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  Valvular Heart Disease

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Articles published in Circulation

Retrieve available abstracts of 78 articles:
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Single Articles


    June 2025
  1. BERRY JD, de Lemos JA
    Biomarkers to Guide the Timing of Aortic Valve Replacement in Asymptomatic Aortic Stenosis: Where Do We Stand After Early TAVR?
    Circulation. 2025;151:1565-1567.
    PubMed    


    May 2025
  2. PRABHU NK, Aykut B, Mensah-Mamfo M, Overbey DM, et al
    Partial Heart Transplantation: Early Experience With Pediatric Heart Valve Replacements That Grow.
    Circulation. 2025;151:1477-1490.
    PubMed     Abstract available


  3. DESAI MY, Wolski K, Owens A, Geske JB, et al
    Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results From VALOR-HCM.
    Circulation. 2025;151:1378-1390.
    PubMed     Abstract available


  4. METRA M, Tomasoni D, Adamo M, Anker SD, et al
    Evidence Generation and Implementation of Transcatheter Interventions for Atrioventricular Valvular Heart Disease in Heart Failure: Current Status and Future Directions.
    Circulation. 2025;151:1342-1363.
    PubMed     Abstract available


    April 2025
  5. VEKSTEIN AM, Wegermann ZK, Manandhar P, Mack MJ, et al
    Outcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry.
    Circulation. 2025 Apr 3. doi: 10.1161/CIRCULATIONAHA.124.071838.
    PubMed     Abstract available


    March 2025
  6. LINDMAN BR, Pibarot P, Schwartz A, Oldemeyer JB, et al
    Cardiac Biomarkers in Patients with Asymptomatic Severe Aortic Stenosis: Analysis from the EARLY TAVR Trial.
    Circulation. 2025 Mar 31. doi: 10.1161/CIRCULATIONAHA.125.074425.
    PubMed     Abstract available


  7. TANGUTURI VK, Abou-Karam R, Cheng F, Duan R, et al
    Electronic Provider Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: a Randomized Clinical Trial.
    Circulation. 2025 Mar 30. doi: 10.1161/CIRCULATIONAHA.125.074470.
    PubMed     Abstract available


  8. KAR S, Makkar RR, Whisenant BK, Hamid N, et al
    Two-year Outcomes of Transcatheter Edge-to-edge Repair for Severe Tricuspid Regurgitation: The TRILUMINATE Pivotal Randomized Trial.
    Circulation. 2025 Mar 30. doi: 10.1161/CIRCULATIONAHA.125.074536.
    PubMed     Abstract available


  9. MEISNER JK, Renberg A, Smith ED, Tsan YC, et al
    Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.
    Circulation. 2025;151:783-798.
    PubMed     Abstract available


    February 2025
  10. ROSA M, Dupont A, Smadja DM, Soquet J, et al
    Aortic Valve Calcification Is Induced by the Loss of ALDH1A1 and Can Be Prevented by Agonists of Retinoic Acid Receptor Alpha: Preclinical Evidence for Drug Repositioning.
    Circulation. 2025 Feb 24. doi: 10.1161/CIRCULATIONAHA.124.071954.
    PubMed     Abstract available


  11. ZHANG B, Enriquez-Sarano M, Schaff HV, Michelena HI, et al
    Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy.
    Circulation. 2025 Feb 24. doi: 10.1161/CIRCULATIONAHA.123.066523.
    PubMed     Abstract available


    January 2025
  12. PARK SJ, Kang DH
    Response by Park and Kang to Letter Regarding Article, "Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial".
    Circulation. 2025;151:e28.
    PubMed    


  13. WANG J, Peng Y
    Letter by Wang and Peng Regarding Article, "Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial".
    Circulation. 2025;151:e27.
    PubMed    


  14. GUDMUNDSDOTTIR HL, Axelsson Raja A, Rossing K, Rasmusen H, et al
    Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial.
    Circulation. 2025;151:132-144.
    PubMed     Abstract available


    December 2024
  15. TOMII D, Pilgrim T, Borger MA, De Backer O, et al
    Aortic Stenosis and Coronary Artery Disease: Decision-Making Between Surgical and Transcatheter Management.
    Circulation. 2024;150:2046-2069.
    PubMed     Abstract available


    November 2024
  16. URENA M
    Transseptal Transcatheter Valve-in-Valve Mitral Valve Implantation: Ready for Prime Time.
    Circulation. 2024;150:1505-1507.
    PubMed    


    October 2024
  17. RUDOLPH F, Geyer M, Baldus S, De Luca VM, et al
    Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation - a Post-hoc Analysis of the MATTERHORN Trial.
    Circulation. 2024 Oct 30. doi: 10.1161/CIRCULATIONAHA.124.072648.
    PubMed    


  18. WEDIN JO, Naslund V, Rodin S, Simonson OE, et al
    Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis.
    Circulation. 2024 Oct 23. doi: 10.1161/CIRCULATIONAHA.124.070753.
    PubMed     Abstract available


  19. MAURIZI N, Antiochos P, Owens A, Lakdwala N, et al
    Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry.
    Circulation. 2024;150:1377-1390.
    PubMed     Abstract available


  20. BENKHOFF M, Barcik M, Mourikis P, Dahlmanns J, et al
    Targeting Sphingosine-1-Phosphate Signaling to Prevent the Progression of Aortic Valve Disease.
    Circulation. 2024 Oct 21. doi: 10.1161/CIRCULATIONAHA.123.067270.
    PubMed     Abstract available


  21. HOEDEMAKERS S, Cosyns B, Droogmans S, Verbrugge FH, et al
    Response by Hoedemakers et al to Letter Regarding Article, "mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis".
    Circulation. 2024;150:e278-e279.
    PubMed    


  22. JHA AK
    Letter by Jha Regarding Article, "mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis".
    Circulation. 2024;150:e276-e277.
    PubMed    


    September 2024
  23. SANNINO A, Mahkmudova U
    Artificial Intelligence and Mitral Regurgitation: Friend or Foe?
    Circulation. 2024;150:934-937.
    PubMed    



  24. Correction to: 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    Circulation. 2024;150:e267.
    PubMed    


  25. CRIBIER A, Eltchaninoff H
    Transcatheter Aortic Valve Implantation: Two Decades of a Revolutionary and Ongoing Odyssey.
    Circulation. 2024;150:821-822.
    PubMed    


  26. RAMO J, Jurgens SJ, Kany S, Choi SH, et al
    Rare Genetic Variants in LDLR, APOB, and PCSK9 are Associated with Aortic Stenosis.
    Circulation. 2024 Sep 2. doi: 10.1161/CIRCULATIONAHA.124.070982.
    PubMed     Abstract available


    August 2024
  27. SHRIDHAR P, Pal S, Clavere NG, Becker JR, et al
    Response by Shridhar et al to Letter Regarding Article, "MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy".
    Circulation. 2024;150:e201-e202.
    PubMed    


  28. DAVID TE
    Perspectives on Heart Valve Repair.
    Circulation. 2024;150:661-662.
    PubMed    


  29. SUN Y, Ren J
    Letter by Sun and Ren Regarding Article, "MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy".
    Circulation. 2024;150:e200.
    PubMed    


  30. VRUDHULA A, Duffy G, Vukadinovic M, Liang D, et al
    High-Throughput Deep Learning Detection of Mitral Regurgitation.
    Circulation. 2024 Aug 12. doi: 10.1161/CIRCULATIONAHA.124.069047.
    PubMed     Abstract available


  31. GOEL K, Makkar R, Krishnaswamy A, Kapadia S, et al
    Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States.
    Circulation. 2024 Aug 5. doi: 10.1161/CIRCULATIONAHA.124.068847.
    PubMed     Abstract available


    July 2024
  32. CARRIER L
    RNA Editing Holds Promise for Hypertrophic Cardiomyopathy Therapy.
    Circulation. 2024;150:299-301.
    PubMed    


  33. YANG P, Lou Y, Geng Z, Guo Z, et al
    Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy.
    Circulation. 2024;150:283-298.
    PubMed     Abstract available


    June 2024
  34. LONG A, Haggerty CM, Finer J, Hartzel D, et al
    Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR).
    Circulation. 2024 Jun 17. doi: 10.1161/CIRCULATIONAHA.124.068996.
    PubMed     Abstract available


  35. SMALL AM, Yutzey KE, Binstadt BA, Voigts Key K, et al
    Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.
    Circulation. 2024 Jun 17. doi: 10.1161/CIR.0000000000001254.
    PubMed     Abstract available


  36. QUAST C, Bonner F, Polzin A, Veulemans V, et al
    Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.
    Circulation. 2024 Jun 5. doi: 10.1161/CIRCULATIONAHA.123.064747.
    PubMed     Abstract available


  37. MCGURK KA, Bilgehan N, Ware JS
    Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy.
    Circulation. 2024;149:1786-1788.
    PubMed    


  38. OMMEN SR, Ho CY, Asif IM, Balaji S, et al
    2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
    Circulation. 2024;149:e1239-e1311.
    PubMed     Abstract available


    May 2024
  39. EVANGELISTA A, Galian-Gay L, Guala A, Teixido-Tura G, et al
    Atorvastatin Effect on Aortic Dilatation and Valvular Calcification Progression in Bicuspid Aortic Valve (BICATOR): A Randomized Clinical Trial.
    Circulation. 2024 May 28. doi: 10.1161/CIRCULATIONAHA.123.067537.
    PubMed     Abstract available


  40. KANG DH, Park SJ, Shin SH, Hwang IC, et al
    Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial.
    Circulation. 2024 May 1. doi: 10.1161/CIRCULATIONAHA.124.069144.
    PubMed     Abstract available


    April 2024
  41. SHEN M, Wu JC
    Empowering Valvular Heart Disease Research With Stem Cell-Derived Valve Cells.
    Circulation. 2024;149:1457-1460.
    PubMed    


  42. DAVIDSON LJ, Tang GHL, Ho EC, Fudim M, et al
    The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association.
    Circulation. 2024 Apr 25. doi: 10.1161/CIR.0000000000001232.
    PubMed     Abstract available


  43. LI B, Liu F, Chen X, Chen T, et al
    FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System.
    Circulation. 2024;149:1268-1284.
    PubMed     Abstract available


    February 2024
  44. HERRMANN HC, Desai ND
    Incidence, Implications, and Treatment of Patients With Severe Aortic Stenosis and Small Aortic Annulus.
    Circulation. 2024;149:656-657.
    PubMed    


  45. HOEDEMAKERS S, Pugliese NR, Stassen J, Vanoppen A, et al
    mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis.
    Circulation. 2024 Feb 27. doi: 10.1161/CIRCULATIONAHA.123.067130.
    PubMed     Abstract available


  46. CRESCI S, Bach RG, Saberi S, Owens AT, et al
    Effect of Mavacamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM.
    Circulation. 2024;149:498-509.
    PubMed     Abstract available


    January 2024
  47. HAN D, Zhou T, Li L, Ma Y, et al
    AVCAPIR: A Novel Procalcific PIWI-Interacting RNA in Calcific Aortic Valve Disease.
    Circulation. 2024 Jan 23. doi: 10.1161/CIRCULATIONAHA.123.065213.
    PubMed     Abstract available


  48. TOPRICEANU CC, Pereira AC, Moon JC, Captur G, et al
    Meta-Analysis of Penetrance and Systematic Review on Transition to Disease in Genetic Hypertrophic Cardiomyopathy.
    Circulation. 2024;149:107-123.
    PubMed     Abstract available


    December 2023
  49. SHRIDHAR P, Glennon MS, Pal S, Waldron CJ, et al
    MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:1870-1886.
    PubMed     Abstract available


    November 2023
  50. LIN Y, Yang Q, Lin X, Liu X, et al
    Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.
    Circulation. 2023 Nov 29. doi: 10.1161/CIRCULATIONAHA.123.065458.
    PubMed     Abstract available


  51. ROWIN EJ, Link MS, Maron MS, Maron BJ, et al
    Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:1797-1811.
    PubMed     Abstract available


  52. SEO K, Yamamoto Y, Kirillova A, Kawana M, et al
    Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-beta-Blocking R-Enantiomer Carvedilol.
    Circulation. 2023;148:1691-1704.
    PubMed     Abstract available



  53. Correction to: 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    Circulation. 2023;148:e185.
    PubMed    


  54. ROGERS MA, Bartoli-Leonard F, Zheng KH, Small AM, et al
    Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.
    Circulation. 2023 Nov 8. doi: 10.1161/CIRCULATIONAHA.123.066822.
    PubMed     Abstract available


    October 2023
  55. RODES-CABAU J, Ribeiro H, Mohammadi S, Serra V, et al
    Transcatheter or Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Small Aortic Annulus: A Randomized Clinical Trial.
    Circulation. 2023 Oct 26. doi: 10.1161/CIRCULATIONAHA.123.067326.
    PubMed     Abstract available


  56. KAPADIA SR, Krishnaswamy A, Whisenant B, Potluri S, et al
    Concomitant Left Atrial Appendage Occlusion and Transcatheter Aortic Valve Replacement Among Patients with Atrial Fibrillation.
    Circulation. 2023 Oct 24. doi: 10.1161/CIRCULATIONAHA.123.067312.
    PubMed     Abstract available


  57. DAHLE G, Al-Atassi T, Kaneko T
    The Future of Cardiac Surgical Training in the Age of Transcatheter Valvular Interventions.
    Circulation. 2023;148:1295-1297.
    PubMed    


  58. HARIRI E, Kassis N, Kapadia SR
    Letter by Hariri et al Regarding Article, "Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial".
    Circulation. 2023;148:1267-1268.
    PubMed    


  59. HASIFIC S, Rasmussen LM, Dahl JS, Diederichsen ACP, et al
    Response by Hasific et al to Letter Regarding Article, "Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial".
    Circulation. 2023;148:1269-1270.
    PubMed    


    September 2023
  60. JEX N, Greenwood JP, Cubbon RM, Rider OJ, et al
    Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
    Circulation. 2023 Sep 25. doi: 10.1161/CIRCULATIONAHA.122.063444.
    PubMed     Abstract available


  61. FIGLIOZZI S, Georgiopoulos G, Masci PG
    Letter by Figliozzi et al Regarding Article, "The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum".
    Circulation. 2023;148:978-979.
    PubMed    


  62. ESSAYAGH B, Benfari G, Antoine C, Grigioni F, et al
    Response by Essayagh et al to Letter Regarding Article, "The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum".
    Circulation. 2023;148:980-981.
    PubMed    


  63. AYERS MP, Kramer CM
    Imaging Myofibrillar Disarray and Microvascular Dysfunction in Hypertrophic Cardiomyopathy: Novel Imaging Biomarkers for a New Era in Therapeutics.
    Circulation. 2023;148:819-821.
    PubMed    


  64. JOY G, Kelly CI, Webber M, Pierce I, et al
    Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:808-818.
    PubMed     Abstract available


    August 2023
  65. REINDL M, Lechner I, Holzknecht M, Tiller C, et al
    Cardiac Magnetic Resonance Imaging Versus Computed Tomography to Guide Transcatheter Aortic Valve Replacement (TAVR-CMR): A Randomized, Open-Label, Non-Inferiority Trial.
    Circulation. 2023 Aug 27. doi: 10.1161/CIRCULATIONAHA.123.066498.
    PubMed     Abstract available


  66. PRAKASH SK, Michelena HI, Milewicz DM
    Bicuspid Aortic Valve and Thoracic Aortic Disease: Further Evidence of Clinically Silent but Deadly Risk to Family Members of Affected Individuals.
    Circulation. 2023;148:648-650.
    PubMed    



  67. Correction to: 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    Circulation. 2023;148:e8.
    PubMed    


  68. ABOU ALAIWI S, Roston TM, Marstrand P, Claggett BL, et al
    Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry.
    Circulation. 2023;148:394-404.
    PubMed     Abstract available


    July 2023
  69. ARMSTRONG DWJ, Riley LA, Su YR, Shah AS, et al
    Myocardial Neprilysin Is Increased in Hypertrophic Cardiomyopathy.
    Circulation. 2023;148:167-169.
    PubMed    


  70. BLASER MC, Buffolo F, Halu A, Turner ME, et al
    Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
    Circulation. 2023 Jul 10. doi: 10.1161/CIRCULATIONAHA.122.063402.
    PubMed     Abstract available


  71. MONDA E, Limongelli G
    Letter by Monda and Limongelli Regarding Article, "The Prevalence and Association of Exercise Test Abnormalities With Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy".
    Circulation. 2023;148:73.
    PubMed    


    June 2023
  72. GLOTZBACH JP, Hanson HA, Tonna JE, Horns JJ, et al
    Familial Associations of Prevalence and Cause-Specific Mortality for Thoracic Aortic Disease and Bicuspid Aortic Valve in a Large-Population Database.
    Circulation. 2023 Jun 15. doi: 10.1161/CIRCULATIONAHA.122.060439.
    PubMed     Abstract available


    May 2023
  73. GALPER BZ, Chinnakondepalli KM, Wang K, Magnuson EA, et al
    Economic Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Low Surgical Risk: Results from the PARTNER 3 Trial.
    Circulation. 2023 May 8. doi: 10.1161/CIRCULATIONAHA.122.062481.
    PubMed     Abstract available


    April 2023
  74. GOLLMANN-TEPEKOYLU C, Graber M, Hirsch J, Mair S, et al
    Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.
    Circulation. 2023 Apr 4. doi: 10.1161/CIRCULATIONAHA.122.063481.
    PubMed     Abstract available


    March 2023
  75. RAKOWSKI H, Bataiosu R
    Can Novel Myosin Inhibitors Defer Septal Reduction Therapy in HCM? At What Risk and at What Cost?
    Circulation. 2023;147:864-866.
    PubMed    


  76. DESAI MY, Owens A, Geske JB, Wolski K, et al
    Dose-Blinded Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Outcomes Through 32 Weeks.
    Circulation. 2023;147:850-863.
    PubMed     Abstract available


    February 2023
  77. TURER AT, Wang A
    Cardiac Myosin Inhibitors: Unlocking Potential to Improve Treatment in Hypertrophic Cardiomyopathy.
    Circulation. 2023;147:700-702.
    PubMed    


  78. CONWAY J, Min S, Villa C, Weintraub RG, et al
    The Prevalence and Association of Exercise Test Abnormalities With Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy.
    Circulation. 2023;147:718-727.
    PubMed     Abstract available


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