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  Diabetes

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Articles published in J Biol Chem

Retrieve available abstracts of 21 articles:
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Single Articles


    March 2026
  1. HU R, Wang Y, Yagan M, Xu Y, et al
    Deregulated translation of the transcription factor Myt3 predisposes islet beta cells to dysfunction under obesity-induced metabolic stress.
    J Biol Chem. 2026;302:111164.
    PubMed     Abstract available


    November 2025
  2. QI B, Chen Y, Lan Y, Lou Y, et al
    Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy.
    J Biol Chem. 2025 Nov 5:110909. doi: 10.1016/j.jbc.2025.110909.
    PubMed     Abstract available


    October 2025
  3. ZHANG S, Hu X, Zhang B, Liu J, et al
    Mapping cellular cytosolic pH in vivo under physiological and pathophysiological conditions.
    J Biol Chem. 2025;301:110637.
    PubMed     Abstract available


    September 2025
  4. GU J, Qi MX, Zhang RX, Song YY, et al
    Sidt2 inhibits islet beta-cell dedifferentiation by regulating insulin secretion.
    J Biol Chem. 2025;301:110544.
    PubMed     Abstract available


    May 2025
  5. GUAN J, Shi X, Ma J, Yin Y, et al
    Circular RNA-OGDH Promotes PANoptosis in Diabetic Cardiomyopathy: A Novel Mechanistic Insight.
    J Biol Chem. 2025 May 22:110280. doi: 10.1016/j.jbc.2025.110280.
    PubMed     Abstract available


  6. FANG J, Hu Z, Luo T, Chen S, et al
    beta-hydroxybutyrate serves as a regulator in ketone body metabolism through lysine beta-hydroxybutyrylation.
    J Biol Chem. 2025;301:108475.
    PubMed     Abstract available


    March 2025
  7. JACOBS R, Herinckx G, Galland N, Balty C, et al
    Combined deletion of cytosolic 5'-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and lowering hepatic glucose production.
    J Biol Chem. 2025;301:108295.
    PubMed     Abstract available


    January 2025
  8. SUNILKUMAR S, Yerlikaya EI, VanCleave A, Subrahmanian SM, et al
    REDD1-dependent GSK3beta signaling in podocytes promotes canonical NF-kappaB activation in diabetic nephropathy.
    J Biol Chem. 2025 Jan 27:108244. doi: 10.1016/j.jbc.2025.108244.
    PubMed     Abstract available


  9. YOKOO T, Watanabe K, Iida K, Nakachi Y, et al
    Betagenin ameliorates diabetes by inducing insulin secretion and beta-cell proliferation.
    J Biol Chem. 2025 Jan 16:108202. doi: 10.1016/j.jbc.2025.108202.
    PubMed     Abstract available


  10. SITTON J, Pickett D, Rodriguez A, Kurouski D, et al
    Lipids determine the toxicity of human islet polypeptide aggregates in vivo.
    J Biol Chem. 2025;301:108029.
    PubMed     Abstract available


    December 2024
  11. YAO TF, Wang ZY, Sun L, Yu SX, et al
    DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.
    J Biol Chem. 2024 Dec 25:108137. doi: 10.1016/j.jbc.2024.108137.
    PubMed     Abstract available


  12. HUANG Y, Zhang Y, Liu Y, Jin Y, et al
    PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Muller cells.
    J Biol Chem. 2024 Dec 18:108111. doi: 10.1016/j.jbc.2024.108111.
    PubMed     Abstract available


  13. LI H, Lin L, Huang X, Lu Y, et al
    2-Hydroxylation is a chemical switch linking fatty acids to glucose-stimulated insulin secretion.
    J Biol Chem. 2024;300:107912.
    PubMed     Abstract available


    September 2024
  14. COLLINS J, Piscopio RA, Reyland ME, Johansen CG, et al
    Cleavage of protein kinase c delta by caspase-3 mediates proinflammatory cytokine-induced apoptosis in pancreatic islets.
    J Biol Chem. 2024;300:107611.
    PubMed     Abstract available


  15. TRAN MT, Lim JJ, Loh TJ, Mannering SI, et al
    A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8.
    J Biol Chem. 2024;300:107612.
    PubMed     Abstract available


    August 2024
  16. SHARMA R, Amdare NP, Ghosh A, Schloss J, et al
    Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.
    J Biol Chem. 2024 Aug 20:107702. doi: 10.1016/j.jbc.2024.107702.
    PubMed     Abstract available


    July 2024
  17. DING Z, Ge W, Xu X, Xu X, et al
    A crucial role of adenosine deaminase in regulating gluconeogenesis in mice.
    J Biol Chem. 2024;300:107425.
    PubMed     Abstract available


    June 2024
  18. ZHANG B, Bu C, Wang Q, Chen Q, et al
    Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy.
    J Biol Chem. 2024 Jun 24:107493. doi: 10.1016/j.jbc.2024.107493.
    PubMed     Abstract available


  19. YAMAGUCHI H, Matsumura T, Sugawa H, Niimi N, et al
    Glucoselysine, a unique advanced glycation end-product of the polyol pathway and its association with vascular complications in type 2 diabetes.
    J Biol Chem. 2024 Jun 13:107479. doi: 10.1016/j.jbc.2024.107479.
    PubMed     Abstract available


  20. BREUNIG SL, Chapman AM, LeBon J, Quijano JC, et al
    4S-fluorination of ProB29 in insulin lispro slows fibril formation.
    J Biol Chem. 2024;300:107332.
    PubMed     Abstract available


    March 2024
  21. LI L, Yao Y, Wang Y, Cao J, et al
    G protein-coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting AMPK-dependent signaling.
    J Biol Chem. 2024;300:105661.
    PubMed     Abstract available


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