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  Neoplasms of the CNS

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Articles published in Cancer Res

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    July 2021
  1. NAJM P, Zhao P, Steklov M, Sewduth RN, et al
    Loss-of-function mutations in TRAF7 and KLF4 cooperatively activate RAS-like GTPase signaling and promote meningioma development.
    Cancer Res. 2021 Jul 2. pii: 0008-5472.CAN-20-3669.
    PubMed     Abstract available


    May 2021
  2. MA R, Lu T, Li Z, Teng KY, et al
    An oncolytic virus expressing IL-15/IL-15Ralpha combined with off-the-shelf EGFR-CAR NK cells targets glioblastoma.
    Cancer Res. 2021 May 18. pii: 0008-5472.CAN-21-0035.
    PubMed     Abstract available


    April 2021
  3. GAO M, Fu Y, Zhou W, Gui G, et al
    EGFR Activates a TAZ-driven Oncogenic Program in Glioblastoma.
    Cancer Res. 2021 Apr 28. pii: 0008-5472.CAN-20-2773.
    PubMed     Abstract available


  4. LI M, Kirtane AR, Kiyokawa J, Nagashima H, et al
    Local Targeting of NAD(+) Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma.
    Cancer Res. 2021;81:1922.
    PubMed    


    March 2021
  5. JALALI A, Yu K, Beechar V, Bosquez Huerta N, et al
    POT1 regulates proliferation and confers sexual dimorphism in glioma.
    Cancer Res. 2021 Mar 29. pii: 0008-5472.CAN-20-3755.
    PubMed     Abstract available


    February 2021
  6. SEGURA-COLLAR B, Garranzo-Asensio M, Herranz B, Hernandez-SanMiguel E, et al
    Tumor-derived pericytes driven by EGFR mutations govern the vascular and immune microenvironment of gliomas.
    Cancer Res. 2021 Feb 16. pii: 0008-5472.CAN-20-3558.
    PubMed     Abstract available


  7. DAY EK, Zhong Q, Purow B, Lazzara MJ, et al
    Data-driven computational modeling identifies determinants of glioblastoma response to SHP2 inhibition.
    Cancer Res. 2021 Feb 11. pii: 0008-5472.CAN-20-1756.
    PubMed     Abstract available


  8. SUTCLIFFE MD, Galvao RP, Wang L, Kim J, et al
    Premalignant oligodendrocyte precursor cells stall in a heterogeneous state of replication stress prior to gliomagenesis.
    Cancer Res. 2021 Feb 2. pii: 0008-5472.CAN-20-1037.
    PubMed     Abstract available


    January 2021
  9. OH H, Hwang I, Jang JY, Wu L, et al
    Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling.
    Cancer Res. 2021 Jan 28. pii: 0008-5472.CAN-20-1810.
    PubMed     Abstract available


  10. BERG TJ, Marques C, Pantazopoulou V, Johansson E, et al
    The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2.
    Cancer Res. 2021 Jan 22. pii: 0008-5472.CAN-20-1785.
    PubMed     Abstract available


  11. NOR C, Ramaswamy V
    Next-Generation Profiling of Medulloblastoma: Old Drugs Are an Elegant Weapon in a Civilized Age.
    Cancer Res. 2021;81:264-265.
    PubMed     Abstract available


    December 2020
  12. NEY GM, McKay L, Koschmann C, Mody R, et al
    The Emerging Role of Ras Pathway Signaling in Pediatric Cancer.
    Cancer Res. 2020;80:5155-5163.
    PubMed     Abstract available


    November 2020
  13. LI J, Liao T, Liu H, Yuan H, et al
    Hypoxic glioma stem cell-derived exosomes containing Linc01060 promote progression of glioma by regulating the MZF1/c-Myc/HIF-1alpha.
    Cancer Res. 2020 Nov 6. pii: 0008-5472.CAN-20-2270.
    PubMed     Abstract available


    October 2020
  14. SARMIENTO SOTO M, Larkin JR, Martin C, Khrapitchev AA, et al
    STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction.
    Cancer Res. 2020 Oct 26. pii: 0008-5472.CAN-20-2251.
    PubMed     Abstract available


  15. RESTALL IJ, Cseh O, Richards LM, Pugh TJ, et al
    Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway.
    Cancer Res. 2020 Oct 26. pii: 0008-5472.CAN-19-3923.
    PubMed     Abstract available


  16. TATEISHI K, Miyake Y, Kawazu M, Sasaki N, et al
    A hyperactive RelA/p65-hexokinase 2 signaling axis drives primary central nervous system lymphoma.
    Cancer Res. 2020 Oct 16. pii: 0008-5472.CAN-20-2425.
    PubMed     Abstract available


  17. RUSERT JM, Juarez EF, Brabetz S, Jensen J, et al
    Functional precision medicine identifies new therapeutic candidates for medulloblastoma.
    Cancer Res. 2020 Oct 12. pii: 0008-5472.CAN-20-1655.
    PubMed     Abstract available


  18. VOLI F, Valli E, Lerra L, Kimpton K, et al
    Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion.
    Cancer Res. 2020;80:4129-4144.
    PubMed     Abstract available


    September 2020
  19. LI M, Kirtane AR, Kiyokawa J, Nagashima H, et al
    Local targeting of NAD+ salvage pathway alters the immune tumor microenvironment and enhances checkpoint immunotherapy in glioblastoma.
    Cancer Res. 2020 Sep 30. pii: 0008-5472.CAN-20-1094.
    PubMed     Abstract available


  20. SUBRAMANI E, Radoul M, Najac C, Batsios G, et al
    Glutamate is a non-invasive metabolic biomarker of IDH1 mutant glioma response to temozolomide treatment.
    Cancer Res. 2020 Sep 21. pii: 0008-5472.CAN-20-1314.
    PubMed     Abstract available


  21. VOSS DM, Sloan A, Spina R, Ames HM, et al
    The Alternative Splicing Factor MBNL1 Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness.
    Cancer Res. 2020 Sep 14. pii: 0008-5472.CAN-20-1233.
    PubMed     Abstract available


    August 2020
  22. KONCAR RF, Agnihotri S
    Anarchy or Respect the Hierarchy? The Complexity of Glioblastoma.
    Cancer Res. 2020;80:3195-3196.
    PubMed     Abstract available


  23. DUNCAN RM, Reyes L, Moats K, Robinson RM, et al
    ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors.
    Cancer Res. 2020;80:3279-3291.
    PubMed     Abstract available


    July 2020
  24. XIAO L, Li X, Mu Z, Zhou J, et al
    FTO inhibition enhances the anti-tumor effect of temozolomide by targeting MYC-miR-155/23a cluster-MXI1 feedback circuit in glioma.
    Cancer Res. 2020 Jul 17. pii: 0008-5472.CAN-20-0132.
    PubMed     Abstract available


  25. MONJE M
    Synaptic Communication in Brain Cancer.
    Cancer Res. 2020;80:2979-2982.
    PubMed     Abstract available


  26. VALIENTE M, Van Swearingen AED, Anders CK, Bairoch A, et al
    Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines.
    Cancer Res. 2020 Jul 8. pii: 0008-5472.CAN-20-0291.
    PubMed     Abstract available


  27. WU F, Zhang C, Zhao C, Wu H, et al
    Prostaglandin E1 Inhibits GLI2 Amplification-Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth.
    Cancer Res. 2020;80:2818-2832.
    PubMed     Abstract available


    April 2020
  28. LOPEZ-BERTONI H, Kotchetkov IS, Mihelson N, Lal B, et al
    A Sox2:miR-486-5p Axis Regulates Survival of GBM Cells by Inhibiting Tumor Suppressor Networks.
    Cancer Res. 2020;80:1644-1655.
    PubMed     Abstract available


  29. CHANDRA A, Jahangiri A, Chen W, Nguyen AT, et al
    Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance.
    Cancer Res. 2020;80:1498-1511.
    PubMed     Abstract available


    March 2020
  30. TAN AW, Weljie AM
    Metabolite Imaging at the Margin: Visualizing Metabolic Tumor Gradients Using Mass Spectrometry.
    Cancer Res. 2020;80:1231-1233.
    PubMed     Abstract available


    February 2020
  31. KIM HS, Chang CY, Yoon HJ, Kim KS, et al
    Glial TIM-3 modulates immune responses in the brain tumor microenvironment.
    Cancer Res. 2020 Feb 24. pii: 0008-5472.CAN-19-2834.
    PubMed     Abstract available


  32. HEBERT JD, Myers SA, Naba A, Abbruzzese G, et al
    Proteomic profiling of the ECM of xenograft breast cancer metastases in different organs reveals distinct metastatic niches.
    Cancer Res. 2020 Feb 4. pii: 0008-5472.CAN-19-2961.
    PubMed     Abstract available


    January 2020
  33. WIJAYA J, Vo BT, Liu J, Xu B, et al
    An ABC transporter drives medulloblastoma pathogenesis by regulating Sonic Hedgehog signaling.
    Cancer Res. 2020 Jan 16. pii: 0008-5472.CAN-19-2054.
    PubMed     Abstract available


    December 2019
  34. CHEN Y, Fang R, Yue C, Chang G, et al
    Wnt-Induced Stabilization of KDM4C Is Required for Wnt/beta-Catenin Target Gene Expression and Glioblastoma Tumorigenesis.
    Cancer Res. 2019 Dec 30. pii: 0008-5472.CAN-19-1229.
    PubMed     Abstract available


  35. WONG RA, Luo X, Lu M, An Z, et al
    Cooperative blockade of PKCalpha and JAK2 drives apoptosis in glioblastoma.
    Cancer Res. 2019 Dec 5. pii: 0008-5472.CAN-18-2808.
    PubMed     Abstract available


    November 2019
  36. RANDALL EC, Lopez BGC, Peng S, Regan MS, et al
    Localized metabolomic gradients in patient-derived xenograft models of glioblastoma.
    Cancer Res. 2019 Nov 25. pii: 0008-5472.CAN-19-0638.
    PubMed     Abstract available


  37. ITO H, Watari K, Shibata T, Miyamoto T, et al
    Bi-directional regulation between NDRG1 and GSK3beta controls tumor growth and is targeted by differentiation inducing factor-1 in glioblastoma.
    Cancer Res. 2019 Nov 13. pii: 0008-5472.CAN-19-0438.
    PubMed     Abstract available


  38. LONG Y, Tao H, Karachi A, Grippin AJ, et al
    Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma.
    Cancer Res. 2019 Nov 13. pii: 0008-5472.CAN-19-1577.
    PubMed     Abstract available


  39. ZHANG Y, Nguyen TTT, Shang E, Mela A, et al
    MET Inhibition Elicits PGC1alpha-Dependent Metabolic Reprogramming in Glioblastoma.
    Cancer Res. 2019 Nov 6. pii: 0008-5472.CAN-19-1389.
    PubMed     Abstract available


  40. AN Z, Knobbe-Thomsen CB, Wan X, Fan QW, et al
    Correction: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.
    Cancer Res. 2019;79:5681.
    PubMed    


    October 2019
  41. CHEN J, Ananthanarayanan B, Springer KS, Wolf KJ, et al
    Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion.
    Cancer Res. 2019 Oct 22. pii: 0008-5472.CAN-19-1237.
    PubMed     Abstract available


  42. MCABEE JH, Rath BH, Valdez K, Young DL, et al
    Radiation drives the evolution of orthotopic xenografts initiated from glioblastoma stem-like cells.
    Cancer Res. 2019 Oct 15. pii: 0008-5472.CAN-19-2452.
    PubMed     Abstract available


    September 2019
  43. LI F, Yi Y, Miao Y, Long W, et al
    N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma.
    Cancer Res. 2019 Sep 17. pii: 0008-5472.CAN-18-2868.
    PubMed     Abstract available


  44. JUNG J, Zhang Y, Celiku O, Zhang W, et al
    Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma.
    Cancer Res. 2019 Sep 5. pii: 0008-5472.CAN-19-0198.
    PubMed     Abstract available


    August 2019
  45. SONG X, Wan X, Huang T, Zeng C, et al
    SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes.
    Cancer Res. 2019 Aug 28. pii: 0008-5472.CAN-19-1504.
    PubMed     Abstract available


  46. OHKA F, Shinjo K, Deguchi S, Matsui Y, et al
    Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.
    Cancer Res. 2019 Aug 20. pii: 0008-5472.CAN-19-1272.
    PubMed     Abstract available


  47. LI X, Martinez-Ledesma E, Zhang C, Gao F, et al
    Tie2-FGFR1 interaction induces adaptive PI3K inhibitor resistance by upregulating Aurora A/PLK1/CDK1 signaling in glioblastoma.
    Cancer Res. 2019 Aug 15. pii: 0008-5472.CAN-19-0325.
    PubMed     Abstract available


  48. ZHANG Y, Pusch S, Innes J, Sidlauskas K, et al
    Mutant IDH sensitizes gliomas to endoplasmic reticulum stress and triggers apoptosis by MicroRNA183-mediated inhibition of Semaphorin 3E.
    Cancer Res. 2019 Aug 7. pii: 0008-5472.CAN-19-0054.
    PubMed     Abstract available


    July 2019
  49. STEPHEN ZR, Chiarelli P, Revia RA, Wang K, et al
    Time-resolved MRI assessment of convection-enhanced delivery by targeted and non-targeted nanoparticles in a human glioblastoma mouse model.
    Cancer Res. 2019 Jul 22. pii: 0008-5472.CAN-18-2998.
    PubMed     Abstract available


  50. HARA T, Verma IM
    Modeling Gliomas Using Two Recombinases.
    Cancer Res. 2019 Jul 17. pii: 0008-5472.CAN-19-0717.
    PubMed     Abstract available


  51. SACHDEVA R, Wu M, Smiljanic S, Kaskun O, et al
    ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma.
    Cancer Res. 2019 Jul 10. pii: 0008-5472.CAN-18-1357.
    PubMed     Abstract available


    June 2019
  52. PELUFFO G, Subedee A, Harper NW, Kingston N, et al
    EN1 is a transcriptional dependency in triple-negative breast cancer associated with brain metastasis.
    Cancer Res. 2019 Jun 25. pii: 0008-5472.CAN-18-3264.
    PubMed     Abstract available


  53. KONCAR RF, Dey BR, Stanton AJ, Agrawal N, et al
    Identification of novel RAS signaling therapeutic vulnerabilities in Diffuse Intrinsic Pontine Gliomas.
    Cancer Res. 2019 Jun 14. pii: 0008-5472.CAN-18-3521.
    PubMed     Abstract available


  54. AMIRY-MOGHADDAM M
    AQP4 and the Fate of Gliomas.
    Cancer Res. 2019;79:2810-2811.
    PubMed     Abstract available


    May 2019
  55. TODOROVA PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, et al
    Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas.
    Cancer Res. 2019 May 14. pii: 0008-5472.CAN-19-0680.
    PubMed     Abstract available


  56. AMOOZGAR Z, Jain RK, Duda DG
    Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?
    Cancer Res. 2019;79:2104-2106.
    PubMed     Abstract available


  57. WANG J, Merino DM, Light N, Murphy BL, et al
    Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.
    Cancer Res. 2019;79:2208-2219.
    PubMed     Abstract available


    April 2019
  58. HANSEN LJ, Sun R, Yang R, Singh SX, et al
    MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation.
    Cancer Res. 2019 Apr 30. pii: 0008-5472.CAN-18-1010.
    PubMed     Abstract available


  59. LIU Y, Ji W, Shergalis A, Xu J, et al
    Activation of the unfolded protein response via inhibition of protein disulfide isomerase decreases the capacity for DNA repair to sensitize glioblastoma to radiotherapy.
    Cancer Res. 2019 Apr 17. pii: 0008-5472.CAN-18-2540.
    PubMed     Abstract available


  60. JIANG Y, Song Y, Wang R, Hu T, et al
    NFAT1-mediated regulation of NDEL1 promotes growth and invasion of glioma stem-like cells.
    Cancer Res. 2019 Apr 2. pii: 0008-5472.CAN-18-3297.
    PubMed     Abstract available


  61. VOCE DJ, Bernal GM, Wu L, Crawley CD, et al
    Temozolomide treatment induces lncRNA MALAT1 in an NF-small ka, CyrillicB and p53 co-dependent manner in glioblastoma.
    Cancer Res. 2019 Apr 2. pii: 0008-5472.CAN-18-2170.
    PubMed     Abstract available


    March 2019
  62. XIA S, Ma D, Liu S, Lal B, et al
    Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 loss of function in glioblastoma.
    Cancer Res. 2019 Mar 21. pii: 0008-5472.CAN-18-3125.
    PubMed     Abstract available


  63. WOOLMAN M, Kuzan-Fischer CM, Ferry I, Kiyota T, et al
    Picosecond infrared laser desorption mass spectrometry identifies medulloblastoma subgroups on intrasurgical timescales.
    Cancer Res. 2019 Mar 19. pii: 0008-5472.CAN-18-3411.
    PubMed     Abstract available


  64. SIMONE L, Pisani F, Mola MG, De Bellis M, et al
    AQP4 aggregation state is a determinant for glioma cell fate.
    Cancer Res. 2019 Mar 15. pii: 0008-5472.CAN-18-2015.
    PubMed     Abstract available


  65. HOFFMAN M, Gillmor A, Kunz DJ, Johnston MJ, et al
    Intratumoral genetic and functional heterogeneity in pediatric glioblastoma.
    Cancer Res. 2019 Mar 15. pii: 0008-5472.CAN-18-3441.
    PubMed     Abstract available


  66. XIAO W, Zhang R, Sohrabi A, Ehsanipour A, et al
    Correction: Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma.
    Cancer Res. 2019;79:1260.
    PubMed    


  67. LATHIA JD
    Drak, Drak, Goose: A New Signaling Axis in Glioblastoma.
    Cancer Res. 2019;79:1036-1037.
    PubMed     Abstract available


  68. TAO R, Murad N, Xu Z, Zhang P, et al
    MYC drives Group 3 medulloblastoma through transformation of Sox2+ astrocyte progenitor cells.
    Cancer Res. 2019 Mar 12. pii: 0008-5472.CAN-18-1787.
    PubMed     Abstract available


  69. BECKMANN PJ, Larson JD, Larsson AT, Ostergaard JP, et al
    Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.
    Cancer Res. 2019;79:905-917.
    PubMed     Abstract available


    February 2019
  70. VISA A, Sallan MC, Maiques O, Alza L, et al
    T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma.
    Cancer Res. 2019 Feb 12. pii: 0008-5472.CAN-18-1924.
    PubMed     Abstract available


  71. MASTRELLA G, Hou M, Li M, Stoecklein VM, et al
    Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma.
    Cancer Res. 2019 Feb 4. pii: 0008-5472.CAN-18-0881.
    PubMed     Abstract available


  72. ATKINS I, Kinnersley B, Ostrom QT, Labreche K, et al
    Transcriptome-wide association study identifies new candidate susceptibility genes for glioma.
    Cancer Res. 2019 Feb 1. pii: 0008-5472.CAN-18-2888.
    PubMed     Abstract available


    January 2019
  73. PARK HK, Hong JH, Oh YT, Kim SS, et al
    Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells.
    Cancer Res. 2019 Jan 25. pii: 0008-5472.CAN-18-2558.
    PubMed     Abstract available


  74. DORON H, Pukrop T, Erez N
    A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis.
    Cancer Res. 2019 Jan 24. pii: 0008-5472.CAN-18-1805.
    PubMed     Abstract available


  75. GOBIN M, Nazarov PV, Warta R, Timmer M, et al
    A DNA repair and cell cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.
    Cancer Res. 2019 Jan 23. pii: 0008-5472.CAN-18-2076.
    PubMed     Abstract available


  76. SUN T, Patil R, Galstyan A, Klymyshyn D, et al
    Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk.
    Cancer Res. 2019 Jan 18. pii: 0008-5472.CAN-18-2725.
    PubMed     Abstract available


    November 2018
  77. MORGAN MA, Canman CE
    Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells.
    Cancer Res. 2018 Nov 29. pii: 0008-5472.CAN-18-2439.
    PubMed     Abstract available


  78. MA L, Lin K, Chang G, Chen Y, et al
    Aberrant activation of beta-catenin signaling drives glioma tumorigenesis via USP1-mediated stabilization of EZH2.
    Cancer Res. 2018 Nov 13. pii: 0008-5472.CAN-18-1304.
    PubMed     Abstract available


  79. AN Z, Knobbe-Thomsen CB, Wan X, Fan QW, et al
    EGFR cooperates with EGFRvIII to recruit macrophages in glioblastoma.
    Cancer Res. 2018 Nov 6. pii: 0008-5472.CAN-17-3551.
    PubMed     Abstract available


  80. MAIR R, Mouliere F, Smith CG, Chandrananda D, et al
    Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.
    Cancer Res. 2018 Nov 2. pii: 0008-5472.CAN-18-0074.
    PubMed     Abstract available


    October 2018
  81. AASLAND D, Gotzinger L, Hauck L, Berte N, et al
    Temozolomide induces senescence and repression of DNA repair pathways in glioblastoma cells via activation of ATR-CHK1, p21, and NF-kB.
    Cancer Res. 2018 Oct 25. pii: 0008-5472.CAN-18-1733.
    PubMed     Abstract available


  82. ALMIRON BONNIN DA, Havrda MC, Israel MA
    Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target.
    Cancer Res. 2018 Oct 17. pii: 0008-5472.CAN-18-0345.
    PubMed     Abstract available


  83. LIU T, Xu H, Huang M, Ma W, et al
    Circulating glioma cells exhibit stem cell-like properties.
    Cancer Res. 2018 Oct 15. pii: 0008-5472.CAN-18-0650.
    PubMed     Abstract available


  84. EINO D, Tsukada Y, Naito H, Kanemura Y, et al
    LPA4-mediated vascular network formation increases the efficacy of anti-PD-1 therapy against brain tumors.
    Cancer Res. 2018 Oct 9. pii: 0008-5472.CAN-18-0498.
    PubMed     Abstract available


  85. BIRCH JL, Strathdee K, Gilmour L, Vallatos A, et al
    A novel small molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma.
    Cancer Res. 2018 Oct 2. pii: 0008-5472.CAN-18-1697.
    PubMed     Abstract available


    August 2018
  86. GOUDARZI KM, Espinoza JA, Guo M, Bartek J, et al
    Reduced expression of PROX1 transitions glioblastoma cells into a mesenchymal gene expression subtype.
    Cancer Res. 2018 Aug 22. pii: 0008-5472.CAN-18-0320.
    PubMed     Abstract available


    July 2018
  87. MAIR R, Wright A, Ros S, Hu DE, et al
    Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma.
    Cancer Res. 2018 Jul 27. pii: 0008-5472.CAN-18-0759.
    PubMed     Abstract available


  88. XING F, Liu Y, Wu SY, Wu K, et al
    Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis.
    Cancer Res. 2018 Jul 19. pii: 0008-5472.CAN-18-1102.
    PubMed     Abstract available


  89. SINGH M, Venugopal C, Tokar T, McFarlane N, et al
    Therapeutic targeting of the pre-metastatic stage in human brain metastasis.
    Cancer Res. 2018 Jul 9. pii: 0008-5472.CAN-18-1022.
    PubMed     Abstract available


  90. CARRUTHERS RD, Ahmed SU, Ramachandran S, Strathdee K, et al
    Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells.
    Cancer Res. 2018 Jul 5. pii: 0008-5472.CAN-18-0569.
    PubMed     Abstract available


  91. WANG R, Zhang S, Chen X, Li N, et al
    CircNT5E acts as a sponge of microRNA-422a to promote glioblastoma tumorigenesis.
    Cancer Res. 2018 Jul 2. pii: 0008-5472.CAN-18-0532.
    PubMed     Abstract available


    June 2018
  92. QAZI MA, Vora P, Venugopal C, Adams J, et al
    Co-targeting ephrin receptor tyrosine kinases A2 and A3 in cancer stem cells reduces growth of recurrent glioblastoma.
    Cancer Res. 2018 Jun 26. pii: 0008-5472.CAN-18-0267.
    PubMed     Abstract available


  93. LIANG L, Morrison LC, Tatari N, Stromecki M, et al
    CD271+ cells are diagnostic and prognostic and exhibit elevated MAPK activity in SHH medulloblastoma.
    Cancer Res. 2018 Jun 21. pii: 0008-5472.CAN-18-0027.
    PubMed     Abstract available


  94. LUOTO S, Hermelo I, Vuorinen EM, Hannus P, et al
    Computational characterization of suppressive immune microenvironments in glioblastoma.
    Cancer Res. 2018 Jun 19. pii: 0008-5472.CAN-17-3714.
    PubMed     Abstract available


  95. PALLAVICINI G, Sgro F, Garello F, Falcone M, et al
    Inactivation of citron kinase inhibits medulloblastoma progression by inducing apoptosis and cell senescence.
    Cancer Res. 2018 Jun 19. pii: 0008-5472.CAN-17-4060.
    PubMed     Abstract available


    May 2018
  96. OLMEZ I, Zhang Y, Manigat L, Benamar M, et al
    Combined c-Met/Trk inhibition overcomes resistance to CDK4/6 inhibitors in Glioblastoma.
    Cancer Res. 2018 May 29. pii: 0008-5472.CAN-17-3124.
    PubMed     Abstract available


  97. MILOUSHEV VZ, Granlund KL, Boltyanskiy R, Lyashchenko SK, et al
    Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients.
    Cancer Res. 2018 May 16. pii: 0008-5472.CAN-18-0221.
    PubMed     Abstract available


  98. PAL S, Kozono D, Yang X, Fendler W, et al
    Dual HDAC and PI3K inhibition abrogates NFkappaB- and FOXM1-mediated DNA damage response to radiosensitize pediatric high-grade gliomas.
    Cancer Res. 2018 May 14. pii: 0008-5472.CAN-17-3691.
    PubMed     Abstract available


  99. CHEN Z, Morales JE, Guerrero PA, Sun H, et al
    PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells.
    Cancer Res. 2018 May 9. pii: 0008-5472.CAN-18-0085.
    PubMed     Abstract available


    April 2018
  100. KAID C, Goulart E, Caires-Junior LC, Araujo BHS, et al
    Zika virus selectively kills aggressive human embryonal CNS tumor cells in vitro and in vivo.
    Cancer Res. 2018 Apr 26. pii: 0008-5472.CAN-17-3201.
    PubMed     Abstract available


  101. LIU J, Sareddy GR, Zhou M, Viswanadhapalli S, et al
    Differential effects of estrogen receptor beta isoforms on glioblastoma progression.
    Cancer Res. 2018 Apr 16. pii: 0008-5472.CAN-17-3470.
    PubMed     Abstract available


  102. ORLANDO D, Miele E, De Angelis B, Guercio M, et al
    Adoptive immunotherapy using PRAME-specific T cells in medulloblastoma.
    Cancer Res. 2018 Apr 3. pii: 0008-5472.CAN-17-3140.
    PubMed     Abstract available


    March 2018
  103. REN D, Zhu X, Kong R, Zhao Z, et al
    Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer.
    Cancer Res. 2018 Mar 22. pii: 0008-5472.CAN-17-2994.
    PubMed     Abstract available


  104. HALL AW, Battenhouse AM, Shivram H, Morris AR, et al
    Bivalent chromatin domains in glioblastoma reveal a subtype-specific signature of glioma stem cells.
    Cancer Res. 2018 Mar 16. pii: 0008-5472.CAN-17-1724.
    PubMed     Abstract available


  105. MUKHERJEE J, Johannessen TA, Ohba S, Chow TT, et al
    Mutant IDH1 cooperates with ATRX loss to drive the alternative lengthening of telomere (ALT) phenotype in glioma.
    Cancer Res. 2018 Mar 15. pii: 0008-5472.CAN-17-2269.
    PubMed     Abstract available


  106. SADAHIRO H, Kang KD, Gibson JT, Minata M, et al
    Activation of the receptor tyrosine kinase AXL regulates the immune microenvironment in glioblastoma.
    Cancer Res. 2018 Mar 12. pii: 0008-5472.CAN-17-2433.
    PubMed     Abstract available


    February 2018
  107. RIMKUS TK, Carpenter RL, Sirkisoon SR, Zhu D, et al
    Truncated glioma-associated oncogene homolog 1 (tGLI1) mediates mesenchymal glioblastoma via transcriptional activation of CD44.
    Cancer Res. 2018 Feb 20. pii: 0008-5472.CAN-17-2933.
    PubMed     Abstract available


  108. CHOI JS, Kim CS, Berdis A
    Inhibition of Translesion DNA Synthesis as a Novel Therapeutic Strategy to Treat Brain Cancer.
    Cancer Res. 2018;78:1083-1096.
    PubMed     Abstract available


  109. DELWAR ZM, Kuo Y, Wen YH, Rennie PS, et al
    Oncolytic Virotherapy Blockade by Microglia and Macrophages Requires STAT1/3.
    Cancer Res. 2018;78:718-730.
    PubMed     Abstract available


    January 2018
  110. SANG Y, Li Y, Song L, Alvarez AA, et al
    TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3.
    Cancer Res. 2018 Jan 31. pii: 0008-5472.CAN-17-2774.
    PubMed     Abstract available


  111. VISWANATH P, Radoul M, Izquierdo-Garcia JL, Ong WQ, et al
    2-hydroxyglutarate-mediated autophagy of the endoplasmic reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas.
    Cancer Res. 2018 Jan 22. pii: 0008-5472.CAN-17-2926.
    PubMed     Abstract available


    December 2017
  112. XIAO W, Zhang R, Sohrabi A, Ehsanipour A, et al
    Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma.
    Cancer Res. 2017 Dec 27. pii: 0008-5472.CAN-17-2429.
    PubMed     Abstract available


  113. ZHANG Y, Wang T, Wang S, Xiong Y, et al
    Nkx2-2as suppression contributes to the pathogenesis of Sonic Hedgehog medulloblastoma.
    Cancer Res. 2017 Dec 11. pii: 0008-5472.CAN-17-1631.
    PubMed     Abstract available


  114. WEISS T, Weller M, Guckenberger M, Sentman CL, et al
    NKG2D-based CAR-T cells and radiotherapy exert synergistic efficacy in glioblastoma.
    Cancer Res. 2017 Dec 8. pii: 0008-5472.CAN-17-1788.
    PubMed     Abstract available


  115. ZAKARIA R, Platt-Higgins A, Rathi N, Radon M, et al
    T cell densities in brain metastases are associated with patient survival times and diffusion tensor MRI changes.
    Cancer Res. 2017 Dec 6. pii: 0008-5472.CAN-17-1720.
    PubMed     Abstract available


    November 2017
  116. LV D, Jia F, Hou Y, Sang Y, et al
    Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.
    Cancer Res. 2017;77:6190-6201.
    PubMed     Abstract available


  117. WAITKUS MS, Pirozzi CJ, Moure CJ, Diplas BH, et al
    Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1R132H induced metabolic liabilities.
    Cancer Res. 2017 Nov 2. pii: canres.1352.2017.
    PubMed     Abstract available


  118. MIYAUCHI JT, Caponegro MD, Chen D, Choi MK, et al
    Deletion of neuropilin 1 from microglia or bone marrow-derived macrophages slows glioma progression.
    Cancer Res. 2017 Nov 2. pii: canres.1435.2017.
    PubMed     Abstract available


  119. HOLLON TC, Lewis S, Pandian B, Niknafs YS, et al
    Rapid Intraoperative Diagnosis of Pediatric Brain Tumors Using Stimulated Raman Histology.
    Cancer Res. 2017 Nov 1. pii: canres.1974.2017.
    PubMed     Abstract available


  120. REAP E, Suryadevara CM, Batich KA, Sanchez-Perez L, et al
    Dendritic cells enhance polyfunctionality of adoptively transferred T cells which target cytomegalovirus in glioblastoma.
    Cancer Res. 2017 Nov 1. pii: canres.0469.2017.
    PubMed     Abstract available


  121. NORTON I, Essayed W, Zhang F, Pujol S, et al
    SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research.
    Cancer Res. 2017;77:e101-e103.
    PubMed     Abstract available


    October 2017
  122. LIU Y, Yuelling LW, Wang Y, Du F, et al
    Astrocytes promote medulloblastoma progression through hedgehog secretion.
    Cancer Res. 2017 Oct 6. pii: canres.1463.2017.
    PubMed     Abstract available


    September 2017
  123. YANG R, Chen LH, Hansen LJ, Carpenter AB, et al
    Cic loss promotes gliomagenesis via aberrant neural stem cell proliferation and differentiation.
    Cancer Res. 2017 Sep 22. pii: canres.1018.2017.
    PubMed     Abstract available


  124. STEPANOVA DS, Semenova G, Kuo YM, Andrews AJ, et al
    An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.
    Cancer Res. 2017;77:5026-5038.
    PubMed     Abstract available


    August 2017
  125. FIGUEROA J, Phillips LM, Shahar T, Hossain A, et al
    Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587.
    Cancer Res. 2017 Aug 30. pii: canres.2524.2016.
    PubMed     Abstract available


  126. LEE E, Pain M, Wang H, Herman JA, et al
    Sensitivity to BUB1B inhibition defines an alternative classification of glioblastoma.
    Cancer Res. 2017 Aug 30. pii: canres.0736.2017.
    PubMed     Abstract available


  127. CHOW KH, Park HJ, George J, Yamamoto K, et al
    S100A4 is a biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastoma.
    Cancer Res. 2017 Aug 14. pii: canres.1294.2017.
    PubMed     Abstract available


  128. CHEN X, Ma H, Wang Z, Zhang S, et al
    EZH2 palmitoylation mediated by ZDHHC5 in p53 mutant glioma drives malignant development and progression.
    Cancer Res. 2017 Aug 3. pii: canres.1139.2017.
    PubMed     Abstract available


    July 2017
  129. YIN J, Oh YT, Kim JY, Kim SS, et al
    Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBPbeta signaling.
    Cancer Res. 2017 Jul 28. pii: canres.0388.2017.
    PubMed     Abstract available


  130. WANG X, Huang Z, Wu Q, Prager BC, et al
    MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells.
    Cancer Res. 2017 Jul 20. pii: canres.0114.2017.
    PubMed     Abstract available



  131. Correction: Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells.
    Cancer Res. 2017;77:3962.
    PubMed    


  132. JERMYN M, Mercier J, Aubertin K, Desroches J, et al
    Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy.
    Cancer Res. 2017;77:3942-3950.
    PubMed     Abstract available


  133. KURTSDOTTER I, Topcic D, Karlen A, Singla B, et al
    SOX5/6/21 prevent oncogene-driven transformation of brain stem cells.
    Cancer Res. 2017 Jul 7. pii: canres.0704.2017.
    PubMed     Abstract available


    May 2017
  134. YAN H, Romero-Lopez M, Benitez LI, Di K, et al
    3D mathematical modeling of glioblastoma suggests that transdifferentiated vascular endothelial cells mediate resistance to current standard-of-care therapy.
    Cancer Res. 2017 May 23. pii: canres.3094.2016.
    PubMed     Abstract available


  135. TECH K, Tikunov AP, Farooq H, Morrissy AS, et al
    Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation.
    Cancer Res. 2017 May 17. pii: canres.3304.2016.
    PubMed     Abstract available


  136. ZHANG Y, Cruickshanks N, Yuan F, Wang B, et al
    Targetable T-type calcium channels drive glioblastoma.
    Cancer Res. 2017 May 16. pii: canres.2347.2016.
    PubMed     Abstract available


  137. GRAUSAM KB, Dooyema SD, Bihannic L, Premathilake H, et al
    ATOH1 promotes leptomeningeal dissemination and metastasis of Sonic Hedgehog subgroup medulloblastomas.
    Cancer Res. 2017 May 10. pii: canres.1836.2016.
    PubMed     Abstract available


    April 2017
  138. SARKAR S, Mirzaei R, Zemp FJ, Wu W, et al
    Activation of NOTCH signaling by tenascin-C promotes growth of human brain tumor-initiating cells.
    Cancer Res. 2017 Apr 17. pii: canres.2171.2016.
    PubMed     Abstract available


  139. STEVENS LE, Cheung WKC, Adua SJ, Arnal-Estape A, et al
    Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases.
    Cancer Res. 2017;77:1905-1917.
    PubMed     Abstract available


  140. ZINNHARDT B, Pigeon H, Theze B, Viel T, et al
    Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake.
    Cancer Res. 2017;77:1831-1841.
    PubMed     Abstract available


  141. SCHNEPP PM, Lee DD, Guldner IH, O'Tighearnaigh TK, et al
    GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment.
    Cancer Res. 2017 Apr 11. pii: canres.2289.2016.
    PubMed     Abstract available


    February 2017
  142. CHEN Z, Feng X, Herting CJ, Alvarez Garcia V, et al
    Cellular and molecular identity of tumor-associated macrophages in glioblastoma.
    Cancer Res. 2017 Feb 24. pii: canres.2310.2016.
    PubMed     Abstract available


  143. LU Y, Kwintkiewicz J, Liu Y, Tech K, et al
    Chemosensitivity of IDH1 mutant gliomas due to an impairment in PARP1-mediated DNA repair.
    Cancer Res. 2017 Feb 15. pii: canres.2773.2016.
    PubMed     Abstract available


    January 2017
  144. KOSSATZ S, Carney B, Schweitzer ME, Carlucci G, et al
    Biomarker based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models.
    Cancer Res. 2017 Jan 20. pii: canres.2850.2016.
    PubMed     Abstract available


  145. NIKLASSON M, Maddalo G, Sramkova Z, Mutlu E, et al
    Membrane-depolarizing channel blockers induce selective glioma cell death by impairing nutrient transport and unfolded protein/amino acid responses.
    Cancer Res. 2017 Jan 13. pii: canres.2274.2016.
    PubMed     Abstract available


    December 2016
  146. WARD SA, Warrington NM, Taylor S, Kfoury N, et al
    Reprogramming medulloblastoma-propagating cells via combined antagonism of Sonic Hedgehog and CXCR4.
    Cancer Res. 2016 Dec 28. pii: canres.0847.2016.
    PubMed     Abstract available


  147. BINDA E, Visioli A, Giani F, Trivieri N, et al
    Wnt5a drives an invasive phenotype in human glioblastoma stem-like cells.
    Cancer Res. 2016 Dec 23. pii: canres.1693.2016.
    PubMed     Abstract available



  148. Correction: IFN-beta Down-Regulates the Expression of DNA Repair Gene MGMT and Sensitizes Resistant Glioma Cells to Temozolomide.
    Cancer Res. 2016;76:7293.
    PubMed    


  149. WAHL DR, Dresser J, Wilder-Romans K, Parsels JD, et al
    Glioblastoma therapy can be augmented by targeting IDH1-mediated NADPH biosynthesis.
    Cancer Res. 2016 Dec 6. pii: canres.2008.2016.
    PubMed     Abstract available


    November 2016
  150. SREEDHARAN S, Maturi NP, Xie Y, Sundstrom A, et al
    Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.
    Cancer Res. 2016 Nov 15. doi: 10.1158/0008-5472.CAN-16-2482.
    PubMed     Abstract available


  151. MITTAPALLI RK, Adkins CE, Bohn KA, Mohammad AS, et al
    Quantitative Fluorescent Microscopy to Measure Vascular Pore Sizes in Primary and Metastatic Brain Tumors.
    Cancer Res. 2016 Nov 4. pii: canres.1711.2016.
    PubMed     Abstract available


  152. ZHU G, Rankin SL, Larson JD, Zhu X, et al
    PTEN signaling in the postnatal perivascular progenitor niche drives medulloblastoma formation.
    Cancer Res. 2016 Nov 4. pii: canres.1991.2016.
    PubMed     Abstract available


    October 2016
  153. NAGEL ZD, Kitange GJ, Gupta SK, Joughin BA, et al
    DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme.
    Cancer Res. 2016 Oct 28. pii: canres.1151.2016.
    PubMed     Abstract available


    September 2016
  154. KAUR A, Denisova O, Qiao X, Jumppanen M, et al
    PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells.
    Cancer Res. 2016 Sep 26. pii: canres.1134.2016.
    PubMed     Abstract available


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