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  Valvular Heart Disease

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Articles published in Circulation

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Single Articles


    September 2024
  1. CRIBIER A, Eltchaninoff H
    Transcatheter Aortic Valve Implantation: Two Decades of a Revolutionary and Ongoing Odyssey.
    Circulation. 2024;150:821-822.
    PubMed    


  2. RAMO J, Jurgens SJ, Kany S, Choi SH, et al
    Rare Genetic Variants in LDLR, APOB, and PCSK9 are Associated with Aortic Stenosis.
    Circulation. 2024 Sep 2. doi: 10.1161/CIRCULATIONAHA.124.070982.
    PubMed     Abstract available


    August 2024
  3. SHRIDHAR P, Pal S, Clavere NG, Becker JR, et al
    Response by Shridhar et al to Letter Regarding Article, "MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy".
    Circulation. 2024;150:e201-e202.
    PubMed    


  4. DAVID TE
    Perspectives on Heart Valve Repair.
    Circulation. 2024;150:661-662.
    PubMed    


  5. SUN Y, Ren J
    Letter by Sun and Ren Regarding Article, "MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy".
    Circulation. 2024;150:e200.
    PubMed    


  6. VRUDHULA A, Duffy G, Vukadinovic M, Liang D, et al
    High-Throughput Deep Learning Detection of Mitral Regurgitation.
    Circulation. 2024 Aug 12. doi: 10.1161/CIRCULATIONAHA.124.069047.
    PubMed     Abstract available


  7. GOEL K, Makkar R, Krishnaswamy A, Kapadia S, et al
    Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States.
    Circulation. 2024 Aug 5. doi: 10.1161/CIRCULATIONAHA.124.068847.
    PubMed     Abstract available


    July 2024
  8. CARRIER L
    RNA Editing Holds Promise for Hypertrophic Cardiomyopathy Therapy.
    Circulation. 2024;150:299-301.
    PubMed    


  9. YANG P, Lou Y, Geng Z, Guo Z, et al
    Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy.
    Circulation. 2024;150:283-298.
    PubMed     Abstract available


    June 2024
  10. LONG A, Haggerty CM, Finer J, Hartzel D, et al
    Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR).
    Circulation. 2024 Jun 17. doi: 10.1161/CIRCULATIONAHA.124.068996.
    PubMed     Abstract available


  11. SMALL AM, Yutzey KE, Binstadt BA, Voigts Key K, et al
    Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.
    Circulation. 2024 Jun 17. doi: 10.1161/CIR.0000000000001254.
    PubMed     Abstract available


  12. QUAST C, Bonner F, Polzin A, Veulemans V, et al
    Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.
    Circulation. 2024 Jun 5. doi: 10.1161/CIRCULATIONAHA.123.064747.
    PubMed     Abstract available


  13. MCGURK KA, Bilgehan N, Ware JS
    Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy.
    Circulation. 2024;149:1786-1788.
    PubMed    


  14. OMMEN SR, Ho CY, Asif IM, Balaji S, et al
    2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
    Circulation. 2024;149:e1239-e1311.
    PubMed     Abstract available


    May 2024
  15. EVANGELISTA A, Galian-Gay L, Guala A, Teixido-Tura G, et al
    Atorvastatin Effect on Aortic Dilatation and Valvular Calcification Progression in Bicuspid Aortic Valve (BICATOR): A Randomized Clinical Trial.
    Circulation. 2024 May 28. doi: 10.1161/CIRCULATIONAHA.123.067537.
    PubMed     Abstract available


  16. KANG DH, Park SJ, Shin SH, Hwang IC, et al
    Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial.
    Circulation. 2024 May 1. doi: 10.1161/CIRCULATIONAHA.124.069144.
    PubMed     Abstract available


    April 2024
  17. SHEN M, Wu JC
    Empowering Valvular Heart Disease Research With Stem Cell-Derived Valve Cells.
    Circulation. 2024;149:1457-1460.
    PubMed    


  18. DAVIDSON LJ, Tang GHL, Ho EC, Fudim M, et al
    The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association.
    Circulation. 2024 Apr 25. doi: 10.1161/CIR.0000000000001232.
    PubMed     Abstract available


  19. LI B, Liu F, Chen X, Chen T, et al
    FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System.
    Circulation. 2024;149:1268-1284.
    PubMed     Abstract available


    February 2024
  20. HERRMANN HC, Desai ND
    Incidence, Implications, and Treatment of Patients With Severe Aortic Stenosis and Small Aortic Annulus.
    Circulation. 2024;149:656-657.
    PubMed    


  21. HOEDEMAKERS S, Pugliese NR, Stassen J, Vanoppen A, et al
    mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis.
    Circulation. 2024 Feb 27. doi: 10.1161/CIRCULATIONAHA.123.067130.
    PubMed     Abstract available


  22. CRESCI S, Bach RG, Saberi S, Owens AT, et al
    Effect of Mavacamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM.
    Circulation. 2024;149:498-509.
    PubMed     Abstract available


    January 2024
  23. HAN D, Zhou T, Li L, Ma Y, et al
    AVCAPIR: A Novel Procalcific PIWI-Interacting RNA in Calcific Aortic Valve Disease.
    Circulation. 2024 Jan 23. doi: 10.1161/CIRCULATIONAHA.123.065213.
    PubMed     Abstract available


  24. TOPRICEANU CC, Pereira AC, Moon JC, Captur G, et al
    Meta-Analysis of Penetrance and Systematic Review on Transition to Disease in Genetic Hypertrophic Cardiomyopathy.
    Circulation. 2024;149:107-123.
    PubMed     Abstract available


    December 2023
  25. SHRIDHAR P, Glennon MS, Pal S, Waldron CJ, et al
    MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:1870-1886.
    PubMed     Abstract available


    November 2023
  26. LIN Y, Yang Q, Lin X, Liu X, et al
    Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.
    Circulation. 2023 Nov 29. doi: 10.1161/CIRCULATIONAHA.123.065458.
    PubMed     Abstract available


  27. ROWIN EJ, Link MS, Maron MS, Maron BJ, et al
    Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:1797-1811.
    PubMed     Abstract available


  28. SEO K, Yamamoto Y, Kirillova A, Kawana M, et al
    Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-beta-Blocking R-Enantiomer Carvedilol.
    Circulation. 2023;148:1691-1704.
    PubMed     Abstract available



  29. Correction to: 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    Circulation. 2023;148:e185.
    PubMed    


  30. ROGERS MA, Bartoli-Leonard F, Zheng KH, Small AM, et al
    Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.
    Circulation. 2023 Nov 8. doi: 10.1161/CIRCULATIONAHA.123.066822.
    PubMed     Abstract available


    October 2023
  31. RODES-CABAU J, Ribeiro H, Mohammadi S, Serra V, et al
    Transcatheter or Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Small Aortic Annulus: A Randomized Clinical Trial.
    Circulation. 2023 Oct 26. doi: 10.1161/CIRCULATIONAHA.123.067326.
    PubMed     Abstract available


  32. KAPADIA SR, Krishnaswamy A, Whisenant B, Potluri S, et al
    Concomitant Left Atrial Appendage Occlusion and Transcatheter Aortic Valve Replacement Among Patients with Atrial Fibrillation.
    Circulation. 2023 Oct 24. doi: 10.1161/CIRCULATIONAHA.123.067312.
    PubMed     Abstract available


  33. DAHLE G, Al-Atassi T, Kaneko T
    The Future of Cardiac Surgical Training in the Age of Transcatheter Valvular Interventions.
    Circulation. 2023;148:1295-1297.
    PubMed    


  34. HARIRI E, Kassis N, Kapadia SR
    Letter by Hariri et al Regarding Article, "Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial".
    Circulation. 2023;148:1267-1268.
    PubMed    


  35. HASIFIC S, Rasmussen LM, Dahl JS, Diederichsen ACP, et al
    Response by Hasific et al to Letter Regarding Article, "Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial".
    Circulation. 2023;148:1269-1270.
    PubMed    


    September 2023
  36. JEX N, Greenwood JP, Cubbon RM, Rider OJ, et al
    Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
    Circulation. 2023 Sep 25. doi: 10.1161/CIRCULATIONAHA.122.063444.
    PubMed     Abstract available


  37. FIGLIOZZI S, Georgiopoulos G, Masci PG
    Letter by Figliozzi et al Regarding Article, "The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum".
    Circulation. 2023;148:978-979.
    PubMed    


  38. ESSAYAGH B, Benfari G, Antoine C, Grigioni F, et al
    Response by Essayagh et al to Letter Regarding Article, "The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum".
    Circulation. 2023;148:980-981.
    PubMed    


  39. AYERS MP, Kramer CM
    Imaging Myofibrillar Disarray and Microvascular Dysfunction in Hypertrophic Cardiomyopathy: Novel Imaging Biomarkers for a New Era in Therapeutics.
    Circulation. 2023;148:819-821.
    PubMed    


  40. JOY G, Kelly CI, Webber M, Pierce I, et al
    Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:808-818.
    PubMed     Abstract available


    August 2023
  41. REINDL M, Lechner I, Holzknecht M, Tiller C, et al
    Cardiac Magnetic Resonance Imaging Versus Computed Tomography to Guide Transcatheter Aortic Valve Replacement (TAVR-CMR): A Randomized, Open-Label, Non-Inferiority Trial.
    Circulation. 2023 Aug 27. doi: 10.1161/CIRCULATIONAHA.123.066498.
    PubMed     Abstract available


  42. PRAKASH SK, Michelena HI, Milewicz DM
    Bicuspid Aortic Valve and Thoracic Aortic Disease: Further Evidence of Clinically Silent but Deadly Risk to Family Members of Affected Individuals.
    Circulation. 2023;148:648-650.
    PubMed    



  43. Correction to: 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    Circulation. 2023;148:e8.
    PubMed    


  44. ABOU ALAIWI S, Roston TM, Marstrand P, Claggett BL, et al
    Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry.
    Circulation. 2023;148:394-404.
    PubMed     Abstract available


    July 2023
  45. ARMSTRONG DWJ, Riley LA, Su YR, Shah AS, et al
    Myocardial Neprilysin Is Increased in Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:167-169.
    PubMed    


  46. BLASER MC, Buffolo F, Halu A, Turner ME, et al
    Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
    Circulation. 2023 Jul 10. doi: 10.1161/CIRCULATIONAHA.122.063402.
    PubMed     Abstract available


  47. MONDA E, Limongelli G
    Letter by Monda and Limongelli Regarding Article, "The Prevalence and Association of Exercise Test Abnormalities With Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy".
    Circulation. 2023;148:73.
    PubMed    


    June 2023
  48. GLOTZBACH JP, Hanson HA, Tonna JE, Horns JJ, et al
    Familial Associations of Prevalence and Cause-Specific Mortality for Thoracic Aortic Disease and Bicuspid Aortic Valve in a Large-Population Database.
    Circulation. 2023 Jun 15. doi: 10.1161/CIRCULATIONAHA.122.060439.
    PubMed     Abstract available


    May 2023
  49. GALPER BZ, Chinnakondepalli KM, Wang K, Magnuson EA, et al
    Economic Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Low Surgical Risk: Results from the PARTNER 3 Trial.
    Circulation. 2023 May 8. doi: 10.1161/CIRCULATIONAHA.122.062481.
    PubMed     Abstract available


    April 2023
  50. GOLLMANN-TEPEKOYLU C, Graber M, Hirsch J, Mair S, et al
    Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.
    Circulation. 2023 Apr 4. doi: 10.1161/CIRCULATIONAHA.122.063481.
    PubMed     Abstract available


    March 2023
  51. RAKOWSKI H, Bataiosu R
    Can Novel Myosin Inhibitors Defer Septal Reduction Therapy in HCM? At What Risk and at What Cost?
    Circulation. 2023;147:864-866.
    PubMed    


  52. DESAI MY, Owens A, Geske JB, Wolski K, et al
    Dose-Blinded Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Outcomes Through 32 Weeks.
    Circulation. 2023;147:850-863.
    PubMed     Abstract available


    February 2023
  53. TURER AT, Wang A
    Cardiac Myosin Inhibitors: Unlocking Potential to Improve Treatment in Hypertrophic Cardiomyopathy.
    Circulation. 2023;147:700-702.
    PubMed    


  54. CONWAY J, Min S, Villa C, Weintraub RG, et al
    The Prevalence and Association of Exercise Test Abnormalities With Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy.
    Circulation. 2023;147:718-727.
    PubMed     Abstract available


  55. OSTROMINSKI JW, Bhatt DL, Scirica BM
    Pulling Out All the Stops: A Case of Progressive Dyspnea.
    Circulation. 2023;147:688-693.
    PubMed    



  56. Correction to: Overestimation of Stroke Risk in Rheumatic Mitral Stenosis and the Implications for Oral Anticoagulation.
    Circulation. 2023;147:e623.
    PubMed    


  57. SMALL AM, Peloso G, Linefsky J, Aragam J, et al
    Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.
    Circulation. 2023 Feb 20. doi: 10.1161/CIRCULATIONAHA.122.061451.
    PubMed     Abstract available


    January 2023
  58. DAR JA, Manickavasagam A, Jacob JR
    Syncope After Transcatheter Aortic Valve Implantation: Pace or Not?
    Circulation. 2023;147:442-446.
    PubMed    


  59. HALUSHKA MK, Witwer KW
    Letter by Halushka and Witwer Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracel
    Circulation. 2023;147:e64-e65.
    PubMed    


  60. GUTMANN C, Stojkovic S, Mayr M
    Letter by Gutmann et al Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular
    Circulation. 2023;147:e68-e69.
    PubMed    


  61. LI Q, Li Z, Lu C
    Letter by Li et al Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesic
    Circulation. 2023;147:e66-e67.
    PubMed    


  62. MONDA E, Limongelli G
    Integrated Sudden Cardiac Death Risk Prediction Model For Patients With Hypertrophic Cardiomyopathy.
    Circulation. 2023;147:281-283.
    PubMed    



  63. Correction to: A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.
    Circulation. 2023;147:e63.
    PubMed    


    December 2022
  64. ESSAYAGH B, Benfari G, Antoine C, Grigioni F, et al
    The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum.
    Circulation. 2022 Dec 27. doi: 10.1161/CIRCULATIONAHA.122.062612.
    PubMed     Abstract available


  65. SHELBAYA K, Claggett B, Dorbala P, Skali H, et al
    Stages of Valvular Heart Disease Among Older Adults in the Community: The Atherosclerosis Risk in Communities Study.
    Circulation. 2022 Dec 16. doi: 10.1161/CIRCULATIONAHA.122.061396.
    PubMed     Abstract available


  66. ISSELBACHER EM, Preventza O, Hamilton Black J 3rd, Augoustides JG, et al
    2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
    Circulation. 2022;146:e334-e482.
    PubMed     Abstract available


    November 2022
  67. SIGUERO-ALVAREZ M, Salguero-Jimenez A, Grego-Bessa J, de la Barrera J, et al
    Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.
    Circulation. 2022 Nov 3. doi: 10.1161/CIRCULATIONAHA.121.058767.
    PubMed     Abstract available


    October 2022
  68. HAHN RT, Chan V, Adams DH
    Current Indications for Transcatheter Edge-to-Edge Repair in a Patient With Primary Mitral Regurgitation.
    Circulation. 2022;146:1263-1265.
    PubMed    


  69. OMARJEE L
    Letter by Omarjee Regarding Article, "Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial".
    Circulation. 2022;146:e225-e226.
    PubMed    


  70. DIEDERICHSEN ACP, Hasific S, Dahl JS
    Response by Diederichsen et al to Letter Regarding Article, "Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial".
    Circulation. 2022;146:e227-e228.
    PubMed    


  71. JANUZZI JL, Omar AMS, Liu Y, Murphy S, et al
    Association Between Sacubitril/Valsartan Initiation and Mitral Regurgitation Severity in Heart Failure With Reduced Ejection Fraction: The PROVE-HF Study.
    Circulation. 2022 Oct 2. doi: 10.1161/CIRCULATIONAHA.122.061693.
    PubMed    


    September 2022
  72. GOTO S, Solanki D, John JE, Yagi R, et al
    Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection.
    Circulation. 2022;146:755-769.
    PubMed     Abstract available


    August 2022
  73. WEDIN JO, Vedin O, Rodin S, Simonson OE, et al
    Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure.
    Circulation. 2022 Aug 16:101161CIRCULATIONAHA122060125.
    PubMed     Abstract available


  74. BANOVIC M, Putnik S, Iung B, Bartunek J, et al
    Response by Banovic et al to Letter Regarding Article, "Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial".
    Circulation. 2022;146:e48-e49.
    PubMed    


  75. ENNEZAT PV, Malergue MC, Abergel E
    Letter by Ennezat et al Regarding Article, "Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial".
    Circulation. 2022;146:e44-e45.
    PubMed    


  76. DWECK MR, Dahl JS
    Letter by Dweck and Dahl Regarding Article, "Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial".
    Circulation. 2022;146:e46-e47.
    PubMed    


  77. MAKKAR R, Chakravarty T
    Missing Pieces of the Transcatheter Aortic Valve Replacement Subclinical Leaflet Thrombosis Puzzle.
    Circulation. 2022;146:494-497.
    PubMed    


    July 2022
  78. HOSEN MR, Goody PR, Zietzer A, Xiang X, et al
    Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles.
    Circulation. 2022 Jul 8:101161CIRCULATIONAHA122060258.
    PubMed     Abstract available


  79. FUKUI M, Bapat VN, Garcia S, Dworak MW, et al
    Deformation of Transcatheter Aortic Valve Prostheses: Implications for Hypoattenuating Leaflet Thickening and Clinical Outcomes.
    Circulation. 2022 Jul 8:101161CIRCULATIONAHA121058339.
    PubMed     Abstract available


    June 2022
  80. VAN BELLE E, Debry N, Vincent F, Kuchcinski G, et al
    Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort.
    Circulation. 2022 Jun 20:101161CIRCULATIONAHA121057145.
    PubMed     Abstract available


  81. RAWSHANI A, Sattar N, McGuire DK, Wallstrom O, et al
    Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2 Diabetes.
    Circulation. 2022 Jun 9. doi: 10.1161/CIRCULATIONAHA.121.058072.
    PubMed     Abstract available


    April 2022
  82. DIEDERICHSEN ACP, Lindholt JS, Moller S, Ovrehus KA, et al
    Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.
    Circulation. 2022 Apr 25. doi: 10.1161/CIRCULATIONAHA.121.057008.
    PubMed     Abstract available


  83. RIAZ M, Park J, Sewanan LR, Ren Y, et al
    Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.
    Circulation. 2022;145:1238-1253.
    PubMed     Abstract available


  84. TRIMAILLE A, Hmadeh S, Morel O
    Letter by Trimaille et al Regarding Article, "Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation".
    Circulation. 2022;145:e807-e808.
    PubMed    


  85. REED AK, Chiu P, Carreon CK, Sanders SP, et al
    Unrepairable Infant Mitral Valve: An Unexpected Case of Decompensated Heart Failure.
    Circulation. 2022;145:1175-1178.
    PubMed    


  86. KWIECINSKI J, Tzolos E, Bing R, Dweck MR, et al
    Response by Kwiecinski et al to Letter Regarding Article, "Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation".
    Circulation. 2022;145:e809-e810.
    PubMed    


  87. PARK DW, Ahn JM, Kang DY, Kim KW, et al
    Edoxaban versus Dual Antiplatelet Therapy for Leaflet Thrombosis and Cerebral Thromboembolism after TAVR: The ADAPT-TAVR Randomized Clinical Trial.
    Circulation. 2022 Apr 4. doi: 10.1161/CIRCULATIONAHA.122.059512.
    PubMed     Abstract available


    March 2022
  88. HILLIS GS, McCann GP, Newby DE
    Is Asymptomatic Severe Aortic Stenosis Still a Waiting Game?
    Circulation. 2022;145:874-876.
    PubMed    



  89. Correction to: Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial.
    Circulation. 2022;145:e761.
    PubMed    


    February 2022
  90. RABER I, Palmeri NO, Tahir UA, Zimetbaum PJ, et al
    A Pacemaker Red Herring and a Hypertrophic Cardiomyopathy Copycat.
    Circulation. 2022;145:622-625.
    PubMed    


  91. PASSOS LSA, Jha PK, Becker-Greene D, Blaser MC, et al
    Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8(+) T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.
    Circulation. 2022;145:531-548.
    PubMed     Abstract available


    January 2022
  92. VIJ A, Kavinsky CJ
    The Clinical Impact of Device Lead-Associated Tricuspid Regurgitation: Need for a Multidisciplinary Approach.
    Circulation. 2022;145:239-241.
    PubMed    


  93. AGUADO BA, Walker CJ, Grim JC, Schroeder ME, et al
    Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts.
    Circulation. 2022 Jan 10. doi: 10.1161/CIRCULATIONAHA.121.054108.
    PubMed     Abstract available


    December 2021
  94. BERNDT N, Eckstein J, Wallach I, Nordmeyer S, et al
    CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases.
    Circulation. 2021;144:1926-1939.
    PubMed     Abstract available


    November 2021
  95. SPIERING W, Mali WP, de Jong PA
    Letter by Spiering et al Regarding Article, "Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial".
    Circulation. 2021;144:e334.
    PubMed    


  96. BING R, Newby DE, Ralston SH, Dweck MR, et al
    Response by Bing et al to Letter Regarding Article, "Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial".
    Circulation. 2021;144:e335.
    PubMed    


  97. RANJBARVAZIRI S, Kooiker KB, Ellenberger M, Fajardo G, et al
    Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
    Circulation. 2021;144:1714-1731.
    PubMed     Abstract available


  98. RAMAN B, Tunnicliffe EM, Chan K, Ariga R, et al
    Association Between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights From a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach.
    Circulation. 2021;144:1656-1658.
    PubMed    


  99. BANOVIC M, Putnik S, Penicka M, Doros G, et al
    Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis: The AVATAR Trial.
    Circulation. 2021 Nov 13. doi: 10.1161/CIRCULATIONAHA.121.057639.
    PubMed     Abstract available


  100. ABDEL-WAHAB M, Hartung P, Dumpies O, Obradovic D, et al
    Comparison of a Pure Plug-Based versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial.
    Circulation. 2021 Nov 5. doi: 10.1161/CIRCULATIONAHA.121.057856.
    PubMed     Abstract available


    October 2021
  101. BELHASSEN B, Shauer A, Biton Y
    Left Bundle-Branch Block Tachycardia After Transcatheter Aortic Valve Replacement.
    Circulation. 2021;144:1444-1448.
    PubMed    


    September 2021
  102. DANIELS MJ, Fusi L, Semsarian C, Naidu SS, et al
    Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine.
    Circulation. 2021;144:759-762.
    PubMed    


    August 2021
  103. AGUIB Y, Allouba M, Walsh R, Ibrahim AM, et al
    New Variant With a Previously Unrecognized Mechanism of Pathogenicity in Hypertrophic Cardiomyopathy.
    Circulation. 2021;144:754-757.
    PubMed    


  104. KWIECINSKI J, Tzolos E, Cartlidge TRG, Fletcher A, et al
    Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients with Transcatheter Aortic Valve Implantation.
    Circulation. 2021 Aug 29. doi: 10.1161/CIRCULATIONAHA.121.056891.
    PubMed     Abstract available


  105. MANISTY CH, Jordan JH, Hundley WG
    Automated Noncontrast Myocardial Tissue Characterization for Hypertrophic Cardiomyopathy: Holy Grail or False Prophet?
    Circulation. 2021;144:600-603.
    PubMed    


  106. EZEKOWITZ JA
    Residuals: Mitral Regurgitation, Bias, and Effects of Medical Therapy.
    Circulation. 2021;144:438-440.
    PubMed    


    July 2021
  107. KUMBHANI DJ, Peterson ED
    Sequential Evolution of Quality Assessment for Aortic Valvular Heart Interventions.
    Circulation. 2021;144:195-198.
    PubMed    


  108. DESAI ND, O'Brien SM, Cohen DJ, Carroll J, et al
    Composite Metric for Benchmarking Site Performance in Transcatheter Aortic Valve Replacement: Results From the STS/ACC TVT Registry.
    Circulation. 2021;144:186-194.
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  109. ZHANG Q, Burrage MK, Lukaschuk E, Shanmuganathan M, et al
    Towards Replacing Late Gadolinium Enhancement with Artificial Intelligence Virtual Native Enhancement for Gadolinium-Free Cardiovascular Magnetic Resonance Tissue Characterization in Hypertrophic Cardiomyopathy.
    Circulation. 2021 Jul 7. doi: 10.1161/CIRCULATIONAHA.121.054432.
    PubMed     Abstract available


    June 2021
  110. DEMER LL, Tintut Y
    Hearts of Stone: Calcific Aortic Stenosis and Antiresorptive Agents for Osteoporosis.
    Circulation. 2021;143:2428-2430.
    PubMed    


  111. WATKINS H
    Time to Think Differently About Sarcomere-Negative Hypertrophic Cardiomyopathy.
    Circulation. 2021;143:2415-2417.
    PubMed    


  112. TAM DY, Wijeysundera HC
    A Real-World Examination of Embolic Protection Devices for Transcatheter Aortic Valve Replacement.
    Circulation. 2021;143:2241-2243.
    PubMed    


    May 2021
  113. KAR S, Mack MJ, Lindenfeld J, Abraham WT, et al
    Relationship Between Residual Mitral Regurgitation and Clinical and Quality-of-Life Outcomes After Transcatheter and Medical Treatments in Heart Failure: The COAPT Trial.
    Circulation. 2021 May 27. doi: 10.1161/CIRCULATIONAHA.120.053061.
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    Evaluation and Management of Aortic Stenosis in Chronic Kidney Disease: A Scientific Statement From the American Heart Association.
    Circulation. 2021 May 13:CIR0000000000000979. doi: 10.1161/CIR.0000000000000979.
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    April 2021
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    Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial.
    Circulation. 2021 Apr 29. doi: 10.1161/CIRCULATIONAHA.121.053708.
    PubMed     Abstract available


  116. LINDMAN BR, Merryman WD
    Unloading the Stenotic Path to Identifying Medical Therapy for Calcific Aortic Valve Disease: Barriers and Opportunities.
    Circulation. 2021;143:1455-1457.
    PubMed    


    March 2021
  117. KIM WK, Walther T, Burgdorf C, Mollmann H, et al
    One-Year Outcomes of a Randomized Trial Comparing a Self-Expanding With a Balloon-Expandable Transcatheter Aortic Valve.
    Circulation. 2021;143:1267-1269.
    PubMed    


  118. MARON MS, Ommen SR
    Exploring New and Old Therapies for Obstructive Hypertrophic Cardiomyopathy: Mavacamten in Perspective.
    Circulation. 2021;143:1181-1183.
    PubMed    


  119. GRACE A, Mellor G, Williams L
    Letter by Grace et al Regarding Article, "A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy".
    Circulation. 2021;143:e786-e787.
    PubMed    


  120. MITAL S, Armstrong KR, Butts RJ, Conway J, et al
    Response by Mital et al to Letter Regarding Article, "A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy".
    Circulation. 2021;143:e788-e789.
    PubMed    


  121. CONSTANT DIT BEAUFILS AL, Huttin O, Jobbe-Duval A, Senage T, et al
    Replacement Myocardial Fibrosis in Patients with Mitral Valve Prolapse: Relation to Mitral Regurgitation, Ventricular Remodeling and Arrhythmia.
    Circulation. 2021 Mar 12. doi: 10.1161/CIRCULATIONAHA.120.050214.
    PubMed     Abstract available



  122. Correction to: 2020 ACC/AHA Guideline on the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
    Circulation. 2021;143:e784.
    PubMed    


  123. VINCENT F, Ternacle J, Denimal T, Shen M, et al
    Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis.
    Circulation. 2021;143:1043-1061.
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    February 2021
  124. BUTALA NM, Makkar R, Secemsky EA, Gallup D, et al
    Cerebral Embolic Protection and Outcomes of Transcatheter Aortic Valve Replacement: Results from the TVT Registry.
    Circulation. 2021 Feb 23. doi: 10.1161/CIRCULATIONAHA.120.052874.
    PubMed     Abstract available


  125. WORKMAN V, Forrest JK, Enriquez A
    A Case of Presyncope After Transcatheter Aortic Valve Replacement.
    Circulation. 2021;143:857-861.
    PubMed    


  126. SHAH SV, Bavry AA, Kumbhani DJ
    Transcatheter Mitral Valve Edge-to-Edge Repair for Secondary Mitral Regurgitation: Why Sex Matters.
    Circulation. 2021;143:621-623.
    PubMed    


  127. SABERI S, Cardim N, Yamani M, Schulz-Menger J, et al
    Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis.
    Circulation. 2021;143:606-608.
    PubMed    



  128. Correction to: 2020 ACC/AHA Guideline on the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
    Circulation. 2021;143:e228.
    PubMed    



  129. Correction to: 2020 ACC/AHA Guideline on the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
    Circulation. 2021;143:e229.
    PubMed    


    January 2021
  130. HO CY
    Guidelines on the Verge of a More Evidence-Based Era for Hypertrophic Cardiomyopathy.
    Circulation. 2021;143:295-297.
    PubMed    


  131. MESSAS E, IJsselmuiden A, Goudot G, Vlieger S, et al
    Feasibility and Performance of Noninvasive Ultrasound Therapy in Patients With Severe Symptomatic Aortic Valve Stenosis: A First-in-Human Study.
    Circulation. 2021 Jan 25. doi: 10.1161/CIRCULATIONAHA.120.050672.
    PubMed    


  132. FORTUNI F, Bax JJ, Delgado V
    Changing the Paradigm in the Management of Valvular Heart Disease: In Addition to Left Ventricular Ejection Fraction, Focus on the Myocardium.
    Circulation. 2021;143:209-211.
    PubMed    


  133. URENA M, Vahanian A, Brochet E, Ducrocq G, et al
    Current Indications for Transcatheter Mitral Valve Replacement Using Transcatheter Aortic Valves: Valve-in-Valve, Valve-in-Ring, and Valve-in-Mitral Annulus Calcification.
    Circulation. 2021;143:178-196.
    PubMed     Abstract available


  134. BAPAT VN
    Mitral Valve-in-Valve, Valve-in-Ring, and Valve-in-Mitral Annular Calcification: Are We There Yet?
    Circulation. 2021;143:117-119.
    PubMed    


  135. PELLICCIA F, Gersh BJ, Camici PG
    Gaps in Evidence for Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.
    Circulation. 2021;143:101-103.
    PubMed    


    December 2020
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    2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
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    PubMed    


  137. OTTO CM, Nishimura RA, Bonow RO, Carabello BA, et al
    2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    Circulation. 2020 Dec 17:CIR0000000000000932. doi: 10.1161/CIR.0000000000000932.
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  138. BAVRY AA, Arnaoutakis GJ
    Perspective to 2020 AHA/ACC Guideline for the Management of Patients with Valvular Heart Disease.
    Circulation. 2020 Dec 17. doi: 10.1161/CIRCULATIONAHA.120.051501.
    PubMed    


  139. MEHMOOD M
    Letter by Mehmood Regarding Article, "Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction".
    Circulation. 2020;142:e375-e376.
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  140. PETERZAN MA, Neubauer S, Rodgers CT, Rider OJ, et al
    Response by Peterzan et al to Letter Regarding Article, "Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction".
    Circulation. 2020;142:e377-e378.
    PubMed    


    November 2020
  141. USEINI D, Strauch J
    Letter by Useini and Strauch Regarding Article, "Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients: The PARTNER 3 Trial".
    Circulation. 2020;142:e310-e311.
    PubMed    


  142. LOARDI C, Zanobini M
    Letter by Loardi and Zanobini Regarding Article, "Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients: The PARTNER 3 Trial".
    Circulation. 2020;142:e312-e313.
    PubMed    


  143. PIBAROT P, Mack MJ, Leon MB, Hahn RT, et al
    Response by Pibarot et al to Letter Regarding Article, "Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients: The PARTNER 3 Trial".
    Circulation. 2020;142:e314-e315.
    PubMed    


  144. POLLARI F, Vogt F, Fischlein T
    Letter by Pollari et al Regarding Article, "Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients: The PARTNER 3 Trial".
    Circulation. 2020;142:e308-e309.
    PubMed    


  145. KARTHIKEYAN G, Connolly SJ, Yusuf S
    Overestimation of Stroke Risk in Rheumatic Mitral Stenosis and the Implications for Oral Anticoagulation.
    Circulation. 2020;142:1697-1699.
    PubMed    


    October 2020
  146. LURZ P, Unterhuber M, Rommel KP, Kresoja KP, et al
    Closure of Iatrogenic Atrial Septal Defect Following Transcatheter Mitral Valve Repair: The Randomized MITHRAS Trial.
    Circulation. 2020 Oct 15. doi: 10.1161/CIRCULATIONAHA.120.051989.
    PubMed    


  147. TAMBURINO C, Bleiziffer S, Thiele H, Scholtz S, et al
    Comparison of Self-Expanding Bioprostheses for Transcatheter Aortic Valve Replacement in Patients with Symptomatic Severe Aortic Stenosis: The SCOPE 2 Randomized Clinical Trial.
    Circulation. 2020 Oct 15. doi: 10.1161/CIRCULATIONAHA.120.051547.
    PubMed     Abstract available


  148. DEL VAL D, Linke A, Abdel-Wahab M, Latib A, et al
    Long-Term Outcomes After Infective Endocarditis After Transcatheter Aortic Valve Replacement.
    Circulation. 2020;142:1497-1499.
    PubMed    


  149. CHAN V, Mazer CD, Ali FM, Quan A, et al
    Randomized, Controlled Trial Comparing Mitral Valve Repair With Leaflet Resection Versus Leaflet Preservation on Functional Mitral Stenosis: The CAMRA CardioLink-2 Study.
    Circulation. 2020;142:1342-1350.
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  150. HANZEL GS, Gersh BJ
    Transcatheter Aortic Valve Replacement in Low-Risk, Young Patients: Natural Expansion or Cause for Concern?
    Circulation. 2020;142:1317-1319.
    PubMed    


    September 2020
  151. SIMONATO M, Whisenant B, Barbosa Ribeiro H, Webb JG, et al
    Transcatheter Mitral Valve Replacement After Surgical Repair or Replacement: Comprehensive Mid-Term Evaluation of Valve-in-Valve and Valve-in-Ring Implantation from the VIVID Registry.
    Circulation. 2020 Sep 25. doi: 10.1161/CIRCULATIONAHA.120.049088.
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    April 2020
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    Hypertrophic Cardiomyopathy With Left Ventricular Systolic Dysfunction: Insights From the SHaRe Registry.
    Circulation. 2020;141:1371-1383.
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    March 2020
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    Response by Weissler-Snir and Dorian to Letter Regarding Article, "Hypertrophic Cardiomyopathy-Related Sudden Cardiac Death in Young People in Ontario".
    Circulation. 2020;141:e703-e704.
    PubMed    


  154. MADIAS JE
    Letter by Madias Regarding Article, "Hypertrophic Cardiomyopathy-Related Sudden Cardiac Death in Young People in Ontario".
    Circulation. 2020;141:e701-e702.
    PubMed    


  155. TOEPFER CN, Garfinkel AC, Venturini G, Wakimoto H, et al
    Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
    Circulation. 2020;141:828-842.
    PubMed     Abstract available


    November 2019
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    Slowing Progression of Cardiovascular Calcification with SNF472 in Patients on Hemodialysis: Results of a Randomized, Phase 2b Study.
    Circulation. 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044195.
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