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  Drug Resistance

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Articles published in Proc Natl Acad Sci U S A

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    February 2021
  1. HUEMER M, Mairpady Shambat S, Bergada-Pijuan J, Soderholm S, et al
    Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  2. CHE Y, Yang Y, Xu X, Brinda K, et al
    Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  3. CARD KJ, Thomas MD, Graves JL Jr, Barrick JE, et al
    Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  4. GIRGIS HS, DuPai CD, Lund J, Reeder J, et al
    Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  5. OLDENKAMP R, Schultsz C, Mancini E, Cappuccio A, et al
    Filling the gaps in the global prevalence map of clinical antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  6. AUNINS TR, Erickson KE, Chatterjee A
    Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coli.
    Proc Natl Acad Sci U S A. 2020;117:30699-30709.
    PubMed     Abstract available


    November 2020
  7. ZULAUF KE, Kirby JE
    Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach.
    Proc Natl Acad Sci U S A. 2020;117:29839-29850.
    PubMed     Abstract available


  8. OLESEN SW, Lipsitch M, Grad YH
    The role of "spillover" in antibiotic resistance.
    Proc Natl Acad Sci U S A. 2020;117:29063-29068.
    PubMed     Abstract available


  9. LILIC M, Chen J, Boyaci H, Braffman N, et al
    The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
    Proc Natl Acad Sci U S A. 2020 Nov 16. pii: 2013706117.
    PubMed     Abstract available


  10. FLEEMAN RM, Macias LA, Brodbelt JS, Davies BW, et al
    Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae.
    Proc Natl Acad Sci U S A. 2020;117:27620-27626.
    PubMed     Abstract available


    October 2020
  11. WOODS LC, Gorrell RJ, Taylor F, Connallon T, et al
    Horizontal gene transfer potentiates adaptation by reducing selective constraints on the spread of genetic variation.
    Proc Natl Acad Sci U S A. 2020;117:26868-26875.
    PubMed     Abstract available


  12. TOMLINSON JH, Kalverda AP, Calabrese AN
    Fusidic acid resistance through changes in the dynamics of the drug target.
    Proc Natl Acad Sci U S A. 2020;117:25523-25531.
    PubMed     Abstract available


  13. DAVID S, Cohen V, Reuter S, Sheppard AE, et al
    Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae.
    Proc Natl Acad Sci U S A. 2020;117:25043-25054.
    PubMed     Abstract available


    September 2020
  14. KOWALSKI CH, Morelli KA, Schultz D, Nadell CD, et al
    Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance.
    Proc Natl Acad Sci U S A. 2020;117:22473-22483.
    PubMed     Abstract available


    August 2020
  15. ZHANG C, Song W, Ma HR, Peng X, et al
    Temporal encoding of bacterial identity and traits in growth dynamics.
    Proc Natl Acad Sci U S A. 2020;117:20202-20210.
    PubMed     Abstract available


  16. VIEGAS J
    Profile of Paul E. Turner.
    Proc Natl Acad Sci U S A. 2020;117:18906-18908.
    PubMed    


  17. LAKSHMAIAH NARAYANA J, Mishra B, Lushnikova T, Wu Q, et al
    Two distinct amphipathic peptide antibiotics with systemic efficacy.
    Proc Natl Acad Sci U S A. 2020;117:19446-19454.
    PubMed     Abstract available


  18. ALEXANDER HK, MacLean RC
    Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells.
    Proc Natl Acad Sci U S A. 2020;117:19455-19464.
    PubMed     Abstract available


  19. MORENO-GAMEZ S, Kiviet DJ, Vulin C, Schlegel S, et al
    Wide lag time distributions break a trade-off between reproduction and survival in bacteria.
    Proc Natl Acad Sci U S A. 2020;117:18729-18736.
    PubMed     Abstract available


    July 2020
  20. MELNIKOV SV, Stevens DL, Fu X, Kwok HS, et al
    Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.
    Proc Natl Acad Sci U S A. 2020;117:17924-17931.
    PubMed     Abstract available


  21. GATO E, Vazquez-Ucha JC, Rumbo-Feal S, Alvarez-Fraga L, et al
    Kpi, a chaperone-usher pili system associated with the worldwide-disseminated high-risk clone Klebsiella pneumoniae ST-15.
    Proc Natl Acad Sci U S A. 2020;117:17249-17259.
    PubMed     Abstract available


  22. BOLLA JR, Howes AC, Fiorentino F, Robinson CV, et al
    Assembly and regulation of the chlorhexidine-specific efflux pump AceI.
    Proc Natl Acad Sci U S A. 2020;117:17011-17018.
    PubMed     Abstract available


  23. CHEN X, Chen J, Yan B, Zhang W, et al
    Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
    Proc Natl Acad Sci U S A. 2020;117:16324-16332.
    PubMed     Abstract available


  24. RODRIGUEZ-BELTRAN J, Sorum V, Toll-Riera M, de la Vega C, et al
    Genetic dominance governs the evolution and spread of mobile genetic elements in bacteria.
    Proc Natl Acad Sci U S A. 2020;117:15755-15762.
    PubMed     Abstract available


    May 2020
  25. BURMEISTER AR, Fortier A, Roush C, Lessing AJ, et al
    Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.
    Proc Natl Acad Sci U S A. 2020;117:11207-11216.
    PubMed     Abstract available


  26. YANG Y, Gupta K, Ekinci KL
    All-electrical monitoring of bacterial antibiotic susceptibility in a microfluidic device.
    Proc Natl Acad Sci U S A. 2020;117:10639-10644.
    PubMed     Abstract available


  27. CHILAMBI GS, Nordstrom HR, Evans DR, Ferrolino JA, et al
    Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients.
    Proc Natl Acad Sci U S A. 2020 May 11. pii: 1917130117.
    PubMed     Abstract available


    April 2020
  28. GUPTA S, Louis JM, Tycko R
    Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles.
    Proc Natl Acad Sci U S A. 2020 Apr 27. pii: 1917755117.
    PubMed     Abstract available


  29. GUSA A, Williams JD, Cho JE, Averette AF, et al
    Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro.
    Proc Natl Acad Sci U S A. 2020 Apr 17. pii: 2001451117.
    PubMed     Abstract available


  30. STARR CG, Ghimire J, Guha S, Hoffmann JP, et al
    Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria.
    Proc Natl Acad Sci U S A. 2020;117:8437-8448.
    PubMed     Abstract available


    March 2020
  31. JONES JC, Pascua PNQ, Fabrizio TP, Marathe BM, et al
    Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility.
    Proc Natl Acad Sci U S A. 2020 Mar 26. pii: 1916825117.
    PubMed     Abstract available


  32. TARAFDER AK, von Kugelgen A, Mellul AJ, Schulze U, et al
    Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped bacteria.
    Proc Natl Acad Sci U S A. 2020;117:4724-4731.
    PubMed     Abstract available


  33. MCDANIEL CT, Panmanee W, Winsor GL, Gill E, et al
    AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.
    Proc Natl Acad Sci U S A. 2020;117:4921-4930.
    PubMed     Abstract available


  34. ZUO W, Wu Y
    Dynamic motility selection drives population segregation in a bacterial swarm.
    Proc Natl Acad Sci U S A. 2020;117:4693-4700.
    PubMed     Abstract available


    February 2020
  35. HINGLEY-WILSON SM, Ma N, Hu Y, Casey R, et al
    Loss of phenotypic inheritance associated with ydcI mutation leads to increased frequency of small, slow persisters in Escherichia coli.
    Proc Natl Acad Sci U S A. 2020;117:4152-4157.
    PubMed     Abstract available


  36. HUSEBY DL, Brandis G, Praski Alzrigat L, Hughes D, et al
    Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene.
    Proc Natl Acad Sci U S A. 2020;117:3185-3191.
    PubMed     Abstract available


    January 2020
  37. PENG H, Borg RE, Dow LP, Pruitt BL, et al
    Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages.
    Proc Natl Acad Sci U S A. 2020;117:1951-1961.
    PubMed     Abstract available


  38. BOWYER P, Bromley MJ, Denning DW
    Linking calcium signaling and mitochondrial function in fungal drug resistance.
    Proc Natl Acad Sci U S A. 2020;117:1254-1256.
    PubMed    


  39. LI Y, Zhang Y, Zhang C, Wang H, et al
    Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance.
    Proc Natl Acad Sci U S A. 2020;117:1711-1721.
    PubMed     Abstract available


  40. RUDRA P, Hurst-Hess KR, Cotten KL, Partida-Miranda A, et al
    Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance.
    Proc Natl Acad Sci U S A. 2020;117:629-634.
    PubMed     Abstract available


    November 2019
  41. PATRO SC, Brandt LD, Bale MJ, Halvas EK, et al
    Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.
    Proc Natl Acad Sci U S A. 2019 Nov 27. pii: 1910334116.
    PubMed     Abstract available


  42. TEPEKULE B, Abel Zur Wiesch P, Kouyos RD, Bonhoeffer S, et al
    Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota.
    Proc Natl Acad Sci U S A. 2019;116:23106-23116.
    PubMed     Abstract available


    September 2019
  43. SAFI H, Gopal P, Lingaraju S, Ma S, et al
    Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance.
    Proc Natl Acad Sci U S A. 2019 Sep 5. pii: 1907631116.
    PubMed     Abstract available


  44. HASSAN KA, Naidu V, Edgerton JR, Mettrick KA, et al
    Short-chain diamines are the physiological substrates of PACE family efflux pumps.
    Proc Natl Acad Sci U S A. 2019;116:18015-18020.
    PubMed     Abstract available


    August 2019
  45. FELDMAN MF, Mayer Bridwell AE, Scott NE, Vinogradov E, et al
    A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae.
    Proc Natl Acad Sci U S A. 2019 Aug 27. pii: 1907833116.
    PubMed     Abstract available


    July 2019
  46. KIM W, Zou G, Hari TPA, Wilt IK, et al
    A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2019 Jul 29. pii: 1904700116.
    PubMed     Abstract available


  47. LI H, Zhang TT, Chen ZG, Ye JZ, et al
    Reply to Nikaido: The pyruvate cycle provides respiratory energy and potentiates aminoglycosides to kill multidrug-resistant bacteria.
    Proc Natl Acad Sci U S A. 2019;116:14802-14803.
    PubMed    


  48. TCHESNOKOVA V, Radey M, Chattopadhyay S, Larson L, et al
    Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci.
    Proc Natl Acad Sci U S A. 2019;116:14740-14748.
    PubMed     Abstract available


  49. DI RUSCIO F, Guzzetta G, Bjornholt JV, Leegaard TM, et al
    Quantifying the transmission dynamics of MRSA in the community and healthcare settings in a low-prevalence country.
    Proc Natl Acad Sci U S A. 2019;116:14599-14605.
    PubMed     Abstract available


  50. LEVIN-REISMAN I, Brauner A, Ronin I, Balaban NQ, et al
    Epistasis between antibiotic tolerance, persistence, and resistance mutations.
    Proc Natl Acad Sci U S A. 2019;116:14734-14739.
    PubMed     Abstract available


  51. MISHRA B, Lakshmaiah Narayana J, Lushnikova T, Wang X, et al
    Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens.
    Proc Natl Acad Sci U S A. 2019;116:13517-13522.
    PubMed     Abstract available


    May 2019
  52. FLENTIE K, Harrison GA, Tukenmez H, Livny J, et al
    Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2019 May 6. pii: 1818009116.
    PubMed     Abstract available


    April 2019
  53. VAN DUYNE R, Kuo LS, Pham P, Fujii K, et al
    Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle.
    Proc Natl Acad Sci U S A. 2019 Apr 11. pii: 1820333116.
    PubMed     Abstract available


    March 2019
  54. CAREY J
    News Feature: Interested in gauging a population's health? Look to sewage.
    Proc Natl Acad Sci U S A. 2019;116:5836-5839.
    PubMed    


  55. VERMA J, Bag S, Saha B, Kumar P, et al
    Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae.
    Proc Natl Acad Sci U S A. 2019;116:6226-6231.
    PubMed     Abstract available


  56. DROHAN SE, Levin SA, Grenfell BT, Laxminarayan R, et al
    Incentivizing hospital infection control.
    Proc Natl Acad Sci U S A. 2019;116:6221-6225.
    PubMed     Abstract available


  57. STOCKS CJ, Phan MD, Achard MES, Nhu NTK, et al
    Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination.
    Proc Natl Acad Sci U S A. 2019;116:6341-6350.
    PubMed     Abstract available


  58. ZHANG AT, Montgomery MG, Leslie AGW, Cook GM, et al
    The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs.
    Proc Natl Acad Sci U S A. 2019;116:4206-4211.
    PubMed     Abstract available


    February 2019
  59. JIANG JH, Bhuiyan MS, Shen HH, Cameron DR, et al
    Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation.
    Proc Natl Acad Sci U S A. 2019;116:3722-3727.
    PubMed     Abstract available



  60. Correction for Copin et al., Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2019 Feb 25. pii: 1902207116.
    PubMed    


    January 2019
  61. DI VENANZIO G, Moon KH, Weber BS, Lopez J, et al
    Multidrug-resistant plasmids repress chromosomally encoded T6SS to enable their dissemination.
    Proc Natl Acad Sci U S A. 2019;116:1378-1383.
    PubMed     Abstract available


  62. DE METS F, Van Melderen L, Gottesman S
    Regulation of acetate metabolism and coordination with the TCA cycle via a processed small RNA.
    Proc Natl Acad Sci U S A. 2019;116:1043-1052.
    PubMed     Abstract available


  63. COPIN R, Sause WE, Fulmer Y, Balasubramanian D, et al
    Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2019 Jan 11. pii: 1814265116.
    PubMed     Abstract available


  64. PETHE MA, Rubenstein AB, Khare SD
    Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations.
    Proc Natl Acad Sci U S A. 2019;116:168-176.
    PubMed     Abstract available


    December 2018
  65. DUVAL M, Dar D, Carvalho F, Rocha EPC, et al
    HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance.
    Proc Natl Acad Sci U S A. 2018;115:13359-13364.
    PubMed     Abstract available


  66. TEDIJANTO C, Olesen SW, Grad YH, Lipsitch M, et al
    Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora.
    Proc Natl Acad Sci U S A. 2018;115:E11988-E11995.
    PubMed     Abstract available


  67. BLOOM DE, Black S, Salisbury D, Rappuoli R, et al
    Antimicrobial resistance and the role of vaccines.
    Proc Natl Acad Sci U S A. 2018;115:12868-12871.
    PubMed    


  68. SEVILLA JP, Bloom DE, Cadarette D, Jit M, et al
    Toward economic evaluation of the value of vaccines and other health technologies in addressing AMR.
    Proc Natl Acad Sci U S A. 2018;115:12911-12919.
    PubMed     Abstract available


  69. KLEMM EJ, Wong VK, Dougan G
    Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.
    Proc Natl Acad Sci U S A. 2018;115:12872-12877.
    PubMed     Abstract available


  70. KENNEDY DA, Read AF
    Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.
    Proc Natl Acad Sci U S A. 2018;115:12878-12886.
    PubMed     Abstract available


  71. KLUGMAN KP, Black S
    Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects.
    Proc Natl Acad Sci U S A. 2018;115:12896-12901.
    PubMed     Abstract available


  72. BAKER SJ, Payne DJ, Rappuoli R, De Gregorio E, et al
    Technologies to address antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2018;115:12887-12895.
    PubMed     Abstract available


  73. RELMAN DA, Lipsitch M
    Microbiome as a tool and a target in the effort to address antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2018;115:12902-12910.
    PubMed     Abstract available


  74. PURDY MD, Shi D, Chrustowicz J, Hattne J, et al
    MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.
    Proc Natl Acad Sci U S A. 2018 Dec 10. pii: 1806806115.
    PubMed     Abstract available


    November 2018
  75. DEMERS EG, Biermann AR, Masonjones S, Crocker AW, et al
    Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection.
    Proc Natl Acad Sci U S A. 2018 Nov 2. pii: 1807698115.
    PubMed     Abstract available


    October 2018
  76. GOLDHILL DH, Te Velthuis AJW, Fletcher RA, Langat P, et al
    The mechanism of resistance to favipiravir in influenza.
    Proc Natl Acad Sci U S A. 2018 Oct 23. pii: 1811345115.
    PubMed     Abstract available


  77. PETERS K, Pazos M, Edoo Z, Hugonnet JE, et al
    Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins.
    Proc Natl Acad Sci U S A. 2018;115:10786-10791.
    PubMed     Abstract available


    September 2018
  78. ROEMHILD R, Gokhale CS, Dirksen P, Blake C, et al
    Cellular hysteresis as a principle to maximize the efficacy of antibiotic therapy.
    Proc Natl Acad Sci U S A. 2018;115:9767-9772.
    PubMed     Abstract available


  79. MARTINS D, McKay G, Sampathkumar G, Khakimova M, et al
    Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.
    Proc Natl Acad Sci U S A. 2018;115:9797-9802.
    PubMed     Abstract available


  80. BEAUPERE C, Dinatto L, Wasko BM, Chen RB, et al
    Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.
    Proc Natl Acad Sci U S A. 2018;115:9586-9591.
    PubMed     Abstract available


  81. TEREKHOV SS, Smirnov IV, Malakhova MV, Samoilov AE, et al
    Ultrahigh-throughput functional profiling of microbiota communities.
    Proc Natl Acad Sci U S A. 2018;115:9551-9556.
    PubMed     Abstract available


  82. CROWE-MCAULIFFE C, Graf M, Huter P, Takada H, et al
    Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.
    Proc Natl Acad Sci U S A. 2018;115:8978-8983.
    PubMed     Abstract available


    August 2018
  83. TIWARI S, van Tonder AJ, Vilcheze C, Mendes V, et al
    Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2018 Aug 24. pii: 1808874115.
    PubMed     Abstract available


  84. OVCHINNIKOV V, Stone TA, Deber CM, Karplus M, et al
    Structure of the EmrE multidrug transporter and its use for inhibitor peptide design.
    Proc Natl Acad Sci U S A. 2018;115:E7932-E7941.
    PubMed     Abstract available


  85. LI Y, Sharma MR, Koripella RK, Yang Y, et al
    Zinc depletion induces ribosome hibernation in mycobacteria.
    Proc Natl Acad Sci U S A. 2018;115:8191-8196.
    PubMed     Abstract available


  86. PARACINI N, Clifton LA, Skoda MWA, Lakey JH, et al
    Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility.
    Proc Natl Acad Sci U S A. 2018;115:E7587-E7594.
    PubMed     Abstract available


  87. VERMAAS JV, Rempe SB, Tajkhorshid E
    Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE.
    Proc Natl Acad Sci U S A. 2018;115:E7502-E7511.
    PubMed     Abstract available


    July 2018
  88. KIRKMAN LA, Zhan W, Visone J, Dziedziech A, et al
    Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
    Proc Natl Acad Sci U S A. 2018;115:E6863-E6870.
    PubMed     Abstract available


  89. KE R, Li H, Wang S, Ding W, et al
    Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence.
    Proc Natl Acad Sci U S A. 2018 Jul 9. pii: 1805267115.
    PubMed     Abstract available


  90. HARRIS KA, Zhou Z, Peters ML, Wilkins SG, et al
    A second RNA-binding protein is essential for ethanol tolerance provided by the bacterial OLE ribonucleoprotein complex.
    Proc Natl Acad Sci U S A. 2018;115:E6319-E6328.
    PubMed     Abstract available


    June 2018
  91. NYERGES A, Csorgo B, Draskovits G, Kintses B, et al
    Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
    Proc Natl Acad Sci U S A. 2018;115:E5726-E5735.
    PubMed     Abstract available


    May 2018
  92. CORNFORTH DM, Dees JL, Ibberson CB, Huse HK, et al
    Pseudomonas aeruginosa transcriptome during human infection.
    Proc Natl Acad Sci U S A. 2018;115:E5125-E5134.
    PubMed     Abstract available


  93. BEHRINGER MG, Choi BI, Miller SF, Doak TG, et al
    Escherichia coli cultures maintain stable subpopulation structure during long-term evolution.
    Proc Natl Acad Sci U S A. 2018;115:E4642-E4650.
    PubMed     Abstract available


  94. SU W, Kumar V, Ding Y, Ero R, et al
    Ribosome protection by antibiotic resistance ATP-binding cassette protein.
    Proc Natl Acad Sci U S A. 2018;115:5157-5162.
    PubMed     Abstract available


    April 2018
  95. KLEIN EY, Van Boeckel TP, Martinez EM, Pant S, et al
    Global increase and geographic convergence in antibiotic consumption between 2000 and 2015.
    Proc Natl Acad Sci U S A. 2018;115:E3463-E3470.
    PubMed     Abstract available


  96. CHAVEZ A, Pruitt BW, Tuttle M, Shapiro RS, et al
    Precise Cas9 targeting enables genomic mutation prevention.
    Proc Natl Acad Sci U S A. 2018;115:3669-3673.
    PubMed     Abstract available


    March 2018
  97. OBOLSKI U, Lourenco J, Thompson C, Thompson R, et al
    Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae.
    Proc Natl Acad Sci U S A. 2018 Mar 6. pii: 1718712115.
    PubMed     Abstract available


    January 2018
  98. SLUIS-CREMER N
    Future of nonnucleoside reverse transcriptase inhibitors.
    Proc Natl Acad Sci U S A. 2018;115:637-638.
    PubMed    


    October 2017
  99. DESHMUKH L, Tugarinov V, Louis JM, Clore GM, et al
    Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR.
    Proc Natl Acad Sci U S A. 2017 Oct 30. pii: 201716098.
    PubMed     Abstract available


    August 2017
  100. CHAN AH, Lee WG, Spasov KA, Cisneros JA, et al
    Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
    Proc Natl Acad Sci U S A. 2017 Aug 21. pii: 201711463.
    PubMed     Abstract available


    July 2017
  101. DEFRANCESCO AS, Masloboeva N, Syed AK, DeLoughery A, et al
    Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2017 Jul 3. pii: 201704544.
    PubMed     Abstract available


    May 2017
  102. SAITO K, Warrier T, Somersan-Karakaya S, Kaminski L, et al
    Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.
    Proc Natl Acad Sci U S A. 2017 May 30. pii: 201705385.
    PubMed     Abstract available


    April 2017
  103. VILCHEZE C, Hartman T, Weinrick B, Jain P, et al
    Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Apr 10. pii: 201704376.
    PubMed     Abstract available


    February 2017
  104. KOIZUMI Y, Ohashi H, Nakajima S, Tanaka Y, et al
    Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection.
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