  23. LUUKKONEN PK, Dufour S, Lyu K, Zhang XM, et al
    Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:7347-7354.
    PubMed     Abstract available


  24. WANG Y, Yang J, Wang W, Sanidad KZ, et al
    Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation.
    Proc Natl Acad Sci U S A. 2020 Mar 27. pii: 1916189117.
    PubMed     Abstract available


  25. CHATTOPADHYAY T, Maniyadath B, Bagul HP, Chakraborty A, et al
    Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
    Proc Natl Acad Sci U S A. 2020;117:6890-6900.
    PubMed     Abstract available


  26. BUEICHEKU E, Aznarez-Sanado M, Diez I, d'Oleire Uquillas F, et al
    Central neurogenetic signatures of the visuomotor integration system.
    Proc Natl Acad Sci U S A. 2020;117:6836-6843.
    PubMed     Abstract available


    February 2020
  27. HAN MS, White A, Perry RJ, Camporez JP, et al
    Regulation of adipose tissue inflammation by interleukin 6.
    Proc Natl Acad Sci U S A. 2020;117:2751-2760.
    PubMed     Abstract available


  28. LIU K, Lin L, Li Q, Xue Y, et al
    Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.
    Proc Natl Acad Sci U S A. 2020;117:2462-2472.
    PubMed     Abstract available


    November 2019
  29. NURUNNABI M, Ibsen KN, Tanner EEL, Mitragotri S, et al
    Oral ionic liquid for the treatment of diet-induced obesity.
    Proc Natl Acad Sci U S A. 2019 Nov 25. pii: 1914426116.
    PubMed     Abstract available


    October 2019
  30. BENSON KK, Hu W, Weller AH, Bennett AH, et al
    Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene.
    Proc Natl Acad Sci U S A. 2019 Oct 28. pii: 1913199116.
    PubMed     Abstract available


    July 2019
  31. CHALISE JP, Hashimoto S, Parajuli G, Kang S, et al
    Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose tissue homeostasis.
    Proc Natl Acad Sci U S A. 2019;116:15128-15133.
    PubMed     Abstract available


  32. WANG L, Mazagova M, Pan C, Yang S, et al
    YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
    Proc Natl Acad Sci U S A. 2019 Jul 9. pii: 1904360116.
    PubMed     Abstract available


  33. TORRES C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, et al
    p110gamma deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.
    Proc Natl Acad Sci U S A. 2019 Jul 2. pii: 1813012116.
    PubMed     Abstract available


    June 2019
  34. KUZAWA CW, Blair C
    A hypothesis linking the energy demand of the brain to obesity risk.
    Proc Natl Acad Sci U S A. 2019 Jun 17. pii: 1816908116.
    PubMed     Abstract available


  35. AMOASII L, Sanchez-Ortiz E, Fujikawa T, Elmquist JK, et al
    NURR1 activation in skeletal muscle controls systemic energy homeostasis.
    Proc Natl Acad Sci U S A. 2019;116:11299-11308.
    PubMed     Abstract available


  36. HWANG I, Jo K, Shin KC, Kim JI, et al
    GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity.
    Proc Natl Acad Sci U S A. 2019 Jun 3. pii: 1822067116.
    PubMed     Abstract available


    May 2019
  37. SARKER G, Sun W, Rosenkranz D, Pelczar P, et al
    Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs.
    Proc Natl Acad Sci U S A. 2019;116:10547-10556.
    PubMed     Abstract available


    February 2019
  38. LIAO GY, Kinney CE, An JJ, Xu B, et al
    TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding.
    Proc Natl Acad Sci U S A. 2019;116:3256-3261.
    PubMed     Abstract available


    January 2019

  39. Correction for Cheng et al., KDM4B protects against obesity and metabolic dysfunction.
    Proc Natl Acad Sci U S A. 2019 Jan 28. pii: 1820917116.
    PubMed    


    December 2018
  40. WEST-EBERHARD MJ
    Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity.
    Proc Natl Acad Sci U S A. 2018 Dec 31. pii: 1809046116.
    PubMed     Abstract available


  41. FENG Z, Zou X, Chen Y, Wang H, et al
    Modulation of HIF-2alpha PAS-B domain contributes to physiological responses.
    Proc Natl Acad Sci U S A. 2018;115:13240-13245.
    PubMed     Abstract available


    November 2018
  42. BOSWELL RG, Sun W, Suzuki S, Kober H, et al
    Training in cognitive strategies reduces eating and improves food choice.
    Proc Natl Acad Sci U S A. 2018;115:E11238-E11247.
    PubMed     Abstract available


  43. MILLER GE, Chen E, Armstrong CC, Carroll AL, et al
    Functional connectivity in central executive network protects youth against cardiometabolic risks linked with neighborhood violence.
    Proc Natl Acad Sci U S A. 2018;115:12063-12068.
    PubMed     Abstract available


  44. CASTANO C, Kalko S, Novials A, Parrizas M, et al
    Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice.
    Proc Natl Acad Sci U S A. 2018 Nov 14. pii: 1808855115.
    PubMed     Abstract available


  45. KATAFUCHI T, Holland WL, Kollipara RK, Kittler R, et al
    PPARgamma-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice.
    Proc Natl Acad Sci U S A. 2018 Nov 12. pii: 1814522115.
    PubMed     Abstract available


    October 2018
  46. BARCELLOS SH, Carvalho LS, Turley P
    Education can reduce health differences related to genetic risk of obesity.
    Proc Natl Acad Sci U S A. 2018 Oct 2. pii: 1802909115.
    PubMed     Abstract available


    September 2018
  47. LABOUESSE MA, Sartori AM, Weinmann O, Simpson EH, et al
    Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice.
    Proc Natl Acad Sci U S A. 2018 Sep 25. pii: 1800171115.
    PubMed     Abstract available



  48. Correction for Lanaspa et al., High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
    Proc Natl Acad Sci U S A. 2018 Sep 17. pii: 1815006115.
    PubMed    


    August 2018
  49. VAINIK U, Baker TE, Dadar M, Zeighami Y, et al
    Neurobehavioral correlates of obesity are largely heritable.
    Proc Natl Acad Sci U S A. 2018 Aug 28. pii: 1718206115.
    PubMed     Abstract available


  50. NAGANO H, Hashimoto N, Nakayama A, Suzuki S, et al
    p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
    Proc Natl Acad Sci U S A. 2018;115:8370-8375.
    PubMed     Abstract available


    July 2018
  51. WEFERS J, van Moorsel D, Hansen J, Connell NJ, et al
    Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.
    Proc Natl Acad Sci U S A. 2018;115:7789-7794.
    PubMed     Abstract available


  52. SERBULEA V, Upchurch CM, Schappe MS, Voigt P, et al
    Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue.
    Proc Natl Acad Sci U S A. 2018;115:E6254-E6263.
    PubMed     Abstract available


    June 2018
  53. DAI J, Liang K, Zhao S, Jia W, et al
    Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.
    Proc Natl Acad Sci U S A. 2018 Jun 11. pii: 1801745115.
    PubMed     Abstract available


    May 2018
  54. CHENG Y, Yuan Q, Vergnes L, Rong X, et al
    KDM4B protects against obesity and metabolic dysfunction.
    Proc Natl Acad Sci U S A. 2018 May 29. pii: 1721814115.
    PubMed     Abstract available


  55. HILL DA, Lim HW, Kim YH, Ho WY, et al
    Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue.
    Proc Natl Acad Sci U S A. 2018;115:E5096-E5105.
    PubMed     Abstract available


  56. YANG GY
    Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis.
    Proc Natl Acad Sci U S A. 2018 May 16. pii: 1807520115.
    PubMed    


  57. D'ERRICO F, Goverse G, Dai Y, Wu W, et al
    Estrogen receptor beta controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage.
    Proc Natl Acad Sci U S A. 2018 May 14. pii: 1720267115.
    PubMed     Abstract available


  58. WANG W, Yang J, Zhang J, Wang Y, et al
    Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation.
    Proc Natl Acad Sci U S A. 2018 May 1. pii: 1721711115.
    PubMed     Abstract available


    March 2018
  59. LANASPA MA, Kuwabara M, Andres-Hernando A, Li N, et al
    High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
    Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 1713837115.
    PubMed     Abstract available


    February 2018
  60. WARDHANA DA, Ikeda K, Barinda AJ, Nugroho DB, et al
    Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis.
    Proc Natl Acad Sci U S A. 2018;115:1529-1534.
    PubMed     Abstract available


    January 2018
  61. SOTO M, Orliaguet L, Reyzer ML, Manier ML, et al
    Pyruvate induces torpor in obese mice.
    Proc Natl Acad Sci U S A. 2018;115:810-815.
    PubMed     Abstract available


  62. PRESTON SH, Vierboom YC, Stokes A
    The role of obesity in exceptionally slow US mortality improvement.
    Proc Natl Acad Sci U S A. 2018 Jan 16. pii: 1716802115.
    PubMed     Abstract available


  63. JANSSON JO, Palsdottir V, Hagg DA, Schele E, et al
    Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
    Proc Natl Acad Sci U S A. 2018;115:427-432.
    PubMed     Abstract available


    November 2017
  64. LORENZO DN, Bennett V
    Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency.
    Proc Natl Acad Sci U S A. 2017 Nov 13. pii: 201708865.
    PubMed     Abstract available


    October 2017
  65. BAI J, Cervantes C, Liu J, He S, et al
    DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.
    Proc Natl Acad Sci U S A. 2017 Oct 30. pii: 201708744.
    PubMed     Abstract available


    August 2017
  66. LARDER R, Sim MFM, Gulati P, Antrobus R, et al
    Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.
    Proc Natl Acad Sci U S A. 2017 Aug 15. pii: 201707310.
    PubMed     Abstract available


    July 2017
  67. MANER JK, Dittmann A, Meltzer AL, McNulty JK, et al
    Implications of life-history strategies for obesity.
    Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201620482.
    PubMed     Abstract available


  68. SONG W, Owusu-Ansah E, Hu Y, Cheng D, et al
    Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model.
    Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708037.
    PubMed     Abstract available


    May 2017
  69. HOOTMAN KC, Trezzi JP, Kraemer L, Burwell LS, et al
    Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults.
    Proc Natl Acad Sci U S A. 2017 May 8. pii: 201620079.
    PubMed     Abstract available


    December 2016
  70. RAPUANO KM, Zieselman AL, Kelley WM, Sargent JD, et al
    Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues.
    Proc Natl Acad Sci U S A. 2016 Dec 19. pii: 201605548.
    PubMed     Abstract available


    October 2016
  71. NOGARA L, Naber N, Pate E, Canton M, et al
    Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle.
    Proc Natl Acad Sci U S A. 2016 Oct 31. pii: 201607536.
    PubMed     Abstract available


  72. SAMUELSSON AS, Mullier A, Maicas N, Oosterhuis NR, et al
    Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.
    Proc Natl Acad Sci U S A. 2016;113:12298-12303.
    PubMed     Abstract available


  73. ZHANG Z, Turer E, Li X, Zhan X, et al
    Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
    Proc Natl Acad Sci U S A. 2016 Oct 5. pii: 201614467.
    PubMed     Abstract available


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