Retrieve available abstracts of 54 articles: HTML format
Single Articles
July 2025
JIANG Y, Liu Q, Stridh P, Kockum I, et al Multiomics integration prioritizes potential drug targets for multiple sclerosis.
Proc Natl Acad Sci U S A. 2025;122:e2425537122. PubMedAbstract available
June 2025
ATKINSON KC, Desfor S, Feri M, Sekyi MT, et al Decreased mitochondrial activity in the demyelinating cerebellum of progressive
multiple sclerosis and chronic EAE contributes to Purkinje cell loss.
Proc Natl Acad Sci U S A. 2025;122:e2421806122. PubMedAbstract available
Editorial Expression of Concern for Poon et al., Targeting the muscarinic M1
receptor with a selective, brain-penetrant antagonist to promote remyelination in
multiple sclerosis.
Proc Natl Acad Sci U S A. 2025;122:e2512750122. PubMed
May 2025
JENSEN LT, Fugger L Immune perturbation by the ileal microbiota in multiple sclerosis.
Proc Natl Acad Sci U S A. 2025;122:e2506777122. PubMed
GUPTA S, Arnab S, Nguyen KL, Reed M, et al Sex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2
activation in a model of MS and CNP.
Proc Natl Acad Sci U S A. 2025;122:e2426771122. PubMedAbstract available
YOON H, Gerdes LA, Beigel F, Sun Y, et al Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins
trigger MS-like disease in germfree transgenic mice-An unbiased functional study.
Proc Natl Acad Sci U S A. 2025;122:e2419689122. PubMedAbstract available
April 2025
MECHELLI R, Umeton R, Bellucci G, Bigi R, et al A disease-specific convergence of host and Epstein-Barr virus genetics in
multiple sclerosis.
Proc Natl Acad Sci U S A. 2025;122:e2418783122. PubMedAbstract available
HOU J, Magliozzi R, Chen Y, Wu J, et al Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination.
Proc Natl Acad Sci U S A. 2025;122:e2426786122. PubMedAbstract available
MOLITOR TP, Hayashi G, Lin MY, Dunn CJ, et al Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator.
Proc Natl Acad Sci U S A. 2025;122:e2422172122. PubMedAbstract available
March 2025
ORR N, Steinman L Epstein-Barr virus and the immune microenvironment in multiple sclerosis:
Insights from high-dimensional brain tissue imaging.
Proc Natl Acad Sci U S A. 2025;122:e2425670122. PubMedAbstract available
SATTARNEZHAD N, Kockum I, Thomas OG, Liu Y, et al Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis
patients from healthy controls.
Proc Natl Acad Sci U S A. 2025;122:e2424986122. PubMedAbstract available
GHIMIRE S, Lehman PC, Aguilar Meza LS, Shahi SK, et al Specific microbial ratio in the gut microbiome is associated with multiple
sclerosis.
Proc Natl Acad Sci U S A. 2025;122:e2413953122. PubMedAbstract available
February 2025
RAD LM, Hughes KR, Wheeler SN, Decker JT, et al Engineered immunological niche directs therapeutic development in models of
progressive multiple sclerosis.
Proc Natl Acad Sci U S A. 2025;122:e2409852122. PubMedAbstract available
Correction for Cao et al., Circadian clock cryptochrome proteins regulate
autoimmunity.
Proc Natl Acad Sci U S A. 2025;122:e2425633121. PubMed
December 2024
LANZ TV, Robinson WH Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles
connects the two main risk factors of multiple sclerosis.
Proc Natl Acad Sci U S A. 2024;121:e2420070121. PubMed
November 2024
OKAMOTO M, Kuratani A, Okuzaki D, Kamiyama N, et al IFN-gamma-induced Th1-Treg polarization in inflamed brains limits exacerbation of
experimental autoimmune encephalomyelitis.
Proc Natl Acad Sci U S A. 2024;121:e2401692121. PubMedAbstract available
MOURAD NI, Perota A, Xhema D, Duchi R, et al Double transgenic neonatal porcine islets as an alternative source for beta cell
replacement therapy.
Proc Natl Acad Sci U S A. 2024;121:e2409138121. PubMedAbstract available
October 2024
DROSU N, Anderson M, Bilodeau PA, Nishiyama S, et al CD4 T cells restricted to DRB1*15:01 recognize two Epstein-Barr virus
glycoproteins capable of intracellular antigen presentation.
Proc Natl Acad Sci U S A. 2024;121:e2416097121. PubMedAbstract available
Correction for Poon et al., Targeting the muscarinic M1 receptor with a
selective, brain-penetrant antagonist to promote remyelination in multiple
sclerosis.
Proc Natl Acad Sci U S A. 2024;121:e2420080121. PubMed
September 2024
LI W, He S, Tan J, Li N, et al Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15
to modulate the retinal microglial phenotype.
Proc Natl Acad Sci U S A. 2024;121:e2316161121. PubMedAbstract available
OURY J, Gamallo-Lana B, Santana L, Steyaert C, et al Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.
Proc Natl Acad Sci U S A. 2024;121:e2408324121. PubMedAbstract available
LI T, Yum S, Wu J, Li M, et al cGAS activation in classical dendritic cells causes autoimmunity in
TREX1-deficient mice.
Proc Natl Acad Sci U S A. 2024;121:e2411747121. PubMedAbstract available
August 2024
DENEEN B Pipe dream: Remyelination therapy for multiple sclerosis.
Proc Natl Acad Sci U S A. 2024;121:e2414324121. PubMed
ALAKHRAS NS, Zhang W, Barros N, Sharma A, et al An IL-23-STAT4 pathway is required for the proinflammatory function of classical
dendritic cells during CNS inflammation.
Proc Natl Acad Sci U S A. 2024;121:e2400153121. PubMedAbstract available
POON MM, Lorrain KI, Stebbins KJ, Edu GC, et al Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist
to promote remyelination in multiple sclerosis.
Proc Natl Acad Sci U S A. 2024;121:e2407974121. PubMedAbstract available
July 2024
NATARAJAN C, Le LHD, Gunasekaran M, Tracey KJ, et al Electrical stimulation of the vagus nerve ameliorates inflammation and disease
activity in a rat EAE model of multiple sclerosis.
Proc Natl Acad Sci U S A. 2024;121:e2322577121. PubMedAbstract available
June 2024
FAISSNER S, Motte J, Sgodzai M, Geis C, et al Successful use of anti-CD19 CAR T cells in severe treatment-refractory
stiff-person syndrome.
Proc Natl Acad Sci U S A. 2024;121:e2403227121. PubMedAbstract available
PARK J, Lee J, Hur Y, Kim CJ, et al ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by
inducing osteopontin expression.
Proc Natl Acad Sci U S A. 2024;121:e2322009121. PubMedAbstract available
RAKEBRANDT N, Yassini N, Kolz A, Schorer M, et al Innate acting memory Th1 cells modulate heterologous diseases.
Proc Natl Acad Sci U S A. 2024;121:e2312837121. PubMedAbstract available
SULADZE S, Sarkar R, Rodina N, Bokvist K, et al Atomic resolution structure of full-length human insulin fibrils.
Proc Natl Acad Sci U S A. 2024;121:e2401458121. PubMedAbstract available
May 2024
Correction for Ichimura et al., Autoimmunity against melanoma
differentiation-associated gene 5 induces interstitial lung disease mimicking
dermatomyositis in mice.
Proc Natl Acad Sci U S A. 2024;121:e2408646121. PubMed
April 2024
COSTANZA M, Ciotti A, Consonni A, Cipelletti B, et al CNS autoimmune response in the MAM/pilocarpine rat model of epileptogenic
cortical malformation.
Proc Natl Acad Sci U S A. 2024;121:e2319607121. PubMedAbstract available
THOMAS MA, Naik P, Wang H, Giles JT, et al The monocyte cell surface is a unique site of autoantigen generation in
rheumatoid arthritis.
Proc Natl Acad Sci U S A. 2024;121:e2304199121. PubMedAbstract available
ICHIMURA Y, Konishi R, Shobo M, Tanaka R, et al Autoimmunity against melanoma differentiation-associated gene 5 induces
interstitial lung disease mimicking dermatomyositis in mice.
Proc Natl Acad Sci U S A. 2024;121:e2313070121. PubMedAbstract available
March 2024
VENEGAS-SOLIS F, Staliunaite L, Rudolph E, Munch CC, et al A type I interferon regulatory network for human plasmacytoid dendritic cells
based on heparin, membrane-bound and soluble BDCA-2.
Proc Natl Acad Sci U S A. 2024;121:e2312404121. PubMedAbstract available
YIN R, Melton S, Huseby ES, Kardar M, et al How persistent infection overcomes peripheral tolerance mechanisms to cause T
cell-mediated autoimmune disease.
Proc Natl Acad Sci U S A. 2024;121:e2318599121. PubMedAbstract available
ANEES F, Montoya DA, Pisetsky DS, Payne CK, et al DNA corona on nanoparticles leads to an enhanced immunostimulatory effect with
implications for autoimmune diseases.
Proc Natl Acad Sci U S A. 2024;121:e2319634121. PubMedAbstract available
February 2024
IVERSEN R, Sollid LM Dissecting autoimmune encephalitis through the lens of intrathecal B cells.
Proc Natl Acad Sci U S A. 2024;121:e2401337121. PubMed
ADAMS C, Manouchehrinia A, Quach HL, Quach DL, et al Evidence supports a causal association between allele-specific vitamin D receptor
binding and multiple sclerosis among Europeans.
Proc Natl Acad Sci U S A. 2024;121:e2302259121. PubMedAbstract available
CHEN Y, Chen K, Zhu H, Qin H, et al Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via
phospholipid remodeling.
Proc Natl Acad Sci U S A. 2024;121:e2314561121. PubMedAbstract available
THEORELL J, Harrison R, Williams R, Raybould MIJ, et al Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells
characterize the cerebrospinal fluid in autoimmune encephalitis.
Proc Natl Acad Sci U S A. 2024;121:e2311049121. PubMedAbstract available
QIN C, Dong MH, Zhou LQ, Wang W, et al Single-cell analysis of refractory anti-SRP necrotizing myopathy treated with
anti-BCMA CAR-T cell therapy.
Proc Natl Acad Sci U S A. 2024;121:e2315990121. PubMedAbstract available
SELCK C, Jhala G, De George DJ, Kwong CJ, et al Extraislet expression of islet antigen boosts T cell exhaustion to partially
prevent autoimmune diabetes.
Proc Natl Acad Sci U S A. 2024;121:e2315419121. PubMedAbstract available
January 2024
SUTTER PA, Willis CM, Menoret A, Nicaise AM, et al Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of
oligodendrocyte differentiation and FTY720 responses.
Proc Natl Acad Sci U S A. 2024;121:e2306816121. PubMedAbstract available
AHMED AR, Kalesinskas M, Kaveri SV Restoring immune tolerance in pemphigus vulgaris.
Proc Natl Acad Sci U S A. 2024;121:e2317762121. PubMedAbstract available
GOTTLIEB A, Pham HPT, Saltarrelli JG, Lindsey JW, et al Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients
are specific for Epstein-Barr-virus-infected B cells.
Proc Natl Acad Sci U S A. 2024;121:e2315857121. PubMedAbstract available
December 2023
DIJKSTRA DJ, van de Bovenkamp FS, Abendstein L, Zuijderduijn R, et al Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance
phagocytosis but not complement activation.
Proc Natl Acad Sci U S A. 2023;120:e2310666120. PubMedAbstract available
YE C, Clements SA, Gu W, Geurts AM, et al Deletion of Vbeta3(+)CD4(+) T cells by endogenous mouse mammary tumor virus 3
prevents type 1 diabetes induction by autoreactive CD8(+) T cells.
Proc Natl Acad Sci U S A. 2023;120:e2312039120. PubMedAbstract available
SHIMO Y, Cathomas F, Lin HY, Chan KL, et al Social stress induces autoimmune responses against the brain.
Proc Natl Acad Sci U S A. 2023;120:e2305778120. PubMedAbstract available
November 2023
SCHMIDT H, Raj T, O'Neill TJ, Muschaweckh A, et al Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation
and the development of autoimmunity.
Proc Natl Acad Sci U S A. 2023;120:e2309205120. PubMedAbstract available
THOMANN AS, McQuade CA, Pinjusic K, Kolz A, et al A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on
CNS autoimmunity.
Proc Natl Acad Sci U S A. 2023;120:e2300733120. PubMedAbstract available
September 2023
GRUCHOT J, Lewen I, Dietrich M, Reiche L, et al Transgenic expression of the HERV-W envelope protein leads to polarized glial
cell populations and a neurodegenerative environment.
Proc Natl Acad Sci U S A. 2023;120:e2308187120. PubMedAbstract available
GAN T, Wang D Picobirnaviruses encode proteins that are functional bacterial lysins.
Proc Natl Acad Sci U S A. 2023;120:e2309647120. PubMedAbstract available
GARCIA CORRALES AV, Verberk SGS, Haidar M, Grajchen E, et al Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory
foam cell formation during demyelination.
Proc Natl Acad Sci U S A. 2023;120:e2301030120. PubMedAbstract available