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  Hypertension

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Articles published in Circulation

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Single Articles


    April 2025
  1. YU Q, Tai YY, Tang Y, Zhao J, et al
    Correction to: BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
    Circulation. 2025;151:e967.
    PubMed    


  2. AGRAWAL V, Hemnes AR
    Integrin Targeting Therapies in Pulmonary Arterial Hypertension: A Roadmap for Traversing the Translational Valley of Death?
    Circulation. 2025;151:1184-1186.
    PubMed    


  3. SINGH R, Kulthinee S, Nasci VL, Akwo EA, et al
    G-Protein-Coupled Estrogen Receptor 1 and Pregnancy Confer Protection Against Hypertension in Older Females.
    Circulation. 2025;151:1126-1129.
    PubMed    


  4. HONG J, Medzikovic L, Sun W, Wong B, et al
    Correction to: Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.
    Circulation. 2025;151:e921.
    PubMed    


  5. CAO N, Lan C, Chen C, Xu Z, et al
    Correction to: Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension.
    Circulation. 2025;151:e866.
    PubMed    


    March 2025
  6. NIIRANEN TJ, Schnabel RB, Schutte AE, Biton Y, et al
    Hypertension and Atrial Fibrillation: A Frontier Review From the AF-SCREEN International Collaboration.
    Circulation. 2025;151:863-877.
    PubMed     Abstract available


  7. HOEPER MM, Oerke B, Wissmuller M, Leuchte H, et al
    Correction to: Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study.
    Circulation. 2025;151:e763.
    PubMed    


  8. VONGPATANASIN W, Turcu AF
    The Journey of Resistant Hypertension: From the Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure to American Heart Association/American College of Cardiology Guidelines.
    Circulation. 2025;151:653-655.
    PubMed    


  9. DAI H, Lu X, Zhou X
    Letter by Dai et al Regarding Article, "Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction".
    Circulation. 2025;151:e686.
    PubMed    


    February 2025
  10. YU AYX, Auger N, Fu L, Chu A, et al
    Population-Level Screening for Diabetes and Dyslipidemia After Pregnancies Complicated by Hypertension or Diabetes.
    Circulation. 2025;151:508-510.
    PubMed    


  11. COUNTOURIS M, Mahmoud Z, Cohen JB, Crousillat D, et al
    Hypertension in Pregnancy and Postpartum: Current Standards and Opportunities to Improve Care.
    Circulation. 2025;151:490-507.
    PubMed     Abstract available


  12. JOHNSTON A, Petrcich W, Smith GN, Fell DB, et al
    Risk of Incident Atrial Fibrillation in Women With a History of Hypertensive Disorders of Pregnancy: A Population-Based Retrospective Cohort Study.
    Circulation. 2025 Feb 11. doi: 10.1161/CIRCULATIONAHA.124.072418.
    PubMed     Abstract available


  13. KRESS TC, Barris CT, Kovacs L, Khakina BN, et al
    CD4(+) T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1alpha-Mediated Increases in Endothelial NADPH Oxidase 1.
    Circulation. 2025 Feb 5. doi: 10.1161/CIRCULATIONAHA.124.070538.
    PubMed     Abstract available


    January 2025
  14. HOEPER MM, Haughie S, Hassan T, Vogt S, et al
    Response by Hoeper et al to Letter Regarding Article, "Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults with Pulmonary Arterial Hypertension".
    Circulation. 2025;151:e32.
    PubMed    


  15. YAN P, Zhang M, Cao Y
    Letter by Yan et al Regarding Article, "Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults With Pulmonary Arterial Hypertension".
    Circulation. 2025;151:e31.
    PubMed    


  16. LEMAY SE, Montesinos MS, Grobs Y, Yokokawa T, et al
    Exploring Integrin alpha5beta1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies.
    Circulation. 2025 Jan 20. doi: 10.1161/CIRCULATIONAHA.124.070693.
    PubMed     Abstract available


    December 2024
  17. LAFFIN LJ
    Future of Antihypertensive Therapies.
    Circulation. 2024;150:1987-1989.
    PubMed    


    November 2024
  18. ZHANG M, Pan X, Zhu X
    Letter by Zhang et al Regarding Article, "Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era".
    Circulation. 2024;150:e467.
    PubMed    


  19. MCLAUGHLIN VV, Humbert M
    Pulmonary Hypertension: From Therapeutic Nihilism to Multiple Therapeutic Interventions.
    Circulation. 2024;150:1653-1655.
    PubMed    


    October 2024
  20. BARONE GIBBS B, Perera S, Huber KA, Paley JL, et al
    Effects of Sedentary Behavior Reduction on Blood Pressure in Desk Workers: Results From the RESET-BP Randomized Clinical Trial.
    Circulation. 2024;150:1416-1427.
    PubMed     Abstract available


  21. DELCROIX M, Pepke-Zaba J, D'Armini AM, Fadel E, et al
    Worldwide CTEPH Registry: Long-Term Outcomes With Pulmonary Endarterectomy, Balloon Pulmonary Angioplasty, and Medical Therapy.
    Circulation. 2024;150:1354-1365.
    PubMed     Abstract available


  22. VUKADINOVIC D, Lauder L, Kandzari DE, Bhatt DL, et al
    Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis.
    Circulation. 2024 Oct 2. doi: 10.1161/CIRCULATIONAHA.124.069709.
    PubMed     Abstract available


  23. GIANNOPOULOS AA, Gimelli A
    Unveiling the Hidden Layers of Hypertensive Heart Disease Through Quantitative PET Imaging.
    Circulation. 2024;150:1087-1089.
    PubMed    


    September 2024
  24. JIANG X, Mahfoud F, Li W, Dong H, et al
    Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation in Chinese Patients With Uncontrolled Hypertension: The Randomized, Sham-Controlled, Multi-Center Iberis-HTN Trial.
    Circulation. 2024 Sep 4. doi: 10.1161/CIRCULATIONAHA.124.069215.
    PubMed     Abstract available


    August 2024
  25. HONG J, Medzikovic L, Sun W, Wong B, et al
    Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.
    Circulation. 2024 Aug 21. doi: 10.1161/CIRCULATIONAHA.124.069864.
    PubMed     Abstract available


  26. XU X, Divakaran S, Weber BN, Hainer J, et al
    Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension.
    Circulation. 2024 Aug 21. doi: 10.1161/CIRCULATIONAHA.123.067083.
    PubMed     Abstract available


  27. ZHANG Z, Liu K, Chen X
    Letter by Zhang et al Regarding Article, "Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program".
    Circulation. 2024;150:e181-e182.
    PubMed    


    July 2024
  28. LIU B, Yi D, Xia X, Ramirez K, et al
    General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2alpha/Notch4 Pathway.
    Circulation. 2024;150:414-417.
    PubMed    


  29. COOPER LA, Marsteller JA, Carson KA, Dietz KB, et al
    Equitable Care for Hypertension: Blood Pressure and Patient-Reported Outcomes of the RICH LIFE Cluster Randomized Trial.
    Circulation. 2024;150:230-242.
    PubMed     Abstract available


    June 2024
  30. HOEPER MM, Oerke B, Wissmuller M, Leuchte H, et al
    Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study.
    Circulation. 2024 Jun 28. doi: 10.1161/CIRCULATIONAHA.124.069340.
    PubMed     Abstract available


  31. ZHANG Q, Yaoita N, Tabuchi A, Liu S, et al
    Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension.
    Circulation. 2024 Jun 14. doi: 10.1161/CIRCULATIONAHA.124.068726.
    PubMed     Abstract available



  32. Correction to: Status and Future Directions for Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease With and Without Pulmonary Hypertension: A Scientific Statement From the American Heart Association.
    Circulation. 2024;149:e1412.
    PubMed    


    May 2024
  33. SALAHUDDIN A, Harris IS, Sabanayagam A
    Double Whammy Complicating Management of Pulmonary Hypertension.
    Circulation. 2024;149:1770-1774.
    PubMed    


  34. JHENG JR, Bai Y, Noda K, Huot JR, et al
    Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction.
    Circulation. 2024 May 28. doi: 10.1161/CIRCULATIONAHA.124.068624.
    PubMed     Abstract available


  35. HOEPER MM, Ewert R, Jansa P, Sirenko Y, et al
    Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults With Pulmonary Arterial Hypertension.
    Circulation. 2024 May 16. doi: 10.1161/CIRCULATIONAHA.123.068107.
    PubMed     Abstract available


  36. RUBIN LJ
    Is There a Role for Calcium Channel Blockers in the Contemporary Treatment Paradigm for Pulmonary Arterial Hypertension?
    Circulation. 2024;149:1565-1567.
    PubMed    


  37. HARING B, Andrews CA, Hovey K, Shadyab AH, et al
    Systolic Blood Pressure and Survival to Very Old Age: Results From the Women's Health Initiative.
    Circulation. 2024;149:1568-1577.
    PubMed     Abstract available


  38. TANG H, Gupta A, Morrisroe SA, Bao C, et al
    Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension.
    Circulation. 2024 May 2. doi: 10.1161/CIRCULATIONAHA.123.065304.
    PubMed     Abstract available


    April 2024
  39. BORDAN Z, Batori R, Haigh S, Li X, et al
    PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension.
    Circulation. 2024 Apr 29. doi: 10.1161/CIRCULATIONAHA.123.067095.
    PubMed     Abstract available


  40. RAO RJ, Chan SY
    Mediating Metabolism: Inhibition of Malic Enzyme 1 (ME1) Restores Endothelial Bioenergetics and Adenosine Signaling in Pulmonary Hypertension.
    Circulation. 2024;149:1372-1374.
    PubMed    


  41. GERHARDT F, Fiessler E, Olsson KM, Kayser MZ, et al
    Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era.
    Circulation. 2024 Apr 12. doi: 10.1161/CIRCULATIONAHA.122.063821.
    PubMed     Abstract available


  42. KANDZARI DE, Weber MA, Pathak A, Zidar JP, et al
    Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results from the TARGET BP I Randomized Clinical Trial.
    Circulation. 2024 Apr 8. doi: 10.1161/CIRCULATIONAHA.124.069291.
    PubMed     Abstract available


  43. SHEN H, Gao Y, Ge D, Tan M, et al
    BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension.
    Circulation. 2024 Apr 1. doi: 10.1161/CIRCULATIONAHA.123.066430.
    PubMed     Abstract available


    March 2024
  44. PETER JG, Ntusi NAB, Ntsekhe M
    Are Recommendations That Favor Other Agents Over Angiotensin-Converting Enzyme Inhibitors in Africans With Hypertension Justified?
    Circulation. 2024;149:804-806.
    PubMed    


  45. AGGARWAL V, Giri J, Visovatti SH, Mahmud E, et al
    Status and Future Directions for Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease With and Without Pulmonary Hypertension: A Scientific Statement From the American Heart Association.
    Circulation. 2024 Mar 7. doi: 10.1161/CIR.0000000000001197.
    PubMed     Abstract available


    February 2024
  46. REDING KW, Jordan JH
    Multimodal Imaging Evidence for Optimized Blood Pressure Control Following Hypertensive Pregnancy: Mechanistic Insights Into Beneficial Cardiac Remodeling From the POP-HT Trial.
    Circulation. 2024;149:542-544.
    PubMed    


  47. PITT B, Williams GH
    Aldosterone Synthase Inhibitors and Mineralocorticoid Receptor Antagonists: Competitors or Collaborators?
    Circulation. 2024;149:414-416.
    PubMed    


  48. LUO Y, Qi X, Zhang Z, Zhang J, et al
    Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension.
    Circulation. 2024 Feb 5. doi: 10.1161/CIRCULATIONAHA.123.067579.
    PubMed     Abstract available


    January 2024
  49. BIAN JS, Chen J, Zhang J, Tan J, et al
    ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension.
    Circulation. 2024 Jan 12. doi: 10.1161/CIRCULATIONAHA.123.067005.
    PubMed     Abstract available


    December 2023
  50. OSTERGAARD L, Olesen JB, Petersen JK, Nielsen LS, et al
    Arterial Thromboembolism in Patients With Atrial Fibrillation and CHA(2)DS(2)-VASc 1: A Nationwide Study.
    Circulation. 2023 Dec 28. doi: 10.1161/CIRCULATIONAHA.123.066477.
    PubMed     Abstract available


  51. REAY WR, Clarke E, Eslick S, Riveros C, et al
    Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension.
    Circulation. 2023 Dec 22. doi: 10.1161/CIRCULATIONAHA.123.065394.
    PubMed     Abstract available


  52. RASMUSSEN SB, Jeppesen KK, Kjaergaard J, Hassager C, et al
    Blood Pressure and Oxygen Targets on Kidney Injury After Cardiac Arrest.
    Circulation. 2023;148:1860-1869.
    PubMed     Abstract available


    November 2023
  53. HUNDEMER GL, Agharazii M, Madore F, Vaidya A, et al
    Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study.
    Circulation. 2023 Nov 30. doi: 10.1161/CIRCULATIONAHA.123.066389.
    PubMed     Abstract available


  54. WALTERS R, Vasilaki E, Wilkins MR, Zhao L, et al
    Response by Walters et al to Letter Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension".
    Circulation. 2023;148:1825-1826.
    PubMed    


  55. LI G, Chen H, Ren C
    Letter by Li et al Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension".
    Circulation. 2023;148:1823-1824.
    PubMed    


  56. HOSOKAWA K, Watanabe H, Taniguchi Y, Ikeda N, et al
    A Multicenter, Single-Blind, Randomized, Warfarin-Controlled Trial of Edoxaban in Patients With Chronic Thromboembolic Pulmonary Hypertension: KABUKI Trial.
    Circulation. 2023 Nov 13. doi: 10.1161/CIRCULATIONAHA.123.067528.
    PubMed    


  57. KITT J, Krasner S, Barr L, Frost A, et al
    Cardiac Remodeling After Hypertensive Pregnancy Following Physician-Optimized Blood Pressure Self-Management: The POP-HT Randomized Clinical Trial Imaging Sub-study.
    Circulation. 2023 Nov 11. doi: 10.1161/CIRCULATIONAHA.123.067597.
    PubMed     Abstract available


    October 2023
  58. AZIZI M, Sharp ASP, Fisher NDL, Weber MA, et al
    Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure at 6 Months Following Medication Escalation: The RADIANCE Clinical Trial Program.
    Circulation. 2023 Oct 26. doi: 10.1161/CIRCULATIONAHA.123.066941.
    PubMed     Abstract available


  59. OSTROMINSKI JW, Vaduganathan M, Selvaraj S, Claggett BL, et al
    Dapagliflozin and Apparent Treatment-Resistant Hypertension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The DELIVER Trial.
    Circulation. 2023 Oct 13. doi: 10.1161/CIRCULATIONAHA.123.065254.
    PubMed     Abstract available


    September 2023
  60. KUEHN BM
    Experimental Drug, Combination Pill Show Promise for Treating Pulmonary Hypertension.
    Circulation. 2023;148:852-854.
    PubMed    


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