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Articles published in PLoS Pathog

Retrieve available abstracts of 282 articles:
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Single Articles


    May 2022
  1. SIEWERT LK, Dehio C, Pinschewer DD
    Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission.
    PLoS Pathog. 2022;18:e1010489.
    PubMed     Abstract available


  2. VAN ALST AJ, Demey LM, DiRita VJ
    Vibrio cholerae requires oxidative respiration through the bd-I and cbb3 oxidases for intestinal proliferation.
    PLoS Pathog. 2022;18:e1010102.
    PubMed     Abstract available


    April 2022
  3. BARTSCH P, Kilian C, Hellmig M, Paust HJ, et al
    Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.
    PLoS Pathog. 2022;18:e1010430.
    PubMed     Abstract available


  4. TRIPATHI A, Anand K, Das M, O'Niel RA, et al
    Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo.
    PLoS Pathog. 2022;18:e1010475.
    PubMed     Abstract available


  5. LEMBERG C, Martinez de San Vicente K, Frois-Martins R, Altmeier S, et al
    Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation.
    PLoS Pathog. 2022;18:e1010012.
    PubMed     Abstract available


  6. DIAGNE AM, Pelletier A, Durmort C, Faure A, et al
    Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae.
    PLoS Pathog. 2022;18:e1010458.
    PubMed     Abstract available


  7. DA SILVA RAG, Tay WH, Ho FK, Tanoto FR, et al
    Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells.
    PLoS Pathog. 2022;18:e1010434.
    PubMed     Abstract available


  8. SULTAN AS, Theofilou VI, Alfaifi A, Montelongo-Jauregui D, et al
    Is Candida albicans an opportunistic oncogenic pathogen?
    PLoS Pathog. 2022;18:e1010413.
    PubMed    


  9. HOLUBOVA J, Stanek O, Juhasz A, Hamidou Soumana I, et al
    The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.
    PLoS Pathog. 2022;18:e1010402.
    PubMed     Abstract available


  10. JUNG BG, Samten B, Dean K, Wallace RJ Jr, et al
    Early IL-17A production helps establish Mycobacterium intracellulare infection in mice.
    PLoS Pathog. 2022;18:e1010454.
    PubMed     Abstract available


  11. GIBSON JF, Bojarczuk A, Evans RJ, Kamuyango AA, et al
    Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection.
    PLoS Pathog. 2022;18:e1010389.
    PubMed     Abstract available


    March 2022
  12. LAVIN RC, Tan S
    Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy.
    PLoS Pathog. 2022;18:e1010459.
    PubMed     Abstract available


  13. ROSAS MEJIA O, Gloag ES, Li J, Ruane-Foster M, et al
    Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2.
    PLoS Pathog. 2022;18:e1010093.
    PubMed     Abstract available


  14. MANZER HS, Villarreal RI, Doran KS
    Targeting the BspC-vimentin interaction to develop anti-virulence therapies during Group B streptococcal meningitis.
    PLoS Pathog. 2022;18:e1010397.
    PubMed     Abstract available


  15. KOGAN K, Haapasalo K, Kotila T, Moore R, et al
    Mechanism of Borrelia immune evasion by FhbA-related proteins.
    PLoS Pathog. 2022;18:e1010338.
    PubMed     Abstract available


  16. THRIKAWALA S, Niu M, Keller NP, Rosowski EE, et al
    Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish.
    PLoS Pathog. 2022;18:e1010040.
    PubMed     Abstract available


  17. PETERS DT, Reifs A, Alonso-Caballero A, Madkour A, et al
    Unraveling the molecular determinants of the anti-phagocytic protein cloak of plague bacteria.
    PLoS Pathog. 2022;18:e1010447.
    PubMed     Abstract available


  18. ANDERSON MT, Himpsl SD, Mitchell LA, Kingsley LG, et al
    Identification of distinct capsule types associated with Serratia marcescens infection isolates.
    PLoS Pathog. 2022;18:e1010423.
    PubMed     Abstract available


  19. LI J, Ma Y, Paquette JK, Richards AC, et al
    The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNbeta-mediated Lyme arthritis.
    PLoS Pathog. 2022;18:e1010365.
    PubMed     Abstract available


  20. RICHARDS CL, Raffel SJ, Bontemps-Gallo S, Dulebohn DP, et al
    The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii.
    PLoS Pathog. 2022;18:e1010370.
    PubMed     Abstract available


  21. DRECKTRAH D, Hall LS, Crouse B, Schwarz B, et al
    The glycerol-3-phosphate dehydrogenases GpsA and GlpD constitute the oxidoreductive metabolic linchpin for Lyme disease spirochete host infectivity and persistence in the tick.
    PLoS Pathog. 2022;18:e1010385.
    PubMed     Abstract available


  22. KHO ZY, Azad MAK, Han ML, Zhu Y, et al
    Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages.
    PLoS Pathog. 2022;18:e1010308.
    PubMed     Abstract available


    February 2022
  23. RIXON JA, Depew CE, McSorley SJ
    Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice.
    PLoS Pathog. 2022;18:e1010333.
    PubMed     Abstract available


  24. HORSTMANN N, Myers KS, Tran CN, Flores AR, et al
    CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus.
    PLoS Pathog. 2022;18:e1010341.
    PubMed     Abstract available


  25. WILBURN KM, Montague CR, Qin B, Woods AK, et al
    Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis.
    PLoS Pathog. 2022;18:e1009862.
    PubMed     Abstract available


  26. RAMIREZ-ZAVALA B, Kruger I, Dunker C, Jacobsen ID, et al
    The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans.
    PLoS Pathog. 2022;18:e1010283.
    PubMed     Abstract available


  27. TATARA AM, Gandhi RG, Mooney DJ, Nelson SB, et al
    Antiplatelet therapy for Staphylococcus aureus bacteremia: Will it stick?
    PLoS Pathog. 2022;18:e1010240.
    PubMed     Abstract available


  28. CORDSMEIER A, Rinkel S, Jeninga M, Schulze-Luehrmann J, et al
    The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription.
    PLoS Pathog. 2022;18:e1010266.
    PubMed     Abstract available


  29. KROKEN AR, Gajenthra Kumar N, Yahr TL, Smith BE, et al
    Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.
    PLoS Pathog. 2022;18:e1010306.
    PubMed     Abstract available


  30. KOSEOGLU VK, Jones MK, Agaisse H
    The type 3 secretion effector IpgD promotes S. flexneri dissemination.
    PLoS Pathog. 2022;18:e1010324.
    PubMed     Abstract available


  31. WEDDLE EA, Koseoglu VK, DeVasure BA, Agaisse HF, et al
    The type three secretion system effector protein IpgB1 promotes Shigella flexneri cell-to-cell spread through double-membrane vacuole escape.
    PLoS Pathog. 2022;18:e1010380.
    PubMed     Abstract available


  32. SCHMIDINGER B, Petri K, Lettl C, Li H, et al
    Helicobacter pylori binds human Annexins via Lipopolysaccharide to interfere with Toll-like Receptor 4 signaling.
    PLoS Pathog. 2022;18:e1010326.
    PubMed     Abstract available


  33. PERITORE-GALVE FC, Shupe JA, Cave RJ, Childress KO, et al
    Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection.
    PLoS Pathog. 2022;18:e1010323.
    PubMed     Abstract available


    January 2022
  34. YANG M, Solis NV, Marshall M, Garleb R, et al
    Control of beta-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence.
    PLoS Pathog. 2022;18:e1010192.
    PubMed     Abstract available


  35. NASEER N, Egan MS, Reyes Ruiz VM, Scott WP, et al
    Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication.
    PLoS Pathog. 2022;18:e1009718.
    PubMed     Abstract available


  36. TRAN TT, Mathmann CD, Gatica-Andrades M, Rollo RF, et al
    Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
    PLoS Pathog. 2022;18:e1010166.
    PubMed     Abstract available


  37. JOHN E, Jacques S, Phan HTT, Liu L, et al
    Variability in an effector gene promoter of a necrotrophic fungal pathogen dictates epistasis and effector-triggered susceptibility in wheat.
    PLoS Pathog. 2022;18:e1010149.
    PubMed     Abstract available


  38. HOSMER J, Nasreen M, Dhouib R, Essilfie AT, et al
    Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells.
    PLoS Pathog. 2022;18:e1010209.
    PubMed     Abstract available


  39. HERNANDEZ SB, Castanheira S, Pucciarelli MG, Cestero JJ, et al
    Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling.
    PLoS Pathog. 2022;18:e1010241.
    PubMed     Abstract available


  40. ZHAO BR, Wang XX, Wang XW
    Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate.
    PLoS Pathog. 2022;18:e1010253.
    PubMed     Abstract available


  41. NEGRON O, Hur WS, Prasad J, Paul DS, et al
    Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.
    PLoS Pathog. 2022;18:e1010227.
    PubMed     Abstract available


  42. HSIEH LT, Dos Santos SJ, Hall BS, Ogbechi J, et al
    Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1beta, are linked to fibrin formation in Buruli ulcer lesions.
    PLoS Pathog. 2022;18:e1010280.
    PubMed     Abstract available


    December 2021
  43. REITHOFER V, Fernandez-Pereira J, Alvarado M, de Groot P, et al
    A novel class of Candida glabrata cell wall proteins with beta-helix fold mediates adhesion in clinical isolates.
    PLoS Pathog. 2021;17:e1009980.
    PubMed     Abstract available


  44. SPENCER BL, Tak U, Mendonca JC, Nagao PE, et al
    A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence.
    PLoS Pathog. 2021;17:e1010121.
    PubMed     Abstract available


  45. MA Q, Pan Y, Chen Y, Yu S, et al
    Acetylation of glucosyltransferases regulates Streptococcus mutans biofilm formation and virulence.
    PLoS Pathog. 2021;17:e1010134.
    PubMed     Abstract available


  46. CARROLL KC, Burnham CD, Westblade LF
    From canines to humans: Clinical importance of Staphylococcus pseudintermedius.
    PLoS Pathog. 2021;17:e1009961.
    PubMed    


  47. OLBRICH L, Stockdale L, Basu Roy R, Song R, et al
    Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward.
    PLoS Pathog. 2021;17:e1010061.
    PubMed     Abstract available


  48. HURST JR, Brouwer S, Walker MJ, McCormick JK, et al
    Streptococcal superantigens and the return of scarlet fever.
    PLoS Pathog. 2021;17:e1010097.
    PubMed     Abstract available


  49. IVANOV SS, Castore R, Juarez Rodriguez MD, Circu M, et al
    Neisseria gonorrhoeae subverts formin-dependent actin polymerization to colonize human macrophages.
    PLoS Pathog. 2021;17:e1010184.
    PubMed     Abstract available


  50. ELDRIDGE MJG, Hamon MA
    Histone H3 deacetylation promotes host cell viability for efficient infection by Listeria monocytogenes.
    PLoS Pathog. 2021;17:e1010173.
    PubMed     Abstract available


  51. CHEN K, Zhang S, Shao Y, Guo M, et al
    A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin.
    PLoS Pathog. 2021;17:e1010145.
    PubMed     Abstract available


  52. ROY S, Bahar AA, Gu H, Nangia S, et al
    Persister control by leveraging dormancy associated reduction of antibiotic efflux.
    PLoS Pathog. 2021;17:e1010144.
    PubMed     Abstract available


  53. BASTOS RW, Rossato L, Goldman GH, Santos DA, et al
    Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond.
    PLoS Pathog. 2021;17:e1010073.
    PubMed     Abstract available


  54. CHU TH, Khairallah C, Shieh J, Cho R, et al
    gammadelta T cell IFNgamma production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans.
    PLoS Pathog. 2021;17:e1010103.
    PubMed     Abstract available


  55. GRASSMANN AA, Zavala-Alvarado C, Bettin EB, Picardeau M, et al
    The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.
    PLoS Pathog. 2021;17:e1009078.
    PubMed     Abstract available


  56. ZAVALA-ALVARADO C, G Huete S, Vincent AT, Sismeiro O, et al
    The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.
    PLoS Pathog. 2021;17:e1009087.
    PubMed     Abstract available


  57. YU Q, Wang LC, Di Benigno S, Stein DC, et al
    Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin.
    PLoS Pathog. 2021;17:e1009592.
    PubMed     Abstract available


    November 2021
  58. PAYROS D, Alonso H, Malaga W, Volle A, et al
    Rv0180c contributes to Mycobacterium tuberculosis cell shape and to infectivity in mice and macrophages.
    PLoS Pathog. 2021;17:e1010020.
    PubMed     Abstract available


  59. VAN TONDER AJ, Thornton MJ, Conlan AJK, Jolley KA, et al
    Inferring Mycobacterium bovis transmission between cattle and badgers using isolates from the Randomised Badger Culling Trial.
    PLoS Pathog. 2021;17:e1010075.
    PubMed     Abstract available


  60. BEKERE I, Huang J, Schnapp M, Rudolph M, et al
    Yersinia remodels epigenetic histone modifications in human macrophages.
    PLoS Pathog. 2021;17:e1010074.
    PubMed     Abstract available


  61. PIENKOSS S, Javadi S, Chaoprasid P, Nolte T, et al
    The gatekeeper of Yersinia type III secretion is under RNA thermometer control.
    PLoS Pathog. 2021;17:e1009650.
    PubMed     Abstract available


  62. DOORDUIJN DJ, Heesterbeek DAC, Ruyken M, de Haas CJC, et al
    Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.
    PLoS Pathog. 2021;17:e1010051.
    PubMed     Abstract available


    October 2021
  63. PEKMEZOVIC M, Kaune AK, Austermeier S, Hitzler SUJ, et al
    Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells.
    PLoS Pathog. 2021;17:e1010037.
    PubMed     Abstract available



  64. Correction: Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.
    PLoS Pathog. 2021;17:e1010008.
    PubMed     Abstract available


  65. LEAL-CALVO T, Avanzi C, Mendes MA, Benjak A, et al
    A new paradigm for leprosy diagnosis based on host gene expression.
    PLoS Pathog. 2021;17:e1009972.
    PubMed     Abstract available


  66. PERES NG, Wang N, Whitney P, Engel S, et al
    CD4+ T cell immunity to Salmonella is transient in the circulation.
    PLoS Pathog. 2021;17:e1010004.
    PubMed     Abstract available


  67. GREGORY AL, Pensinger DA, Hryckowian AJ
    A short chain fatty acid-centric view of Clostridioides difficile pathogenesis.
    PLoS Pathog. 2021;17:e1009959.
    PubMed     Abstract available


  68. COBURN J, Picardeau M, Woods CW, Veldman T, et al
    Pathogenesis insights from an ancient and ubiquitous spirochete.
    PLoS Pathog. 2021;17:e1009836.
    PubMed    


  69. OUTRAM MA, Solomon PS, Williams SJ
    Pro-domain processing of fungal effector proteins from plant pathogens.
    PLoS Pathog. 2021;17:e1010000.
    PubMed    


  70. ABUAITA BH, Lawrence AE, Berger RP, Hill DR, et al
    Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids.
    PLoS Pathog. 2021;17:e1009987.
    PubMed     Abstract available


  71. AGUIRRE AM, Yalcinkaya N, Wu Q, Swennes A, et al
    Bile acid-independent protection against Clostridioides difficile infection.
    PLoS Pathog. 2021;17:e1010015.
    PubMed     Abstract available


  72. EARLE SG, Lobanovska M, Lavender H, Tang C, et al
    Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis.
    PLoS Pathog. 2021;17:e1009992.
    PubMed     Abstract available


  73. GU H, Cai X, Zhang X, Luo J, et al
    A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis.
    PLoS Pathog. 2021;17:e1010005.
    PubMed     Abstract available


  74. BLAND DM, Miarinjara A, Bosio CF, Calarco J, et al
    Acquisition of yersinia murine toxin enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague.
    PLoS Pathog. 2021;17:e1009995.
    PubMed     Abstract available


  75. BJANES E, Sillas RG, Matsuda R, Demarco B, et al
    Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection.
    PLoS Pathog. 2021;17:e1009967.
    PubMed     Abstract available


  76. SULLIVAN JR, Lupien A, Kalthoff E, Hamela C, et al
    Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline.
    PLoS Pathog. 2021;17:e1009965.
    PubMed     Abstract available


  77. KELLIHER JL, Grunenwald CM, Abrahams RR, Daanen ME, et al
    PASTA kinase-dependent control of peptidoglycan synthesis via ReoM is required for cell wall stress responses, cytosolic survival, and virulence in Listeria monocytogenes.
    PLoS Pathog. 2021;17:e1009881.
    PubMed     Abstract available


    September 2021
  78. COLLINS JM, Jones DP, Sharma A, Khadka M, et al
    TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.
    PLoS Pathog. 2021;17:e1009941.
    PubMed     Abstract available


  79. GIBSON JF, Pidwill GR, Carnell OT, Surewaard BGJ, et al
    Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species.
    PLoS Pathog. 2021;17:e1009880.
    PubMed     Abstract available


  80. CHEN X, Teoh WP, Stock MR, Resko ZJ, et al
    Branched chain fatty acid synthesis drives tissue-specific innate immune response and infection dynamics of Staphylococcus aureus.
    PLoS Pathog. 2021;17:e1009930.
    PubMed     Abstract available


  81. STELZNER K, Boyny A, Hertlein T, Sroka A, et al
    Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells.
    PLoS Pathog. 2021;17:e1009874.
    PubMed     Abstract available


  82. RAMOS Y, Sansone S, Morales DK
    Sugarcoating it: Enterococcal polysaccharides as key modulators of host-pathogen interactions.
    PLoS Pathog. 2021;17:e1009822.
    PubMed    


  83. LIU J, Willems HME, Sansevere EA, Allert S, et al
    A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis.
    PLoS Pathog. 2021;17:e1009884.
    PubMed     Abstract available


  84. DE LAY BD, Cameron TA, De Lay NR, Norris SJ, et al
    Comparison of transcriptional profiles of Treponema pallidum during experimental infection of rabbits and in vitro culture: Highly similar, yet different.
    PLoS Pathog. 2021;17:e1009949.
    PubMed     Abstract available


  85. GUTIERREZ S, Fischer J, Ganesan R, Hos NJ, et al
    Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense.
    PLoS Pathog. 2021;17:e1009943.
    PubMed     Abstract available


  86. MCDOUGAL CE, Morrow ZT, Christopher T, Kim S, et al
    Phagocytes produce prostaglandin E2 in response to cytosolic Listeria monocytogenes.
    PLoS Pathog. 2021;17:e1009493.
    PubMed     Abstract available


  87. GOLDSMITH JA, DiVenere AM, Maynard JA, McLellan JS, et al
    Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes.
    PLoS Pathog. 2021;17:e1009920.
    PubMed     Abstract available


  88. WU X, Ning C, Key FM, Andrades Valtuena A, et al
    A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road.
    PLoS Pathog. 2021;17:e1009886.
    PubMed     Abstract available


  89. DEMARS A, Vitali A, Comein A, Carlier E, et al
    Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.
    PLoS Pathog. 2021;17:e1009887.
    PubMed     Abstract available


  90. BAGAYOKO S, Leon-Icaza SA, Pinilla M, Hessel A, et al
    Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology.
    PLoS Pathog. 2021;17:e1009927.
    PubMed     Abstract available


  91. RUSSO BC, Duncan-Lowey JK, Chen P, Goldberg MB, et al
    The type 3 secretion system requires actin polymerization to open translocon pores.
    PLoS Pathog. 2021;17:e1009932.
    PubMed     Abstract available


  92. CULYBA MJ, Van Tyne D
    Bacterial evolution during human infection: Adapt and live or adapt and die.
    PLoS Pathog. 2021;17:e1009872.
    PubMed     Abstract available


  93. TAGGART MG, Snelling WJ, Naughton PJ, La Ragione RM, et al
    Biofilm regulation in Clostridioides difficile: Novel systems linked to hypervirulence.
    PLoS Pathog. 2021;17:e1009817.
    PubMed     Abstract available


  94. GUO Z, Kang S, Wu Q, Wang S, et al
    The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host.
    PLoS Pathog. 2021;17:e1009917.
    PubMed     Abstract available


  95. XIA Y, Cebrian R, Xu C, Jong A, et al
    Elucidating the mechanism by which synthetic helper peptides sensitize Pseudomonas aeruginosa to multiple antibiotics.
    PLoS Pathog. 2021;17:e1009909.
    PubMed     Abstract available


  96. VAIL KJ, da Silveira BP, Bell SL, Cohen ND, et al
    The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages.
    PLoS Pathog. 2021;17:e1009888.
    PubMed     Abstract available


    August 2021
  97. YADAV B, Specht CA, Lee CK, Pokrovskii M, et al
    Lung eosinophils elicited during allergic and acute aspergillosis express RORt and IL-23R but do not require IL-23 for IL-17 production.
    PLoS Pathog. 2021;17:e1009891.
    PubMed     Abstract available


  98. WAGNER AS, Hancock TJ, Lumsdaine SW, Kauffman SJ, et al
    Activation of Cph1 causes ss(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner.
    PLoS Pathog. 2021;17:e1009839.
    PubMed     Abstract available


  99. SINGH DK, Tousif S, Bhaskar A, Devi A, et al
    Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis.
    PLoS Pathog. 2021;17:e1009805.
    PubMed     Abstract available


  100. KOYUNCU D, Niazi MKK, Tavolara T, Abeijon C, et al
    CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice.
    PLoS Pathog. 2021;17:e1009773.
    PubMed     Abstract available


  101. MIN K, Jannace TF, Si H, Veeramah KR, et al
    Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans.
    PLoS Pathog. 2021;17:e1009861.
    PubMed     Abstract available


  102. FRANZA T, Rogstam A, Thiyagarajan S, Sullivan MJ, et al
    NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.
    PLoS Pathog. 2021;17:e1009791.
    PubMed     Abstract available


  103. SOUZA ACO, Martin-Vicente A, Nywening AV, Ge W, et al
    Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus.
    PLoS Pathog. 2021;17:e1009806.
    PubMed     Abstract available


  104. MORELLI KA, Kerkaert JD, Cramer RA
    Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression.
    PLoS Pathog. 2021;17:e1009794.
    PubMed     Abstract available


  105. SILAO FGS, Ryman K, Jiang T, Ward M, et al
    Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.
    PLoS Pathog. 2021;17:e1009877.
    PubMed     Abstract available


  106. SINGH DK, Dwivedi VP, Singh SP, Kumari A, et al
    Correction: Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
    PLoS Pathog. 2021;17:e1009896.
    PubMed     Abstract available


  107. POWERS TR, Haeberle AL, Predeus AV, Hammarlof DL, et al
    Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica.
    PLoS Pathog. 2021;17:e1009280.
    PubMed     Abstract available


  108. DAVIDSON A, Tyler J, Hume P, Singh V, et al
    A kinase-independent function of PAK is crucial for pathogen-mediated actin remodelling.
    PLoS Pathog. 2021;17:e1009902.
    PubMed     Abstract available


  109. BARBOSA CHD, Lantier L, Reynolds J, Wang J, et al
    Critical role of IL-25-ILC2-IL-5 axis in the production of anti-Francisella LPS IgM by B1 B cells.
    PLoS Pathog. 2021;17:e1009905.
    PubMed     Abstract available


  110. HANSON MA, Cohen LB, Marra A, Iatsenko I, et al
    The Drosophila Baramicin polypeptide gene protects against fungal infection.
    PLoS Pathog. 2021;17:e1009846.
    PubMed     Abstract available


  111. KUHN HW, Lasseter AG, Adams PP, Avile CF, et al
    BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments.
    PLoS Pathog. 2021;17:e1009869.
    PubMed     Abstract available


  112. ANAYA-SANCHEZ A, Feng Y, Berude JC, Portnoy DA, et al
    Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes.
    PLoS Pathog. 2021;17:e1009819.
    PubMed     Abstract available


  113. HALSEY CR, Glover RC, Thomason MK, Reniere ML, et al
    The redox-responsive transcriptional regulator Rex represses fermentative metabolism and is required for Listeria monocytogenes pathogenesis.
    PLoS Pathog. 2021;17:e1009379.
    PubMed     Abstract available


  114. ZHANG HB, Cao Z, Qiao JX, Zhong ZQ, et al
    Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster.
    PLoS Pathog. 2021;17:e1009859.
    PubMed     Abstract available


  115. GONG Y, Wei X, Sun W, Ren X, et al
    Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean.
    PLoS Pathog. 2021;17:e1009837.
    PubMed     Abstract available


  116. SYCZ G, Di Venanzio G, Distel JS, Sartorio MG, et al
    Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages.
    PLoS Pathog. 2021;17:e1009802.
    PubMed     Abstract available


  117. GRAEF FA, Celiberto LS, Allaire JM, Kuan MTY, et al
    Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection.
    PLoS Pathog. 2021;17:e1009719.
    PubMed     Abstract available


  118. MA L, Dewan KK, Taylor-Mulneix DL, Wagner SM, et al
    Pertactin contributes to shedding and transmission of Bordetella bronchiseptica.
    PLoS Pathog. 2021;17:e1009735.
    PubMed     Abstract available


  119. RYTTER H, Jamet A, Ziveri J, Ramond E, et al
    The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella.
    PLoS Pathog. 2021;17:e1009326.
    PubMed     Abstract available


  120. CUI J, Duizer C, Bouwman LI, van Rooijen KS, et al
    The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells.
    PLoS Pathog. 2021;17:e1009787.
    PubMed     Abstract available


    July 2021
  121. CAI Y, Jaecklein E, Mackenzie J, Papavinasasundaram K, et al
    Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.
    PLoS Pathog. 2021;17:e1008911.
    PubMed     Abstract available


  122. ALONSO-MONGE R, Gresnigt MS, Roman E, Hube B, et al
    Candida albicans colonization of the gastrointestinal tract: A double-edged sword.
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    PubMed    


  123. BURKS C, Darby A, Gomez Londono L, Momany M, et al
    Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance.
    PLoS Pathog. 2021;17:e1009711.
    PubMed     Abstract available


  124. RASTOGI S, Ellinwood S, Augenstreich J, Mayer-Barber KD, et al
    Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF.
    PLoS Pathog. 2021;17:e1009712.
    PubMed     Abstract available


  125. SCHERER AK, Hopke A, Sykes DB, Irimia D, et al
    Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities?
    PLoS Pathog. 2021;17:e1009691.
    PubMed    


  126. MEAGHER RB, Lewis ZA, Ambati S, Lin X, et al
    Aiming for a bull's-eye: Targeting antifungals to fungi with dectin-decorated liposomes.
    PLoS Pathog. 2021;17:e1009699.
    PubMed     Abstract available


    June 2021
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    Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion.
    PLoS Pathog. 2021;17:e1009643.
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  128. HWANG W, Yong JH, Min KB, Lee KM, et al
    Genome-wide association study of signature genetic alterations among pseudomonas aeruginosa cystic fibrosis isolates.
    PLoS Pathog. 2021;17:e1009681.
    PubMed     Abstract available


  129. SANDS NA, Beernink PT
    Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
    PLoS Pathog. 2021;17:e1009655.
    PubMed     Abstract available


    May 2021
  130. TRIPATHI D, Radhakrishnan RK, Thandi RS, Paidipally P, et al
    Correction: IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis.
    PLoS Pathog. 2021;17:e1009578.
    PubMed     Abstract available


  131. CHEN X, Zhou X, Liao B, Zhou Y, et al
    The cross-kingdom interaction between Helicobacter pylori and Candida albicans.
    PLoS Pathog. 2021;17:e1009515.
    PubMed    


  132. DOW A, Sule P, O'Donnell TJ, Burger A, et al
    Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis.
    PLoS Pathog. 2021;17:e1009570.
    PubMed     Abstract available


  133. SAH SK, Hayes JJ, Rustchenko E
    The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans.
    PLoS Pathog. 2021;17:e1009564.
    PubMed    


  134. STEINER SE, Choong FX, Antypas H, Morado-Urbina CE, et al
    UPEC kidney infection triggers neuro-immune communication leading to modulation of local renal inflammation by splenic IFNgamma.
    PLoS Pathog. 2021;17:e1009553.
    PubMed     Abstract available


  135. DAVIS MM, Brock AM, DeHart TG, Boribong BP, et al
    The peptidoglycan-associated protein NapA plays an important role in the envelope integrity and in the pathogenesis of the lyme disease spirochete.
    PLoS Pathog. 2021;17:e1009546.
    PubMed     Abstract available


  136. CHAU NYE, Ahmad S, Whitney JC, Coombes BK, et al
    Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.
    PLoS Pathog. 2021;17:e1009532.
    PubMed     Abstract available


  137. STEVENS EJ, Bates KA, King KC
    Host microbiota can facilitate pathogen infection.
    PLoS Pathog. 2021;17:e1009514.
    PubMed     Abstract available


  138. WALKER AC, Bhargava R, Vaziriyan-Sani AS, Pourciau C, et al
    Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate.
    PLoS Pathog. 2021;17:e1009510.
    PubMed     Abstract available


  139. HUI WW, Emerson LE, Clapp B, Sheppe AE, et al
    Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo.
    PLoS Pathog. 2021;17:e1009465.
    PubMed     Abstract available


  140. LIN T, Quellier D, Lamb J, Voisin T, et al
    Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection.
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    PubMed     Abstract available


  141. PEREZ-MORALES D, Nava-Galeana J, Rosales-Reyes R, Teehan P, et al
    An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium.
    PLoS Pathog. 2021;17:e1009630.
    PubMed     Abstract available


  142. PHENN J, Pane-Farre J, Meukow N, Klein A, et al
    RegAB Homolog of Burkholderia pseudomallei is the Master Regulator of Redox Control and involved in Virulence.
    PLoS Pathog. 2021;17:e1009604.
    PubMed     Abstract available


  143. BESSAIAH H, Pokharel P, Loucif H, Kulbay M, et al
    The RyfA small RNA regulates oxidative and osmotic stress responses and virulence in uropathogenic Escherichia coli.
    PLoS Pathog. 2021;17:e1009617.
    PubMed     Abstract available


  144. LIU C, Stocke K, Fitzsimonds ZR, Yakoumatos L, et al
    A bacterial tyrosine phosphatase modulates cell proliferation through targeting RGCC.
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    PubMed     Abstract available


  145. YEBRA G, Haag AF, Neamah MM, Wee BA, et al
    Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen.
    PLoS Pathog. 2021;17:e1009606.
    PubMed     Abstract available


  146. RETCHLESS AC, Chen A, Chang HY, Blain AE, et al
    Using Neisseria meningitidis genomic diversity to inform outbreak strain identification.
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    PubMed     Abstract available


  147. GOMES MTR, Guimaraes ES, Marinho FV, Macedo I, et al
    STING regulates metabolic reprogramming in macrophages via HIF-1alpha during Brucella infection.
    PLoS Pathog. 2021;17:e1009597.
    PubMed     Abstract available


    April 2021
  148. PENARANDA C, Chumbler NM, Hung DT
    Dual transcriptional analysis reveals adaptation of host and pathogen to intracellular survival of Pseudomonas aeruginosa associated with urinary tract infection.
    PLoS Pathog. 2021;17:e1009534.
    PubMed     Abstract available


  149. MORI G, Morrison M, Blumenthal A
    Microbiome-immune interactions in tuberculosis.
    PLoS Pathog. 2021;17:e1009377.
    PubMed     Abstract available


  150. EICHNER H, Karlsson J, Spelmink L, Pathak A, et al
    RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion.
    PLoS Pathog. 2021;17:e1009513.
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  151. NAKAMURA K, Ogura Y, Gotoh Y, Hayashi T, et al
    Prophages integrating into prophages: A mechanism to accumulate type III secretion effector genes and duplicate Shiga toxin-encoding prophages in Escherichia coli.
    PLoS Pathog. 2021;17:e1009073.
    PubMed     Abstract available


  152. TECLE E, Chhan CB, Franklin L, Underwood RS, et al
    The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans.
    PLoS Pathog. 2021;17:e1009350.
    PubMed     Abstract available


  153. WRIGHT K, de Silva K, Plain KM, Purdie AC, et al
    Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis.
    PLoS Pathog. 2021;17:e1009186.
    PubMed     Abstract available


  154. LUK CH, Valenzuela C, Gil M, Swistak L, et al
    Salmonella enters a dormant state within human epithelial cells for persistent infection.
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    PubMed     Abstract available


  155. VORNHAGEN J, Bassis CM, Ramakrishnan S, Hein R, et al
    A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor.
    PLoS Pathog. 2021;17:e1009537.
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  156. CHEN Y, Vargas SM, Smith TC 2nd, Karna SLR, et al
    Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease.
    PLoS Pathog. 2021;17:e1009535.
    PubMed     Abstract available


  157. BORTELL N, Aguilera ER, Lenz LL
    Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells.
    PLoS Pathog. 2021;17:e1009531.
    PubMed     Abstract available


  158. NNADI NE, Carter DA
    Climate change and the emergence of fungal pathogens.
    PLoS Pathog. 2021;17:e1009503.
    PubMed    


  159. AN J, Zhao X, Wang Y, Noriega J, et al
    Western-style diet impedes colonization and clearance of Citrobacter rodentium.
    PLoS Pathog. 2021;17:e1009497.
    PubMed     Abstract available


  160. QIN W, Brands X, Van't Veer C, F de Vos A, et al
    Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
    PLoS Pathog. 2021;17:e1009491.
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    March 2021
  161. O'BRIEN CE, Oliveira-Pacheco J, O Cinneide E, Haase MAB, et al
    Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.
    PLoS Pathog. 2021;17:e1009138.
    PubMed     Abstract available


  162. SUTTON JAF, Carnell OT, Lafage L, Gray J, et al
    Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction.
    PLoS Pathog. 2021;17:e1009468.
    PubMed     Abstract available


  163. LIU H, Xu W, Bruno VM, Phan QT, et al
    Determining Aspergillus fumigatus transcription factor expression and function during invasion of the mammalian lung.
    PLoS Pathog. 2021;17:e1009235.
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  164. NAZ S, Dabral S, Nagarajan SN, Arora D, et al
    Compromised base excision repair pathway in Mycobacterium tuberculosis imparts superior adaptability in the host.
    PLoS Pathog. 2021;17:e1009452.
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  165. KLOPFENSTEIN N, Brandt SL, Castellanos S, Gunzer M, et al
    SOCS-1 inhibition of type I interferon restrains Staphylococcus aureus skin host defense.
    PLoS Pathog. 2021;17:e1009387.
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  166. DAMMANN AN, Chamby AB, Catomeris AJ, Davidson KM, et al
    Genome-Wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.
    PLoS Pathog. 2021;17:e1009116.
    PubMed     Abstract available


  167. CHO J, Costa SK, Wierzbicki RM, Rigby WFC, et al
    The extracellular loop of the membrane permease VraG interacts with GraS to sense cationic antimicrobial peptides in Staphylococcus aureus.
    PLoS Pathog. 2021;17:e1009338.
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  168. TABUSI M, Thorsdottir S, Lysandrou M, Narciso AR, et al
    Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with beta-actin.
    PLoS Pathog. 2021;17:e1009432.
    PubMed     Abstract available


  169. RISTOW LC, Davis JM
    The granuloma in cryptococcal disease.
    PLoS Pathog. 2021;17:e1009342.
    PubMed     Abstract available


  170. BRIARD B, Malireddi RKS, Kanneganti TD
    Role of inflammasomes/pyroptosis and PANoptosis during fungal infection.
    PLoS Pathog. 2021;17:e1009358.
    PubMed    


  171. FROST LR, Cheng JKJ, Unnikrishnan M
    Clostridioides difficile biofilms: A mechanism of persistence in the gut?
    PLoS Pathog. 2021;17:e1009348.
    PubMed    


  172. HENNEMANN LC, LaFayette SL, Malet JK, Bortolotti P, et al
    LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation.
    PLoS Pathog. 2021;17:e1009375.
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  173. BREWER SM, Twittenhoff C, Kortmann J, Brubaker SW, et al
    A Salmonella Typhi RNA thermosensor regulates virulence factors and innate immune evasion in response to host temperature.
    PLoS Pathog. 2021;17:e1009345.
    PubMed     Abstract available


  174. PARMAR N, Burrows K, Vornewald PM, Lindholm HT, et al
    Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
    PLoS Pathog. 2021;17:e1009476.
    PubMed     Abstract available


  175. STATON GJ, Clegg SR, Ainsworth S, Armstrong S, et al
    Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.
    PLoS Pathog. 2021;17:e1009464.
    PubMed     Abstract available


  176. LUANGTRAKUL W, Boonchuen P, Jaree P, Kumar R, et al
    Cytotoxicity of Vibrio parahaemolyticus AHPND toxin on shrimp hemocytes, a newly identified target tissue, involves binding of toxin to aminopeptidase N1 receptor.
    PLoS Pathog. 2021;17:e1009463.
    PubMed     Abstract available


  177. SPINSANTI M, Brignoli T, Bodini M, Fontana LE, et al
    Deconvolution of intergenic polymorphisms determining high expression of Factor H binding protein in meningococcus and their association with invasive disease.
    PLoS Pathog. 2021;17:e1009461.
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  178. RENIERIS G, Droggiti DE, Katrini K, Koufargyris P, et al
    Host cystathionine-gamma lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis.
    PLoS Pathog. 2021;17:e1009473.
    PubMed     Abstract available


  179. MOLLAH MMI, Ahmed S, Kim Y
    Immune mediation of HMG-like DSP1 via Toll-Spatzle pathway and its specific inhibition by salicylic acid analogs.
    PLoS Pathog. 2021;17:e1009467.
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  180. KAWABATA M, Matsuo H, Koito T, Murata M, et al
    Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionella-containing vacuole with the ER.
    PLoS Pathog. 2021;17:e1009437.
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  181. WU Y, Wang Y, Yang H, Li Q, et al
    Resident bacteria contribute to opportunistic infections of the respiratory tract.
    PLoS Pathog. 2021;17:e1009436.
    PubMed     Abstract available


  182. COHEN E, Azriel S, Auster O, Gal A, et al
    Pathoadaptation of the passerine-associated Salmonella enterica serovar Typhimurium lineage to the avian host.
    PLoS Pathog. 2021;17:e1009451.
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  183. NADEEM A, Alam A, Toh E, Myint SL, et al
    Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA.
    PLoS Pathog. 2021;17:e1009414.
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  184. LOOD C, Peeters C, Lamy-Besnier Q, Wagemans J, et al
    Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity.
    PLoS Pathog. 2021;17:e1009418.
    PubMed     Abstract available


  185. QUEVAL CJ, Fearns A, Botella L, Smyth A, et al
    Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation.
    PLoS Pathog. 2021;17:e1009410.
    PubMed     Abstract available


  186. MIKE LA, Stark AJ, Forsyth VS, Vornhagen J, et al
    A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness.
    PLoS Pathog. 2021;17:e1009376.
    PubMed     Abstract available


  187. BARMAN TK, Racine R, Bonin JL, Califano D, et al
    Sequential targeting of interferon pathways for increased host resistance to bacterial superinfection during influenza.
    PLoS Pathog. 2021;17:e1009405.
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  188. DORRINGTON MG, Bradfield CJ, Lack JB, Lin B, et al
    Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol.
    PLoS Pathog. 2021;17:e1009395.
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    February 2021
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    PspC domain-containing protein (PCP) determines Streptococcus mutans biofilm formation through bacterial extracellular DNA release and platelet adhesion in experimental endocarditis.
    PLoS Pathog. 2021;17:e1009289.
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  190. BOTH A, Huang J, Qi M, Lausmann C, et al
    Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations.
    PLoS Pathog. 2021;17:e1009304.
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  191. DINKELE R, Gessner S, McKerry A, Leonard B, et al
    Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols.
    PLoS Pathog. 2021;17:e1009262.
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  192. MILLS JO, Ghosh P
    Nonimmune antibody interactions of Group A Streptococcus M and M-like proteins.
    PLoS Pathog. 2021;17:e1009248.
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  193. WANG X, Zhang C, Wang S, Rashu R, et al
    SND1 promotes Th1/17 immunity against chlamydial lung infection through enhancing dendritic cell function.
    PLoS Pathog. 2021;17:e1009295.
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  194. CHAGNEAU CV, Massip C, Bossuet-Greif N, Fremez C, et al
    Uropathogenic E. coli induces DNA damage in the bladder.
    PLoS Pathog. 2021;17:e1009310.
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  195. CHEUNG GYC, Bae JS, Liu R, Hunt RL, et al
    Bacterial virulence plays a crucial role in MRSA sepsis.
    PLoS Pathog. 2021;17:e1009369.
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  196. BATTU A, Purushotham R, Dey P, Vamshi SS, et al
    An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival.
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  197. CHOWDHURY R, Pavinski Bitar PD, Keresztes I, Condo AM Jr, et al
    A diffusible signal factor of the intestine dictates Salmonella invasion through its direct control of the virulence activator HilD.
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  198. RODRIGUEZ-GARCIA C, Heerman MC, Cook SC, Evans JD, et al
    Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera.
    PLoS Pathog. 2021;17:e1009270.
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  199. CARTER ED, Bletz MC, Le Sage M, LaBumbard B, et al
    Winter is coming-Temperature affects immune defenses and susceptibility to Batrachochytrium salamandrivorans.
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  200. BOYLE WK, Richards CL, Dulebohn DP, Zalud AK, et al
    DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity.
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  201. BARNIER JP, Euphrasie D, Join-Lambert O, Audry M, et al
    Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model.
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  202. JUNG HJ, Sorbara MT, Pamer EG
    TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection.
    PLoS Pathog. 2021;17:e1009309.
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  203. TALYANSKY Y, Nielsen TB, Yan J, Carlino-Macdonald U, et al
    Capsule carbohydrate structure determines virulence in Acinetobacter baumannii.
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  204. WARR AR, Kuehl CJ, Waldor MK
    Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli.
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  205. CASSELLI T, Divan A, Vomhof-DeKrey EE, Tourand Y, et al
    A murine model of Lyme disease demonstrates that Borrelia burgdorferi colonizes the dura mater and induces inflammation in the central nervous system.
    PLoS Pathog. 2021;17:e1009256.
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    January 2021
  206. SWIDERGALL M, Solis NV, Millet N, Huang MY, et al
    Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.
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  207. GAYTAN MO, Singh AK, Woodiga SA, Patel SA, et al
    A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of Infective endocarditis.
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  208. TAYLOR JC, Gao X, Xu J, Holder M, et al
    A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors.
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  209. ZEDEN MS, Burke O, Vallely M, Fingleton C, et al
    Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus.
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  210. PAN Z, Zhang Y, Luo J, Li D, et al
    Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology.
    PLoS Pathog. 2021;17:e1009197.
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  211. VENKATESH SR, Singh V
    G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans.
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    PubMed    


  212. DEVARAJ A, Gonzalez JF, Eichar B, Thilliez G, et al
    Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi.
    PLoS Pathog. 2021;17:e1009209.
    PubMed     Abstract available


  213. DENIC M, Turlin E, Michel V, Fischer F, et al
    A novel mode of control of nickel uptake by a multifunctional metallochaperone.
    PLoS Pathog. 2021;17:e1009193.
    PubMed     Abstract available


  214. WAGLEY S, Morcrette H, Kovacs-Simon A, Yang ZR, et al
    Bacterial dormancy: A subpopulation of viable but non-culturable cells demonstrates better fitness for revival.
    PLoS Pathog. 2021;17:e1009194.
    PubMed     Abstract available


  215. GROSHONG AM, McLain MA, Radolf JD
    Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle.
    PLoS Pathog. 2021;17:e1009180.
    PubMed     Abstract available


  216. NICHOLSON KR, Mousseau CB, Champion MM, Champion PA, et al
    The genetic proteome: Using genetics to inform the proteome of mycobacterial pathogens.
    PLoS Pathog. 2021;17:e1009124.
    PubMed     Abstract available


  217. MCLELLAN LK, McAllaster MR, Kim AS, Tothova L, et al
    A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.
    PLoS Pathog. 2021;17:e1009314.
    PubMed     Abstract available


    December 2020
  218. BELLO C, Smail Y, Sainte-Rose V, Podglajen I, et al
    Role of astroglial Connexin 43 in pneumolysin cytotoxicity and during pneumococcal meningitis.
    PLoS Pathog. 2020;16:e1009152.
    PubMed     Abstract available


  219. MATA E, Farrell D, Ma R, Uranga S, et al
    Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference.
    PLoS Pathog. 2020;16:e1009061.
    PubMed     Abstract available


  220. ROSS ZK, Lorenz A
    Is Candida auris sexual?
    PLoS Pathog. 2020;16:e1009094.
    PubMed    


  221. SANDALA JL, Eichar BW, Kuo LG, Hahn MM, et al
    A dual-therapy approach for the treatment of biofilm-mediated Salmonella gallbladder carriage.
    PLoS Pathog. 2020;16:e1009192.
    PubMed     Abstract available


  222. JACKSON LK, Potter B, Schneider S, Fitzgibbon M, et al
    Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes.
    PLoS Pathog. 2020;16:e1008686.
    PubMed     Abstract available


  223. DONNERT M, Elsheikh S, Arce-Rodriguez A, Pawar V, et al
    Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria.
    PLoS Pathog. 2020;16:e1009126.
    PubMed     Abstract available


  224. FOULON M, Robbe-Saule M, Manry J, Esnault L, et al
    Mycolactone toxin induces an inflammatory response by targeting the IL-1beta pathway: Mechanistic insight into Buruli ulcer pathophysiology.
    PLoS Pathog. 2020;16:e1009107.
    PubMed     Abstract available


  225. PONT S, Fraikin N, Caspar Y, Van Melderen L, et al
    Bacterial behavior in human blood reveals complement evaders with some persister-like features.
    PLoS Pathog. 2020;16:e1008893.
    PubMed     Abstract available


  226. BARTELL JA, Cameron DR, Mojsoska B, Haagensen JAJ, et al
    Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment.
    PLoS Pathog. 2020;16:e1009112.
    PubMed     Abstract available


  227. MARTINOT AJ, Blass E, Yu J, Aid M, et al
    Protective efficacy of an attenuated Mtb DeltaLprG vaccine in mice.
    PLoS Pathog. 2020;16:e1009096.
    PubMed     Abstract available


  228. CARROW HC, Batachari LE, Chu H
    Strain diversity in the microbiome: Lessons from Bacteroides fragilis.
    PLoS Pathog. 2020;16:e1009056.
    PubMed    


  229. LEDUC I, Connolly KL, Begum A, Underwood K, et al
    The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae.
    PLoS Pathog. 2020;16:e1008602.
    PubMed     Abstract available


  230. DOMBACH JL, Quintana JLJ, Nagy TA, Wan C, et al
    A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids.
    PLoS Pathog. 2020;16:e1009119.
    PubMed     Abstract available


  231. BOSIO CF, Jarrett CO, Scott DP, Fintzi J, et al
    Comparison of the transmission efficiency and plague progression dynamics associated with two mechanisms by which fleas transmit Yersinia pestis.
    PLoS Pathog. 2020;16:e1009092.
    PubMed     Abstract available


    November 2020
  232. HICKS ND, Giffen SR, Culviner PH, Chao MC, et al
    Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.
    PLoS Pathog. 2020;16:e1009063.
    PubMed     Abstract available


  233. BROWN MM, Horswill AR
    Staphylococcus epidermidis-Skin friend or foe?
    PLoS Pathog. 2020;16:e1009026.
    PubMed     Abstract available


  234. BADGUJAR DC, Anil A, Green AE, Surve MV, et al
    Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle.
    PLoS Pathog. 2020;16:e1009016.
    PubMed     Abstract available


  235. BROWN AO, Garsin DA
    The pathogenesis of cardiac microlesion formation during severe bacteremic infection.
    PLoS Pathog. 2020;16:e1009021.
    PubMed    


  236. GUPTA A, Arora G, Rosen CE, Kloos Z, et al
    A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
    PLoS Pathog. 2020;16:e1009030.
    PubMed     Abstract available


    October 2020
  237. MASTERS EA, de Mesy Bentley KL, Gill AL, Hao SP, et al
    Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.
    PLoS Pathog. 2020;16:e1008988.
    PubMed     Abstract available


  238. SUTIWISESAK R, Hicks ND, Boyce S, Murphy KC, et al
    A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
    PLoS Pathog. 2020;16:e1009000.
    PubMed     Abstract available


  239. GENOULA M, Marin Franco JL, Maio M, Dolotowicz B, et al
    Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1alpha activation.
    PLoS Pathog. 2020;16:e1008929.
    PubMed     Abstract available


  240. DU H, Bing J, Hu T, Ennis CL, et al
    Candida auris: Epidemiology, biology, antifungal resistance, and virulence.
    PLoS Pathog. 2020;16:e1008921.
    PubMed     Abstract available


  241. CAMILLI G, Griffiths JS, Ho J, Richardson JP, et al
    Some like it hot: Candida activation of inflammasomes.
    PLoS Pathog. 2020;16:e1008975.
    PubMed    


  242. MAIDEN MM, Waters CM
    Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance.
    PLoS Pathog. 2020;16:e1008529.
    PubMed     Abstract available


  243. VEGGI D, Bianchi F, Santini L, Lo Surdo P, et al
    4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.
    PLoS Pathog. 2020;16:e1008882.
    PubMed     Abstract available


  244. KAMARAJAN P, Ateia I, Shin JM, Fenno JC, et al
    Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.
    PLoS Pathog. 2020;16:e1008881.
    PubMed     Abstract available


  245. TETREAU G, Dhinaut J, Galinier R, Audant-Lacour P, et al
    Deciphering the molecular mechanisms of mother-to-egg immune protection in the mealworm beetle Tenebrio molitor.
    PLoS Pathog. 2020;16:e1008935.
    PubMed     Abstract available


  246. ZHANG Y, Chen T, Raghunandanan S, Xiang X, et al
    YebC regulates variable surface antigen VlsE expression and is required for host immune evasion in Borrelia burgdorferi.
    PLoS Pathog. 2020;16:e1008953.
    PubMed     Abstract available


  247. OHNO M, Hasegawa M, Hayashi A, Caballero-Flores G, et al
    Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3.
    PLoS Pathog. 2020;16:e1008928.
    PubMed     Abstract available


  248. ZAVALA-ALVARADO C, Sismeiro O, Legendre R, Varet H, et al
    The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress.
    PLoS Pathog. 2020;16:e1008904.
    PubMed     Abstract available


  249. KHAN M, Harms JS, Liu Y, Eickhoff J, et al
    Brucella suppress STING expression via miR-24 to enhance infection.
    PLoS Pathog. 2020;16:e1009020.
    PubMed     Abstract available


  250. THANH DUY P, Thieu NTV, Nguyen Thi Nguyen T, Ngoc Dan Thanh H, et al
    Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.
    PLoS Pathog. 2020;16:e1008998.
    PubMed     Abstract available


  251. BARNAWI H, Masri N, Hussain N, Al-Lawati B, et al
    RNA-based thermoregulation of a Campylobacter jejuni zinc resistance determinant.
    PLoS Pathog. 2020;16:e1009008.
    PubMed     Abstract available


  252. PERON-CANE C, Fernandez JC, Leblanc J, Wingertsmann L, et al
    Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells.
    PLoS Pathog. 2020;16:e1009001.
    PubMed     Abstract available


    September 2020
  253. GODFROID M, Dagan T, Merker M, Kohl TA, et al
    Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak.
    PLoS Pathog. 2020;16:e1008357.
    PubMed     Abstract available


  254. SINGH DK, Dwivedi VP, Singh SP, Kumari A, et al
    Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
    PLoS Pathog. 2020;16:e1008887.
    PubMed     Abstract available


  255. KASTELBERG B, Tubau-Juni N, Ayubi T, Leung A, et al
    NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
    PLoS Pathog. 2020;16:e1008854.
    PubMed     Abstract available


  256. FARIS R, McCullough A, Andersen SE, Moninger TO, et al
    The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion.
    PLoS Pathog. 2020;16:e1008878.
    PubMed     Abstract available


  257. ZARATE-POTES A, Yang W, Pees B, Schalkowski R, et al
    The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.
    PLoS Pathog. 2020;16:e1008826.
    PubMed     Abstract available


  258. BILVERSTONE TW, Garland M, Cave RJ, Kelly ML, et al
    The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.
    PLoS Pathog. 2020;16:e1008852.
    PubMed     Abstract available


  259. LUTHRA A, Montezuma-Rusca JM, La Vake CJ, LeDoyt M, et al
    Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.
    PLoS Pathog. 2020;16:e1008871.
    PubMed     Abstract available


  260. VRLA GD, Esposito M, Zhang C, Kang Y, et al
    Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa.
    PLoS Pathog. 2020;16:e1008867.
    PubMed     Abstract available


  261. BABB-BIERNACKI SJ, Esselstyn JA, Doyle VP
    Rethinking host range in Pneumocystis.
    PLoS Pathog. 2020;16:e1008824.
    PubMed    


  262. ALERU O, Barber MF
    Battlefronts of evolutionary conflict between bacteria and animal hosts.
    PLoS Pathog. 2020;16:e1008797.
    PubMed    


  263. HUANG H, Ren L, Li H, Schmidt A, et al
    The nesting preference of an invasive ant is associated with the cues produced by actinobacteria in soil.
    PLoS Pathog. 2020;16:e1008800.
    PubMed     Abstract available


  264. MOYE-ROWLEY WS
    Linkage between genes involved in azole resistance and ergosterol biosynthesis.
    PLoS Pathog. 2020;16:e1008819.
    PubMed    


  265. RAJAN A, Robertson MJ, Carter HE, Poole NM, et al
    Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.
    PLoS Pathog. 2020;16:e1008851.
    PubMed     Abstract available


    August 2020
  266. ALAMEH S, Bartolo G, O'Brien S, Henderson EA, et al
    Anthrax toxin component, Protective Antigen, protects insects from bacterial infections.
    PLoS Pathog. 2020;16:e1008836.
    PubMed     Abstract available


  267. MA YC, Yang ZS, Ma LQ, Shu R, et al
    YAP in epithelium senses gut barrier loss to deploy defenses against pathogens.
    PLoS Pathog. 2020;16:e1008766.
    PubMed     Abstract available


  268. BELMONT-MONROY L, Saitz-Rojas W, Soria-Bustos J, Mickey AS, et al
    Characterization of a novel AraC/XylS-regulated family of N-acyltransferases in pathogens of the order Enterobacterales.
    PLoS Pathog. 2020;16:e1008776.
    PubMed     Abstract available


  269. SAENKHAM P, Ritter M, Donati GL, Subashchandrabose S, et al
    Copper primes adaptation of uropathogenic Escherichia coli to superoxide stress by activating superoxide dismutases.
    PLoS Pathog. 2020;16:e1008856.
    PubMed     Abstract available


  270. HONEYCUTT JD, Wenner N, Li Y, Brewer SM, et al
    Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa.
    PLoS Pathog. 2020;16:e1008763.
    PubMed     Abstract available


  271. BRANDT P, Garbe E, Vylkova S
    Catch the wave: Metabolomic analyses in human pathogenic fungi.
    PLoS Pathog. 2020;16:e1008757.
    PubMed    


  272. SHROPSHIRE JD, Kalra M, Bordenstein SR
    Evolution-guided mutagenesis of the cytoplasmic incompatibility proteins: Identifying CifA's complex functional repertoire and new essential regions in CifB.
    PLoS Pathog. 2020;16:e1008794.
    PubMed     Abstract available


  273. ANTONI C, Quentin D, Lang AE, Aktories K, et al
    Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
    PLoS Pathog. 2020;16:e1008530.
    PubMed     Abstract available


  274. BONHOMME D, Santecchia I, Vernel-Pauillac F, Caroff M, et al
    Leptospiral LPS escapes mouse TLR4 internalization and TRIFassociated antimicrobial responses through O antigen and associated lipoproteins.
    PLoS Pathog. 2020;16:e1008639.
    PubMed     Abstract available


  275. BAYRAM J, Malcova I, Sinkovec L, Holubova J, et al
    Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.
    PLoS Pathog. 2020;16:e1008512.
    PubMed     Abstract available


  276. DALLMANN-SAUER M, Fava VM, Gzara C, Orlova M, et al
    The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions.
    PLoS Pathog. 2020;16:e1008818.
    PubMed     Abstract available


  277. TUCEY TM, Verma J, Olivier FAB, Lo TL, et al
    Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection.
    PLoS Pathog. 2020;16:e1008695.
    PubMed     Abstract available


  278. CHANG YY, Stevenin V, Duchateau M, Giai Gianetto Q, et al
    Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape.
    PLoS Pathog. 2020;16:e1008822.
    PubMed     Abstract available


  279. TASCON I, Li X, Lucas M, Nelson D, et al
    Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD.
    PLoS Pathog. 2020;16:e1008734.
    PubMed     Abstract available


  280. TRZILOVA D, Anjuwon-Foster BR, Torres Rivera D, Tamayo R, et al
    Rho factor mediates flagellum and toxin phase variation and impacts virulence in Clostridioides difficile.
    PLoS Pathog. 2020;16:e1008708.
    PubMed     Abstract available


  281. CHEN GY, Ayres JS
    Beyond tug-of-war: Iron metabolism in cooperative host-microbe interactions.
    PLoS Pathog. 2020;16:e1008698.
    PubMed    


  282. JIANG W, Ubhayasekera W, Breed MC, Norsworthy AN, et al
    MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation.
    PLoS Pathog. 2020;16:e1008707.
    PubMed     Abstract available


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