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Bacterial Infections and Mycoses

Free Subscription Articles published in J Med Chem Retrieve available abstracts of 97 articles: HTML format

Single Articles

March 2024
1. YANG W, Liu R, Li Z, Tu J, et al
   Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis.
   J Med Chem. 2024;67:4726-4738.
   PubMed     Abstract available
   
   
   
2. MUSZALSKA-KOLOS I, Dwiecki PM
   Searching for Conjugates as New Structures for Antifungal Therapies.
   J Med Chem. 2024;67:4298-4321.
   PubMed     Abstract available
   
   
   
3. FRANCO AR, Sadones O, Romerio A, Artusa V, et al
   Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.
   J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02215.
   PubMed     Abstract available
   
   
   
4. XU T, Yan X, Kang A, Yang L, et al
   Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus.
   J Med Chem. 2024 Mar 16. doi: 10.1021/acs.jmedchem.4c00436.
   PubMed     Abstract available
   
   
   
5. HEIDTMANN CV, Fejer AR, Staerk K, Pedersen M, et al
   Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
   J Med Chem. 2024;67:3692-3710.
   PubMed     Abstract available
   
   
   
6. XIE F, Hao Y, Liu Y, Bao J, et al
   From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo.
   J Med Chem. 2024;67:4007-4025.
   PubMed     Abstract available
   
   
   
7. HUANG Z, Gou X, Hang X, Shi T, et al
   Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus.
   J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02355.
   PubMed     Abstract available
   
   
   February 2024
8. NEGI A, Perveen S, Gupta R, Singh PP, et al
   Unraveling Dilemmas and Lacunae in the Escalating Drug Resistance of Mycobacterium tuberculosis to Bedaquiline, Delamanid, and Pretomanid.
   J Med Chem. 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c01892.
   PubMed     Abstract available
   
   
   
9. CUI Y, Lanne A, Peng X, Browne E, et al
   Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly.
   J Med Chem. 2024 Feb 8. doi: 10.1021/acs.jmedchem.3c01643.
   PubMed     Abstract available
   
   
   
10. MADDIRALA AR, Pinkner JS, Tamadonfar K, Sanick D, et al
    Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
    J Med Chem. 2024 Feb 3. doi: 10.1021/acs.jmedchem.3c02128.
    PubMed     Abstract available
    
    
    January 2024
11. GUO W, Yang Z, Wang K, Li W, et al
    Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2024 Jan 30. doi: 10.1021/acs.jmedchem.3c02064.
    PubMed     Abstract available
    
    
    
12. SOUKARIEH F, Mashabi A, Richardson W, Oton EV, et al
    Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections.
    J Med Chem. 2024;67:1008-1023.
    PubMed     Abstract available
    
    
    
13. YANG L, Hu X, Lu Y, Xu R, et al
    Discovery of N-(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis.
    J Med Chem. 2024 Jan 17. doi: 10.1021/acs.jmedchem.3c01703.
    PubMed     Abstract available
    
    
    
14. GALLARDO-MACIAS R, Russo R, Sherwood M, Jaskowski M, et al
    Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection.
    J Med Chem. 2024 Jan 15. doi: 10.1021/acs.jmedchem.3c01846.
    PubMed     Abstract available
    
    
    
15. SANYAL K, Haldar J, Lindsley CW, Chibale K, et al
    Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery.
    J Med Chem. 2024;67:1.
    PubMed    
    
    
    
16. CUN WY, Bate CE, Srikhanta YN, Hutton ML, et al
    Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile.
    J Med Chem. 2024;67:450-466.
    PubMed     Abstract available
    
    
    
17. LI C, Zhou Z, Wang W, Zhao Y, et al
    Development of Antibacterial Peptides with Membrane Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Jan 3. doi: 10.1021/acs.jmedchem.3c01360.
    PubMed     Abstract available
    
    
    
18. YUE C, Yuan Z, Xu G, Guan XN, et al
    Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent Staphylococcus aureus Sortase A Inhibitors.
    J Med Chem. 2024 Jan 3. doi: 10.1021/acs.jmedchem.3c01615.
    PubMed     Abstract available
    
    
    December 2023
19. RENARD S, Versluys S, Taillier T, Dubarry N, et al
    Optimization of the Antibacterial Spectrum and the Developability Profile of the Novel-Class Natural Product Corramycin.
    J Med Chem. 2023;66:16869-16887.
    PubMed     Abstract available
    
    
    
20. OLIVEIRA NJC, Dos Santos Junior VS, Pierotte IC, Leocadio VAT, et al
    Discovery of Lead 2-Thiazolylhydrazones with Broad-Spectrum and Potent Antifungal Activity.
    J Med Chem. 2023;66:16628-16645.
    PubMed     Abstract available
    
    
    
21. LIN H, Song L, Zhou S, Fan C, et al
    A Hybrid Antimicrobial Peptide Targeting Staphylococcus aureus with a Dual Function of Inhibiting Quorum Sensing Signaling and an Antibacterial Effect.
    J Med Chem. 2023 Dec 15. doi: 10.1021/acs.jmedchem.3c02027.
    PubMed     Abstract available
    
    
    
22. LIN Y, Jung H, Bulman CA, Ng J, et al
    Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry.
    J Med Chem. 2023;66:15867-15882.
    PubMed     Abstract available
    
    
    
23. MIAO ZY, Zhang XY, Yang MH, Huang YJ, et al
    3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa.
    J Med Chem. 2023;66:15823-15846.
    PubMed     Abstract available
    
    
    
24. LI L, Wu H, Wang J, Ji Z, et al
    Discovery of Novel 8-Hydroxyquinoline Derivatives with Potent In Vitro and In Vivo Antifungal Activity.
    J Med Chem. 2023;66:16364-16376.
    PubMed     Abstract available
    
    
    
25. YANG Y, Zhao N, Xu X, Zhou Y, et al
    Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors.
    J Med Chem. 2023 Dec 13. doi: 10.1021/acs.jmedchem.3c01054.
    PubMed     Abstract available
    
    
    November 2023
26. CEBULA J, Fink K, Goldeman W, Szermer-Olearnik B, et al
    Structural Patterns Enhancing the Antibacterial Activity of Metallacarborane-Based Antibiotics.
    J Med Chem. 2023;66:14948-14962.
    PubMed     Abstract available
    
    
    October 2023
27. KARAN S, Cho MY, Lee H, Kim HM, et al
    Hypoxia-Directed and Self-Immolative Theranostic Agent: Imaging and Treatment of Cancer and Bacterial Infections.
    J Med Chem. 2023;66:14175-14187.
    PubMed     Abstract available
    
    
    
28. BARBACHYN MR
    Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat.
    J Med Chem. 2023;66:13888-13890.
    PubMed     Abstract available
    
    
    
29. WANG F, Wu J, Yuan M, Yan Z, et al
    Novel Nitric Oxide Donor-Azole Conjugation Strategy for Efficient Treatment of Cryptococcus neoformans Infections.
    J Med Chem. 2023;66:14221-14240.
    PubMed     Abstract available
    
    
    
30. LIMWONGYUT J, Moreland AS, Zhang K, Raynor M, et al
    Amidine-Based Cationic Conjugated Oligoelectrolytes with Antimicrobial Activity against Pseudomonas aeruginosa Biofilms.
    J Med Chem. 2023;66:14303-14314.
    PubMed     Abstract available
    
    
    
31. KIM D, Lee J, Shyaka C, Kwak JH, et al
    Identification of Micrococcin P2-Derivatives as Antibiotic Candidates against Two Gram-Positive Pathogens.
    J Med Chem. 2023;66:14263-14277.
    PubMed     Abstract available
    
    
    
32. QIAN Y, Birhanu BT, Yang J, Ding D, et al
    A Potent and Narrow-Spectrum Antibacterial against Clostridioides difficile Infection.
    J Med Chem. 2023;66:13891-13899.
    PubMed     Abstract available
    
    
    
33. NANDAKUMAR M, Ollodart A, Fleck N, Kapadia NR, et al
    Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline.
    J Med Chem. 2023 Oct 23. doi: 10.1021/acs.jmedchem.3c01273.
    PubMed     Abstract available
    
    
    
34. PESLALZ P, Grieshober M, Kraus F, Bleisch A, et al
    Unnatural Endotype B PPAPs as Novel Compounds with Activity against Mycobacterium tuberculosis.
    J Med Chem. 2023 Oct 12. doi: 10.1021/acs.jmedchem.3c01172.
    PubMed     Abstract available
    
    
    
35. WANG X, Jin X, Xie Z, Zhang H, et al
    Benzamidine Conjugation Converts Expelled Potential Active Agents into Antifungals against Drug-Resistant Fungi.
    J Med Chem. 2023;66:13684-13704.
    PubMed     Abstract available
    
    
    September 2023
36. YAN Z, Huang Y, Zhao D, Li Z, et al
    Developing Novel Coumarin-Containing Azoles Antifungal Agents by the Scaffold Merging Strategy for Treating Azole-Resistant Candidiasis.
    J Med Chem. 2023;66:13247-13265.
    PubMed     Abstract available
    
    
    
37. WANG Q, Tu J, Yang W, Liang T, et al
    Discovery of Pyrazolone Carbothioamide Derivatives as Inhibitors of the Pdr1-KIX Interaction for Combinational Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2023;66:11893-11904.
    PubMed     Abstract available
    
    
    
38. GOGDE K, Paul S, Pujari AK, Yadav AK, et al
    Synthesis of Metallo-Chromone Porphyrin Nano-Starch Sensitizers as Photodynamic Therapeutics for the Eradication of Enterococci Dental Pathogens.
    J Med Chem. 2023 Sep 6. doi: 10.1021/acs.jmedchem.3c01087.
    PubMed     Abstract available
    
    
    August 2023
39. DEY S, Patel A, Haloi N, Srimayee S, et al
    Quinoline Thiourea-Based Zinc Ionophores with Antibacterial Activity.
    J Med Chem. 2023;66:11078-11093.
    PubMed     Abstract available
    
    
    July 2023
40. SARKAR S, Mayer Bridwell AE, Good JAD, Wang ER, et al
    Design, Synthesis, and Evaluation of Novel Delta(2)-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant.
    J Med Chem. 2023 Jul 24. doi: 10.1021/acs.jmedchem.3c00358.
    PubMed     Abstract available
    
    
    
41. VENNARD C, Oropo T, Sintim HO
    Engineered Vancomycin, with Increased Interactions with Peptidoglycan Stem Peptide, Conquers Non-tuberculosis Mycobacteria.
    J Med Chem. 2023 Jul 21. doi: 10.1021/acs.jmedchem.3c01219.
    PubMed     Abstract available
    
    
    June 2023
42. KOTEVA K, Xu M, Wang W, Fiebig-Comyn AA, et al
    Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus.
    J Med Chem. 2023 Jun 14. doi: 10.1021/acs.jmedchem.3c00633.
    PubMed     Abstract available
    
    
    
43. BENDOVA K, Raclavsky V, Novotny R, Luptakova D, et al
    [(68)Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography.
    J Med Chem. 2023;66:7584-7593.
    PubMed     Abstract available
    
    
    
44. AHIRWAR P, Kozlovskaya V, Nijampatnam B, Rojas EM, et al
    Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity of Streptococcus mutans.
    J Med Chem. 2023 Jun 7. doi: 10.1021/acs.jmedchem.3c00272.
    PubMed     Abstract available
    
    
    May 2023
45. MALWAL SR, Mazurek B, Ko J, Xie P, et al
    Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
    J Med Chem. 2023 May 26. doi: 10.1021/acs.jmedchem.3c00398.
    PubMed     Abstract available
    
    
    
46. KONG H, Qin S, Yan D, Shen B, et al
    Development of Aromatic-Linked Diamino Acid Antimicrobial Peptide Mimics with Low Hemolytic Toxicity and Excellent Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2023 May 16. doi: 10.1021/acs.jmedchem.2c01583.
    PubMed     Abstract available
    
    
    April 2023
47. LANG M, Ganapathy US, Mann L, Abdelaziz R, et al
    Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
    J Med Chem. 2023;66:5079-5098.
    PubMed     Abstract available
    
    
    
48. TAN YM, Wang Y, Li S, Zhang SL, et al
    Azolylpyrimidinediols as Novel Structural Scaffolds of DNA-Groove Binders against Intractable Acinetobacter baumannii.
    J Med Chem. 2023;66:4910-4931.
    PubMed     Abstract available
    
    
    
49. LI Z, Huang Y, Tu J, Yang W, et al
    Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicans.
    J Med Chem. 2023 Apr 10. doi: 10.1021/acs.jmedchem.3c00165.
    PubMed     Abstract available
    
    
    March 2023
50. DURCIK M, Cotman AE, Toplak Z, Mozina S, et al
    New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
    J Med Chem. 2023 Mar 6. doi: 10.1021/acs.jmedchem.2c01905.
    PubMed     Abstract available
    
    
    February 2023
51. PATIL NA, Ma W, Jiang X, He X, et al
    Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity.
    J Med Chem. 2023;66:2865-2876.
    PubMed     Abstract available
    
    
    
52. TENG P, Shao H, Huang B, Xie J, et al
    Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy To Combat Bacterial Resistance.
    J Med Chem. 2023;66:2211-2234.
    PubMed     Abstract available
    
    
    
53. WANG YY, Zhang XY, Zhong XL, Huang YJ, et al
    Design and Synthesis of 3-Hydroxy-pyridin-4(1H)-ones-Ciprofloxacin Conjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa.
    J Med Chem. 2023;66:2169-2193.
    PubMed     Abstract available
    
    
    
54. LI C, Tian X, Huang Z, Gou X, et al
    Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis.
    J Med Chem. 2023 Feb 3. doi: 10.1021/acs.jmedchem.2c01647.
    PubMed     Abstract available
    
    
    January 2023
55. HUANG Y, Liu N, Pan Z, Li Z, et al
    BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.
    J Med Chem. 2023;66:1239-1253.
    PubMed     Abstract available
    
    
    
56. BHATTARAI P, Hegde P, Li W, Prathipati PK, et al
    Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.
    J Med Chem. 2023;66:170-187.
    PubMed     Abstract available
    
    
    December 2022
57. CHENG W, Xu T, Cui L, Xue Z, et al
    Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2022 Dec 30. doi: 10.1021/acs.jmedchem.2c01793.
    PubMed     Abstract available
    
    
    
58. MANDAL M, Xiao L, Pan W, Scapin G, et al
    Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
    J Med Chem. 2022;65:16234-16251.
    PubMed     Abstract available
    
    
    
59. YANG R, Hou E, Cheng W, Yan X, et al
    Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.
    J Med Chem. 2022 Dec 13. doi: 10.1021/acs.jmedchem.2c01674.
    PubMed     Abstract available
    
    
    November 2022
60. GUO X, Yan T, Rao J, An Y, et al
    Novel Feleucin-K3-Derived Peptides Modified with Sulfono-gamma-AA Building Blocks Targeting Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus Infections.
    J Med Chem. 2022 Nov 9. doi: 10.1021/acs.jmedchem.2c01396.
    PubMed     Abstract available
    
    
    
61. SAINI V, Mehta D, Gupta S, Kumar S, et al
    Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates.
    J Med Chem. 2022 Nov 4. doi: 10.1021/acs.jmedchem.2c01293.
    PubMed     Abstract available
    
    
    October 2022
62. MEIERS J, Rox K, Titz A
    Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release.
    J Med Chem. 2022;65:13988-14014.
    PubMed     Abstract available
    
    
    
63. KUBINSKI K, Maslyk M, Janeczko M, Goldeman W, et al
    Metallacarborane Derivatives as Innovative Anti-Candida albicans Agents.
    J Med Chem. 2022 Oct 11. doi: 10.1021/acs.jmedchem.2c01167.
    PubMed     Abstract available
    
    
    September 2022
64. ZHANG W, Lun S, Wang SS, Cai YP, et al
    Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment.
    J Med Chem. 2022 Sep 29. doi: 10.1021/acs.jmedchem.2c01064.
    PubMed     Abstract available
    
    
    
65. ANG CW, Lee BM, Jackson CJ, Wang Y, et al
    Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
    J Med Chem. 2022 Sep 16. doi: 10.1021/acs.jmedchem.2c00972.
    PubMed     Abstract available
    
    
    August 2022
66. LI L, Wu H, Zhu S, Ji Z, et al
    Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species.
    J Med Chem. 2022;65:11257-11269.
    PubMed     Abstract available
    
    
    
67. HE T, Xu L, Hu Y, Tang X, et al
    Lysine-Tethered Stable Bicyclic Cationic Antimicrobial Peptide Combats Bacterial Infection in Vivo.
    J Med Chem. 2022;65:10523-10533.
    PubMed     Abstract available
    
    
    
68. LI C, Liu S, Dong B, Li C, et al
    Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors.
    J Med Chem. 2022 Aug 4. doi: 10.1021/acs.jmedchem.2c00289.
    PubMed     Abstract available
    
    
    
69. ZHAO H, Gao Y, Li W, Sheng L, et al
    Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis.
    J Med Chem. 2022 Aug 1. doi: 10.1021/acs.jmedchem.2c00718.
    PubMed     Abstract available
    
    
    July 2022
70. BEN HUR D, Kapach G, Wani NA, Kiper E, et al
    Antimicrobial Peptides against Multidrug-Resistant Pseudomonas aeruginosa Biofilm from Cystic Fibrosis Patients.
    J Med Chem. 2022;65:9050-9062.
    PubMed     Abstract available
    
    
    June 2022
71. BURASTERO O, Defelipe LA, Gola G, Tateosian NL, et al
    Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
    J Med Chem. 2022 Jun 23. doi: 10.1021/acs.jmedchem.1c02012.
    PubMed     Abstract available
    
    
    
72. ZHANG X, Wang M, Zhu X, Peng Y, et al
    Development of Lipo-gamma-AA Peptides as Potent Antifungal Agents.
    J Med Chem. 2022;65:8029-8039.
    PubMed     Abstract available
    
    
    May 2022
73. WU Y, Jiang W, Cong Z, Chen K, et al
    An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections.
    J Med Chem. 2022;65:7296-7311.
    PubMed     Abstract available
    
    
    
74. FERNANDES GFS, Thompson AM, Castagnolo D, Denny WA, et al
    Tuberculosis Drug Discovery: Challenges and New Horizons.
    J Med Chem. 2022 May 25. doi: 10.1021/acs.jmedchem.2c00227.
    PubMed     Abstract available
    
    
    
75. KOKOT M, Anderluh M, Hrast M, Minovski N, et al
    The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.
    J Med Chem. 2022;65:6431-6440.
    PubMed     Abstract available
    
    
    
76. NACLERIO GA, Abutaleb NS, Onyedibe KI, Karanja C, et al
    Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.
    J Med Chem. 2022;65:6612-6630.
    PubMed     Abstract available
    
    
    
77. LI W, Yun Z, Ji C, Tu J, et al
    Discovery of Novel Sertraline Derivatives as Potent Anti-Cryptococcus Agents.
    J Med Chem. 2022;65:6541-6554.
    PubMed     Abstract available
    
    
    April 2022
78. GURVIC D, Leach AG, Zachariae U
    Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria.
    J Med Chem. 2022;65:6088-6099.
    PubMed     Abstract available
    
    
    
79. LELLA M, Oh MW, Kuo SH, Lau GW, et al
    Attenuating the Streptococcus pneumoniae Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs.
    J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.2c00148.
    PubMed     Abstract available
    
    
    
80. YIN W, Wu T, Liu L, Jiang H, et al
    Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2022;65:5539-5564.
    PubMed     Abstract available
    
    
    March 2022
81. MA Z, He S, Yuan Y, Zhuang Z, et al
    Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
    J Med Chem. 2022;65:4481-4495.
    PubMed     Abstract available
    
    
    
82. KOBAURI P, Galenkamp NS, Schulte AM, de Vries J, et al
    Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors.
    J Med Chem. 2022;65:4798-4817.
    PubMed     Abstract available
    
    
    February 2022
83. ACEBRON-GARCIA-DE-EULATE M, Mayol-Llinas J, Holland MTO, Kim SY, et al
    Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
    J Med Chem. 2022;65:2149-2173.
    PubMed     Abstract available
    
    
    
84. MODAK B, Girkar S, Narayan R, Kapoor S, et al
    Mycobacterial Membranes as Actionable Targets for Lipid-Centric Therapy in Tuberculosis.
    J Med Chem. 2022 Feb 8. doi: 10.1021/acs.jmedchem.1c01870.
    PubMed     Abstract available
    
    
    January 2022
85. OTTAVI S, Scarry SM, Mosior J, Ling Y, et al
    In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
    J Med Chem. 2022 Jan 19. doi: 10.1021/acs.jmedchem.1c01565.
    PubMed     Abstract available
    
    
    
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