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	COVID-19: Daily Top 10 Papers

Obesity

Free Subscription 05.07.2021 1 Am J Epidemiol 5 Diabetes 2 J Clin Endocrinol Metab 1 J Pediatr 1 Metabolism 6 N Engl J Med 66 Obes Surg 1 Proc Natl Acad Sci U S A 2 Science

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Single Articles

Am J Epidemiol

1. LEPPERT B, Riglin L, Wootton RE, Dardani C, et al
   The Effect of Attention Deficit/Hyperactivity Disorder on Physical Health Outcomes: A 2-Sample Mendelian Randomization Study.
   Am J Epidemiol. 2021;190:1047-1055.
   PubMed         Abstract available
   
   

   
   Diabetes

2. CHOI C, Son Y, Kim J, Cho YK, et al
   TM4SF5 knockout protects mice from diet-induced obesity partly by regulating autophagy in adipose tissue.
   Diabetes. 2021 Jun 29. pii: db21-0145. doi: 10.2337/db21-0145.
   PubMed         Abstract available
   
   
3. 
   Statement of Retraction. Qilong Wang, Zhonglin Xie, Wencheng Zhang, Jun Zhou, Yue Wu, Miao Zhang, Huaiping Zhu, and Ming-Hui Zou. Myeloperoxidase Deletion Prevents High-Fat Diet-Induced Obesity and Insulin Resistance. Diabetes 2014;63:4172-4185. DOI:
   Diabetes. 2021 Jun 28. pii: db21-rt08c. doi: 10.2337.
   PubMed        
   
   
4. SCHASCHKOW A, Pang L, Vandenbempt V, Elvira B, et al
   STAT3 regulates mitochondrial gene expression in pancreatic beta-cells and its deficiency induces glucose intolerance in obesity.
   Diabetes. 2021 Jun 28. pii: db20-1222. doi: 10.2337/db20-1222.
   PubMed         Abstract available
   
   
5. WANG Q, Zhang P, Cakir I, Mi L, et al
   Deletion of the feeding-induced hepatokine TSK ameliorates the melanocortin obesity syndrome.
   Diabetes. 2021 Jun 28. pii: db21-0161. doi: 10.2337/db21-0161.
   PubMed         Abstract available
   
   
6. FUKUDA M
   The role of GIP receptor in the CNS for the pathogenesis of obesity.
   Diabetes. 2021 Jun 27. pii: dbi21-0001. doi: 10.2337/dbi21-0001.
   PubMed         Abstract available
   
   

   
   J Clin Endocrinol Metab

7. KIVELA J, Sormunen-Harju H, Girchenko PV, Huvinen E, et al
   Longitudinal metabolic profiling of maternal obesity, gestational diabetes and hypertensive pregnancy disorders.
   J Clin Endocrinol Metab. 2021 Jun 29. pii: 6311296. doi: 10.1210.
   PubMed         Abstract available
   
   
8. FRANDSEN J, Hansen IMD, Wismann JF, Olsen MH, et al
   Maximal fat oxidation rate is higher in fit women and unfit women with obesity, compared to normal weight unfit women.
   J Clin Endocrinol Metab. 2021 Jun 29. pii: 6311336. doi: 10.1210.
   PubMed         Abstract available
   
   

   
   J Pediatr

9. BRIX N, Ramlau-Hansen CH
   Obesity in both boys and girls associated with earlier pubertal timing.
   J Pediatr. 2021;234:286-288.
   PubMed        
   
   

   
   Metabolism

10. WANG Y, Xu J, Wang Y, Hou H, et al
    Obesity and COVID-19 mortality.
    Metabolism. 2021 Jun 22:154820. doi: 10.1016/j.metabol.2021.154820.
    PubMed        
    
    

    
    N Engl J Med

11. JAVOR E, Lucijanic M, Skelin M
    Once-Weekly Semaglutide in Adults with Overweight or Obesity.
    N Engl J Med. 2021;385:e4.
    PubMed        
    
    
12. KHOO TK, Lin J
    Once-Weekly Semaglutide in Adults with Overweight or Obesity.
    N Engl J Med. 2021;385:e4.
    PubMed        
    
    
13. NADOLSKY KZ, Agarwal M
    Once-Weekly Semaglutide in Adults with Overweight or Obesity.
    N Engl J Med. 2021;385:e4.
    PubMed        
    
    
14. SRIVASTAVA G, Kumar RB
    Once-Weekly Semaglutide in Adults with Overweight or Obesity.
    N Engl J Med. 2021;385:e4.
    PubMed        
    
    
15. WILDING JPH, Calanna S, Kushner RF
    Once-Weekly Semaglutide in Adults with Overweight or Obesity. Reply.
    N Engl J Med. 2021;385:e4.
    PubMed        
    
    
16. ROSEN CJ, Ingelfinger JR
    Once-Weekly Semaglutide in Adults with Overweight or Obesity. Reply.
    N Engl J Med. 2021;385:e4.
    PubMed        
    
    

    
    Obes Surg

17. CURRIE AC, Glaysher MA, Blencowe NS, Kelly J, et al
    Systematic Review of Innovation Reporting in Endoscopic Sleeve Gastroplasty.
    Obes Surg. 2021;31:2962-2978.
    PubMed         Abstract available
    
    
18. TRIANTAFYLLOU T, Eleftheriou MM, Theodoropoulos C, Schizas D, et al
    Long-Term Manometric Impact of the Adjustable Gastric Band on Esophageal Motility: a Prospective Case-Control Study.
    Obes Surg. 2021;31:3333-3336.
    PubMed        
    
    
19. FARIELLO RM, de Carvalho RC, Spaine DM, Andretta RR, et al
    Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery.
    Obes Surg. 2021;31:2887-2895.
    PubMed         Abstract available
    
    
20. RAYMAN S, Assaf D, Azran C, Sroka G, et al
    Sleeve Gastrectomy Failure-Revision to Laparoscopic One-Anastomosis Gastric Bypass or Roux-n-Y Gastric Bypass: a Multicenter Study.
    Obes Surg. 2021;31:2927-2934.
    PubMed         Abstract available
    
    
21. NAJJARI K, Gouravani M, Talebpour M, Kor F, et al
    Gastric Lumen Obstruction after Open VBG and Guillain-Barre Syndrome Following Revisional Surgery: A Case Report.
    Obes Surg. 2021;31:3324-3326.
    PubMed        
    
    
22. SUSSTRUNK J, Wartmann L, Mattiello D, Kostler T, et al
    Incidence and Prognostic Factors for the Development of Symptomatic and Asymptomatic Marginal Ulcers After Roux-en-Y Gastric Bypass Procedures.
    Obes Surg. 2021;31:3005-3014.
    PubMed         Abstract available
    
    
23. DALBOH A, Al-Shehri DM, Abd El Maksoud WM, Abbas KS, et al
    Impact of Laparoscopic Sleeve Gastrectomy on Gastroesophageal Reflux Disease and Risk Factors Associated with Its Occurrence Based Upon Quality of Life.
    Obes Surg. 2021;31:3065-3074.
    PubMed         Abstract available
    
    
24. O'KANE M, Parmar C
    Letter to Editor Concerning: Global Bariatric Research Collaborative. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Obes Surg. 2021;31:3337-3338.
    PubMed        
    
    
25. FANGUEIRO FS, Franca CN, Fernandez M, Ilias EJ, et al
    Binge Eating After Bariatric Surgery in Patients Assisted by the Reference Service in a Brazilian Hospital and the Correlation with Weight Loss.
    Obes Surg. 2021;31:3144-3150.
    PubMed         Abstract available
    
    
26. ZHANG W, Fan M, Wang C, Mahawar K, et al
    Importance of Maintaining Zinc and Copper Supplement Dosage Ratio After Metabolic and Bariatric Surgery.
    Obes Surg. 2021;31:3339-3340.
    PubMed        
    
    
27. DIMOU FM, Ackermann N, Chang SH, Freeman D, et al
    Understanding the Current Role of Robotic-Assisted Bariatric Surgery.
    Obes Surg. 2021;31:3130-3137.
    PubMed         Abstract available
    
    
28. ABRAHAMSSON N
    Postprandial Normoglycemic Hypokalemia-an Overlooked Complication to Gastric Bypass Surgery?
    Obes Surg. 2021;31:3369-3371.
    PubMed         Abstract available
    
    
29. DURO A, Corradetti S, Cano Busnelli VM, Wright FG, et al
    Laparoscopic Conversion of Gastric Plication to Roux-en-Y Gastric Bypass.
    Obes Surg. 2021;31:3382-3383.
    PubMed         Abstract available
    
    
30. AKPINAR EO, Marang-van de Mheen PJ, Nienhuijs SW, Greve JWM, et al
    National Bariatric Surgery Registries: an International Comparison.
    Obes Surg. 2021;31:3031-3039.
    PubMed         Abstract available
    
    
31. VALENTE M, Dalmonte G, Ricco M, Debs T, et al
    Effects of Bariatric Surgery on Influenza-Like Illness: a Two-Center Cross-sectional Study.
    Obes Surg. 2021;31:3341-3346.
    PubMed        
    
    
32. CASTANEDA D, Azar FF, Hussain I, Hasan B, et al
    Clinical and Endoscopic Predictors of Hydrostatic Balloon Dilation Failure for Post-Bariatric Anastomotic Stricture Treatment.
    Obes Surg. 2021;31:2935-2941.
    PubMed         Abstract available
    
    
33. DANYS D, Sikarske A, Poskus T
    Bikini Line Sleeve Gastrectomy: the First Experience in Europe.
    Obes Surg. 2021;31:3320-3323.
    PubMed        
    
    
34. CHOI SJ, Kim SM
    Intrathoracic Migration of Gastric Sleeve Affects Weight Loss as well as GERD-an Analysis of Remnant Gastric Morphology for 100 Patients at One Year After Laparoscopic Sleeve Gastrectomy.
    Obes Surg. 2021;31:2878-2886.
    PubMed         Abstract available
    
    
35. ZHANG LY, Dinary F, Farha J, Itani MI, et al
    Gastric Per-Oral Endoscopic Myotomy for Treatment of Chronic Proximal Staple Line Leak Precipitated by Downstream Stenosis.
    Obes Surg. 2021;31:3347-3352.
    PubMed         Abstract available
    
    
36. HAQ Z, Itani MI, Zhang L, Dinary F, et al
    The Utility of EndoFLIP for Measuring Gastrojejunal Anastomosis Diameter and Distensibility in Patients Experiencing Weight Regain Post Roux-en-Y Gastric Bypass.
    Obes Surg. 2021;31:3353-3359.
    PubMed         Abstract available
    
    
37. LAUTENBACH A, Stoll F, Mann O, Busch P, et al
    Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery.
    Obes Surg. 2021;31:2913-2920.
    PubMed         Abstract available
    
    
38. MONTE SV, Rafi E, Cantie S, Wohaibi E, et al
    Reduction in Opiate Use, Pain, Nausea, and Length of Stay After Implementation of a Bariatric Enhanced Recovery After Surgery Protocol.
    Obes Surg. 2021;31:2896-2905.
    PubMed         Abstract available
    
    
39. ZABATIERO J, Smith A, Gucciardi DF, Hamdorf Am JM, et al
    Patterns of Change in Device-Based Physical Activity and Sedentary Time Following Bariatric Surgery: a Longitudinal Observational Study.
    Obes Surg. 2021;31:3015-3025.
    PubMed         Abstract available
    
    
40. KARPINSKA IA, Kulawik J, Pisarska-Adamczyk M, Wysocki M, et al
    Is It Possible to Predict Weight Loss After Bariatric Surgery?-External Validation of Predictive Models.
    Obes Surg. 2021;31:2994-3004.
    PubMed         Abstract available
    
    
41. PLAMPER A, Kakuan M, Conejero FR, Parmar C, et al
    The First Report of One Anastomosis Gastric Bypass in a Patient with Intestinal Malrotation.
    Obes Surg. 2021;31:3317-3319.
    PubMed        
    
    
42. GUETTER CR, Ivano VK, Pintan RV, Cavassola AP, et al
    Predictive Factors of Gastroesophageal Reflux Disease Symptoms Following Open Sleeve Gastrectomy in Brazil Using Clinical Questionnaire.
    Obes Surg. 2021;31:3090-3096.
    PubMed         Abstract available
    
    
43. DONG L, Karantanis W, Suh H, Magdy M, et al
    A Case Report of Subfertility Post Bariatric Surgery-a Rare Yet Significant Complication.
    Obes Surg. 2021;31:3312-3314.
    PubMed        
    
    
44. GAGNER M
    Metabolic Surgery Needs Stronger Endorsement.
    Obes Surg. 2021;31:3315-3316.
    PubMed        
    
    
45. GUYOT E, Dougkas A, Robert M, Nazare JA, et al
    Food Preferences and Their Perceived Changes Before and After Bariatric Surgery: a Cross-sectional Study.
    Obes Surg. 2021;31:3075-3082.
    PubMed         Abstract available
    
    
46. SEZAVAR H, Yousefi R, Abbasi M, Safari S, et al
    Anthropometric and Biochemical Measures in Bariatric Surgery Candidates: What Is the Role of Inflammatory Potential of Diet?
    Obes Surg. 2021;31:3097-3108.
    PubMed         Abstract available
    
    
47. LAZZARA C, Osorio J, Valcarcel J, Pujol-Gebelli J, et al
    Gastrointestinal Bleeding After Laparoscopic Duodenal Switch and SADI-S Caused by Pseudoaneurysm of Gastroduodenal Artery: First Reported Cases.
    Obes Surg. 2021;31:3330-3332.
    PubMed        
    
    
48. RUANO-CAMPOS A, Cruz-Utrilla A, Lopez-Antonanzas L, Luaces M, et al
    Evaluation of Myocardial Function Following SADI-S.
    Obes Surg. 2021;31:3109-3115.
    PubMed         Abstract available
    
    
49. OMAR I, Sam MA, Pegler ME, Pearson EJB, et al
    Effect of One Anastomosis Gastric Bypass on Haematinics, Vitamin D and Parathyroid Hormone Levels: a Comparison Between 150 and 200 cm Bilio-Pancreatic Limbs.
    Obes Surg. 2021;31:2954-2961.
    PubMed         Abstract available
    
    
50. WALTER LB, Dolzan D, Areias T, Bergmann CG, et al
    Adverse Neonatal and Obstetric Outcomes in a 20-year Brazilian Retrospective Cohort of Pregnancies after Bariatric Surgery.
    Obes Surg. 2021;31:2859-2868.
    PubMed         Abstract available
    
    
51. NOPARATAYAPORN P, Thavorncharoensap M, Chaikledkaew U, Bagepally BS, et al
    Incremental Net Monetary Benefit of Bariatric Surgery: Systematic Review and Meta-Analysis of Cost-Effectiveness Evidences.
    Obes Surg. 2021;31:3279-3290.
    PubMed         Abstract available
    
    
52. BLACKHAM RE, Hamdorf JM
    Video-Rated Performance Assessment of Simulated Laparoscopic Sleeve Gastrectomy: Validation of a Sleeve Gastrectomy Rating Scale.
    Obes Surg. 2021;31:3188-3193.
    PubMed         Abstract available
    
    
53. BRAUN TD, Gorin AA, Puhl RM, Stone A, et al
    Shame and Self-compassion as Risk and Protective Mechanisms of the Internalized Weight Bias and Emotional Eating Link in Individuals Seeking Bariatric Surgery.
    Obes Surg. 2021;31:3177-3187.
    PubMed         Abstract available
    
    
54. MEUNIER H, Menahem B, Le Roux Y, Bion AL, et al
    Development of the "OS-SEV90 Score" to Predict Severe Postoperative Complications at 90 Days Following Bariatric Surgery.
    Obes Surg. 2021;31:3053-3064.
    PubMed         Abstract available
    
    
55. KAKELA P, Rantanen T, Virtanen KA
    The Importance of Intestinal Length in Triglyceride Metabolism and in Predicting the Outcomes of Comorbidities in Laparoscopic Roux-en-Y Gastric Bypass-a Narrative Review.
    Obes Surg. 2021;31:3291-3295.
    PubMed         Abstract available
    
    
56. VELOTTI N, Vitiello A, Berardi G, Musella M, et al
    Roux-en-Y Gastric Bypass and Heller Myotomy: One-Step Surgical Treatment of Symptomatic Achalasia in a Morbid Obese Patient.
    Obes Surg. 2021;31:3379-3381.
    PubMed        
    
    
57. ANTONSSON T, Wennersten A, Sorensen K, Regner S, et al
    Differences in Health-Related Quality of Life After Gastric Bypass Surgery: a Cross-Sectional Study.
    Obes Surg. 2021;31:3194-3202.
    PubMed         Abstract available
    
    
58. DE LUCA M, Piatto G, Merola G, Himpens J, et al
    IFSO Update Position Statement on One Anastomosis Gastric Bypass (OAGB).
    Obes Surg. 2021;31:3251-3278.
    PubMed         Abstract available
    
    
59. SUNDARESAN N, Sullivan M, Hiticas BA, Hui BY, et al
    Impacts of Gastrojejunal Anastomotic Technique on Rates of Marginal Ulcer Formation and Anastomotic Bleeding Following Roux-en-Y Gastric Bypass.
    Obes Surg. 2021;31:2921-2926.
    PubMed         Abstract available
    
    
60. OSPANOV O, Akilzhanova A, Buchwald JN, Fursov A, et al
    Stapleless vs Stapled Gastric Bypass vs Hypocaloric Diet: a Three-Arm Randomized Controlled Trial of Body Mass Evolution with Secondary Outcomes for Telomere Length and Metabolic Syndrome Changes.
    Obes Surg. 2021;31:3165-3176.
    PubMed         Abstract available
    
    
61. LI C, Lin S, Liang H
    Single-Anastomosis Duodenal Switch: Conceptual Difference between East and West.
    Obes Surg. 2021;31:3296-3302.
    PubMed         Abstract available
    
    
62. WANG Y, Wang G, Bai J, Zhao N, et al
    Role of Indole-3-Acetic Acid in NAFLD Amelioration After Sleeve Gastrectomy.
    Obes Surg. 2021;31:3040-3052.
    PubMed         Abstract available
    
    
63. OSPANOV O
    Biography: Oral Ospanov, M.D., PhD, DMedSc, Professor.
    Obes Surg. 2021;31:2849-2850.
    PubMed        
    
    
64. LIAGRE A, Martini F, Kassir R, Juglard G, et al
    Is One Anastomosis Gastric Bypass with a Biliopancreatic Limb of 150 cm Effective in the Treatment of People with Severe Obesity with BMI > 50?
    Obes Surg. 2021 Jun 26. pii: 10.1007/s11695-021-05499.
    PubMed         Abstract available
    
    
65. TSAOUSI G, Stavrou G, Papakostas P, Pyankova G, et al
    Benchmarking the Discriminatory Performance of Body Mass Index and Body Fat for Obesity Detection in Patients Treated by Intragastric Balloon.
    Obes Surg. 2021 Jun 29. pii: 10.1007/s11695-021-05530.
    PubMed         Abstract available
    
    
66. STEVENSON M, Srivastava A, Lee J, Hall C, et al
    RYGB Is More Effective than VSG at Protecting Mice from Prolonged High-Fat Diet Exposure: An Occasion to Roll Up Our Sleeves?
    Obes Surg. 2021;31:3227-3241.
    PubMed         Abstract available
    
    
67. IBISOGLU E, Tekin DDN, Kizilirmak F, Gunes ST, et al
    Evaluation of Changes in Ventricular Repolarization Parameters in Morbidly Obese Patients Undergoing Bariatric Surgery.
    Obes Surg. 2021;31:3138-3143.
    PubMed         Abstract available
    
    
68. WANG L, Wuyun Q, Du D, Sang Q, et al
    Primary SADI-S in Chinese with Diabetes and BMI < 35 kg/m(2): a Retrospective Study with 2-Year Follow-up.
    Obes Surg. 2021;31:3116-3122.
    PubMed         Abstract available
    
    
69. DE PAEP K, Van Campenhout I, Van Cauwenberge S, Dillemans B, et al
    Post-bariatric Abdominoplasty: Identification of Risk Factors for Complications.
    Obes Surg. 2021;31:3203-3209.
    PubMed         Abstract available
    
    
70. GOHIER H, Guyard-Boileau B, Tuyeras G, Bertrand M, et al
    Glucose Abnormalities and Inappropriate Weight Gain Predict Negative Pregnancy Outcomes After Gastric Bypass Surgery.
    Obes Surg. 2021;31:3123-3129.
    PubMed         Abstract available
    
    
71. SCHMITZ SM, Kroh A, Koch A, Brozat JF, et al
    Comparison of Liver Recovery After Sleeve Gastrectomy and Roux-en-Y-Gastric Bypass.
    Obes Surg. 2021;31:3218-3226.
    PubMed         Abstract available
    
    
72. KUNST I, Krebs M, Dreschl B, Prager G, et al
    Iron Deficiency - Not Only a Premenopausal Topic After Bariatric Surgery?
    Obes Surg. 2021;31:3242-3250.
    PubMed         Abstract available
    
    
73. NIJLAND LMG, de Castro SMM, Vogel M, Coumou JF, et al
    Feasibility of Same-Day Discharge After Laparoscopic Roux-en-Y Gastric Bypass Using Remote Monitoring.
    Obes Surg. 2021;31:2851-2858.
    PubMed         Abstract available
    
    
74. VARBAN OA, Bonham AJ, Stricklen AL, Ross R, et al
    Am I on Track? Evaluating Patient-Specific Weight Loss After Bariatric Surgery Using an Outcomes Calculator.
    Obes Surg. 2021;31:3210-3217.
    PubMed         Abstract available
    
    
75. OVED I, Endevelt R, Mardy-Tilbor L, Raziel A, et al
    Health Status, Eating, and Lifestyle Habits in the Long Term Following Sleeve Gastrectomy.
    Obes Surg. 2021;31:2979-2987.
    PubMed         Abstract available
    
    
76. FECSO AB, Maeda A, Duggal S, Okrainec A, et al
    The Effect of Tissue Adhesive on Surgical Site Infection Following Elective Bariatric Surgery: a Retrospective Cohort Study.
    Obes Surg. 2021;31:2988-2993.
    PubMed         Abstract available
    
    
77. DONATELLI G, Cereatti F, Daho F
    EUS-guided Anastomosis Complication in a Patient with Roux-en-Y Gastric Bypass: Dehiscence of the Surgical Anastomosis During Endoscopic Mucosal Resection Across EUS-guided Jejunum-gastric Anastomosis with Lumen Apposing Metal Stent.
    Obes Surg. 2021;31:3384-3385.
    PubMed         Abstract available
    
    
78. CHAN DL, Chern TY, Iliopoulos J, Hennessy A, et al
    Accuracy of High-Resolution Manometry in Hiatal Hernia Diagnosis in Primary and Revision Bariatric Surgery.
    Obes Surg. 2021;31:2906-2912.
    PubMed         Abstract available
    
    
79. MOHAMED F, Jeram M, Coomarasamy C, Lauti M, et al
    Does Bariatric Surgery Improve Faecal Incontinence? A Systematic Review and Meta-analysis.
    Obes Surg. 2021;31:2942-2953.
    PubMed         Abstract available
    
    
80. LUKER J, Tajran J, Marquette L, Tepper D, et al
    Long-Term Weight Loss with Body Contour Surgery After Roux-en-Y Gastric Bypass.
    Obes Surg. 2021;31:3159-3164.
    PubMed         Abstract available
    
    
81. STEFANOVA I, Currie AC, Newton RC, Albon L, et al
    Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Lower Urinary Tract Symptoms in Males.
    Obes Surg. 2021;31:3151-3158.
    PubMed         Abstract available
    
    
82. ELHAG W, El Ansari W
    Durability of Cardiometabolic Outcomes Among Adolescents After Sleeve Gastrectomy: First Study with 9-Year Follow-up.
    Obes Surg. 2021;31:2869-2877.
    PubMed         Abstract available
    
    

    
    Proc Natl Acad Sci U S A

83. 
    Correction for Edwards et al., Exhaled aerosol increases with COVID-19 infection, age, and obesity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed        
    
    

    
    Science

84. O'BRIEN CJO, Domingos A
    An anti-obesity immunotherapy?
    Science. 2021;373:24-25.
    PubMed        
    
    
85. AKBARI P, Gilani A, Sosina O, Kosmicki JA, et al
    Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.
    Science. 2021;373.
    PubMed         Abstract available
    
    

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