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  Leukemia

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19.05.2025

3 Am J Hematol
3 Ann Hematol
1 Biochem Biophys Res Commun
5 Blood
2 Bone Marrow Transplant
6 Br J Haematol
1 Cancer
2 Cancer Res
1 Exp Hematol
1 J Clin Oncol
1 J Pediatr Hematol Oncol
1 Leuk Lymphoma
1 Leuk Res
4 Leukemia
1 N Engl J Med
1 Oncogene
1 Oncol Rep
1 Proc Natl Acad Sci U S A


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Am J Hematol

  1. KANTARJIAN H, Jabbour E
    Adult Acute Lymphoblastic Leukemia: 2025 Update on Diagnosis, Therapy, and Monitoring.
    Am J Hematol. 2025 May 16. doi: 10.1002/ajh.27708.
    PubMed         Abstract available

  2. OKADA Y, Kondo T, Miyazaki T, Shimazu Y, et al
    Optimal Depth of the Treatment Response Before Allogeneic Hematopoietic Transplantation for Chronic Myeloid Leukemia in Chronic Phase.
    Am J Hematol. 2025 May 12. doi: 10.1002/ajh.27706.
    PubMed        

  3. SHAH MV, Arber DA, Hiwase DK
    TP53 -Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk-Stratification, and Management.
    Am J Hematol. 2025;100 Suppl 4.
    PubMed         Abstract available


    Ann Hematol

  4. LEWANDOWSKI K, Janicki M, Baranska M, Kandula Z, et al
    Inotuzumab therapy resulted in molecular remission of relapsed/resistant B-cell acute lymphoblastic leukemia with BCR::ABL1 Lys404Glu mutation.
    Ann Hematol. 2025 May 16. doi: 10.1007/s00277-025-06385.
    PubMed         Abstract available

  5. CECCHI N, Sciume M, Ricchiuti A, Bosi A, et al
    Rituximab efficacy for minimal residual disease eradication in philadelphia-negative acute lymphoblastic leukemia CD20.
    Ann Hematol. 2025 May 16. doi: 10.1007/s00277-025-06332.
    PubMed         Abstract available

  6. SAMMARTANO V, Sicuranza A, Pacelli P, Bestoso E, et al
    Prognostic value of CD47 overexpression measured by flow cytometry in acute myeloid leukemia.
    Ann Hematol. 2025 May 15. doi: 10.1007/s00277-025-06401.
    PubMed         Abstract available


    Biochem Biophys Res Commun

  7. XIMEI WU, Lin C, Wang H, Gao J, et al
    Connectivity-map unveils Gemcitabine's efficacy in overcoming nelarabine resistance in T-cell acute lymphoblastic leukemia.
    Biochem Biophys Res Commun. 2025;769:151971.
    PubMed         Abstract available


    Blood

  8. ARAUJO JL, Wagenblast E, Voisin V, McLeod J, et al
    FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.
    Blood. 2025 Jan 22:blood.2024025886. doi: 10.1182/blood.2024025886.
    PubMed         Abstract available

  9. ALDOSS I, Clark MC, Forman SJ
    How I Treat: Revisiting the myth of second remission in acute lymphoblastic leukemia in the era of immunotherapy.
    Blood. 2025 May 12:blood.2024027267. doi: 10.1182/blood.2024027267.
    PubMed         Abstract available

  10. SAORIN A, Dehler A, Galvan B, Steffen FD, et al
    Transcriptional remodeling shapes therapeutic vulnerability to necroptosis in acute lymphoblastic leukemia.
    Blood. 2025 May 13:blood.2025028938. doi: 10.1182/blood.2025028938.
    PubMed         Abstract available

  11. WANG X, Yi H
    Adult T-cell leukemia/lymphoma coexistent with immune dysregulation-associated EBV+ lymphoproliferative disorder.
    Blood. 2025;145:2396.
    PubMed        

  12. YOSHIMITSU M, Choi I, Kusumoto S, Shimokawa M, et al
    A phase 2 Trial of CHOP with Anti-CCR4 Antibody Mogamulizumab for older Patients with Adult T-Cell Leukemia/Lymphoma.
    Blood. 2025 May 15:blood.2024027902. doi: 10.1182/blood.2024027902.
    PubMed         Abstract available


    Bone Marrow Transplant

  13. BATTIPAGLIA G, Labopin M, Kulagin A, Versluis J, et al
    Addition of mycophenolate mofetil to a calcineurin inhibitor and post-transplant cyclophosphamide results in lower incidence of extensive chronic graft-versus-host disease in HLA-matched allogeneic hematopoietic stem cell transplantation for acute mye
    Bone Marrow Transplant. 2025 May 13. doi: 10.1038/s41409-025-02610.
    PubMed         Abstract available

  14. ZHOU J, Wang F, Yang S, Zhang Y, et al
    Survival outcomes between haploidentical stem cell transplantation and chemotherapy for blastic plasmacytoid dendritic cell neoplasm.
    Bone Marrow Transplant. 2025 Feb 12. doi: 10.1038/s41409-025-02528.
    PubMed         Abstract available


    Br J Haematol

  15. STASIK S, Eckardt JN, Rollig C, Baldus CD, et al
    The IKZF1 N159S mutation is associated with poor outcome and a distinct molecular profile in adult patients with AML.
    Br J Haematol. 2025;206:1373-1379.
    PubMed         Abstract available

  16. SUTTORP M, Sembill S, Lensker P, Hildebrand V, et al
    Therapeutic drug monitoring of imatinib in paediatric chronic myeloid leukaemia: Data from a real-world setting.
    Br J Haematol. 2025;206:1397-1405.
    PubMed         Abstract available

  17. LIU J, Zhao XS, Chang YJ, Qin YZ, et al
    Monitoring the KMT2A gene post-chemotherapy independently predicts the relapse and survival risk after allogeneic haematopoietic stem cell transplantation.
    Br J Haematol. 2025;206:1418-1429.
    PubMed         Abstract available

  18. VICENTE-GARCES C, Fernandez G, Esperanza-Cebollada E, Richarte-Franques M, et al
    RNA-sequencing: A reliable tool to unveil transcriptional landscape of paediatric B-other acute lymphoblastic leukaemia.
    Br J Haematol. 2025;206:1355-1365.
    PubMed         Abstract available

  19. ZHENG Z, Wang W, Feng M, Chen X, et al
    The mechanism of EZH2/H3K27me3 downregulating CXCL10 to affect CD8(+) T cell exhaustion to participate in the transformation from myelodysplastic syndrome to acute myeloid leukaemia.
    Br J Haematol. 2025;206:1335-1349.
    PubMed         Abstract available

  20. SCARADAVOU A
    Cord blood transplants: Advancing leukaemia treatments and addressing health disparities.
    Br J Haematol. 2025;206:1312-1314.
    PubMed         Abstract available


    Cancer

  21. ATALLAH E, Lipton JH
    Has the time for treatment-free remission in Philadelphia chromosome-positive acute lymphoblastic leukemia arrived?
    Cancer. 2025;131:e35880.
    PubMed        


    Cancer Res

  22. BAYET M, Fregona V, Bouttier M, Rouzier C, et al
    Modeling the PAX5P80R Mutation Reveals HIF2alpha Activation as a Common Feature and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia.
    Cancer Res. 2025 May 12. doi: 10.1158/0008-5472.CAN-24-1698.
    PubMed         Abstract available

  23. CHEN Y, He L, Ianevski A, Nader K, et al
    A Machine Learning-Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia.
    Cancer Res. 2025 May 12. doi: 10.1158/0008-5472.CAN-24-3840.
    PubMed         Abstract available


    Exp Hematol

  24. LU J, Xue X, Wang H, Hao Y, et al
    Notch1 activation and inhibition in T cell acute lymphoblastic leukemia subtypes.
    Exp Hematol. 2025 May 8:104771. doi: 10.1016/j.exphem.2025.104771.
    PubMed         Abstract available


    J Clin Oncol

  25. KIRKWOOD AA, Goulden N, Moppett J, Samarasinghe S, et al
    High-Dose Methotrexate in Children and Young Adults With ALL and Lymphoblastic Lymphoma: Results of the Randomized Phase III Study UKALL 2011.
    J Clin Oncol. 2025 Apr 7:JCO2401851. doi: 10.1200/JCO-24-01851.
    PubMed         Abstract available


    J Pediatr Hematol Oncol

  26. DEANA A, Gomez SM, Fynn AB, Freigeiro D, et al
    Comparison of Consolidation Strategies for Pediatric Patients With Acute Myeloid Leukemia: Results of the Randomized GATLA 8-LMA-P'07 Trial.
    J Pediatr Hematol Oncol. 2025 May 12. doi: 10.1097/MPH.0000000000003028.
    PubMed         Abstract available


    Leuk Lymphoma

  27. TADMOR T, Lavie G, Melamed G, Alapi H, et al
    Intake of benzodiazepines in treatment naive chronic lymphocytic leukemia patients is associate with a shorter time to first treatment.
    Leuk Lymphoma. 2025 May 15:1-6. doi: 10.1080/10428194.2025.2504155.
    PubMed         Abstract available


    Leuk Res

  28. CAVALLARO G, Salmoiraghi S, Cavagna R, Pavoni C, et al
    Clinical impact of tyrosine kinases related mutations in NPM1 mutated acute myeloid leukaemia: A report from the Northern Italy Leukaemia Group (NILG) multicentre randomized trial 02/06.
    Leuk Res. 2025;153:107702.
    PubMed         Abstract available


    Leukemia

  29. KUHN MWM, Pemmaraju N, Heidel FH
    The evolving landscape of epigenetic target molecules and therapies in myeloid cancers: focus on acute myeloid leukemia and myeloproliferative neoplasms.
    Leukemia. 2025 May 15. doi: 10.1038/s41375-025-02639.
    PubMed         Abstract available

  30. NGUYEN NTK, Yao H, Hosokawa K, Esaki Y, et al
    Acute myeloid leukemia stem cells remodel the bone marrow niche via TGF-beta-activated Alcam(+) bone lining cells, creating a self-sustaining environment.
    Leukemia. 2025 May 13. doi: 10.1038/s41375-025-02640.
    PubMed        

  31. WANG'ONDU RW, Ashcraft E, Chang TC, Roberts KG, et al
    Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.
    Leukemia. 2025 May 13. doi: 10.1038/s41375-025-02633.
    PubMed         Abstract available

  32. BATALLER A, Goulart HE, Issa GC, DiNardo CD, et al
    Characteristics and outcomes of newly diagnosed acute myeloid Leukemia with KMT2A rearrangements.
    Leukemia. 2025 May 9. doi: 10.1038/s41375-025-02634.
    PubMed         Abstract available


    N Engl J Med

  33. FOA R
    Ph-Positive Acute Lymphoblastic Leukemia - 25 Years of Progress.
    N Engl J Med. 2025;392:1941-1952.
    PubMed        


    Oncogene

  34. LI YQ, Liu D, Wang LL, Shao YL, et al
    WTAP-mediated m(6)A methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML.
    Oncogene. 2025;44:1504-1516.
    PubMed         Abstract available


    Oncol Rep

  35. WANG C, Yang X, Shen X, Yan S, et al
    SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway.
    Oncol Rep. 2025;54:78.
    PubMed         Abstract available


    Proc Natl Acad Sci U S A

  36. HOSSEINI A, Qiu X, Xiong Y, Chiang KHN, et al
    Discovery of an LSD1 PROTAC degrader.
    Proc Natl Acad Sci U S A. 2025;122:e2425812122.
    PubMed         Abstract available


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