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  Malaria

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Articles published in PLoS Pathog

Retrieve available abstracts of 81 articles:
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Single Articles


    September 2025
  1. KWECKA D, Wang Z, Eigminas E, Liu L, et al
    A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito.
    PLoS Pathog. 2025;21:e1013467.
    PubMed     Abstract available


    July 2025
  2. SHERRARD-SMITH E, Fillinger U, Tia JB, Winskill P, et al
    Heterogeneous impacts for malaria control from larviciding across villages and considerations for monitoring and evaluation.
    PLoS Pathog. 2025;21:e1013287.
    PubMed     Abstract available


  3. ROPER B, Kannan D, Mathews ES, Odom John AR, et al
    Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites.
    PLoS Pathog. 2025;21:e1013313.
    PubMed     Abstract available


  4. ANDREW AK, Bracken TC, Nazario-Maldonado NM, Russ BN, et al
    Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria.
    PLoS Pathog. 2025;21:e1013259.
    PubMed     Abstract available


  5. SAMANTSIDIS GR, Kwon H, Wendland M, Fonder C, et al
    TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae.
    PLoS Pathog. 2025;21:e1013329.
    PubMed     Abstract available


  6. FENG Y, Gao W, Wang C, Shi S, et al
    Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei.
    PLoS Pathog. 2025;21:e1013318.
    PubMed     Abstract available


  7. ALBERIONE MP, Avalos-Padilla Y, Rangel GW, Ramirez M, et al
    Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages.
    PLoS Pathog. 2025;21:e1012832.
    PubMed     Abstract available


  8. KETPRASIT N, Tai CW, Sharma VK, Manickam Y, et al
    Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.
    PLoS Pathog. 2025;21:e1013057.
    PubMed     Abstract available


  9. TISSAWAK A, Rosin Y, Katz Galay S, Qasem A, et al
    A chaperonin complex regulates organelle proteostasis in malaria parasites.
    PLoS Pathog. 2025;21:e1013275.
    PubMed     Abstract available


  10. WALSH B, Summers RL, Rangel GW, Hagenah LM, et al
    The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.
    PLoS Pathog. 2025;21:e1012779.
    PubMed     Abstract available


    June 2025
  11. PEREZ-CANTERO A, Llora-Batlle O, Pelaez-Conde I, Martinez-Guardiola C, et al
    Heterochromatin de novo formation and maintenance in Plasmodium falciparum.
    PLoS Pathog. 2025;21:e1013137.
    PubMed     Abstract available


  12. CEESAY S, Kampmann M, Votborg-Novel L, Hansson HS, et al
    Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases.
    PLoS Pathog. 2025;21:e1013210.
    PubMed     Abstract available


    May 2025
  13. DE MENEZES MN, Ge Z, Cozijnsen A, Gras S, et al
    Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.
    PLoS Pathog. 2025;21:e1012731.
    PubMed     Abstract available


  14. NGOTHO P, Dantzler Press K, Peedell M, Muasya W, et al
    Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes.
    PLoS Pathog. 2025;21:e1013110.
    PubMed     Abstract available


    April 2025
  15. MESEN-RAMIREZ JP, Fuchs G, Burmester J, Farias GB, et al
    HOPS/CORVET tethering complexes are critical for endocytosis and protein trafficking to invasion related organelles in malaria parasites.
    PLoS Pathog. 2025;21:e1013053.
    PubMed     Abstract available


  16. SMITH C, Hajisadeghian M, van Noort GJVH, Deery MJ, et al
    Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium.
    PLoS Pathog. 2025;21:e1013032.
    PubMed     Abstract available


  17. OCHWEDO KO, Wang X, Cespedes N, Bentil RE, et al
    Regulation of diel locomotor activity and retinal responses of Anopheles stephensi by ingested histamine and serotonin is temperature- and infection-dependent.
    PLoS Pathog. 2025;21:e1013139.
    PubMed     Abstract available


  18. BASSI MR, Cristinoi B, Buitenwerf F, Cuadrado MB, et al
    Deposition of complement regulators on the surface of Plasmodium falciparum merozoites depends on the immune status of the host.
    PLoS Pathog. 2025;21:e1013107.
    PubMed     Abstract available


    March 2025
  19. HILDEBRAND JA, Daniels NR, Dehm EM, Fisher BD, et al
    Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.
    PLoS Pathog. 2025;21:e1012993.
    PubMed     Abstract available


  20. SAAB SA, Cardoso-Jaime V, Kefi M, Dimopoulos G, et al
    Advances in the dissection of Anopheles-Plasmodium interactions.
    PLoS Pathog. 2025;21:e1012965.
    PubMed     Abstract available


    February 2025
  21. ACEVEDO GR, Samiee SS, Ilala M, Levan J, et al
    Liver stage P. falciparum antigens highly targeted by CD4+ T cells in malaria-exposed Ugandan children.
    PLoS Pathog. 2025;21:e1012943.
    PubMed     Abstract available


  22. TAN MH, Tiedje KE, Feng Q, Zhan Q, et al
    A paradoxical population structure of var DBLalpha types in Africa.
    PLoS Pathog. 2025;21:e1012813.
    PubMed     Abstract available


  23. RAWAT M, Padalino G, Adika E, Okombo J, et al
    Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.
    PLoS Pathog. 2025;21:e1012216.
    PubMed     Abstract available


    January 2025
  24. SEVENO M, Loubens MN, Berry L, Graindorge A, et al
    The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole.
    PLoS Pathog. 2025;21:e1012455.
    PubMed     Abstract available


  25. SU XZ, Xu F, Stadler RV, Teklemichael AA, et al
    Malaria: Factors affecting disease severity, immune evasion mechanisms, and reversal of immune inhibition to enhance vaccine efficacy.
    PLoS Pathog. 2025;21:e1012853.
    PubMed     Abstract available


  26. KOCHAYOO P, Moriyama S, Kotaki R, Thawornpan P, et al
    Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants.
    PLoS Pathog. 2025;21:e1012866.
    PubMed     Abstract available


  27. RIOS KT, McGee JP, Sebastian A, Gedara SA, et al
    Widespread release of translational repression across Plasmodium's host-to-vector transmission event.
    PLoS Pathog. 2025;21:e1012823.
    PubMed     Abstract available


  28. MCLEAN FE, Omondi BR, Diallo N, Otoboh S, et al
    Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.
    PLoS Pathog. 2025;21:e1012434.
    PubMed     Abstract available


  29. DORIN-SEMBLAT D, Semblat JP, Hamelin R, Srivastava A, et al
    Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion.
    PLoS Pathog. 2025;21:e1012861.
    PubMed     Abstract available


  30. LEFEBVRE MJM, Degrugillier F, Arnathau C, Fontecha GA, et al
    Genomic exploration of the journey of Plasmodium vivax in Latin America.
    PLoS Pathog. 2025;21:e1012811.
    PubMed     Abstract available


    December 2024
  31. XIE SC, Tai CW, Morton CJ, Ma L, et al
    A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
    PLoS Pathog. 2024;20:e1012429.
    PubMed     Abstract available


  32. KEHRER J, Pietsch E, Ricken D, Strauss L, et al
    APEX-based proximity labeling in Plasmodium identifies a membrane protein with dual functions during mosquito infection.
    PLoS Pathog. 2024;20:e1012788.
    PubMed     Abstract available


    November 2024
  33. ONCHURU TO, Makhulu EE, Ronnie PC, Mandere S, et al
    The Plasmodium transmission-blocking symbiont, Microsporidia MB, is vertically transmitted through Anopheles arabiensis germline stem cells.
    PLoS Pathog. 2024;20:e1012340.
    PubMed     Abstract available


    October 2024
  34. GAO L, Zhang B, Feng Y, Yang W, et al
    Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis.
    PLoS Pathog. 2024;20:e1012638.
    PubMed     Abstract available


  35. FERREIRA LT, Cassiano GC, Alvarez LCS, Okombo J, et al
    A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
    PLoS Pathog. 2024;20:e1012627.
    PubMed     Abstract available


  36. REYES RA, Turner L, Ssewanyana I, Jagannathan P, et al
    Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.
    PLoS Pathog. 2024;20:e1012661.
    PubMed     Abstract available


  37. BARRETO C, Cardoso-Jaime V, Dimopoulos G
    A novel broad-spectrum antibacterial and anti-malarial Anopheles gambiae Cecropin promotes microbial clearance during pupation.
    PLoS Pathog. 2024;20:e1012652.
    PubMed     Abstract available


    September 2024
  38. CHEN YA, Vickers EN, Aranda-Diaz A, Murphy M, et al
    Genomic epidemiology demonstrates spatially clustered, local transmission of Plasmodium falciparum in forest-going populations in southern Lao PDR.
    PLoS Pathog. 2024;20:e1012194.
    PubMed     Abstract available


  39. NAHID DS, Coffey KA, Bei AK, Cordy RJ, et al
    Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory.
    PLoS Pathog. 2024;20:e1012514.
    PubMed     Abstract available


  40. BULLOCH MS, Huynh LK, Kennedy K, Ralton JE, et al
    Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum.
    PLoS Pathog. 2024;20:e1012484.
    PubMed     Abstract available


  41. KALS E, Kals M, Lees RA, Introini V, et al
    Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium falciparum merozoite-erythrocyte attachment.
    PLoS Pathog. 2024;20:e1012041.
    PubMed     Abstract available


    August 2024
  42. KILPATRICK AM, Seidl CM, Ipsaro IJ, Garrison CE, et al
    Transinfection of Wolbachia wAlbB into Culex quinquefasciatus mosquitoes does not alter vector competence for Hawaiian avian malaria (Plasmodium relictum GRW4).
    PLoS Pathog. 2024;20:e1012052.
    PubMed     Abstract available


    July 2024
  43. CHENG Q, Yang X, Zou T, Sun L, et al
    RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.
    PLoS Pathog. 2024;20:e1012352.
    PubMed     Abstract available


    June 2024
  44. KOUSSIS K, Haase S, Withers-Martinez C, Flynn HR, et al
    Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.
    PLoS Pathog. 2024;20:e1012360.
    PubMed     Abstract available


  45. MORANO AA, Ali I, Dvorin JD
    Elucidating the spatio-temporal dynamics of the Plasmodium falciparum basal complex.
    PLoS Pathog. 2024;20:e1012265.
    PubMed     Abstract available


  46. LAURENSON AJ, Laurens MB
    A new landscape for malaria vaccine development.
    PLoS Pathog. 2024;20:e1012309.
    PubMed    


  47. VANHOVE M, Schwabl P, Clementson C, Early AM, et al
    Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana.
    PLoS Pathog. 2024;20:e1012013.
    PubMed     Abstract available


  48. LU F, Xu J, Liu Y, Ren Z, et al
    Plasmodium vivax serological exposure markers: PvMSP1-42-induced humoral and memory B-cell response generates long-lived antibodies.
    PLoS Pathog. 2024;20:e1012334.
    PubMed     Abstract available


    April 2024
  49. VANDANA V, Dong S, Sheth T, Sun Q, et al
    Wolbachia infection-responsive immune genes suppress Plasmodium falciparum infection in Anopheles stephensi.
    PLoS Pathog. 2024;20:e1012145.
    PubMed     Abstract available


    March 2024
  50. MA R, Salinas ND, Orr-Gonzalez S, Richardson B, et al
    Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine.
    PLoS Pathog. 2024;20:e1011879.
    PubMed     Abstract available


  51. SHARMA S, Ramachandran A, Sharma A
    Role of riboflavin deficiency in malaria pathophysiology.
    PLoS Pathog. 2024;20:e1011991.
    PubMed     Abstract available


    February 2024
  52. ZMARLAK NM, Lavazec C, Brito-Fravallo E, Geneve C, et al
    The Anopheles leucine-rich repeat protein APL1C is a pathogen binding factor recognizing Plasmodium ookinetes and sporozoites.
    PLoS Pathog. 2024;20:e1012008.
    PubMed     Abstract available


    January 2024
  53. CRISPIM M, Verdaguer IB, Hernandez A, Kronenberger T, et al
    Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites.
    PLoS Pathog. 2024;20:e1011557.
    PubMed     Abstract available


  54. POLLENUS E, Possemiers H, Knoops S, Prenen F, et al
    Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome.
    PLoS Pathog. 2024;20:e1011929.
    PubMed     Abstract available


  55. DORITCHAMOU JYA, Renn JP, Hviid L, Duffy PE, et al
    Correction: A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
    PLoS Pathog. 2024;20:e1011503.
    PubMed     Abstract available


    December 2023
  56. VOSS Y, Klaus S, Lichti NP, Ganter M, et al
    Malaria parasite centrins can assemble by Ca2+-inducible condensation.
    PLoS Pathog. 2023;19:e1011899.
    PubMed     Abstract available


  57. STURMER VS, Stopper S, Binder P, Klemmer A, et al
    Progeny counter mechanism in malaria parasites is linked to extracellular resources.
    PLoS Pathog. 2023;19:e1011807.
    PubMed     Abstract available


  58. SCHMIDT S, Wichers-Misterek JS, Behrens HM, Birnbaum J, et al
    The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites.
    PLoS Pathog. 2023;19:e1011814.
    PubMed     Abstract available


  59. SOLEBO O, Ling L, Nwankwo I, Zhou J, et al
    Plasmodium falciparum utilizes pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage.
    PLoS Pathog. 2023;19:e1011818.
    PubMed     Abstract available


    November 2023
  60. RAWAT RS, Gupta A, Antil N, Bhatnagar S, et al
    Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite.
    PLoS Pathog. 2023;19:e1011770.
    PubMed     Abstract available


  61. SEKAR P, Rajagopalan S, Shabani E, Kanjee U, et al
    NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG.
    PLoS Pathog. 2023;19:e1011585.
    PubMed     Abstract available


  62. ABBERGER H, Hose M, Ninnemann A, Menne C, et al
    Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections.
    PLoS Pathog. 2023;19:e1011837.
    PubMed     Abstract available


    October 2023
  63. WIDEMAN SK, Frost JN, Richter FC, Naylor C, et al
    Cellular iron governs the host response to malaria.
    PLoS Pathog. 2023;19:e1011679.
    PubMed     Abstract available


  64. MANDAL RK, Schmidt NW
    Mechanistic insights into the interaction between the host gut microbiome and malaria.
    PLoS Pathog. 2023;19:e1011665.
    PubMed     Abstract available


  65. SRIBOONVORAKUL N, Chotivanich K, Silachamroon U, Phumratanaprapin W, et al
    Intestinal injury and the gut microbiota in patients with Plasmodium falciparum malaria.
    PLoS Pathog. 2023;19:e1011661.
    PubMed     Abstract available


  66. OKADA M, Sigala PA
    The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites.
    PLoS Pathog. 2023;19:e1011713.
    PubMed     Abstract available


  67. TSEBRIY O, Khomiak A, Miguel-Blanco C, Sparkes PC, et al
    Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.
    PLoS Pathog. 2023;19:e1011711.
    PubMed     Abstract available


    August 2023
  68. KEFI M, Balabanidou V, Sarafoglou C, Charamis J, et al
    ABCH2 transporter mediates deltamethrin uptake and toxicity in the malaria vector Anopheles coluzzii.
    PLoS Pathog. 2023;19:e1011226.
    PubMed     Abstract available


    June 2023
  69. RAMAPRASAD A, Burda PC, Koussis K, Thomas JA, et al
    A malaria parasite phospholipase facilitates efficient asexual blood stage egress.
    PLoS Pathog. 2023;19:e1011449.
    PubMed     Abstract available


  70. MARKWALTER CF, Petersen JEV, Zeno EE, Sumner KM, et al
    Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites.
    PLoS Pathog. 2023;19:e1011442.
    PubMed     Abstract available


  71. GOMEZ GM, D'Arrigo G, Sanchez CP, Berger F, et al
    PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.
    PLoS Pathog. 2023;19:e1011436.
    PubMed     Abstract available


  72. ADAMS KL, Selland EK, Willett BC, Carew JW, et al
    Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles.
    PLoS Pathog. 2023;19:e1011448.
    PubMed     Abstract available


  73. WICHERS-MISTEREK JS, Krumkamp R, Held J, von Thien H, et al
    The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections.
    PLoS Pathog. 2023;19:e1011468.
    PubMed     Abstract available


    May 2023
  74. OYONG DA, Duffy FJ, Neal ML, Du Y, et al
    Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge.
    PLoS Pathog. 2023;19:e1011051.
    PubMed     Abstract available


  75. GUISSOU E, Da DF, Hien DFS, Yameogo KB, et al
    Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae.
    PLoS Pathog. 2023;19:e1011084.
    PubMed     Abstract available


  76. DORITCHAMOU JYA, Renn JP, Hviid L, Duffy PE, et al
    A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
    PLoS Pathog. 2023;19:e1011370.
    PubMed     Abstract available


    March 2023
  77. KLUG D, Gautier A, Calvo E, Marois E, et al
    The salivary protein Saglin facilitates efficient midgut colonization of Anopheles mosquitoes by malaria parasites.
    PLoS Pathog. 2023;19:e1010538.
    PubMed     Abstract available


  78. VOSS Y, Klaus S, Guizetti J, Ganter M, et al
    Plasmodium schizogony, a chronology of the parasite's cell cycle in the blood stage.
    PLoS Pathog. 2023;19:e1011157.
    PubMed     Abstract available


  79. LOUBENS M, Marinach C, Paquereau CE, Hamada S, et al
    The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites.
    PLoS Pathog. 2023;19:e1011261.
    PubMed     Abstract available


  80. LEVRAY YS, Bana B, Tarr SJ, McLaughlin EJ, et al
    Formation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences.
    PLoS Pathog. 2023;19:e1011281.
    PubMed     Abstract available


    July 2021
  81. SAINI E, Sheokand PK, Sharma V, Agrawal P, et al
    Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes.
    PLoS Pathog. 2021;17:e1009750.
    PubMed     Abstract available


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