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Multiple Sclerosis

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 48 articles: HTML format

Single Articles

October 2026
1. BAIER S, Wang Z, Loll N, Mader S, et al
   T-B interactions yield CD3(+) B cells and CD20(+) T cells with pathogenic features in multiple sclerosis.
   Proc Natl Acad Sci U S A. 2026;123:e2605806123.
   PubMed     Abstract available
   
   
   
2. VIETZEN H, Waubant EL, Casper TC, Benson LA, et al
   Impaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives.
   Proc Natl Acad Sci U S A. 2026;123:e2607529123.
   PubMed     Abstract available
   
   
   September 2026
3. NANOU A, Apostolou-Karampelis K, Triantafyllidou V, Sakkou M, et al
   Fibronectin inhibition restores myelination in endothelial TNFR2-dependent nonremitting experimental autoimmune encephalomyelitis.
   Proc Natl Acad Sci U S A. 2026;123:e2616799123.
   PubMed     Abstract available
   
   
   
4. LUTTEROTTI A, Ludersdorfer T, Docampo MJ, Morax M, et al
   Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells.
   Proc Natl Acad Sci U S A. 2026;123:e2614908123.
   PubMed     Abstract available
   
   
   July 2026
5. DE VIRGILIIS F, Barnoud C, He W, Zeng Q, et al
   Circadian screening of neutrophils identifies therapeutic targets in multiple sclerosis.
   Proc Natl Acad Sci U S A. 2026;123:e2536812123.
   PubMed     Abstract available
   
   
   March 2026
6. LUM FM, Sattarnezhad N, Ho PP, Orr N, et al
   Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis.
   Proc Natl Acad Sci U S A. 2026;123:e2519445123.
   PubMed     Abstract available
   
   
   
7. ZURAWSKI J, Tuncer A, Profant MR, Wang J, et al
   ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study.
   Proc Natl Acad Sci U S A. 2026;123:e2526147123.
   PubMed     Abstract available
   
   
   
8. CHIA PHJ, Toyonaga T, Tong J, Le H, et al
   SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.
   Proc Natl Acad Sci U S A. 2026;123:e2517709123.
   PubMed     Abstract available
   
   
   February 2026
9. SARRAZIN N, Arab R, Cordano C, Brazhnikova E, et al
   Clemastine fumarate promotes myelin repair in a nonhuman primate model of demyelination characterized by absent spontaneous remyelination.
   Proc Natl Acad Sci U S A. 2026;123:e2520161123.
   PubMed     Abstract available
   
   
   
10. CUI T, Wen Q, An Z, Kang J, et al
    Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1-astrocytic integrin alpha4 interaction.
    Proc Natl Acad Sci U S A. 2026;123:e2520566123.
    PubMed     Abstract available
    
    
    
11. OLCHANYI MD, Schreier DR, Li J, Maffei C, et al
    Probabilistic mapping and automated segmentation of human brainstem white matter bundles.
    Proc Natl Acad Sci U S A. 2026;123:e2509321123.
    PubMed     Abstract available
    
    
    November 2025
12. KAPNICK SM, Gosselin EA, Tsai SJ, Oakes RS, et al
    Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity.
    Proc Natl Acad Sci U S A. 2025;122:e2409563122.
    PubMed     Abstract available
    
    
    September 2025
13. MYKICKI N, Eble JA, Weighardt H, Gonnelli E, et al
    AhR signaling in skin-resident CD207(+) cells is involved in UV-B-induced amelioration of neuroinflammation.
    Proc Natl Acad Sci U S A. 2025;122:e2424009122.
    PubMed     Abstract available
    
    
    August 2025
14. NEMATULLAH M, Fatma M, Zhou G, Prajapati B, et al
    Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity.
    Proc Natl Acad Sci U S A. 2025;122:e2427052122.
    PubMed     Abstract available
    
    
    July 2025
15. SIMKA M
    Previous epidemiological studies support the idea of ileal microbiota triggering multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2514491122.
    PubMed    
    
    
    
16. JIANG Y, Liu Q, Stridh P, Kockum I, et al
    Multiomics integration prioritizes potential drug targets for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2425537122.
    PubMed     Abstract available
    
    
    June 2025
17. ATKINSON KC, Desfor S, Feri M, Sekyi MT, et al
    Decreased mitochondrial activity in the demyelinating cerebellum of progressive multiple sclerosis and chronic EAE contributes to Purkinje cell loss.
    Proc Natl Acad Sci U S A. 2025;122:e2421806122.
    PubMed     Abstract available
    
    
    
18. 
    Editorial Expression of Concern for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2512750122.
    PubMed    
    
    
    May 2025
19. JENSEN LT, Fugger L
    Immune perturbation by the ileal microbiota in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2506777122.
    PubMed    
    
    
    
20. GUPTA S, Arnab S, Nguyen KL, Reed M, et al
    Sex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2 activation in a model of MS and CNP.
    Proc Natl Acad Sci U S A. 2025;122:e2426771122.
    PubMed     Abstract available
    
    
    
21. YOON H, Gerdes LA, Beigel F, Sun Y, et al
    Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.
    Proc Natl Acad Sci U S A. 2025;122:e2419689122.
    PubMed     Abstract available
    
    
    April 2025
22. MECHELLI R, Umeton R, Bellucci G, Bigi R, et al
    A disease-specific convergence of host and Epstein-Barr virus genetics in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2418783122.
    PubMed     Abstract available
    
    
    
23. HOU J, Magliozzi R, Chen Y, Wu J, et al
    Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination.
    Proc Natl Acad Sci U S A. 2025;122:e2426786122.
    PubMed     Abstract available
    
    
    
24. MOLITOR TP, Hayashi G, Lin MY, Dunn CJ, et al
    Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator.
    Proc Natl Acad Sci U S A. 2025;122:e2422172122.
    PubMed     Abstract available
    
    
    March 2025
25. ORR N, Steinman L
    Epstein-Barr virus and the immune microenvironment in multiple sclerosis: Insights from high-dimensional brain tissue imaging.
    Proc Natl Acad Sci U S A. 2025;122:e2425670122.
    PubMed     Abstract available
    
    
    
26. SATTARNEZHAD N, Kockum I, Thomas OG, Liu Y, et al
    Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls.
    Proc Natl Acad Sci U S A. 2025;122:e2424986122.
    PubMed     Abstract available
    
    
    
27. GHIMIRE S, Lehman PC, Aguilar Meza LS, Shahi SK, et al
    Specific microbial ratio in the gut microbiome is associated with multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2413953122.
    PubMed     Abstract available
    
    
    February 2025
28. RAD LM, Hughes KR, Wheeler SN, Decker JT, et al
    Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2409852122.
    PubMed     Abstract available
    
    
    December 2024
29. LANZ TV, Robinson WH
    Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles connects the two main risk factors of multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2420070121.
    PubMed    
    
    
    November 2024
30. OKAMOTO M, Kuratani A, Okuzaki D, Kamiyama N, et al
    IFN-gamma-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.
    Proc Natl Acad Sci U S A. 2024;121:e2401692121.
    PubMed     Abstract available
    
    
    October 2024
31. 
    Correction for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2420080121.
    PubMed    
    
    
    
32. DROSU N, Anderson M, Bilodeau PA, Nishiyama S, et al
    CD4 T cells restricted to DRB1*15:01 recognize two Epstein-Barr virus glycoproteins capable of intracellular antigen presentation.
    Proc Natl Acad Sci U S A. 2024;121:e2416097121.
    PubMed     Abstract available
    
    
    August 2024
33. DENEEN B
    Pipe dream: Remyelination therapy for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2414324121.
    PubMed    
    
    
    
34. ALAKHRAS NS, Zhang W, Barros N, Sharma A, et al
    An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation.
    Proc Natl Acad Sci U S A. 2024;121:e2400153121.
    PubMed     Abstract available
    
    
    
35. POON MM, Lorrain KI, Stebbins KJ, Edu GC, et al
    Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407974121.
    PubMed     Abstract available
    
    
    July 2024
36. NATARAJAN C, Le LHD, Gunasekaran M, Tracey KJ, et al
    Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2322577121.
    PubMed     Abstract available
    
    
    June 2024
37. RAKEBRANDT N, Yassini N, Kolz A, Schorer M, et al
    Innate acting memory Th1 cells modulate heterologous diseases.
    Proc Natl Acad Sci U S A. 2024;121:e2312837121.
    PubMed     Abstract available
    
    
    February 2024
38. ADAMS C, Manouchehrinia A, Quach HL, Quach DL, et al
    Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans.
    Proc Natl Acad Sci U S A. 2024;121:e2302259121.
    PubMed     Abstract available
    
    
    January 2024
39. SUTTER PA, Willis CM, Menoret A, Nicaise AM, et al
    Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses.
    Proc Natl Acad Sci U S A. 2024;121:e2306816121.
    PubMed     Abstract available
    
    
    
40. GOTTLIEB A, Pham HPT, Saltarrelli JG, Lindsey JW, et al
    Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells.
    Proc Natl Acad Sci U S A. 2024;121:e2315857121.
    PubMed     Abstract available
    
    
    November 2023
41. THOMANN AS, McQuade CA, Pinjusic K, Kolz A, et al
    A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity.
    Proc Natl Acad Sci U S A. 2023;120:e2300733120.
    PubMed     Abstract available
    
    
    September 2023
42. GRUCHOT J, Lewen I, Dietrich M, Reiche L, et al
    Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.
    Proc Natl Acad Sci U S A. 2023;120:e2308187120.
    PubMed     Abstract available
    
    
    
43. GARCIA CORRALES AV, Verberk SGS, Haidar M, Grajchen E, et al
    Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination.
    Proc Natl Acad Sci U S A. 2023;120:e2301030120.
    PubMed     Abstract available
    
    
    May 2023
44. CAVERZASI E, Papinutto N, Cordano C, Kirkish G, et al
    MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial.
    Proc Natl Acad Sci U S A. 2023;120:e2217635120.
    PubMed     Abstract available
    
    
    April 2023
45. KAPATE N, Dunne M, Kumbhojkar N, Prakash S, et al
    A backpack-based myeloid cell therapy for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2023;120:e2221535120.
    PubMed     Abstract available
    
    
    
46. GHAREGHANI M, Zibara K, Rivest S
    Melatonin and vitamin D, two sides of the same coin, better to land on its edge to improve multiple sclerosis.
    Proc Natl Acad Sci U S A. 2023;120:e2219334120.
    PubMed     Abstract available
    
    
    March 2023
47. MADER S, Ho S, Wong HK, Baier S, et al
    Dissection of complement and Fc-receptor-mediated pathomechanisms of autoantibodies to myelin oligodendrocyte glycoprotein.
    Proc Natl Acad Sci U S A. 2023;120:e2300648120.
    PubMed     Abstract available
    
    
    March 2021
48. RONIN E, Pouchy C, Khosravi M, Hilaire M, et al
    Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells.
    Proc Natl Acad Sci U S A. 2021;118:e2014043118.
    PubMed     Abstract available
    
    

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