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  Drug Resistance

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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 57 articles:
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Single Articles


    March 2024
  1. SCHWARTZMAN JA, Lebreton F, Salamzade R, Shea T, et al
    Global diversity of enterococci and description of 18 previously unknown species.
    Proc Natl Acad Sci U S A. 2024;121:e2310852121.
    PubMed     Abstract available


    December 2023
  2. ALONSO-DEL VALLE A, Toribio-Celestino L, Quirant A, Pi CT, et al
    Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.
    Proc Natl Acad Sci U S A. 2023;120:e2314135120.
    PubMed     Abstract available


    October 2023
  3. KOBRAS CM, Monteith W, Somerville S, Delaney JM, et al
    Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae.
    Proc Natl Acad Sci U S A. 2023;120:e2308029120.
    PubMed     Abstract available


    August 2023
  4. MEHROTRA T, Konar D, Pragasam AK, Kumar S, et al
    Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
    Proc Natl Acad Sci U S A. 2023;120:e2305465120.
    PubMed     Abstract available


    July 2023
  5. LI M, Wang P, Zhang K, Zhang H, et al
    Single cobalt atoms anchored on Ti(3)C(2)T(x) with dual reaction sites for efficient adsorption-degradation of antibiotic resistance genes.
    Proc Natl Acad Sci U S A. 2023;120:e2305705120.
    PubMed     Abstract available


    May 2023
  6. VILLALBA MI, Rossetti E, Bonvallat A, Yvanoff C, et al
    Simple optical nanomotion method for single-bacterium viability and antibiotic response testing.
    Proc Natl Acad Sci U S A. 2023;120:e2221284120.
    PubMed     Abstract available


    April 2023
  7. BENZ F, Hall AR
    Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids.
    Proc Natl Acad Sci U S A. 2023;120:e2212147120.
    PubMed     Abstract available


    February 2023
  8. DHINDWAL P, Thompson C, Kos D, Planedin K, et al
    A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.
    Proc Natl Acad Sci U S A. 2023;120:e2219827120.
    PubMed     Abstract available


  9. ORNES S
    Researchers turn to tiny robots to fight antibiotic resistance.
    Proc Natl Acad Sci U S A. 2023;120:e2300515120.
    PubMed    


    January 2023
  10. WANG Y, Yu Z, Ding P, Lu J, et al
    Antidepressants can induce mutation and enhance persistence toward multiple antibiotics.
    Proc Natl Acad Sci U S A. 2023;120:e2208344120.
    PubMed     Abstract available


  11. PEARL MIZRAHI S, Goyal A, Gore J
    Community interactions drive the evolution of antibiotic tolerance in bacteria.
    Proc Natl Acad Sci U S A. 2023;120:e2209043119.
    PubMed     Abstract available


  12. BRANDIS G, Larsson J, Elf J
    Antibiotic perseverance increases the risk of resistance development.
    Proc Natl Acad Sci U S A. 2023;120:e2216216120.
    PubMed     Abstract available


    October 2022
  13. NYE TM, Tukenmez H, Singh P, Flores-Mireles AL, et al
    Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
    Proc Natl Acad Sci U S A. 2022;119:e2210912119.
    PubMed     Abstract available


  14. LI L, Chai Y, Peng W, Li D, et al
    Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel.
    Proc Natl Acad Sci U S A. 2022;119:e2210724119.
    PubMed     Abstract available


  15. LI HZ, Yang K, Liao H, Lassen SB, et al
    Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics.
    Proc Natl Acad Sci U S A. 2022;119:e2201473119.
    PubMed     Abstract available


    September 2022
  16. DAS SG, Krug J
    Unpredictable repeatability in molecular evolution.
    Proc Natl Acad Sci U S A. 2022;119:e2209373119.
    PubMed     Abstract available


  17. HUANG KJ, Pantua H, Diao J, Skippington E, et al
    Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2022;119:e2123117119.
    PubMed     Abstract available


  18. WONG JLC, David S, Sanchez-Garrido J, Woo JZ, et al
    Recurrent emergence of Klebsiella pneumoniae carbapenem resistance mediated by an inhibitory ompK36 mRNA secondary structure.
    Proc Natl Acad Sci U S A. 2022;119:e2203593119.
    PubMed     Abstract available


  19. ZARNOWSKI R, Sanchez H, Jaromin A, Zarnowska UJ, et al
    A common vesicle proteome drives fungal biofilm development.
    Proc Natl Acad Sci U S A. 2022;119:e2211424119.
    PubMed     Abstract available


  20. ROGAWSKI MCQUADE ET, Brennhofer SA, Elwood SE, McMurry TL, et al
    Frequency of bystander exposure to antibiotics for enteropathogenic bacteria among young children in low-resource settings.
    Proc Natl Acad Sci U S A. 2022;119:e2208972119.
    PubMed     Abstract available


  21. WILLIS JA, Cheburkanov V, Chen S, Soares JM, et al
    Breaking down antibiotic resistance in methicillin-resistant Staphylococcus aureus: Combining antimicrobial photodynamic and antibiotic treatments.
    Proc Natl Acad Sci U S A. 2022;119:e2208378119.
    PubMed     Abstract available


  22. TOBA S, Sato A, Kawai M, Taoda Y, et al
    Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
    Proc Natl Acad Sci U S A. 2022;119:e2206104119.
    PubMed     Abstract available


    July 2022
  23. SINGH AK, De Wijngaert B, Bijnens M, Uyttersprot K, et al
    Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
    Proc Natl Acad Sci U S A. 2022;119:e2203660119.
    PubMed     Abstract available


  24. FAIT A, Seif Y, Mikkelsen K, Poudel S, et al
    Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories.
    Proc Natl Acad Sci U S A. 2022;119:e2118262119.
    PubMed     Abstract available


  25. RASOULY A, Nudler E
    The very hungry bactericidal antibiotics.
    Proc Natl Acad Sci U S A. 2022;119:e2208035119.
    PubMed    


    May 2022
  26. NEWBURY A, Dawson B, Klumper U, Hesse E, et al
    Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks.
    Proc Natl Acad Sci U S A. 2022;119:e2118361119.
    PubMed     Abstract available


  27. LIAKOPOULOS A, Aulin LBS, Buffoni M, Fragkiskou E, et al
    Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.
    Proc Natl Acad Sci U S A. 2022;119:e2121768119.
    PubMed     Abstract available


    April 2022
  28. HERNANDO-AMADO S, Laborda P, Valverde JR, Martinez JL, et al
    Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness.
    Proc Natl Acad Sci U S A. 2022;119:e2109370119.
    PubMed     Abstract available


  29. LAUGHLIN ZT, Nandi S, Dey D, Zelinskaya N, et al
    50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
    Proc Natl Acad Sci U S A. 2022;119:e2120352119.
    PubMed     Abstract available


  30. GEORGE NL, Schilmiller AL, Orlando BJ
    Conformational snapshots of the bacitracin sensing and resistance transporter BceAB.
    Proc Natl Acad Sci U S A. 2022;119:e2123268119.
    PubMed     Abstract available


    March 2022
  31. ZHANG Q, Wang R, Wang M, Liu C, et al
    Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver.
    Proc Natl Acad Sci U S A. 2022;119:e2119417119.
    PubMed     Abstract available


    February 2022
  32. VASAN AK, Haloi N, Ulrich RJ, Metcalf ME, et al
    Role of internal loop dynamics in antibiotic permeability of outer membrane porins.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  33. KARITA Y, Limmer DT, Hallatschek O
    Scale-dependent tipping points of bacterial colonization resistance.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    November 2021
  34. MARTIN MJ, Corey BW, Sannio F, Hall LR, et al
    Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  35. REITHUBER E, Wixe T, Ludwig KC, Muller A, et al
    THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  36. KONIG G, Sokkar P, Pryk N, Heinrich S, et al
    Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021
  37. DAN L, Li Y, Chen S, Liu J, et al
    A rapidly reversible mutation generates subclonal genetic diversity and unstable drug resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  38. LI J, Sae Her A, Traaseth NJ
    Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  39. ADKINS-JABLONSKY SJ, Clark CM, Papoulis SE, Kuhl MD, et al
    Market forces determine the distribution of a leaky function in a simple microbial community.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021
  40. LIM J, Lee JJ, Lee SK, Kim S, et al
    Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  41. CHAHAL J, Gebert LFR, Camargo C, MacRae IJ, et al
    miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  42. OTTONI C, Boric D, Cheronet O, Sparacello V, et al
    Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  43. DIMITRIU T, Matthews AC, Buckling A
    Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    July 2021
  44. GRASS LM, Wollenhaupt J, Barthel T, Parfentev I, et al
    Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  45. ZHANG J, Zhao X, Cappiello JR, Yang Y, et al
    Identification of simple arylfluorosulfates as potent agents against resistant bacteria.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  46. ARAGAW WW, Lee BM, Yang X, Zimmerman MD, et al
    Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  47. QIAN X, Gunturu S, Sun W, Cole JR, et al
    Long-read sequencing revealed cooccurrence, host range, and potential mobility of antibiotic resistome in cow feces.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  48. CHE Y, Yang Y, Xu X, Brinda K, et al
    Reply to Shaw: Challenges for enrichment analysis of AMR gene-bearing plasmids.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  49. SCHUBERT MG, Goodman DB, Wannier TM, Kaur D, et al
    High-throughput functional variant screens via in vivo production of single-stranded DNA.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  50. JO WK, Schadenhofer A, Habierski A, Kaiser FK, et al
    Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  51. ANGST DC, Tepekule B, Sun L, Bogos B, et al
    Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  52. LU EY, Chen HH, Zhao H, Ozawa S, et al
    Health and economic impact of the pneumococcal conjugate vaccine in hindering antimicrobial resistance in China.
    Proc Natl Acad Sci U S A. 2021;118:e2004933118.
    PubMed     Abstract available


    February 2021
  53. HUEMER M, Mairpady Shambat S, Bergada-Pijuan J, Soderholm S, et al
    Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  54. CHE Y, Yang Y, Xu X, Brinda K, et al
    Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  55. CARD KJ, Thomas MD, Graves JL Jr, Barrick JE, et al
    Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  56. GIRGIS HS, DuPai CD, Lund J, Reeder J, et al
    Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  57. OLDENKAMP R, Schultsz C, Mancini E, Cappuccio A, et al
    Filling the gaps in the global prevalence map of clinical antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


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