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Articles published in J Med Chem

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    June 2021
  1. VAN DER WESTHUYZEN R, Mabhula A, Njaria PM, Muller R, et al
    Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
    J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00707.
    PubMed     Abstract available

  2. WANG Z, Li J, Benin BM, Yu B, et al
    Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus.
    J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00656.
    PubMed     Abstract available

  3. NACLERIO GA, Sintim HO
    Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.
    J Med Chem. 2021;64:7272-7274.
    PubMed     Abstract available

  4. YANG H, Kundra S, Chojnacki M, Liu K, et al
    A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.
    J Med Chem. 2021;64:7275-7295.
    PubMed     Abstract available

    May 2021
  5. SUN W, Jian Y, Zhou M, Yao Y, et al
    Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile Ligands.
    J Med Chem. 2021 May 25. doi: 10.1021/acs.jmedchem.0c02257.
    PubMed     Abstract available

  6. KEOUGH DT, Wun SJ, Baszczynski O, Eng WS, et al
    Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
    J Med Chem. 2021;64:5710-5729.
    PubMed     Abstract available

  7. ZHANG H, Hsu HC, Kahne SC, Hara R, et al
    Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
    J Med Chem. 2021 May 5. doi: 10.1021/acs.jmedchem.1c00296.
    PubMed     Abstract available

    April 2021
  8. SHARMA A, De Rosa M, Singla N, Singh G, et al
    Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains.
    J Med Chem. 2021 Apr 7. doi: 10.1021/acs.jmedchem.0c01833.
    PubMed     Abstract available

    March 2021
  9. WU Y, Wang B, Lu H, Zhao H, et al
    Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens.
    J Med Chem. 2021;64:3234-3248.
    PubMed     Abstract available

    February 2021
  10. AZUAR A, Li Z, Shibu MA, Zhao L, et al
    Poly(hydrophobic amino acid)-Based Self-Adjuvanting Nanoparticles for Group A Streptococcus Vaccine Delivery.
    J Med Chem. 2021 Feb 2. doi: 10.1021/acs.jmedchem.0c01660.
    PubMed     Abstract available

    January 2021
  11. KANDALE A, Patel K, Hussein WM, Wun SJ, et al
    Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads.
    J Med Chem. 2021 Jan 29. doi: 10.1021/acs.jmedchem.0c01919.
    PubMed     Abstract available

  12. LI Z, Tu J, Han G, Liu N, et al
    Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2021;64:1116-1126.
    PubMed     Abstract available

    December 2020
  13. SHYAM M, Shilkar D, Verma H, Dev A, et al
    The Mycobactin Biosynthesis Pathway: A Prospective Therapeutic Target in the Battle against Tuberculosis.
    J Med Chem. 2020 Dec 29. doi: 10.1021/acs.jmedchem.0c01176.
    PubMed     Abstract available

  14. KUMAR G, Narayan R, Kapoor S
    Chemical Tools for Illumination of Tuberculosis Biology, Virulence Mechanisms, and Diagnosis.
    J Med Chem. 2020 Dec 13. doi: 10.1021/acs.jmedchem.0c01337.
    PubMed     Abstract available

    November 2020
  15. SCHEUPLEIN NJ, Bzdyl NM, Kibble EA, Lohr T, et al
    Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.
    J Med Chem. 2020;63:13355-13388.
    PubMed     Abstract available

  16. KARAS JA, Carter GP, Howden BP, Turner AM, et al
    Structure-Activity Relationships of Daptomycin Lipopeptides.
    J Med Chem. 2020;63:13266-13290.
    PubMed     Abstract available

  17. LIU W, Yuan L, Wang S
    Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall.
    J Med Chem. 2020;63:12429-12459.
    PubMed     Abstract available

    October 2020
  18. REHBERG N, Sommer GA, Driessen D, Kruppa M, et al
    Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2020 Oct 25. doi: 10.1021/acs.jmedchem.0c00826.
    PubMed     Abstract available

  19. BASARAB GS, Doig P, Eyermann CJ, Galullo V, et al
    Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
    J Med Chem. 2020;63:11882-11901.
    PubMed     Abstract available

    September 2020
  20. LIEUTAUD A, Pieri C, Bolla JM, Brunel JM, et al
    New Polyaminoisoprenyl Antibiotics Enhancers against Two Multidrug-Resistant Gram-Negative Bacteria from Enterobacter and Salmonella Species.
    J Med Chem. 2020;63:10496-10508.
    PubMed     Abstract available

  21. FEI Y, Wu J, An HW, Zhu K, et al
    Identification of New Nitric Oxide-Donating Peptides with Dual Biofilm Eradication and Antibacterial Activities for Intervention of Device-Related Infections.
    J Med Chem. 2020;63:9127-9135.
    PubMed     Abstract available

  22. ETAYASH H, Pletzer D, Kumar P, Straus SK, et al
    Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
    J Med Chem. 2020;63:9228-9236.
    PubMed     Abstract available

    August 2020
  23. NAM S, Ham SY, Kwon H, Kim HS, et al
    Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections.
    J Med Chem. 2020;63:8388-8407.
    PubMed     Abstract available

  24. KONSTANTINOVIC J, Yahiaoui S, Alhayek A, Haupenthal J, et al
    N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
    J Med Chem. 2020;63:8359-8368.
    PubMed     Abstract available

  25. KAUR J, Cao X, Abutaleb NS, Elkashif A, et al
    Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus.
    J Med Chem. 2020 Aug 11. doi: 10.1021/acs.jmedchem.0c00734.
    PubMed     Abstract available

  26. RUDDRARAJU KV, Aggarwal D, Niu C, Baker EA, et al
    Highly Potent and Selective N-aryl Oxamic Acid Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (mPTPB).
    J Med Chem. 2020 Aug 5. doi: 10.1021/acs.jmedchem.0c00302.
    PubMed     Abstract available

    July 2020
  27. HECKER SJ, Reddy KR, Lomovskaya O, Griffith DC, et al
    Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases.
    J Med Chem. 2020;63:7491-7507.
    PubMed     Abstract available

  28. SABBAH M, Mendes V, Vistal RG, Dias DMG, et al
    Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.
    J Med Chem. 2020 Jul 22. doi: 10.1021/acs.jmedchem.0c01187.

  29. ZHAO H, Wang B, Fu L, Li G, et al
    The Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis.
    J Med Chem. 2020 Jul 15. doi: 10.1021/acs.jmedchem.0c00500.
    PubMed     Abstract available

  30. BLAKE S, Thanissery R, Rivera AJ, Hixon MS, et al
    Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice.
    J Med Chem. 2020;63:6898-6908.
    PubMed     Abstract available

  31. YANG T, Zhang T, Guan X, Dong Z, et al
    Tideglusib and its analogs as inhibitors of Staphylococcus aureus SrtA.
    J Med Chem. 2020 Jul 8. doi: 10.1021/acs.jmedchem.0c00803.
    PubMed     Abstract available

    June 2020
  32. FERNANDES P, Pereira D, Watkins PB, Bertrand D, et al
    Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics.
    J Med Chem. 2020;63:6462-6473.
    PubMed     Abstract available

  33. MORI M, Stelitano G, Gelain A, Pini E, et al
    Shedding X-ray light on the role of magnesium in the activity of M. tuberculosis salicylate synthase (MbtI) for drug design.
    J Med Chem. 2020 Jun 12. doi: 10.1021/acs.jmedchem.0c00373.
    PubMed     Abstract available

  34. LIN S, Li H, Tao Y, Liu J, et al
    In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria.
    J Med Chem. 2020;63:5797-5815.
    PubMed     Abstract available

    May 2020
  35. HAN G, Liu N, Li C, Tu J, et al
    Discovery of Novel Fungal Lanosterol 14alpha-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
    J Med Chem. 2020;63:5341-5359.
    PubMed     Abstract available

  36. BALABON O, Pitta E, Rogacki MK, Meiler E, et al
    Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-beta-d-Ribose Oxidase (DprE1) Inhibitors.
    J Med Chem. 2020;63:5367-5386.
    PubMed     Abstract available

    April 2020
  37. MADGE HYR, Sharma H, Hussein WM, Khalil ZG, et al
    Structure-Activity Analysis of Cyclic Multicomponent Lipopeptide Self-Adjuvanting Vaccine Candidates Presenting Group A Streptococcus Antigens.
    J Med Chem. 2020 Apr 29. doi: 10.1021/acs.jmedchem.0c00203.
    PubMed     Abstract available

  38. L MOURE A, Narula G, Sorrentino F, Bojang A, et al
    A MymA bioactivated thioalkyl-benzoxazole prodrug family active against Mycobacterium tuberculosis.
    J Med Chem. 2020 Apr 10. doi: 10.1021/acs.jmedchem.0c00003.
    PubMed     Abstract available

  39. MAYANDI V, Xi Q, Leng Goh ET, Koh SK, et al
    Rational Substitution of epsilon-Lysine for alpha-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin.
    J Med Chem. 2020;63:3522-3537.
    PubMed     Abstract available

  40. MAVRIDIS IM, Yannakopoulou K
    Porphyrinoid-Cyclodextrin Assemblies in Biomedical Research: An Update.
    J Med Chem. 2020;63:3391-3424.
    PubMed     Abstract available

  41. MAKAROV V, Salina E, Reynolds RC, Kyaw Zin PP, et al
    Molecule Property Analyses of Active Compounds for Mycobacterium Tuberculosis.
    J Med Chem. 2020 Apr 7. doi: 10.1021/acs.jmedchem.9b02075.
    PubMed     Abstract available

  42. SABBAH M, Mendes V, Vistal RG, Dias DM, et al
    Fragment-based design of Mycobacterium tuberculosis InhA inhibitors.
    J Med Chem. 2020 Apr 2. doi: 10.1021/acs.jmedchem.0c00007.
    PubMed     Abstract available

    March 2020
  43. LIU B, Trout REL, Chu GH, McGarry D, et al
    Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
    J Med Chem. 2020;63:2789-2801.
    PubMed     Abstract available

  44. CHOW HY, Po KHL, Gao P, Blasco P, et al
    Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens.
    J Med Chem. 2020;63:3161-3171.
    PubMed     Abstract available

  45. JU Y, He L, Zhou Y, Yang T, et al
    Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
    J Med Chem. 2020;63:3104-3119.
    PubMed     Abstract available

  46. MOTA F, Ordonez AA, Firth G, Ruiz-Bedoya CA, et al
    Radiotracer Development for Bacterial Imaging.
    J Med Chem. 2020;63:1964-1977.
    PubMed     Abstract available

  47. GONZALEZ-BELLO C, Rodriguez D, Pernas M, Rodriguez A, et al
    beta-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs.
    J Med Chem. 2020;63:1859-1881.
    PubMed     Abstract available

  48. DENNIS EK, Kim JH, Parkin S, Awuah SG, et al
    Distorted Gold(I)-Phosphine Complexes as Antifungal Agents.
    J Med Chem. 2020;63:2455-2469.
    PubMed     Abstract available

  49. HUANG DS, LeBlanc EV, Shekhar-Guturja T, Robbins N, et al
    Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors.
    J Med Chem. 2020;63:2139-2180.
    PubMed     Abstract available

    February 2020
  50. HUFF LM, Horibata S, Robey RW, Hall MD, et al
    Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale.
    J Med Chem. 2020;63:1434-1439.
    PubMed     Abstract available

    January 2020
  51. BORTHWICK JA, Alemparte C, Wall I, Whitehurst BC, et al
    Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase inhibitors: expeditious reconstruction of sub-optimal hits into a series with potent in vivo activity.
    J Med Chem. 2020 Jan 10. doi: 10.1021/acs.jmedchem.9b01561.
    PubMed     Abstract available

  52. PANCHAUD P, Surivet JP, Diethelm S, Blumstein AC, et al
    Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration.
    J Med Chem. 2020;63:88-102.
    PubMed     Abstract available

  53. SURIVET JP, Panchaud P, Specklin JL, Diethelm S, et al
    Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria.
    J Med Chem. 2020;63:66-87.
    PubMed     Abstract available

    December 2019
  54. RYTER K, Ettenger G, Rasheed OK, Buhl C, et al
    Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis.
    J Med Chem. 2019 Dec 6. doi: 10.1021/acs.jmedchem.9b01598.
    PubMed     Abstract available

    October 2019
  55. HORSWILL AR, Gordon CP
    Structure-Activity-Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
    J Med Chem. 2019 Oct 28. doi: 10.1021/acs.jmedchem.9b00798.
    PubMed     Abstract available

  56. RAJPUT S, McLean KJ, Poddar H, Selvam I, et al
    Structure-activity relationships of cyclo(L-tyrosyl-L-tyrosine) derivatives binding to Mycobacterium tuberculosis CYP121: iodinated analogues promote shift to high-spin adduct.
    J Med Chem. 2019 Oct 16. doi: 10.1021/acs.jmedchem.9b01199.
    PubMed     Abstract available

    September 2019
  57. ZHAN W, Hsu HC, Morgan T, Ouellette T, et al
    Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome.
    J Med Chem. 2019 Sep 27. doi: 10.1021/acs.jmedchem.9b01187.
    PubMed     Abstract available

  58. WHITEHOUSE AJ, Libardo MDJ, Kasbekar M, Brear PD, et al
    Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode.
    J Med Chem. 2019 Sep 13. doi: 10.1021/acs.jmedchem.9b01203.
    PubMed     Abstract available

    August 2019
  59. ASHHURST A, McDonald D, Hanna C, Stanojevic V, et al
    Mucosal vaccination with a self-adjuvanted lipopeptide is immunogenic and protective against Mycobacterium tuberculosis.
    J Med Chem. 2019 Aug 2. doi: 10.1021/acs.jmedchem.9b00832.
    PubMed     Abstract available

    June 2019
  60. KULKARNI A, Soni I, Kelkar D, Dharmaraja AT, et al
    Chemoproteomics of an Indole-Based Quinone-Epoxide identifies druggable vulnerabilities in Vancomycin Resistant Staphylococcus aureus (VRSA).
    J Med Chem. 2019 Jun 26. doi: 10.1021/acs.jmedchem.9b00774.
    PubMed     Abstract available

    April 2019
  61. CRESPO RA, Dang Q, Zhou NE, Guthrie LM, et al
    Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
    J Med Chem. 2019 Apr 19. doi: 10.1021/acs.jmedchem.9b00020.
    PubMed     Abstract available

    March 2019
  62. ZHANG W, Lun S, Liu LL, Xiao S, et al
    Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
    J Med Chem. 2019 Mar 15. doi: 10.1021/acs.jmedchem.9b00010.
    PubMed     Abstract available

    February 2019
  63. WANG X, Zeng Y, Sheng L, Larson P, et al
    A Cinchona Alkaloid Antibiotic that Appears to Target ATP Synthase in Streptococcus pneumoniae.
    J Med Chem. 2019 Feb 19. doi: 10.1021/acs.jmedchem.8b01353.
    PubMed     Abstract available

  64. TU J, Li Z, Jiang Y, Ji C, et al
    Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis.
    J Med Chem. 2019 Feb 12. doi: 10.1021/acs.jmedchem.8b01598.
    PubMed     Abstract available

    November 2018
  65. GUARDIA A, Baiget J, Cacho M, Perez A, et al
    Easy-to-Synthesize Spirocyclic Compounds Possess Remarkable In Vivo Activity Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Nov 20. doi: 10.1021/acs.jmedchem.8b01533.
    PubMed     Abstract available

  66. KUNKLE T, Abdeen S, Salim N, Ray AM, et al
    Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus.
    J Med Chem. 2018 Nov 4. doi: 10.1021/acs.jmedchem.8b01293.
    PubMed     Abstract available

  67. MIZAR P, Arya R, Kim T, Cha S, et al
    Total synthesis of Xanthoangelol B and its various fragments: towards inhibition of virulence factor production of Staphylococcus aureus.
    J Med Chem. 2018 Nov 2. doi: 10.1021/acs.jmedchem.8b01012.
    PubMed     Abstract available

    August 2018
  68. VICKERS C, Silva A, Chakraborty A, Fernandez P, et al
    Structure-based design of MptpB inhibitors that reduce multi-drug-resistant Mycobacterium tuberculosis survival and infection burden in vivo.
    J Med Chem. 2018 Aug 28. doi: 10.1021/acs.jmedchem.8b00832.
    PubMed     Abstract available

    July 2018
  69. ABDEEN S, Kunkle T, Salim N, Ray AM, et al
    Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2018 Jul 30. doi: 10.1021/acs.jmedchem.8b00989.
    PubMed     Abstract available

    June 2018
  70. CLEGHORN LAT, Ray P, Odingo J, Kumar A, et al
    Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
    J Med Chem. 2018 Jun 26. doi: 10.1021/acs.jmedchem.8b00172.
    PubMed     Abstract available

    May 2018
  71. CHIKHALE RV, Barmade MA, Murumkar PR, Yadav MR, et al
    An Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis.
    J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.8b00281.
    PubMed     Abstract available

  72. CHACKO S, Boshoff HIM, Singh V, Ferraris DM, et al
    Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.
    J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.7b01839.
    PubMed     Abstract available

    March 2018
  73. TRAPERO A, Pacitto A, Singh V, Sabbah M, et al
    Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
    J Med Chem. 2018 Mar 23. doi: 10.1021/acs.jmedchem.7b01622.
    PubMed     Abstract available

  74. SONG L, Merceron R, Gracia B, Quintana AL, et al
    Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors.
    J Med Chem. 2018 Mar 6. doi: 10.1021/acs.jmedchem.7b01570.
    PubMed     Abstract available

    February 2018
  75. CAI S, Qiao X, Feng L, Shi N, et al
    Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality.
    J Med Chem. 2018 Feb 21. doi: 10.1021/acs.jmedchem.8b00036.
    PubMed     Abstract available

    January 2018
  76. PARMAR A, Lakshminarayanan R, Iyer A, Mayandi V, et al
    Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE) in vitro and in vivo.
    J Med Chem. 2018 Jan 24. doi: 10.1021/acs.jmedchem.7b01634.
    PubMed     Abstract available

  77. ZHANG W, Lun S, Wang SH, Jiang X, et al
    Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Jan 12. doi: 10.1021/acs.jmedchem.7b01319.
    PubMed     Abstract available

    December 2017
  78. GUAN D, Chen F, Xiong L, Tang F, et al
    Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
    J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01345.
    PubMed     Abstract available

  79. CAMERON AJ, Edwards PJB, Harjes E, Sarojini V, et al
    Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
    J Med Chem. 2017;60:9565-9574.
    PubMed     Abstract available

  80. MOON SH, Zhang X, Zheng G, Meeker DG, et al
    Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin.
    J Med Chem. 2017;60:9630-9640.
    PubMed     Abstract available

  81. CHOI H, Ham SY, Cha E, Shin Y, et al
    Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents.
    J Med Chem. 2017;60:9821-9837.
    PubMed     Abstract available

    October 2017
  82. GOOD JAD, Kulen M, Silver J, Krishnan KS, et al
    Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity.
    J Med Chem. 2017 Oct 20. doi: 10.1021/acs.jmedchem.7b00716.
    PubMed     Abstract available

    September 2017
  83. LI X, Hernandez V, Rock FL, Choi W, et al
    Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
    J Med Chem. 2017 Sep 27. doi: 10.1021/acs.jmedchem.7b00631.
    PubMed     Abstract available

  84. BUCHIERI MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, et al
    Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.
    J Med Chem. 2017;60:7425-7433.
    PubMed     Abstract available

  85. CHEN AY, Thomas PW, Stewart AC, Bergstrom A, et al
    Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-beta-lactamase-1.
    J Med Chem. 2017;60:7267-7283.
    PubMed     Abstract available

  86. ABDEL MONAIM SAH, Ramchuran EJ, El-Faham A, Albericio F, et al
    Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
    J Med Chem. 2017;60:7476-7482.
    PubMed     Abstract available

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