Retrieve available abstracts of 67 articles: HTML format
Single Articles
September 2025
MCKAY CE, Deans M, Connor J, Saunders JC, et al Employing deep mutational scanning in the Escherichia coli periplasm to decode
the thermodynamic landscape for amyloid formation.
Proc Natl Acad Sci U S A. 2025;122:e2516165122. PubMedAbstract available
BROTT BK, Raissi AJ, Micheva KD, Vielmetter J, et al C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and
mediates synapse pruning.
Proc Natl Acad Sci U S A. 2025;122:e2519253122. PubMedAbstract available
DONG Z, Yin T, Deng Z, Zou H, et al Hybridoma-inspired strategy crafts tailored multifunctional exosomes for
precision therapy.
Proc Natl Acad Sci U S A. 2025;122:e2424547122. PubMedAbstract available
VERDUZCO ESPINOZA AP, Na N, Campanati L, Ngo P, et al Microglia-to-neuron signaling links APOE4 and inflammation to enhanced neuronal
lipid metabolism and network activity.
Proc Natl Acad Sci U S A. 2025;122:e2516103122. PubMedAbstract available
ZHANG Y, Chen-Engerer HJ, Zhang K, Zott B, et al Amyloid beta-dependent neuronal silencing through synaptic decoupling.
Proc Natl Acad Sci U S A. 2025;122:e2515113122. PubMedAbstract available
August 2025
FRUITMAN DAVIDI A, Shirenova S, Michaelovich D, Benedetti G, et al Dural ectopic lymphatic structures accumulate during aging and exhibit
dysregulation in neurodegenerative diseases.
Proc Natl Acad Sci U S A. 2025;122:e2425081122. PubMedAbstract available
LEE J, Lee B, Lee H, Kim EJE, et al Pelota-mediated ribosome-associated quality control counteracts aging and
age-associated pathologies across species.
Proc Natl Acad Sci U S A. 2025;122:e2505217122. PubMedAbstract available
July 2025
BEERENDONK L, Mejias JF, Nuiten SA, de Gee JW, et al Adaptive arousal regulation: Pharmacologically shifting the peak of the
Yerkes-Dodson curve by catecholaminergic enhancement of arousal.
Proc Natl Acad Sci U S A. 2025;122:e2419733122. PubMedAbstract available
FALLOT LB, Pinc JR, Buselmeier JE, Palchak JC, et al An aminosterol breaks the autocatalytic cycle of Abeta(42) aggregation and protects
cell membranes from its soluble aggregates.
Proc Natl Acad Sci U S A. 2025;122:e2417944122. PubMedAbstract available
June 2025
TIAN L, Long G, Zhu S, Wang Y, et al Nanoimmunomodulation of the Abeta-STING feedback machinery in microglia for
Alzheimer's disease treatment.
Proc Natl Acad Sci U S A. 2025;122:e2427257122. PubMedAbstract available
May 2025
Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein
accumulation and neuronal deficits in a transgenic mouse model linking
Alzheimer's disease and Parkinson's disease.
Proc Natl Acad Sci U S A. 2025;122:e2509530122. PubMed
KOH Y, Vazquez-Rosa E, Gao F, Li H, et al Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice
from Alzheimer's disease and traumatic brain injury.
Proc Natl Acad Sci U S A. 2025;122:e2417224122. PubMedAbstract available
CHEN W, Liu X, Munoz VR, Kahn CR, et al Loss of insulin signaling in microglia impairs cellular uptake of Abeta and
neuroinflammatory response exacerbating AD-like neuropathology.
Proc Natl Acad Sci U S A. 2025;122:e2501527122. PubMedAbstract available
April 2025
PAULSON AL, Zhang L, Prichard AM, Singer AC, et al 40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding
during navigation in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A. 2025;122:e2419364122. PubMedAbstract available
March 2025
YIN C, Imms P, Chowdhury NF, Chaudhari NN, et al Deep learning to quantify the pace of brain aging in relation to neurocognitive
changes.
Proc Natl Acad Sci U S A. 2025;122:e2413442122. PubMedAbstract available
JOHNSON EA, Nowar R, Viola KL, Huang W, et al Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism
for the treatment of neurodegenerative diseases.
Proc Natl Acad Sci U S A. 2025;122:e2402117122. PubMedAbstract available
ZHANG X, Vlkolinsky R, Wu C, Dolatabadi N, et al S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene
expression induced by neuronal activity.
Proc Natl Acad Sci U S A. 2025;122:e2418179122. PubMedAbstract available
February 2025
NGUYEN L, Ajredini R, Guo S, Romano LEL, et al CASP8 intronic expansion identified by poly-glycine-arginine pathology increases
Alzheimer's disease risk.
Proc Natl Acad Sci U S A. 2025;122:e2416885122. PubMedAbstract available
YANG X, Wang Y, Qiao Y, Lin J, et al Astrocytic EphA4 signaling is important for the elimination of excitatory
synapses in Alzheimer's disease.
Proc Natl Acad Sci U S A. 2025;122:e2420324122. PubMedAbstract available
JIANG WI, Cao Y, Xue Y, Ji Y, et al Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.
Proc Natl Acad Sci U S A. 2025;122:e2417515122. PubMedAbstract available
January 2025
SNEIDERIENE G, Gonzalez Diaz A, Adhikari SD, Wei J, et al Lipid-induced condensate formation from the Alzheimer's Abeta peptide triggers
amyloid aggregation.
Proc Natl Acad Sci U S A. 2025;122:e2401307122. PubMedAbstract available
December 2024
CHAKRABORTY P, Ibanez de Opakua A, Purslow JA, Fromm SA, et al GSK3beta phosphorylation catalyzes the aggregation of tau into Alzheimer's
disease-like filaments.
Proc Natl Acad Sci U S A. 2024;121:e2414176121. PubMedAbstract available
NATALE F, Spinelli M, Rinaudo M, Gulisano W, et al Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits
in an experimental model of Alzheimer's disease.
Proc Natl Acad Sci U S A. 2024;121:e2402604121. PubMedAbstract available
KRISTENSEN M Insulin-inspired peptides may open new pathways to treat Alzheimer's disease.
Proc Natl Acad Sci U S A. 2024;121:e2419741121. PubMed
October 2024
KAMEI N, Ikeda K, Ohmoto Y, Fujisaki S, et al Insulin-inspired hippocampal neuron-targeting technology for protein drug
delivery.
Proc Natl Acad Sci U S A. 2024;121:e2407936121. PubMedAbstract available
September 2024
SATO K, Takayama KI, Saito Y, Inoue S, et al ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease,
inhibiting DKK1 to suppress tau phosphorylation.
Proc Natl Acad Sci U S A. 2024;121:e2406854121. PubMedAbstract available
ZHANG N, Zhang R, Jiang L, Gao Z, et al Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut
microbiota via induction of inflammatory tolerance.
Proc Natl Acad Sci U S A. 2024;121:e2314337121. PubMedAbstract available
JENSEN AMG, Raska J, Fojtik P, Monti G, et al The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal
dominant Alzheimer's disease.
Proc Natl Acad Sci U S A. 2024;121:e2408262121. PubMedAbstract available
August 2024
Retraction for Janczura et al., Inhibition of HDAC3 reverses Alzheimer's
disease-related pathologies in vitro and in the 3xTg-AD mouse model.
Proc Natl Acad Sci U S A. 2024;121:e2415279121. PubMed
YAN K, Zhang C, Kang J, Montenegro P, et al Cortical neurodegeneration caused by Psen1 mutations is independent of Abeta.
Proc Natl Acad Sci U S A. 2024;121:e2409343121. PubMedAbstract available
FRANK M, Ni P, Jensen M, Gerstein MB, et al Leveraging a large language model to predict protein phase transition: A
physical, multiscale, and interpretable approach.
Proc Natl Acad Sci U S A. 2024;121:e2320510121. PubMedAbstract available
WEI X, Campagna JJ, Jagodzinska B, Wi D, et al A therapeutic small molecule enhances gamma-oscillations and improves
cognition/memory in Alzheimer's disease model mice.
Proc Natl Acad Sci U S A. 2024;121:e2400420121. PubMedAbstract available
PLASCENCIA-VILLA G, Castellani RJ, Perry G Central role of brain regulatory T cells in the inflammatory cascade in
Alzheimer's disease.
Proc Natl Acad Sci U S A. 2024;121:e2412255121. PubMed
July 2024
PANWAR A, Rentsendorj A, Jhun M, Cohen RM, et al Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like
neurodegeneration.
Proc Natl Acad Sci U S A. 2024;121:e2401420121. PubMedAbstract available
MALAQUIN S, Lerchundi R, Mougel E, Valette J, et al Capturing alterations of intracellular-extracellular lactate distribution in the
brain using diffusion-weighted MR spectroscopy in vivo.
Proc Natl Acad Sci U S A. 2024;121:e2403635121. PubMedAbstract available
June 2024
AXELL E, Hu J, Lindberg M, Dear AJ, et al The role of shear forces in primary and secondary nucleation of amyloid fibrils.
Proc Natl Acad Sci U S A. 2024;121:e2322572121. PubMedAbstract available
May 2024
TURNER GR, Hewan P, Wearn A, van Dooren R, et al Locus coeruleus integrity is related to an exploitation-based decision-making
bias in older adulthood.
Proc Natl Acad Sci U S A. 2024;121:e2322617121. PubMedAbstract available
April 2024
SINGH PK, Simoes-Pires EN, Chen ZL, Torrente D, et al Lecanemab blocks the effects of the Abeta/fibrinogen complex on blood clots and
synapse toxicity in organotypic culture.
Proc Natl Acad Sci U S A. 2024;121:e2314450121. PubMedAbstract available
March 2024
MAMMERI NE, Dregni AJ, Duan P, Hong M, et al Structures of AT8 and PHF1 phosphomimetic tau: Insights into the
posttranslational modification code of tau aggregation.
Proc Natl Acad Sci U S A. 2024;121:e2316175121. PubMedAbstract available
December 2023
ZHANG H, Chen Y, Yu M, Xi Y, et al Nasal delivery of polymeric nanoDisc mobilizes a synergy of central and
peripheral amyloid-beta clearance to treat Alzheimer's disease.
Proc Natl Acad Sci U S A. 2023;120:e2304213120. PubMedAbstract available
WANG W, Ma X, Bhatta S, Shao C, et al Intraneuronal beta-amyloid impaired mitochondrial proteostasis through the impact on
LONP1.
Proc Natl Acad Sci U S A. 2023;120:e2316823120. PubMedAbstract available
ZHANG J, Wickizer C, Ding W, Van R, et al In vivo three-dimensional brain imaging with chemiluminescence probes in
Alzheimer's disease models.
Proc Natl Acad Sci U S A. 2023;120:e2310131120. PubMedAbstract available
November 2023
BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected
by DNA aptamer-attached portable graphene biosensor.
Proc Natl Acad Sci U S A. 2023;120:e2311565120. PubMedAbstract available
NIERE F, Uneri A, McArdle CJ, Deng Z, et al Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in
dendrites in tuberous sclerosis complex and Alzheimer's disease.
Proc Natl Acad Sci U S A. 2023;120:e2301534120. PubMedAbstract available
October 2023
DUAN P, Dregni AJ, Mammeri NE, Hong M, et al Structure of the nonhelical filament of the Alzheimer's disease tau core.
Proc Natl Acad Sci U S A. 2023;120:e2310067120. PubMedAbstract available
MONTENEGRO P, Chen P, Kang J, Lee SH, et al Human Presenilin-1 delivered by AAV9 rescues impaired gamma-secretase activity,
memory deficits, and neurodegeneration in Psen mutant mice.
Proc Natl Acad Sci U S A. 2023;120:e2306714120. PubMedAbstract available
ABSKHARON R, Pan H, Sawaya MR, Seidler PM, et al Structure-based design of nanobodies that inhibit seeding of Alzheimer's
patient-extracted tau fibrils.
Proc Natl Acad Sci U S A. 2023;120:e2300258120. PubMedAbstract available
LU K, Li C, Liu J, Wang J, et al Impairments in endogenous AMPA receptor dynamics correlates with learning
deficits in Alzheimer's disease model mice.
Proc Natl Acad Sci U S A. 2023;120:e2303878120. PubMedAbstract available
LIM CM, Gonzalez Diaz A, Fuxreiter M, Pun FW, et al Multiomic prediction of therapeutic targets for human diseases associated with
protein phase separation.
Proc Natl Acad Sci U S A. 2023;120:e2300215120. PubMedAbstract available
September 2023
LOPES JR, Zhang X, Mayrink J, Tatematsu BK, et al Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a
mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A. 2023;120:e2309221120. PubMedAbstract available
LE GUEN Y, Luo G, Ambati A, Damotte V, et al Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases
uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
Proc Natl Acad Sci U S A. 2023;120:e2302720120. PubMedAbstract available
CHEN ZL, Singh PK, Calvano M, Norris EH, et al A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in
Alzheimer's disease.
Proc Natl Acad Sci U S A. 2023;120:e2309389120. PubMedAbstract available
August 2023
SOULA M, Maslarova A, Harvey RE, Valero M, et al Interictal epileptiform discharges affect memory in an Alzheimer's disease mouse
model.
Proc Natl Acad Sci U S A. 2023;120:e2302676120. PubMedAbstract available
NAKANO-KOBAYASHI A, Canela A, Yoshihara T, Hagiwara M, et al Astrocyte-targeting therapy rescues cognitive impairment caused by
neuroinflammation via the Nrf2 pathway.
Proc Natl Acad Sci U S A. 2023;120:e2303809120. PubMedAbstract available
July 2023
CAZZARO S, Woo JA, Wang X, Liu T, et al Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from
neuroprotection to neurodegeneration in Alzheimer's disease.
Proc Natl Acad Sci U S A. 2023;120:e2217128120. PubMedAbstract available
June 2023
THACKER D, Barghouth M, Bless M, Zhang E, et al Direct observation of secondary nucleation along the fibril surface of the
amyloid beta 42 peptide.
Proc Natl Acad Sci U S A. 2023;120:e2220664120. PubMedAbstract available
ENNERFELT H, Holliday C, Shapiro DA, Zengeler KE, et al CARD9 attenuates Abeta pathology and modifies microglial responses in an Alzheimer's
disease mouse model.
Proc Natl Acad Sci U S A. 2023;120:e2303760120. PubMedAbstract available
May 2023
KREUTZER AG, Guaglianone G, Yoo S, Parrocha CMT, et al Probing differences among Abeta oligomers with two triangular trimers derived from
Abeta.
Proc Natl Acad Sci U S A. 2023;120:e2219216120. PubMedAbstract available
ZHOU GF, Tang J, Ma YL, Fu X, et al ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology
through FXR1-dependent BACE1 translation initiation.
Proc Natl Acad Sci U S A. 2023;120:e2220148120. PubMedAbstract available
GHOSH S, Tugarinov V, Clore GM Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104
action on amyloid-beta42 aggregation and fibril formation.
Proc Natl Acad Sci U S A. 2023;120:e2305823120. PubMedAbstract available
MILLER A, Wei J, Meehan S, Dobson CM, et al Formation of amyloid loops in brain tissues is controlled by the flexibility of
protofibril chains.
Proc Natl Acad Sci U S A. 2023;120:e2216234120. PubMedAbstract available
CHEN W, Huang Q, Lazdon EK, Gomes A, et al Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in
a 5xFAD mouse model.
Proc Natl Acad Sci U S A. 2023;120:e2220684120. PubMedAbstract available
YANG XK, Zhang FL, Jin XK, Jiao YT, et al Nanoelectrochemistry reveals how soluble Abeta(42) oligomers alter vesicular storage
and release of glutamate.
Proc Natl Acad Sci U S A. 2023;120:e2219994120. PubMedAbstract available
HASSANI SA, Neumann A, Russell J, Jones CK, et al M(1)-selective muscarinic allosteric modulation enhances cognitive flexibility
and effective salience in nonhuman primates.
Proc Natl Acad Sci U S A. 2023;120:e2216792120. PubMedAbstract available
March 2023
CONDELLO C, Ayers JI, Dalgard CL, Garcia Garcia MM, et al Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Abeta
prions.
Proc Natl Acad Sci U S A. 2023;120:e2220984120. PubMedAbstract available
YANG H, Yuan P, Wu Y, Shi M, et al EMBER multidimensional spectral microscopy enables quantitative determination of
disease- and cell-specific amyloid strains.
Proc Natl Acad Sci U S A. 2023;120:e2300769120. PubMedAbstract available
LEE M, Yau WM, Louis JM, Tycko R, et al Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual
molecular conformations and intermolecular interactions.
Proc Natl Acad Sci U S A. 2023;120:e2218831120. PubMedAbstract available