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Articles published in Semin Liver Dis

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    July 2021
  1. KAHL S, Putzer J, Roden M
    Novel Antidiabetic Strategies and Diabetologists' Views in Nonalcoholic Steatohepatitis.
    Semin Liver Dis. 2021 Jul 21. doi: 10.1055/s-0041-1732354.
    PubMed     Abstract available

    June 2021
  2. JENG WJ, Liaw YF
    Finite Antiviral Therapy in Chronic Hepatitis B Patients with Cirrhosis.
    Semin Liver Dis. 2021 Jun 28. doi: 10.1055/s-0041-1729973.
    PubMed     Abstract available

  3. HSU YC, Tseng CH, Huang YT, Yang HI, et al
    Application of Risk Scores for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B: Current Status and Future Perspective.
    Semin Liver Dis. 2021 Jun 23. doi: 10.1055/s-0041-1730924.
    PubMed     Abstract available

  4. BRESSON-HADNI S, Spahr L, Chappuis F
    Hepatic Alveolar Echinococcosis.
    Semin Liver Dis. 2021 Jun 23. doi: 10.1055/s-0041-1730925.
    PubMed     Abstract available

  5. SU YY, Li CC, Lin YJ, Hsu C, et al
    Adjuvant versus Neoadjuvant Immunotherapy for Hepatocellular Carcinoma: Clinical and Immunologic Perspectives.
    Semin Liver Dis. 2021 Jun 15. doi: 10.1055/s-0041-1730949.
    PubMed     Abstract available

    May 2021
  6. HAEP N, Florentino RM, Squires JE, Bell A, et al
    The Inside-Out of End-Stage Liver Disease: Hepatocytes are the Keystone.
    Semin Liver Dis. 2021 May 15. doi: 10.1055/s-0041-1725023.
    PubMed     Abstract available

  7. USON JUNIOR PLS, Nagalo BM, Ahn DH, Bekaii-Saab T, et al
    Combination Immunotherapy for Hepatocellular Carcinoma: Where Are We Currently?
    Semin Liver Dis. 2021 May 6. doi: 10.1055/s-0040-1722646.
    PubMed     Abstract available

  8. MOECKLI B, Majno P, Orci LA, Peloso A, et al
    Liver Transplantation Selection and Allocation Criteria for Hepatocellular Carcinoma: A European Perspective.
    Semin Liver Dis. 2021 May 6. doi: 10.1055/s-0041-1723032.
    PubMed     Abstract available

  9. SEKIBA K, Otsuka M, Koike K
    Potential of HBx Gene for Hepatocarcinogenesis in Noncirrhotic Liver.
    Semin Liver Dis. 2021 May 6. doi: 10.1055/s-0041-1723033.
    PubMed     Abstract available

    January 2021
  10. YAO FY, Fidelman N, Mehta N
    The Key Role of Staging Definitions for Assessment of Downstaging for Hepatocellular Carcinoma.
    Semin Liver Dis. 2021 Jan 14. doi: 10.1055/s-0040-1716565.
    PubMed     Abstract available

  11. ROEDIGER R, Fleckenstein J
    Intrahepatic Cholestasis of Pregnancy: Natural History and Current Management.
    Semin Liver Dis. 2021;41:103-108.
    PubMed     Abstract available

  12. STOTTS MJ, Wentworth BJ, Northup PG
    Management of Portal Vein Thrombosis in Cirrhosis.
    Semin Liver Dis. 2021;41:79-86.
    PubMed     Abstract available

  13. WILKINSON PD, Duncan AW
    Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury.
    Semin Liver Dis. 2021;41:42-49.
    PubMed     Abstract available

  14. ZHANG Y, Solinas A, Cairo S, Evert M, et al
    Molecular Mechanisms of Hepatoblastoma.
    Semin Liver Dis. 2021;41:28-41.
    PubMed     Abstract available

    Deciphering Tumor Heterogeneity in Hepatocellular Carcinoma (HCC)-Multi-Omic and Singulomic Approaches.
    Semin Liver Dis. 2021;41:9-18.
    PubMed     Abstract available

  16. BYRD K, Alqahtani S, Yopp AC, Singal AG, et al
    Role of Multidisciplinary Care in the Management of Hepatocellular Carcinoma.
    Semin Liver Dis. 2021;41:1-8.
    PubMed     Abstract available

    September 2020
    Evolution of Liver Transplant Selection Criteria and U.S. Allocation Policy for Patients with Hepatocellular Carcinoma.
    Semin Liver Dis. 2020 Sep 17. doi: 10.1055/s-0040-1709492.
    PubMed     Abstract available

  18. ROWE IA
    Histological Endpoints for Nonalcoholic Steatohepatitis Trials: Lights and Shadows.
    Semin Liver Dis. 2020 Sep 9. doi: 10.1055/s-0040-1709491.
    PubMed     Abstract available

    August 2020
  19. LIZARDO-THIEBAUD MJ, Cervantes-Alvarez E, Limon-de la Rosa N, Tejeda-Dominguez F, et al
    Direct or Collateral Liver Damage in SARS-CoV-2-Infected Patients.
    Semin Liver Dis. 2020;40:321-330.
    PubMed     Abstract available

    June 2020
  20. MANDORFER M, Hernandez-Gea V, Garcia-Pagan JC, Reiberger T, et al
    Noninvasive Diagnostics for Portal Hypertension: A Comprehensive Review.
    Semin Liver Dis. 2020 Jun 18. doi: 10.1055/s-0040-1708806.
    PubMed     Abstract available

  21. KNORR J, Wree A, Tacke F, Feldstein AE, et al
    The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis.
    Semin Liver Dis. 2020 Jun 11. doi: 10.1055/s-0040-1708540.
    PubMed     Abstract available

  22. IBRAHIM SH, Hirsova P, Malhi H, Gores GJ, et al
    Nonalcoholic Steatohepatitis Promoting Kinases.
    Semin Liver Dis. 2020 Jun 11. doi: 10.1055/s-0040-1713115.
    PubMed     Abstract available

  23. FREEBURG SH, Goessling W
    Hepatobiliary Differentiation: Principles from Embryonic Liver Development.
    Semin Liver Dis. 2020 Jun 11. doi: 10.1055/s-0040-1709679.
    PubMed     Abstract available

    May 2020
  24. SUGAHARA G, Ishida Y, Sun J, Tateno C, et al
    Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice.
    Semin Liver Dis. 2020;40:189-212.
    PubMed     Abstract available

  25. ABERG F, Farkkila M
    Drinking and Obesity: Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Interactions.
    Semin Liver Dis. 2020;40:154-162.
    PubMed     Abstract available

  26. DOLIN CE, Arteel GE
    The Matrisome, Inflammation, and Liver Disease.
    Semin Liver Dis. 2020;40:180-188.
    PubMed     Abstract available

  27. JORDAN RI, Tandon P
    Emerging Role of Palliative Care in Patients with Advanced Liver Disease.
    Semin Liver Dis. 2020;40:163-170.
    PubMed     Abstract available

  28. HILSCHER MB, Shah VH
    Neutrophil Extracellular Traps and Liver Disease.
    Semin Liver Dis. 2020;40:171-179.
    PubMed     Abstract available

    April 2020
  29. MATSUDA M, Seki E
    Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis.
    Semin Liver Dis. 2020 Apr 2. doi: 10.1055/s-0040-1708876.
    PubMed     Abstract available

    February 2020
  30. KANG N
    Mechanotransduction in Liver Diseases.
    Semin Liver Dis. 2020;40:84-90.
    PubMed     Abstract available

  31. FICKERT P, Rosenkranz AR
    Cholemic Nephropathy Reloaded.
    Semin Liver Dis. 2020;40:91-100.
    PubMed     Abstract available

  32. LLEO A, Leung PSC, Hirschfield GM, Gershwin EM, et al
    The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review.
    Semin Liver Dis. 2020;40:34-48.
    PubMed     Abstract available

    December 2019
  33. KOMUTA M, Yeh MM
    A Review on the Update of Combined Hepatocellular Cholangiocarcinoma.
    Semin Liver Dis. 2019 Dec 30. doi: 10.1055/s-0039-3402515.
    PubMed     Abstract available

  34. LIM CJ, Chew V
    Impact of Viral Etiologies on the Development of Novel Immunotherapy for Hepatocellular Carcinoma.
    Semin Liver Dis. 2019 Dec 6. doi: 10.1055/s-0039-3399534.
    PubMed     Abstract available

    September 2019
  35. EL-SHERIF O, Armstrong MJ
    Peculiarities of Cirrhosis due to Nonalcoholic Steatohepatitis (NASH).
    Semin Liver Dis. 2019 Sep 19. doi: 10.1055/s-0039-1697616.
    PubMed     Abstract available

    August 2019
  36. TANDON P, Berzigotti A
    Management of Lifestyle Factors in Individuals with Cirrhosis: A Pragmatic Review.
    Semin Liver Dis. 2019 Aug 30. doi: 10.1055/s-0039-1696639.
    PubMed     Abstract available

    July 2019
  37. BRUSILOVSKAYA K, Konigshofer P, Schwabl P, Reiberger T, et al
    Vascular Targets for the Treatment of Portal Hypertension.
    Semin Liver Dis. 2019 Jul 17. doi: 10.1055/s-0039-1693115.
    PubMed     Abstract available

  38. CAPPELLI A, Modestino F, Mosconi C, De Benedittis C, et al
    Portal Hypertensive Biliopathy in Adult Patients: Findings and Interventional Radiologic Treatment-A Single-Center Experience.
    Semin Liver Dis. 2019 Jul 4. doi: 10.1055/s-0039-1693514.
    PubMed     Abstract available

  39. THOMAS E, Baumert TF
    Hepatitis B Virus-Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms.
    Semin Liver Dis. 2019 Jul 2. doi: 10.1055/s-0039-1685518.
    PubMed     Abstract available

  40. RIMOLA J
    Heterogeneity of Hepatocellular Carcinoma on Imaging.
    Semin Liver Dis. 2019 Jul 2. doi: 10.1055/s-0039-1693512.
    PubMed     Abstract available

    June 2019
  41. AFIFY AY, Ibrahim SA, Aldamsisi MH, Zaghloul MS, et al
    Competing Endogenous RNAs in Hepatocellular Carcinoma-The Pinnacle of Rivalry.
    Semin Liver Dis. 2019 Jun 26. doi: 10.1055/s-0039-1688442.
    PubMed     Abstract available

  42. YANG JD, Liu MC, Kisiel JB
    Circulating Tumor DNA and Hepatocellular Carcinoma.
    Semin Liver Dis. 2019 Jun 21. doi: 10.1055/s-0039-1688503.
    PubMed     Abstract available

  43. FILLIOL A, Schwabe RF
    Contributions of Fibroblasts, Extracellular Matrix, Stiffness, and Mechanosensing to Hepatocarcinogenesis.
    Semin Liver Dis. 2019 Jun 21. doi: 10.1055/s-0039-1685539.
    PubMed     Abstract available

    May 2019
  44. SOOKOIAN S, Pirola CJ
    Genetics of Nonalcoholic Fatty Liver Disease: From Pathogenesis to Therapeutics.
    Semin Liver Dis. 2019;39:124-140.
    PubMed     Abstract available

  45. KIECKHAEFER JE, Maina F, Wells RG, Wangensteen KJ, et al
    Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9.
    Semin Liver Dis. 2019;39:261-274.
    PubMed     Abstract available

  46. TREVISANI F, Garuti F, Neri A
    Alpha-fetoprotein for Diagnosis, Prognosis, and Transplant Selection.
    Semin Liver Dis. 2019;39:163-177.
    PubMed     Abstract available

  47. SHAH RA, Kowdley KV
    Mechanisms and Treatments of Pruritus in Primary Biliary Cholangitis.
    Semin Liver Dis. 2019;39:209-220.
    PubMed     Abstract available

  48. RAMACHANDRAN A, Jaeschke H
    Acetaminophen Hepatotoxicity.
    Semin Liver Dis. 2019;39:221-234.
    PubMed     Abstract available

    April 2019
  49. NAULT JC, Letouze E
    Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid.
    Semin Liver Dis. 2019 Apr 30. doi: 10.1055/s-0039-1685516.
    PubMed     Abstract available

  50. FEHILY SR, Papaluca T, Thompson AJ
    Long-Term Impact of Direct-Acting Antiviral Agent Therapy in HCV Cirrhosis: Critical Review.
    Semin Liver Dis. 2019 Apr 30. doi: 10.1055/s-0039-1685538.
    PubMed     Abstract available

  51. PATTEN DA, Shepherd EL, Weston C, Shetty S, et al
    Erratum: Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases.
    Semin Liver Dis. 2019 Apr 16. doi: 10.1055/s-0039-1688409.

  52. WEINBERG EM, Palecki J, Reddy KR
    Direct-Acting Oral Anticoagulants (DOACs) in Cirrhosis and Cirrhosis-Associated Portal Vein Thrombosis.
    Semin Liver Dis. 2019 Apr 12. doi: 10.1055/s-0039-1679934.
    PubMed     Abstract available

    March 2019
  53. RODRIGUES SG, Cardenas A, Escorsell A, Bosch J, et al
    Balloon Tamponade and Esophageal Stenting for Esophageal Variceal Bleeding in Cirrhosis: A Systematic Review and Meta-analysis.
    Semin Liver Dis. 2019 Mar 25. doi: 10.1055/s-0039-1678726.
    PubMed     Abstract available

  54. PATTEN DA, Shepherd EL, Weston CJ, Shetty S, et al
    Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases.
    Semin Liver Dis. 2019 Mar 25. doi: 10.1055/s-0039-1678727.
    PubMed     Abstract available

  55. MAIERS JL, Malhi H
    Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis.
    Semin Liver Dis. 2019 Mar 25. doi: 10.1055/s-0039-1681032.
    PubMed     Abstract available

  56. KIM G, Kang ES
    Prevention of Hepatocellular Carcinoma by Statins: Clinical Evidence and Plausible Mechanisms.
    Semin Liver Dis. 2019 Mar 25. doi: 10.1055/s-0039-1679956.
    PubMed     Abstract available

  57. FUJIWARA N, Hoshida Y
    Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis.
    Semin Liver Dis. 2019 Mar 25. doi: 10.1055/s-0039-1681031.
    PubMed     Abstract available

    February 2019
  58. YOUNES R, Bugianesi E
    NASH in Lean Individuals.
    Semin Liver Dis. 2019;39:86-95.
    PubMed     Abstract available

  59. URBAN SK, Mocan T, Sanger H, Lukacs-Kornek V, et al
    Extracellular Vesicles in Liver Diseases: Diagnostic, Prognostic, and Therapeutic Application.
    Semin Liver Dis. 2019;39:70-77.
    PubMed     Abstract available

  60. KOK B, Abraldes JG
    Child-Pugh Classification: Time to Abandon?
    Semin Liver Dis. 2019;39:96-103.
    PubMed     Abstract available

  61. DITURI F, Mancarella S, Cigliano A, Chieti A, et al
    TGF-beta as Multifaceted Orchestrator in HCC Progression: Signaling, EMT, Immune Microenvironment, and Novel Therapeutic Perspectives.
    Semin Liver Dis. 2019;39:53-69.
    PubMed     Abstract available

  62. XU MJ, Feng M
    Radiation Therapy in HCC: What Data Exist and What Data Do We Need to Incorporate into Guidelines?
    Semin Liver Dis. 2019;39:43-52.
    PubMed     Abstract available

  63. SALATI M, Braconi C
    Noncoding RNA in Cholangiocarcinoma.
    Semin Liver Dis. 2019;39:13-25.
    PubMed     Abstract available

  64. ALVES VAF, Rimola J
    Malignant Vascular Tumors of the Liver in Adults.
    Semin Liver Dis. 2019;39:1-12.
    PubMed     Abstract available

    November 2018
  65. LIN YY, Tan CT, Chen CW, Ou DL, et al
    Immunomodulatory Effects of Current Targeted Therapies on Hepatocellular Carcinoma: Implication for the Future of Immunotherapy.
    Semin Liver Dis. 2018;38:379-388.
    PubMed     Abstract available

  66. LI Z, Weinman SA
    Regulation of Hepatic Inflammation via Macrophage Cell Death.
    Semin Liver Dis. 2018;38:340-350.
    PubMed     Abstract available

    Unfolded Protein Response Sensors in Hepatic Lipid Metabolism and Nonalcoholic Fatty Liver Disease.
    Semin Liver Dis. 2018;38:320-332.
    PubMed     Abstract available

  68. KHAMBU B, Yan S, Huda N, Liu G, et al
    Homeostatic Role of Autophagy in Hepatocytes.
    Semin Liver Dis. 2018;38:308-319.
    PubMed     Abstract available

  69. NADEAU BA, Fecher LA, Owens SR, Razumilava N, et al
    Liver Toxicity with Cancer Checkpoint Inhibitor Therapy.
    Semin Liver Dis. 2018;38:366-378.
    PubMed     Abstract available

  70. HASSAN A, Fontana RJ
    Liver Injury Associated with Sporting Activities.
    Semin Liver Dis. 2018;38:357-365.
    PubMed     Abstract available

  71. LIM C, Lahat E, Osseis M, Sotirov D, et al
    Liver Transplantation for Neuroendocrine Tumors: What Have We Learned?
    Semin Liver Dis. 2018;38:351-356.
    PubMed     Abstract available

  72. KEITEL V, Haussinger D
    Role of TGR5 (GPBAR1) in Liver Disease.
    Semin Liver Dis. 2018;38:333-339.
    PubMed     Abstract available

  73. REICHERT MC, Lammert F
    ABCB4 Gene Aberrations in Human Liver Disease: An Evolving Spectrum.
    Semin Liver Dis. 2018;38:299-307.
    PubMed     Abstract available

    August 2018
  74. DOU L, Ono Y, Chen YF, Thomson AW, et al
    Erratum: Hepatic Dendritic Cells, the Tolerogenic Liver Environment, and Liver Disease.
    Semin Liver Dis. 2018;38:298.

  75. DEUTSCH-LINK S, Fortuna D, Weinberg EM
    A Comprehensive Review of Hepatic Sarcoid.
    Semin Liver Dis. 2018;38:284-297.
    PubMed     Abstract available

  76. LIU PH, Huo TI, Miksad RA
    Hepatocellular Carcinoma with Portal Vein Tumor Involvement: Best Management Strategies.
    Semin Liver Dis. 2018;38:242-251.
    PubMed     Abstract available

  77. PIANO S, Brocca A, Angeli P
    Renal Function in Cirrhosis: A Critical Review of Available Tools.
    Semin Liver Dis. 2018;38:230-241.
    PubMed     Abstract available

  78. SCHEPIS F, Turco L, Bianchini M, Villa E, et al
    Prevention and Management of Bleeding Risk Related to Invasive Procedures in Cirrhosis.
    Semin Liver Dis. 2018;38:215-229.
    PubMed     Abstract available

  79. SHI SH, Zhai ZL, Zheng SS
    Pyogenic Liver Abscess of Biliary Origin: The Existing Problems and Their Strategies.
    Semin Liver Dis. 2018;38:270-283.
    PubMed     Abstract available

  80. ALFERINK LJM, Kiefte-de Jong JC, Darwish Murad S
    Potential Mechanisms Underlying the Role of Coffee in Liver Health.
    Semin Liver Dis. 2018;38:193-214.
    PubMed     Abstract available

    May 2018
  81. DOU L, Ono Y, Chen YF, Thomson AW, et al
    Hepatic Dendritic Cells, the Tolerogenic Liver Environment, and Liver Disease.
    Semin Liver Dis. 2018;38:170-180.
    PubMed     Abstract available

  82. RIMBAS M, Di Maurizio L, Rizzatti G, Gasbarrini A, et al
    Endoscopic Ultrasound for the Hepatologist: A Comprehensive Review.
    Semin Liver Dis. 2018;38:145-159.
    PubMed     Abstract available

  83. YANG L, Wu T, Li J, Li J, et al
    Bacterial Infections in Acute-on-Chronic Liver Failure.
    Semin Liver Dis. 2018;38:121-133.
    PubMed     Abstract available

    Noninferiority Clinical Trials: The Good, the Bad, and the Ugly.
    Semin Liver Dis. 2018;38:97-102.
    PubMed     Abstract available

    February 2018
    Does Transjugular Intrahepatic Portosystemic Shunt Stent Differentially Improve Survival in a Subset of Cirrhotic Patients?
    Semin Liver Dis. 2018;38:87-96.
    PubMed     Abstract available

  86. HLADY RA, Robertson KD
    Genetic and Epigenetic Heterogeneity in Normal Liver Homeostasis and Its Implications for Liver Disease and Hepatocellular Cancer.
    Semin Liver Dis. 2018;38:41-50.
    PubMed     Abstract available

  87. ANDRADE RJ, Medina-Caliz I, Gonzalez-Jimenez A, Garcia-Cortes M, et al
    Hepatic Damage by Natural Remedies.
    Semin Liver Dis. 2018;38:21-40.
    PubMed     Abstract available

  88. AJMERA V, Loomba R
    Can Elastography Differentiate Isolated Fatty Liver from Nonalcoholic Steatohepatitis?
    Semin Liver Dis. 2018;38:14-20.
    PubMed     Abstract available

  89. DARA L
    The Receptor Interacting Protein Kinases in the Liver.
    Semin Liver Dis. 2018;38:73-86.
    PubMed     Abstract available

  90. LALAZAR G, Simon SM
    Fibrolamellar Carcinoma: Recent Advances and Unresolved Questions on the Molecular Mechanisms.
    Semin Liver Dis. 2018;38:51-59.
    PubMed     Abstract available

  91. MANN JP, Valenti L, Scorletti E, Byrne CD, et al
    Nonalcoholic Fatty Liver Disease in Children.
    Semin Liver Dis. 2018;38:1-13.
    PubMed     Abstract available

    November 2017
  92. RICH NE, Parikh ND, Singal AG
    Overdiagnosis: An Understudied Issue in Hepatocellular Carcinoma Surveillance.
    Semin Liver Dis. 2017;37:296-304.
    PubMed     Abstract available

    August 2017
  93. KAMBADAKONE A, Baliyan V, Zhu AX
    Functional Imaging and Assessment of Antitumor Activity in Systemic Therapy for Hepatocellular Carcinoma.
    Semin Liver Dis. 2017;37:259-274.

  94. HEIKENWALDER M, Pikarsky E
    Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma-Nature's Guide for Successful Cancer Immunotherapy.
    Semin Liver Dis. 2017;37:210-218.

    May 2017
  95. LALIOTI V, Tsubota A, Sandoval IV
    Disorders in Hepatic Copper Secretion: Wilson's Disease and Pleomorphic Syndromes.
    Semin Liver Dis. 2017;37:175-188.

    February 2017
  96. PARES A
    Novel Treatment Strategies for Primary Biliary Cholangitis.
    Semin Liver Dis. 2017;37:60-72.
    PubMed     Abstract available

  97. SANTOS-LASO A, Izquierdo-Sanchez L, Lee-Law PY, Perugorria MJ, et al
    New Advances in Polycystic Liver Diseases.
    Semin Liver Dis. 2017;37:45-55.
    PubMed     Abstract available

    Hemostasis in Acute and Chronic Liver Disease.
    Semin Liver Dis. 2017;37:28-32.
    PubMed     Abstract available

  99. MORALES-RUIZ M, Santel A, Ribera J, Jimenez W, et al
    The Role of Akt in Chronic Liver Disease and Liver Regeneration.
    Semin Liver Dis. 2017;37:11-16.
    PubMed     Abstract available

  100. CAMPANA L, Iredale JP
    Regression of Liver Fibrosis.
    Semin Liver Dis. 2017;37:1-10.
    PubMed     Abstract available

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