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Articles published in PLoS Med

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    July 2021
  1. YU S, Sohn H, Kim HY, Kim H, et al
    Evaluating the impact of the nationwide public-private mix (PPM) program for tuberculosis under National Health Insurance in South Korea: A difference in differences analysis.
    PLoS Med. 2021;18:e1003717.
    PubMed     Abstract available


    May 2021
  2. CATTAMANCHI A, Crowder R, Kityamuwesi A, Kiwanuka N, et al
    Digital adherence technology for tuberculosis treatment supervision: A stepped-wedge cluster-randomized trial in Uganda.
    PLoS Med. 2021;18:e1003628.
    PubMed     Abstract available


    April 2021
  3. CALDERWOOD CJ, Wilson JP, Fielding KL, Harris RC, et al
    Dynamics of sputum conversion during effective tuberculosis treatment: A systematic review and meta-analysis.
    PLoS Med. 2021;18:e1003566.
    PubMed     Abstract available


    February 2021
  4. KLEYNHANS J, Tempia S, Shioda K, von Gottberg A, et al
    Estimated impact of the pneumococcal conjugate vaccine on pneumonia mortality in South Africa, 1999 through 2016: An ecological modelling study.
    PLoS Med. 2021;18:e1003537.
    PubMed     Abstract available


    January 2021
  5. DORJEE K, Topgyal S, Tsewang T, Tsundue T, et al
    Risk of developing active tuberculosis following tuberculosis screening and preventive therapy for Tibetan refugee children and adolescents in India: An impact assessment.
    PLoS Med. 2021;18:e1003502.
    PubMed     Abstract available


    December 2020
  6. CILLONI L, Kranzer K, Stagg HR, Arinaminpathy N, et al
    Trade-offs between cost and accuracy in active case finding for tuberculosis: A dynamic modelling analysis.
    PLoS Med. 2020;17:e1003456.
    PubMed     Abstract available


  7. RICKS S, Denkinger CM, Schumacher SG, Hallett TB, et al
    The potential impact of urine-LAM diagnostics on tuberculosis incidence and mortality: A modelling analysis.
    PLoS Med. 2020;17:e1003466.
    PubMed     Abstract available


    November 2020
  8. BAIK Y, Rickman HM, Hanrahan CF, Mmolawa L, et al
    A clinical score for identifying active tuberculosis while awaiting microbiological results: Development and validation of a multivariable prediction model in sub-Saharan Africa.
    PLoS Med. 2020;17:e1003420.
    PubMed     Abstract available


    October 2020
  9. KAVANAGH MM, Gostin LO, Stephens J
    Tuberculosis, human rights, and law reform: Addressing the lack of progress in the global tuberculosis response.
    PLoS Med. 2020;17:e1003324.
    PubMed     Abstract available


  10. LAWRENCE H, Pick H, Baskaran V, Daniel P, et al
    Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: A case-control test-negative design study.
    PLoS Med. 2020;17:e1003326.
    PubMed     Abstract available


    September 2020
  11. SHALLCROSS L, Rockenschaub P, Blackburn R, Nazareth I, et al
    Antibiotic prescribing for lower UTI in elderly patients in primary care and risk of bloodstream infection: A cohort study using electronic health records in England.
    PLoS Med. 2020;17:e1003336.
    PubMed     Abstract available


    August 2020
  12. HAGEDOORN NN, Borensztajn DM, Nijman R, Balode A, et al
    Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A multicentre observational study.
    PLoS Med. 2020;17:e1003208.
    PubMed     Abstract available


    May 2020
  13. BROGER T, Nicol MP, Szekely R, Bjerrum S, et al
    Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data.
    PLoS Med. 2020;17:e1003113.
    PubMed     Abstract available


  14. DEO S, Singh S, Jha N, Arinaminpathy N, et al
    Predicting the impact of patient and private provider behavior on diagnostic delay for pulmonary tuberculosis patients in India: A simulation modeling study.
    PLoS Med. 2020;17:e1003039.
    PubMed     Abstract available


  15. KUMAR GS, Wien SS, Phares CR, Slim W, et al
    Health profile of adult special immigrant visa holders arriving from Iraq and Afghanistan to the United States, 2009-2017: A cross-sectional analysis.
    PLoS Med. 2020;17:e1003118.
    PubMed     Abstract available


    April 2020
  16. YAESOUBI R, Cohen T, Hsu K, Gift TL, et al
    Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study.
    PLoS Med. 2020;17:e1003077.
    PubMed     Abstract available


    February 2020
  17. LIENHARDT C, Nunn A, Chaisson R, Vernon AA, et al
    Advances in clinical trial design: Weaving tomorrow's TB treatments.
    PLoS Med. 2020;17:e1003059.
    PubMed     Abstract available


    January 2020
  18. DEAN AS, Zignol M, Cabibbe AM, Falzon D, et al
    Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.
    PLoS Med. 2020;17:e1003008.
    PubMed     Abstract available


  19. SULIS G, Pai M
    Isoniazid-resistant tuberculosis: A problem we can no longer ignore.
    PLoS Med. 2020;17:e1003023.
    PubMed     Abstract available


    December 2019
  20. VERNON A, Fielding K, Savic R, Dodd L, et al
    The importance of adherence in tuberculosis treatment clinical trials and its relevance in explanatory and pragmatic trials.
    PLoS Med. 2019;16:e1002884.
    PubMed     Abstract available


  21. LEE EC, Azman AS, Kaminsky J, Moore SM, et al
    The projected impact of geographic targeting of oral cholera vaccination in sub-Saharan Africa: A modeling study.
    PLoS Med. 2019;16:e1003003.
    PubMed     Abstract available


    October 2019
  22. BROWNE SH, Umlauf A, Tucker AJ, Low J, et al
    Wirelessly observed therapy compared to directly observed therapy to confirm and support tuberculosis treatment adherence: A randomized controlled trial.
    PLoS Med. 2019;16:e1002891.
    PubMed     Abstract available


  23. BRIGDEN G, Nhung NV, Skrahina A, Ndjeka N, et al
    Advances in clinical trial design for development of new TB treatments-Translating international tuberculosis treatment guidelines into national strategic plans: Experiences from Belarus, South Africa, and Vietnam.
    PLoS Med. 2019;16:e1002896.
    PubMed    


  24. XU Y, Cancino-Munoz I, Torres-Puente M, Villamayor LM, et al
    High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain.
    PLoS Med. 2019;16:e1002961.
    PubMed     Abstract available


    September 2019
  25. AIBANA O, Huang CC, Aboud S, Arnedo-Pena A, et al
    Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis.
    PLoS Med. 2019;16:e1002907.
    PubMed     Abstract available


  26. LIENHARDT C, Vernon AA, Cavaleri M, Nambiar S, et al
    Development of new TB regimens: Harmonizing trial design, product registration requirements, and public health guidance.
    PLoS Med. 2019;16:e1002915.
    PubMed     Abstract available


    July 2019
  27. SCHUTZ C, Barr D, Andrade BB, Shey M, et al
    Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study.
    PLoS Med. 2019;16:e1002840.
    PubMed     Abstract available


  28. DOOLEY KE, Hanna D, Mave V, Eisenach K, et al
    Advancing the development of new tuberculosis treatment regimens: The essential role of translational and clinical pharmacology and microbiology.
    PLoS Med. 2019;16:e1002842.
    PubMed    


  29. PENN-NICHOLSON A, Hraha T, Thompson EG, Sterling D, et al
    Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
    PLoS Med. 2019;16:e1002880.
    PubMed     Abstract available


  30. OLLIARO PL, Vaillant M
    Designing noninferiority tuberculosis treatment trials: Identifying practical advantages for drug regimens with acceptable effectiveness.
    PLoS Med. 2019;16:e1002850.
    PubMed     Abstract available


  31. DAVIES G, Boeree M, Hermann D, Hoelscher M, et al
    Accelerating the transition of new tuberculosis drug combinations from Phase II to Phase III trials: New technologies and innovative designs.
    PLoS Med. 2019;16:e1002851.
    PubMed     Abstract available


  32. CHOI YH, Andrews N, Miller E
    Estimated impact of revising the 13-valent pneumococcal conjugate vaccine schedule from 2+1 to 1+1 in England and Wales: A modelling study.
    PLoS Med. 2019;16:e1002845.
    PubMed     Abstract available


    June 2019
  33. CAMPBELL JR, Dowdy D, Schwartzman K
    Treatment of latent infection to achieve tuberculosis elimination in low-incidence countries.
    PLoS Med. 2019;16:e1002824.
    PubMed     Abstract available



  34. Correction: Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation.
    PLoS Med. 2019;16:e1002823.
    PubMed     Abstract available


  35. CHIAVENNA C, Presanis AM, Charlett A, de Lusignan S, et al
    Estimating age-stratified influenza-associated invasive pneumococcal disease in England: A time-series model based on population surveillance data.
    PLoS Med. 2019;16:e1002829.
    PubMed     Abstract available


  36. HERNANDEZ-SANTIAGO V, Davey PG, Nathwani D, Marwick CA, et al
    Changes in resistance among coliform bacteraemia associated with a primary care antimicrobial stewardship intervention: A population-based interrupted time series study.
    PLoS Med. 2019;16:e1002825.
    PubMed     Abstract available


  37. KIRBY MA, Nagel CL, Rosa G, Zambrano LD, et al
    Effects of a large-scale distribution of water filters and natural draft rocket-style cookstoves on diarrhea and acute respiratory infection: A cluster-randomized controlled trial in Western Province, Rwanda.
    PLoS Med. 2019;16:e1002812.
    PubMed     Abstract available


    May 2019
  38. LALVANI A, Berrocal-Almanza LC, Halliday A
    Predicting progression to active tuberculosis: A rate-limiting step on the path to elimination.
    PLoS Med. 2019;16:e1002814.
    PubMed     Abstract available


  39. KLEIN K, Bernachea MP, Iribarren S, Gibbons L, et al
    Correction: Evaluation of a social protection policy on tuberculosis treatment outcomes: A prospective cohort study.
    PLoS Med. 2019;16:e1002826.
    PubMed     Abstract available


    April 2019
  40. GUPTA-WRIGHT A, Corbett EL, Wilson D, van Oosterhout JJ, et al
    Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.
    PLoS Med. 2019;16:e1002776.
    PubMed     Abstract available


  41. STRYDOM N, Gupta SV, Fox WS, Via LE, et al
    Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization.
    PLoS Med. 2019;16:e1002773.
    PubMed     Abstract available


  42. KAWASAKI M, Echiverri C, Raymond L, Cadena E, et al
    Lipoarabinomannan in sputum to detect bacterial load and treatment response in patients with pulmonary tuberculosis: Analytic validation and evaluation in two cohorts.
    PLoS Med. 2019;16:e1002780.
    PubMed     Abstract available


  43. PENN-NICHOLSON A, Hraha T, Thompson EG, Sterling D, et al
    Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
    PLoS Med. 2019;16:e1002781.
    PubMed     Abstract available


  44. CHURCHYARD GJ, Swindells S
    Controlling latent TB tuberculosis infection in high-burden countries: A neglected strategy to end TB.
    PLoS Med. 2019;16:e1002787.
    PubMed     Abstract available


  45. WARSINSKE H, Vashisht R, Khatri P
    Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures.
    PLoS Med. 2019;16:e1002786.
    PubMed     Abstract available


  46. VEKEMANS J, O'Brien KL, Farrar J
    Tuberculosis vaccines: Rising opportunities.
    PLoS Med. 2019;16:e1002791.
    PubMed     Abstract available


  47. MANJALY THOMAS ZR, Satti I, Marshall JL, Harris SA, et al
    Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial.
    PLoS Med. 2019;16:e1002790.
    PubMed     Abstract available


  48. COLMAN RE, Mace A, Seifert M, Hetzel J, et al
    Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation.
    PLoS Med. 2019;16:e1002794.
    PubMed     Abstract available


  49. KLEIN K, Bernachea MP, Irribarren S, Gibbons L, et al
    Evaluation of a social protection policy on tuberculosis treatment outcomes: A prospective cohort study.
    PLoS Med. 2019;16:e1002788.
    PubMed     Abstract available


  50. GARCIA-PRATS AJ, Schaaf HS, Draper HR, Garcia-Cremades M, et al
    Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies.
    PLoS Med. 2019;16:e1002789.
    PubMed     Abstract available


  51. HATHERILL M, Chaisson RE, Denkinger CM
    Addressing critical needs in the fight to end tuberculosis with innovative tools and strategies.
    PLoS Med. 2019;16:e1002795.
    PubMed     Abstract available


  52. HANRAHAN CF, Nonyane BAS, Mmolawa L, West NS, et al
    Contact tracing versus facility-based screening for active TB case finding in rural South Africa: A pragmatic cluster-randomized trial (Kharitode TB).
    PLoS Med. 2019;16:e1002796.
    PubMed     Abstract available


    March 2019
  53. MABUD TS, de Lourdes Delgado Alves M, Ko AI, Basu S, et al
    Correction: Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil.
    PLoS Med. 2019;16:e1002764.
    PubMed     Abstract available


  54. PHILLIPS PPJ, Mitnick CD, Neaton JD, Nahid P, et al
    Keeping phase III tuberculosis trials relevant: Adapting to a rapidly changing landscape.
    PLoS Med. 2019;16:e1002767.
    PubMed     Abstract available


  55. LIENHARDT C, Nahid P
    Advances in clinical trial design for development of new TB treatments: A call for innovation.
    PLoS Med. 2019;16:e1002769.
    PubMed     Abstract available


  56. BRADY OJ, Osgood-Zimmerman A, Kassebaum NJ, Ray SE, et al
    The association between Zika virus infection and microcephaly in Brazil 2015-2017: An observational analysis of over 4 million births.
    PLoS Med. 2019;16:e1002755.
    PubMed     Abstract available


    February 2019
  57. SUBBARAMAN R, Nathavitharana RR, Mayer KH, Satyanarayana S, et al
    Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
    PLoS Med. 2019;16:e1002754.
    PubMed     Abstract available


  58. WEI X, Zhang Z, Hicks JP, Walley JD, et al
    Long-term outcomes of an educational intervention to reduce antibiotic prescribing for childhood upper respiratory tract infections in rural China: Follow-up of a cluster-randomised controlled trial.
    PLoS Med. 2019;16:e1002733.
    PubMed     Abstract available


    January 2019
  59. MABUD TS, de Lourdes Delgado Alves M, Ko AI, Basu S, et al
    Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil.
    PLoS Med. 2019;16:e1002737.
    PubMed     Abstract available


    September 2018
  60. SUTHAR AB, Moonan PK, Alexander HL
    Towards national systems for continuous surveillance of antimicrobial resistance: Lessons from tuberculosis.
    PLoS Med. 2018;15:e1002658.
    PubMed     Abstract available


  61. KWAN A, Daniels B, Saria V, Satyanarayana S, et al
    Variations in the quality of tuberculosis care in urban India: A cross-sectional, standardized patient study in two cities.
    PLoS Med. 2018;15:e1002653.
    PubMed     Abstract available


    August 2018
  62. MCINTOSH AI, Jenkins HE, White LF, Barnard M, et al
    Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis.
    PLoS Med. 2018;15:e1002638.
    PubMed     Abstract available


    July 2018
  63. ALIPANAH N, Jarlsberg L, Miller C, Linh NN, et al
    Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies.
    PLoS Med. 2018;15:e1002595.
    PubMed     Abstract available


  64. HARAUSZ EP, Garcia-Prats AJ, Law S, Schaaf HS, et al
    Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.
    PLoS Med. 2018;15:e1002591.
    PubMed     Abstract available


    June 2018
  65. COLDIRON ME, Assao B, Page AL, Hitchings MDT, et al
    Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial.
    PLoS Med. 2018;15:e1002593.
    PubMed     Abstract available


    March 2018
  66. PAI M
    Time for high-burden countries to lead the tuberculosis research agenda.
    PLoS Med. 2018;15:e1002544.
    PubMed     Abstract available


    January 2018
  67. DAVIES B, Turner KME, Benfield T, Frolund M, et al
    Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort.
    PLoS Med. 2018;15:e1002483.
    PubMed     Abstract available


    December 2017
  68. KENDALL EA, Schumacher SG, Denkinger CM, Dowdy DW, et al
    Estimated clinical impact of the Xpert MTB/RIF Ultra cartridge for diagnosis of pulmonary tuberculosis: A modeling study.
    PLoS Med. 2017;14:e1002472.
    PubMed     Abstract available


    November 2017
  69. RUDGARD WE, Evans CA, Sweeney S, Wingfield T, et al
    Comparison of two cash transfer strategies to prevent catastrophic costs for poor tuberculosis-affected households in low- and middle-income countries: An economic modelling study.
    PLoS Med. 2017;14:e1002418.
    PubMed     Abstract available


  70. SHETE PB, Dowdy DW
    Measuring success: The challenge of social protection in helping eliminate tuberculosis.
    PLoS Med. 2017;14:e1002419.
    PubMed     Abstract available


  71. YATES TA, Tomlinson LA, Bhaskaran K, Langan S, et al
    Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.
    PLoS Med. 2017;14:e1002457.
    PubMed     Abstract available


    October 2017
  72. DATTA S, Saunders MJ, Tovar MA, Evans CA, et al
    Improving tuberculosis diagnosis: Better tests or better healthcare?
    PLoS Med. 2017;14:e1002406.
    PubMed     Abstract available


  73. SYLVIA S, Xue H, Zhou C, Shi Y, et al
    Tuberculosis detection and the challenges of integrated care in rural China: A cross-sectional standardized patient study.
    PLoS Med. 2017;14:e1002405.
    PubMed     Abstract available


  74. KEITEL K, Kagoro F, Samaka J, Masimba J, et al
    A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial.
    PLoS Med. 2017;14:e1002411.
    PubMed     Abstract available


  75. WHITTLES LK, White PJ, Didelot X
    Estimating the fitness cost and benefit of cefixime resistance in Neisseria gonorrhoeae to inform prescription policy: A modelling study.
    PLoS Med. 2017;14:e1002416.
    PubMed     Abstract available


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