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Articles published in Am J Pathol

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    July 2021
  1. MATTHEWS DR, Li H, Zhou J, Li Q, et al
    Methionine- and Choline-deficient Diet-induced Non-alcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation.
    Am J Pathol. 2021 Jul 6. pii: S0002-9440(21)00302.
    PubMed     Abstract available


    June 2021
  2. BAGLIERI J, Zhang C, Liang S, Liu X, et al
    Non-degradable collagen increases liver fibrosis but not hepatocellular carcinoma in mice.
    Am J Pathol. 2021 Jun 10. pii: S0002-9440(21)00254.
    PubMed     Abstract available


    May 2021
  3. CHEN Z, Jiang L, Liang L, Koral K, et al
    The Role of Fibroblast Growth Factor 19 in Hepatocellular Carcinoma.
    Am J Pathol. 2021 May 14. pii: S0002-9440(21)00198.
    PubMed     Abstract available


  4. ZHANG Y, Liang B, Song X, Wang H, et al
    Loss of Apc Cooperates with Activated Oncogenes to Induce Liver Tumor Formation in Mice.
    Am J Pathol. 2021;191:930-946.
    PubMed     Abstract available


    April 2021
  5. CHEN CY, Li Y, Zeng N, He L, et al
    Inhibition of estrogen related receptor alpha blocks liver steatosis and steatohepatitis and attenuates triglyceride biosynthesis.
    Am J Pathol. 2021 Apr 21. pii: S0002-9440(21)00162.
    PubMed     Abstract available


    March 2021
  6. PRADHAN-SUNDD T, Liu S, Singh S, Podder M, et al
    Dual beta-catenin and gamma-catenin loss in hepatocytes impacts their polarity through altered transforming growth factor beta and hepatocyte nuclear factor 4 alpha signaling.
    Am J Pathol. 2021 Mar 1. pii: S0002-9440(21)00075.
    PubMed     Abstract available


  7. MENESES-SALAS E, Garcia-Forn M, Castany-Pladevall C, Lu A, et al
    Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein-Deficient Mice.
    Am J Pathol. 2021;191:475-486.
    PubMed     Abstract available


    February 2021
  8. MASUZAKI R, Ray KC, Roland J, Zent R, et al
    Integrin beta1 Establishes Liver Microstructure and Modulates Transforming Growth Factor beta during Liver Development and Regeneration.
    Am J Pathol. 2021;191:309-319.
    PubMed     Abstract available


    December 2020
  9. URUSHIMA H, Yuasa H, Matsubara T, Kuroda N, et al
    Activation of Hepatic Stellate Cells Requires Dissociation of E-Cadherin-Containing Adherens Junctions with Hepatocytes.
    Am J Pathol. 2020 Dec 17. pii: S0002-9440(20)30562.
    PubMed     Abstract available


    November 2020
  10. SLEVIN E, Baiocchi L, Wu N, Ekser B, et al
    Kupffer Cells: Inflammation Pathways and Cell-Cell Interactions in Alcohol-Associated Liver Disease.
    Am J Pathol. 2020;190:2185-2193.
    PubMed     Abstract available


  11. CECI L, Francis H, Zhou T, Giang T, et al
    Knockout of the Tachykinin Receptor 1 in the Mdr2(-/-) (Abcb4(-/-)) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.
    Am J Pathol. 2020;190:2251-2266.
    PubMed     Abstract available


    October 2020
  12. JABER FL, Sharma Y, Mui BG, Kapoor S, et al
    Tumor necrosis factor directs allograft-related innate responses and its neutralization improves hepatocyte engraftment in rats.
    Am J Pathol. 2020 Oct 27. pii: S0002-9440(20)30484.
    PubMed     Abstract available


    August 2020
  13. ZHENG D, Jiang Y, Qu C, Yuan H, et al
    Pyruvate kinase M2 (PKM2) tetramerization protects against hepatic stellate cell activation and liver fibrosis.
    Am J Pathol. 2020 Aug 14. pii: S0002-9440(20)30372.
    PubMed     Abstract available


    July 2020
  14. ZHOU Y, Xu M, Liu P, Liang B, et al
    Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model.
    Am J Pathol. 2020;190:1414-1426.
    PubMed     Abstract available


    June 2020
  15. KIKUCHI A, Singh S, Poddar M, Nakao T, et al
    HEPATIC STELLATE CELL-SPECIFIC PLATELET-DERIVED GROWTH FACTOR RECEPTOR alpha LOSS REDUCES FIBROSIS AND PROMOTES REPAIR FOLLOWING HEPATOCELLULAR INJURY.
    Am J Pathol. 2020 Jun 29. pii: S0002-9440(20)30297.
    PubMed     Abstract available


    April 2020
  16. ZHANG S, Zhang J, Evert K, Li X, et al
    The Hippo effector TAZ cooperates with oncogenic beta-catenin to induce hepatoblastoma development in mice and humans.
    Am J Pathol. 2020 Apr 10. pii: S0002-9440(20)30187.
    PubMed     Abstract available


    March 2020
  17. KRISHNAN A, Katsumi T, Guicciardi ME, Azad AI, et al
    TRAIL Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation and Hepatic Fibrosis in the Mdr2(-/-) Mouse.
    Am J Pathol. 2020 Mar 30. pii: S0002-9440(20)30135.
    PubMed     Abstract available


  18. KOSAR K, Cornuet P, Singh S, Liu S, et al
    The Thyromimetic, GC-1, Alters Bile Acid Metabolism in a Mouse Model of Hepatic Cholestasis.
    Am J Pathol. 2020 Mar 20. pii: S0002-9440(20)30095.
    PubMed     Abstract available


  19. LU H, Ye C, Feng X, Liu J, et al
    Spontaneous development of hepatocellular carcinoma and B-cell lymphoma in mosaic and heterozygous Brca2 and Cdkn1a interacting protein (Bccip) knockout mice.
    Am J Pathol. 2020 Mar 19. pii: S0002-9440(20)30129.
    PubMed     Abstract available


  20. MIURA S, Suzuki A
    Induction of steatohepatitis and liver tumorigenesis by enforced Snail expression in hepatocytes.
    Am J Pathol. 2020 Mar 15. pii: S0002-9440(20)30121.
    PubMed     Abstract available


  21. ZHOU Z, Kim JW, Qi J, Eo SK, et al
    Toll-Like Receptor 5 Signaling Ameliorates Liver Fibrosis by Inducing Interferon beta-Modulated IL-1 Receptor Antagonist in Mice.
    Am J Pathol. 2020;190:614-629.
    PubMed     Abstract available


    February 2020
  22. STAHL EC, Delgado ER, Alencastro F, LoPresti ST, et al
    Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.
    Am J Pathol. 2020;190:372-387.
    PubMed     Abstract available


  23. FENG Q, Zhang H, Nie X, Li Y, et al
    miR-149* Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression.
    Am J Pathol. 2020;190:469-483.
    PubMed     Abstract available


    January 2020
  24. LI SQ, Chen Q, Qin HX, Yu YQ, et al
    LINC00152 promotes hepatocellular carcinoma progression by regulating PI3k/Akt/mTOR signaling pathway through miR-139/PIK3CA.
    Am J Pathol. 2020 Jan 16. pii: S0002-9440(20)30009.
    PubMed     Abstract available


  25. PETRESCU AD, Grant S, Williams E, Frampton G, et al
    Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Mdr2-Knockout Mice.
    Am J Pathol. 2020 Jan 14. pii: S0002-9440(20)30003.
    PubMed     Abstract available


  26. LI Y, Chao X, Wang S, Williams JA, et al
    Role of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury.
    Am J Pathol. 2020;190:158-175.
    PubMed     Abstract available


  27. ZHOU Z, Ye TJ, DeCaro E, Buehler B, et al
    Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
    Am J Pathol. 2020;190:82-92.
    PubMed     Abstract available


  28. NIU M, Luo Z, Gong S, Win S, et al
    Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice.
    Am J Pathol. 2020;190:57-67.
    PubMed     Abstract available


    November 2019
  29. ZHANG XJ, Olsavszky V, Yin Y, Wang B, et al
    Angiocrine Hgf signaling controls physiologic organ and body size and dynamic hepatocyte proliferation to prevent liver damage during regeneration.
    Am J Pathol. 2019 Nov 26. pii: S0002-9440(19)30846.
    PubMed     Abstract available


  30. JEFFERSON B, Ali M, Grant S, Frampton G, et al
    Thrombospondin-1 exacerbates acute liver failure and hepatic encephalopathy pathology in mice by activating transforming growth factor beta 1.
    Am J Pathol. 2019 Nov 14. pii: S0002-9440(19)30800.
    PubMed     Abstract available


    October 2019
  31. LU JG, Ji P, French SW
    The MHC II-CD4 Immunologic Synapse in Alcoholic Hepatitis and Autoimmune Liver Pathology: The Role of Aberrant MHC II in Hepatocytes.
    Am J Pathol. 2019 Oct 25. pii: S0002-9440(19)30771.
    PubMed     Abstract available


  32. JEWELL ML, Gibson JR, Guy CD, Hyun J, et al
    Single cell RNA sequencing identifies YAP1-dependent hepatic mesothelial progenitors in fibrolamellar carcinoma.
    Am J Pathol. 2019 Oct 24. pii: S0002-9440(19)30770.
    PubMed     Abstract available


  33. QI J, Kim JW, Zhou Z, Lim CW, et al
    Ferroptosis affects the progression of non-alcoholic steatohepatitis via the modulation of lipid peroxidation-mediated cell death in mice.
    Am J Pathol. 2019 Oct 11. pii: S0002-9440(19)30759.
    PubMed     Abstract available


  34. ROTH K, Strickland J, Joshi N, Deng M, et al
    Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.
    Am J Pathol. 2019;189:1986-2001.
    PubMed     Abstract available


    September 2019
  35. YAN S, Zhou J, Chen X, Dong Z, et al
    Diverse Consequences in Liver Injury in Mice with Different Autophagy Functional Status Treated with Alcohol.
    Am J Pathol. 2019;189:1744-1762.
    PubMed     Abstract available


    August 2019
  36. ROCKEY DC, Du Q, Shi Z
    Smooth Muscle alpha-actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells.
    Am J Pathol. 2019 Aug 30. pii: S0002-9440(19)30701.
    PubMed     Abstract available


  37. LIU W, Guo TF, Jing ZT, Tong QY, et al
    Repression of death receptor-mediated apoptosis of hepatocytes by Hepatitis B virus e antigen.
    Am J Pathol. 2019 Aug 23. pii: S0002-9440(19)30670.
    PubMed     Abstract available


  38. WILSON DB, Rudnick DA
    Invasive Ductular Reaction: Form and Function.
    Am J Pathol. 2019;189:1501-1504.
    PubMed     Abstract available


    July 2019
  39. RAGGI C, Fiaccadori K, Pastore M, Correnti M, et al
    Antitumor Activity of a Novel Fibroblast Growth Factor Receptor (FGFR) Inhibitor for Intrahepatic Cholangiocarcinoma.
    Am J Pathol. 2019 Jul 24. pii: S0002-9440(19)30624.
    PubMed     Abstract available


  40. NI HM, Chao X, Kaseff J, Deng F, et al
    Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers.
    Am J Pathol. 2019;189:1363-1374.
    PubMed     Abstract available


    June 2019
  41. SUGIURA K, Mishima T, Takano S, Yoshitomi H, et al
    The Expression of Yes-Associated Protein (YAP) Maintains Putative Cancer Stemness and Is Associated with Poor Prognosis in Intrahepatic Cholangiocarcinoma.
    Am J Pathol. 2019 Jun 17. pii: S0002-9440(18)31085.
    PubMed     Abstract available


    May 2019
  42. CLERBAUX LA, Manco R, Van Hul N, Bouzin C, et al
    Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans.
    Am J Pathol. 2019 May 17. pii: S0002-9440(18)30871.
    PubMed     Abstract available


    April 2019
  43. IKARI N, Serizawa A, Mitani S, Yamamoto M, et al
    Near-Comprehensive Resequencing of Cancer-Associated Genes in Surgically Resected Metastatic Liver Tumors of Gastric Cancer.
    Am J Pathol. 2019;189:784-796.
    PubMed     Abstract available


  44. BHUSHAN B, Apte U
    Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities.
    Am J Pathol. 2019;189:719-729.
    PubMed     Abstract available


    March 2019
  45. WILKINSON PD, Alencastro F, Delgado ER, Leek MP, et al
    Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury.
    Am J Pathol. 2019 Mar 27. pii: S0002-9440(18)30970.
    PubMed     Abstract available


  46. GUNTHER S, Perros F, Rautou PE, Girerd B, et al
    Understanding Hepatic and Pulmonary Veno-Occlusive Disease: Similarities and Differences.
    Am J Pathol. 2019 Mar 26. pii: S0002-9440(18)30320.
    PubMed     Abstract available


  47. LIU L, Xie P, Li W, Wu Y, et al
    Augmenter of Liver Regeneration Protects against Ethanol-Induced Acute Liver Injury by Promoting Autophagy.
    Am J Pathol. 2019;189:552-567.
    PubMed     Abstract available


    February 2019
  48. MIN Q, Molina L, Li J, Adebayo Michael AO, et al
    beta-Catenin and yes-associated protein 1 cooperate in hepatoblastoma pathogenesis.
    Am J Pathol. 2019 Feb 19. pii: S0002-9440(18)30759.
    PubMed     Abstract available


  49. ZHANG J, Liu P, Tao J, Wang P, et al
    TEA domain transcription factor 4 (TEAD4) is the major mediator of Yap oncogenic activity in mouse and human hepatoblastoma.
    Am J Pathol. 2019 Feb 19. pii: S0002-9440(18)30776.
    PubMed     Abstract available


    January 2019
  50. JIANG A, Okabe H, Popovic B, Preziosi ME, et al
    Loss of Wnt secretion by macrophages promotes hepatobiliary injury following administration of DDC diet.
    Am J Pathol. 2019 Jan 2. pii: S0002-9440(18)30285.
    PubMed     Abstract available


    December 2018
  51. PALMA E, Ma X, Riva A, Iansante V, et al
    Dynamin-1-like protein inhibition drives megamitochondria formation as an adaptive response in alcohol-induced hepatotoxicity.
    Am J Pathol. 2018 Dec 13. pii: S0002-9440(18)30112.
    PubMed     Abstract available


    November 2018
  52. GREENHALGH SN, Matchett KP, Taylor RS, Huang K, et al
    Loss of integrin alphavbeta8 in murine hepatocytes accelerates liver regeneration.
    Am J Pathol. 2018 Nov 15. pii: S0002-9440(17)30538.
    PubMed     Abstract available


  53. XIE G, Yin S, Zhang ZZ, Qi D, et al
    Hepatocyte PPARalpha enhances liver regeneration after partial hepatectomy in mice.
    Am J Pathol. 2018 Nov 15. pii: S0002-9440(18)30197.
    PubMed     Abstract available


  54. WANG Y, Chen W, Han C, Zhang J, et al
    Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-kappaB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis.
    Am J Pathol. 2018;188:2605-2616.
    PubMed     Abstract available


    September 2018
  55. STROWITZKI MJ, Kirchberg J, Tuffs C, Schiedeck M, et al
    Loss Of Prolyl-Hydroxylase 1 Protects Against Biliary Fibrosis Via Attenuated Activation Of Hepatic Stellate Cells.
    Am J Pathol. 2018 Sep 21. pii: S0002-9440(17)30621.
    PubMed     Abstract available


  56. MATTU S, Saliba C, Sulas P, Zavattari P, et al
    High frequency of beta-catenin mutations in mouse hepatocellular carcinomas induced by a non-genotoxic constitutive androstane receptor agonist.
    Am J Pathol. 2018 Sep 7. pii: S0002-9440(17)31145.
    PubMed     Abstract available


  57. KORAL K, Haynes M, Bowen WC, Orr A, et al
    Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation.
    Am J Pathol. 2018;188:2074-2086.
    PubMed     Abstract available


    August 2018
  58. TU WL, You LR, Tsou AP, Chen CM, et al
    Pten Haplo-Deficiency Accelerates Liver Tumor Growth in microRNA122a-Null Mice via Expansion of Periportal Hepatocyte-Like Cells.
    Am J Pathol. 2018 Aug 27. pii: S0002-9440(18)30136.
    PubMed     Abstract available


  59. ROH YS, Kim JW, Park S, Shon C, et al
    Toll-Like Receptor-7 (TLR7) Signaling Promotes Non-Alcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice.
    Am J Pathol. 2018 Aug 17. pii: S0002-9440(17)31134.
    PubMed     Abstract available


    July 2018
  60. TSAI HC, Li TH, Huang CC, Huang SF, et al
    Beneficial Effects of the Peroxisome Proliferator-Activated Receptor alpha/gamma Agonist Aleglitazar on Progressive Hepatic and Splanchnic Abnormalities in Cirrhotic Rats with Portal Hypertension.
    Am J Pathol. 2018;188:1608-1624.
    PubMed     Abstract available


    June 2018
  61. MOLINA L, Bell D, Tao J, Preziosi M, et al
    Hepatocyte-derived lipocalin 2 is a potential serum biomarker reflecting tumor burden in hepatoblastoma.
    Am J Pathol. 2018 Jun 16. pii: S0002-9440(17)31236.
    PubMed     Abstract available


  62. WANG J, Kainrad N, Shen H, Zhou Z, et al
    Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
    Am J Pathol. 2018 Jun 2. pii: S0002-9440(18)30158.
    PubMed     Abstract available


  63. DUARTE S, Matian P, Ma S, Busuttil RW, et al
    Adeno-Associated Virus-Mediated Gene Transfer of Tissue Inhibitor of Metalloproteinases-1 Impairs Neutrophil Extracellular Trap Formation and Ameliorates Hepatic Ischemia and Reperfusion Injury.
    Am J Pathol. 2018 Jun 2. pii: S0002-9440(18)30029.
    PubMed     Abstract available


    May 2018
  64. LIU W, Jing ZT, Wu SX, He Y, et al
    A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes.
    Am J Pathol. 2018;188:1171-1182.
    PubMed     Abstract available


    March 2018
  65. XUE Y, Mars WM, Bowen W, Singhi AD, et al
    Hepatitis C Virus (HCV) Mimics Effects of Glypican-3 (GPC3) on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes.
    Am J Pathol. 2018 Mar 22. pii: S0002-9440(17)30990.
    PubMed     Abstract available


  66. RUSSELL JO, Ko S, Saggi HS, Singh S, et al
    Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in Hepatocyte-Driven Liver Regeneration.
    Am J Pathol. 2018 Mar 12. pii: S0002-9440(17)30773.
    PubMed     Abstract available


    February 2018
  67. CHIYONOBU N, Shimada S, Akiyama Y, Mogushi K, et al
    Fatty acid binding protein 4 (FABP4) overexpression in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors.
    Am J Pathol. 2018 Feb 15. pii: S0002-9440(17)30959.
    PubMed     Abstract available


  68. PANT A, Kopec AK, Baker KS, Cline-Fedewa H, et al
    Plasminogen Activator Inhibitor-1 Reduces tPA-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose.
    Am J Pathol. 2018 Feb 15. pii: S0002-9440(17)30859.
    PubMed     Abstract available


    January 2018
  69. LORENZO PISARELLO M, Masyuk TV, Gradilone SA, Masyuk AI, et al
    The combination of an HDAC6 inhibitor and a somatostatin receptor agonist synergistically reduces hepato-renal cystogenesis in an animal model of polycystic liver disease.
    Am J Pathol. 2018 Jan 20. pii: S0002-9440(17)30796.
    PubMed     Abstract available


  70. ODA S, Takeuchi M, Akai S, Shirai Y, et al
    microRNA in Rat Liver Sinusoidal Endothelial Cells and Hepatocytes and Application to Circulating Biomarkers that Discern Pathogenesis of Liver Injuries.
    Am J Pathol. 2018 Jan 15. pii: S0002-9440(17)30601.
    PubMed     Abstract available


  71. RAMANI K, Tomasi ML, Berlind J, Mavila N, et al
    Role of A-Kinase Anchoring Protein Phosphorylation in Alcohol-Induced Liver Injury and Hepatic Stellate Cell Activation.
    Am J Pathol. 2018 Jan 2. pii: S0002-9440(17)30858.
    PubMed     Abstract available


  72. SINGAL SS, Nygard K, Dhruv MR, Biggar K, et al
    Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2beta, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay.
    Am J Pathol. 2018;188:111-124.
    PubMed     Abstract available


    December 2017
  73. KENNEDY L, Hargrove L, Demieville J, Bailey J, et al
    Knockout of l-Histidine Decarboxylase (HDC(-/-)) Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.
    Am J Pathol. 2017 Dec 14. pii: S0002-9440(17)30615.
    PubMed     Abstract available


  74. CARPINO G, Cardinale V, Folseraas T, Overi D, et al
    Hepatic stem/progenitor cell activation differs between primary sclerosing and primary biliary cholangitis.
    Am J Pathol. 2017 Dec 14. pii: S0002-9440(17)30740.
    PubMed     Abstract available


  75. SULAS P, Di Tommaso L, Novello C, Rizzo F, et al
    A large set of miRNAs is dysregulated since the earliest steps of human hepatocellular carcinoma development.
    Am J Pathol. 2017 Dec 14. pii: S0002-9440(17)30783.
    PubMed     Abstract available


  76. LI L, Qian M, Chen IH, Finkelstein D, et al
    Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice.
    Am J Pathol. 2017 Dec 14. pii: S0002-9440(17)30865.
    PubMed     Abstract available


  77. WAN Y, McDaniel K, Wu N, Ramos-Lorenzo S, et al
    Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury.
    Am J Pathol. 2017;187:2788-2798.
    PubMed     Abstract available


    November 2017
  78. DAI Y, Liu L, Zeng T, Liang JZ, et al
    Overexpression of MUC13, a Poor Prognostic Predictor, Promotes Cell Growth by Activating Wnt Signaling in Hepatocellular Carcinoma.
    Am J Pathol. 2017 Nov 21. pii: S0002-9440(17)30418.
    PubMed     Abstract available


    October 2017
  79. WARNER DR, Liu H, Miller ME, Ramsden CE, et al
    Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.
    Am J Pathol. 2017;187:2232-2245.
    PubMed     Abstract available



  80. This Month in AJP.
    Am J Pathol. 2017;187:2129.
    PubMed     Abstract available


    September 2017
  81. YAMAMOTO M, Xin B, Watanabe K, Ooshio T, et al
    Oncogenic determination of a broad spectrum of phenotypes of hepatocyte-derived mouse liver tumors.
    Am J Pathol. 2017 Sep 27. pii: S0002-9440(17)30174.
    PubMed     Abstract available


  82. CHOWDHARY V, Teng KY, Thakral S, Zhang B, et al
    miR-122 protects mice and human hepatocytes from acetaminophen toxicity by regulating CYP1A2 and CYP2E1 expression.
    Am J Pathol. 2017 Sep 26. pii: S0002-9440(17)30413.
    PubMed     Abstract available


  83. POZNIAK KN, Pearen MA, Pereira TN, Kramer CS, et al
    Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in pediatric cystic fibrosis liver disease.
    Am J Pathol. 2017 Sep 18. pii: S0002-9440(17)30375.
    PubMed     Abstract available


  84. LIU L, Zhang L, Zhang L, Yang F, et al
    Hepatic Tmem30a deficiency causes intrahepatic cholestasis by impairing expression and localization of bile salt transporters.
    Am J Pathol. 2017 Sep 14. pii: S0002-9440(17)30485.
    PubMed     Abstract available


  85. RANI R, Tandon A, Wang J, Kumar S, et al
    Stellate Cells Orchestrate Concanavalin A-Induced Acute Liver Damage.
    Am J Pathol. 2017;187:2008-2019.
    PubMed     Abstract available


    August 2017
  86. PULIGA E, Min Q, Tao J, Zhang R, et al
    Thyroid hormone receptor-beta agonist GC-1 inhibits Met-beta-catenin driven hepatocellular cancer.
    Am J Pathol. 2017 Aug 11. pii: S0002-9440(17)30403.
    PubMed     Abstract available


  87. JENA PK, Sheng L, Liu HX, Kalanetra KM, et al
    Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment.
    Am J Pathol. 2017;187:1800-1813.
    PubMed     Abstract available


  88. CHIANG JYL
    Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet.
    Am J Pathol. 2017;187:1658-1659.
    PubMed     Abstract available


    July 2017
  89. KIKUCHI A, Pradhan-Sundd T, Singh S, Nagarajan S, et al
    Platelet-Derived Growth Factor Receptor Alpha Contributes to Human Hepatic Stellate Cell Proliferation and Migration.
    Am J Pathol. 2017 Jul 19. pii: S0002-9440(17)30329.
    PubMed     Abstract available


  90. LABGAA I, Stueck A, Ward SC
    Lymphoepithelioma-Like Carcinoma in Liver.
    Am J Pathol. 2017;187:1438-1444.
    PubMed     Abstract available


    June 2017
  91. GUILLAUME M, Handgraaf S, Fabre A, Raymond-Letron I, et al
    Selective Activation of Estrogen Receptor alpha Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse.
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    May 2017
  92. KYRITSI K, Meng F, Zhou T, Wu N, et al
    Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.
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    April 2017
  93. KUMAR S, Wang J, Shanmukhappa SK, Gandhi CR, et al
    Toll-Like Receptor 4-Independent Carbon Tetrachloride-Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice: Role of Hepatic Stellate Cells.
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  94. CHENG S, Zou M, Liu Q, Kuang J, et al
    Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation.
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    February 2017
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    Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
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    January 2017

  96. This Month in AJP.
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  97. ELGILANI F, Mao SA, Glorioso JM, Yin M, et al
    Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.
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