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Alzheimer's Disease

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 96 articles: HTML format

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April 2024
1. SINGH PK, Simoes-Pires EN, Chen ZL, Torrente D, et al
   Lecanemab blocks the effects of the Abeta/fibrinogen complex on blood clots and synapse toxicity in organotypic culture.
   Proc Natl Acad Sci U S A. 2024;121:e2314450121.
   PubMed     Abstract available
   
   
   March 2024
2. MAMMERI NE, Dregni AJ, Duan P, Hong M, et al
   Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation.
   Proc Natl Acad Sci U S A. 2024;121:e2316175121.
   PubMed     Abstract available
   
   
   December 2023
3. ZHANG H, Chen Y, Yu M, Xi Y, et al
   Nasal delivery of polymeric nanoDisc mobilizes a synergy of central and peripheral amyloid-beta clearance to treat Alzheimer's disease.
   Proc Natl Acad Sci U S A. 2023;120:e2304213120.
   PubMed     Abstract available
   
   
   
4. WANG W, Ma X, Bhatta S, Shao C, et al
   Intraneuronal beta-amyloid impaired mitochondrial proteostasis through the impact on LONP1.
   Proc Natl Acad Sci U S A. 2023;120:e2316823120.
   PubMed     Abstract available
   
   
   
5. ZHANG J, Wickizer C, Ding W, Van R, et al
   In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.
   Proc Natl Acad Sci U S A. 2023;120:e2310131120.
   PubMed     Abstract available
   
   
   November 2023
6. BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al
   In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.
   Proc Natl Acad Sci U S A. 2023;120:e2311565120.
   PubMed     Abstract available
   
   
   
7. NIERE F, Uneri A, McArdle CJ, Deng Z, et al
   Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease.
   Proc Natl Acad Sci U S A. 2023;120:e2301534120.
   PubMed     Abstract available
   
   
   October 2023
8. DUAN P, Dregni AJ, Mammeri NE, Hong M, et al
   Structure of the nonhelical filament of the Alzheimer's disease tau core.
   Proc Natl Acad Sci U S A. 2023;120:e2310067120.
   PubMed     Abstract available
   
   
   
9. MONTENEGRO P, Chen P, Kang J, Lee SH, et al
   Human Presenilin-1 delivered by AAV9 rescues impaired gamma-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice.
   Proc Natl Acad Sci U S A. 2023;120:e2306714120.
   PubMed     Abstract available
   
   
   
10. ABSKHARON R, Pan H, Sawaya MR, Seidler PM, et al
    Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
    Proc Natl Acad Sci U S A. 2023;120:e2300258120.
    PubMed     Abstract available
    
    
    
11. LU K, Li C, Liu J, Wang J, et al
    Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice.
    Proc Natl Acad Sci U S A. 2023;120:e2303878120.
    PubMed     Abstract available
    
    
    
12. LIM CM, Gonzalez Diaz A, Fuxreiter M, Pun FW, et al
    Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.
    Proc Natl Acad Sci U S A. 2023;120:e2300215120.
    PubMed     Abstract available
    
    
    September 2023
13. LOPES JR, Zhang X, Mayrink J, Tatematsu BK, et al
    Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309221120.
    PubMed     Abstract available
    
    
    
14. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
    PubMed     Abstract available
    
    
    
15. CHEN ZL, Singh PK, Calvano M, Norris EH, et al
    A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309389120.
    PubMed     Abstract available
    
    
    August 2023
16. SOULA M, Maslarova A, Harvey RE, Valero M, et al
    Interictal epileptiform discharges affect memory in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2302676120.
    PubMed     Abstract available
    
    
    
17. NAKANO-KOBAYASHI A, Canela A, Yoshihara T, Hagiwara M, et al
    Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
    Proc Natl Acad Sci U S A. 2023;120:e2303809120.
    PubMed     Abstract available
    
    
    July 2023
18. CAZZARO S, Woo JA, Wang X, Liu T, et al
    Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2217128120.
    PubMed     Abstract available
    
    
    June 2023
19. THACKER D, Barghouth M, Bless M, Zhang E, et al
    Direct observation of secondary nucleation along the fibril surface of the amyloid beta 42 peptide.
    Proc Natl Acad Sci U S A. 2023;120:e2220664120.
    PubMed     Abstract available
    
    
    
20. ENNERFELT H, Holliday C, Shapiro DA, Zengeler KE, et al
    CARD9 attenuates Abeta pathology and modifies microglial responses in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2303760120.
    PubMed     Abstract available
    
    
    May 2023
21. KREUTZER AG, Guaglianone G, Yoo S, Parrocha CMT, et al
    Probing differences among Abeta oligomers with two triangular trimers derived from Abeta.
    Proc Natl Acad Sci U S A. 2023;120:e2219216120.
    PubMed     Abstract available
    
    
    
22. ZHOU GF, Tang J, Ma YL, Fu X, et al
    ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
    Proc Natl Acad Sci U S A. 2023;120:e2220148120.
    PubMed     Abstract available
    
    
    
23. GHOSH S, Tugarinov V, Clore GM
    Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-beta42 aggregation and fibril formation.
    Proc Natl Acad Sci U S A. 2023;120:e2305823120.
    PubMed     Abstract available
    
    
    
24. MILLER A, Wei J, Meehan S, Dobson CM, et al
    Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
    Proc Natl Acad Sci U S A. 2023;120:e2216234120.
    PubMed     Abstract available
    
    
    
25. CHEN W, Huang Q, Lazdon EK, Gomes A, et al
    Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2220684120.
    PubMed     Abstract available
    
    
    
26. YANG XK, Zhang FL, Jin XK, Jiao YT, et al
    Nanoelectrochemistry reveals how soluble Abeta(42) oligomers alter vesicular storage and release of glutamate.
    Proc Natl Acad Sci U S A. 2023;120:e2219994120.
    PubMed     Abstract available
    
    
    
27. HASSANI SA, Neumann A, Russell J, Jones CK, et al
    M(1)-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.
    Proc Natl Acad Sci U S A. 2023;120:e2216792120.
    PubMed     Abstract available
    
    
    March 2023
28. CONDELLO C, Ayers JI, Dalgard CL, Garcia Garcia MM, et al
    Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Abeta prions.
    Proc Natl Acad Sci U S A. 2023;120:e2220984120.
    PubMed     Abstract available
    
    
    
29. YANG H, Yuan P, Wu Y, Shi M, et al
    EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
    Proc Natl Acad Sci U S A. 2023;120:e2300769120.
    PubMed     Abstract available
    
    
    
30. LEE M, Yau WM, Louis JM, Tycko R, et al
    Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions.
    Proc Natl Acad Sci U S A. 2023;120:e2218831120.
    PubMed     Abstract available
    
    
    February 2023
31. CASTRO-HERNANDEZ R, Berulava T, Metelova M, Epple R, et al
    Conserved reduction of m(6)A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts.
    Proc Natl Acad Sci U S A. 2023;120:e2204933120.
    PubMed     Abstract available
    
    
    
32. FAIRLEY LH, Lai KO, Wong JH, Chong WJ, et al
    Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2209177120.
    PubMed     Abstract available
    
    
    
33. LIU YJ, Ding Y, Yin YQ, Xiao H, et al
    Cspg4(high) microglia contribute to microgliosis during neurodegeneration.
    Proc Natl Acad Sci U S A. 2023;120:e2210643120.
    PubMed     Abstract available
    
    
    
34. GOYAL MS, Blazey T, Metcalf NV, McAvoy MP, et al
    Brain aerobic glycolysis and resilience in Alzheimer disease.
    Proc Natl Acad Sci U S A. 2023;120:e2212256120.
    PubMed     Abstract available
    
    
    
35. QIU Y, Shen X, Ravid O, Atrakchi D, et al
    Definition of the contribution of an Osteopontin-producing CD11c(+) microglial subset to Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2218915120.
    PubMed     Abstract available
    
    
    
36. STEINMAN L
    An intrinsically disordered protein, osteopontin, driving neuropathology in Alzheimer's dementia.
    Proc Natl Acad Sci U S A. 2023;120:e2221816120.
    PubMed    
    
    
    
37. WANG R, Chaudhari P, Davatzikos C
    Bias in machine learning models can be significantly mitigated by careful training: Evidence from neuroimaging studies.
    Proc Natl Acad Sci U S A. 2023;120:e2211613120.
    PubMed     Abstract available
    
    
    January 2023
38. JENSEN AMG, Kitago Y, Fazeli E, Vaegter CB, et al
    Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer.
    Proc Natl Acad Sci U S A. 2023;120:e2212180120.
    PubMed     Abstract available
    
    
    
39. LESTER E, Van Alstyne M, McCann KL, Reddy S, et al
    Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation.
    Proc Natl Acad Sci U S A. 2023;120:e2217759120.
    PubMed     Abstract available
    
    
    
40. PETERS A
    Ambient air pollution and Alzheimer's disease: the role of the composition of fine particles.
    Proc Natl Acad Sci U S A. 2023;120:e2220028120.
    PubMed    
    
    
    
41. YIN C, Imms P, Cheng M, Amgalan A, et al
    Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment.
    Proc Natl Acad Sci U S A. 2023;120:e2214634120.
    PubMed     Abstract available
    
    
    
42. ECK RJ, Kow RL, Black AH, Liachko NF, et al
    SPOP loss of function protects against tauopathy.
    Proc Natl Acad Sci U S A. 2023;120:e2207250120.
    PubMed     Abstract available
    
    
    December 2022
43. SHEA D, Colasurdo E, Smith A, Paschall C, et al
    SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers.
    Proc Natl Acad Sci U S A. 2022;119:e2213157119.
    PubMed     Abstract available
    
    
    
44. MUSTALY-KALIMI S, Gallegos W, Marr RA, Gilman-Sachs A, et al
    Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2211999119.
    PubMed     Abstract available
    
    
    
45. HABASHI M, Vutla S, Tripathi K, Senapati S, et al
    Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Abeta oligomers.
    Proc Natl Acad Sci U S A. 2022;119:e2210766119.
    PubMed     Abstract available
    
    
    November 2022
46. CONDELLO C, Maxwell AM, Castillo E, Aoyagi A, et al
    Abeta and tau prions feature in the neuropathogenesis of Down syndrome.
    Proc Natl Acad Sci U S A. 2022;119:e2212954119.
    PubMed     Abstract available
    
    
    
47. DENG J, Ji Y, Zhu F, Liu L, et al
    Mapping secretome-mediated interaction between paired neuron-macrophage single cells.
    Proc Natl Acad Sci U S A. 2022;119:e2200944119.
    PubMed     Abstract available
    
    
    October 2022
48. DEHGHAN A, Pinto RC, Karaman I, Huang J, et al
    Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2206083119.
    PubMed     Abstract available
    
    
    
49. WANG X, Rimal S, Tantray I, Geng J, et al
    Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1.
    Proc Natl Acad Sci U S A. 2022;119:e2202322119.
    PubMed     Abstract available
    
    
    
50. HUANG Y, Lemke G
    Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.
    Proc Natl Acad Sci U S A. 2022;119:e2204306119.
    PubMed     Abstract available
    
    
    
51. HUANG Y, Rafael Guimaraes T, Todd N, Ferguson C, et al
    G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2204828119.
    PubMed     Abstract available
    
    
    
52. TIAN J, Ren M, Zhao P, Luo S, et al
    Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain.
    Proc Natl Acad Sci U S A. 2022;119:e2202536119.
    PubMed     Abstract available
    
    
    September 2022
53. ORTI-CASAN N, Zuhorn IS, Naude PJW, De Deyn PP, et al
    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2201137119.
    PubMed     Abstract available
    
    
    
54. NGIAN ZK, Tan YY, Choo CT, Lin WQ, et al
    Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties.
    Proc Natl Acad Sci U S A. 2022;119:e2204179119.
    PubMed     Abstract available
    
    
    August 2022
55. SAROJA SR, Gorbachev K, Julia T, Goate AM, et al
    Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2022;119:e2108870119.
    PubMed     Abstract available
    
    
    
56. MURRAY KA, Hu CJ, Griner SL, Pan H, et al
    De novo designed protein inhibitors of amyloid aggregation and seeding.
    Proc Natl Acad Sci U S A. 2022;119:e2206240119.
    PubMed     Abstract available
    
    
    June 2022
57. TAYLOR JL, Pritchard HAT, Walsh KR, Strangward P, et al
    Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204581119.
    PubMed     Abstract available
    
    
    
58. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
    PubMed     Abstract available
    
    
    May 2022
59. LINSE S, Sormanni P, O'Connell DJ
    An aggregation inhibitor specific to oligomeric intermediates of Abeta42 derived from phage display libraries of stable, small proteins.
    Proc Natl Acad Sci U S A. 2022;119:e2121966119.
    PubMed     Abstract available
    
    
    
60. ROGERS MA, Chang CCY, Maue RA, Melton EM, et al
    Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
    Proc Natl Acad Sci U S A. 2022;119:e2201646119.
    PubMed     Abstract available
    
    
    April 2022
61. GUZMAN-VELEZ E, Diez I, Schoemaker D, Pardilla-Delgado E, et al
    Amyloid-beta and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2113641119.
    PubMed     Abstract available
    
    
    March 2022
62. JIN C, Wang J, Wang Y, Jia B, et al
    Modulation of amyloid precursor protein cleavage by gamma-secretase activating protein through phase separation.
    Proc Natl Acad Sci U S A. 2022;119:e2122292119.
    PubMed     Abstract available
    
    
    
63. SHIGEMORI K, Nomura S, Umeda T, Takeda S, et al
    Peripheral Abeta acts as a negative modulator of insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119:e2117723119.
    PubMed     Abstract available
    
    
    February 2022
64. BELSARE KD, Wu H, Mondal D, Bond A, et al
    Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available
    
    
    January 2022
65. PARK MH, Park KH, Choi BJ, Han WH, et al
    Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available
    
    
    December 2021
66. MOULTON MJ, Barish S, Ralhan I, Chang J, et al
    Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    November 2021
67. LATTANZI V, Andre I, Gasser U, Dubackic M, et al
    Amyloid beta 42 fibril structure based on small-angle scattering.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
68. PALMER CR, Liu CS, Romanow WJ, Lee MH, et al
    Altered cell and RNA isoform diversity in aging Down syndrome brains.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
69. GHOSH U, Yau WM, Collinge J, Tycko R, et al
    Structural differences in amyloid-beta fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    October 2021
70. 
    Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    
    
    
    
71. PARKHITKO AA, Wang L, Filine E, Jouandin P, et al
    A genetic model of methionine restriction extends Drosophila health- and lifespan.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    September 2021
72. HOU Y, Wei Y, Lautrup S, Yang B, et al
    NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    August 2021
73. 
    Correction for Sun et al., Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    
    
    
    July 2021
74. WANG H, Robinson JL, Kocabas P, Gustafsson J, et al
    Genome-scale metabolic network reconstruction of model animals as a platform for translational research.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    June 2021
75. WU Z, Chen C, Kang SS, Liu X, et al
    Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
76. SADE YAZDI D, Laor Bar-Yosef D, Adsi H, Kreiser T, et al
    Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease beta-amyloid polypeptide.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    April 2021
77. LORD J, Jermy B, Green R, Wong A, et al
    Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    March 2021
78. IPPATI S, Deng Y, van der Hoven J, Heu C, et al
    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-beta toxicity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
79. RAMESHA S, Rayaprolu S, Bowen CA, Giver CR, et al
    Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
80. 
    Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    
    
    
    January 2021
81. GHOSH U, Thurber KR, Yau WM, Tycko R, et al
    Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
82. GIOVINAZZO D, Bursac B, Sbodio JI, Nalluru S, et al
    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
83. AHMED F
    QnAs with Robert Tycko.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    
    
    
    
84. KIM SH, Yang S, Lim KH, Ko E, et al
    Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
85. ELLWANGER DC, Wang S, Brioschi S, Shao Z, et al
    Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    December 2020
86. LOHR KM, Frost B, Scherzer C, Feany MB, et al
    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
    Proc Natl Acad Sci U S A. 2020;117:33608-33618.
    PubMed     Abstract available
    
    
    
87. BOYKO S, Surewicz K, Surewicz WK
    Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.
    Proc Natl Acad Sci U S A. 2020;117:31882-31890.
    PubMed     Abstract available
    
    
    
88. SWANSON LW, Hahn JD, Sporns O
    Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.
    Proc Natl Acad Sci U S A. 2020;117:31470-31481.
    PubMed     Abstract available
    
    
    
89. DUBEY S, Heinen S, Krantic S, McLaurin J, et al
    Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Dec 7. pii: 1908658117.
    PubMed     Abstract available
    
    
    November 2020
90. LONNEMANN N, Hosseini S, Marchetti C, Skouras DB, et al
    The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 30. pii: 2009680117.
    PubMed     Abstract available
    
    
    
91. CHO HJ, Huynh TT, Rogers BE, Mirica LM, et al
    Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 24. pii: 2014058117.
    PubMed     Abstract available
    
    
    
92. ENGSTROM AK, Walker AC, Moudgal RA, Myrick DA, et al
    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:29133-29143.
    PubMed     Abstract available
    
    
    October 2020
93. 
    Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Oct 26. pii: 2019837117.
    PubMed    
    
    
    September 2020
94. LAU SF, Cao H, Fu AKY, Ip NY, et al
    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 28. pii: 2008762117.
    PubMed     Abstract available
    
    
    August 2020
95. O'CONNELL GC, Alder ML, Smothers CG, Chang JHC, et al
    Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage.
    Proc Natl Acad Sci U S A. 2020;117:20764-20775.
    PubMed     Abstract available
    
    
    
96. CHAKRABORTY D, Straub JE, Thirumalai D
    Differences in the free energies between the excited states of Abeta40 and Abeta42 monomers encode their aggregation propensities.
    Proc Natl Acad Sci U S A. 2020;117:19926-19937.
    PubMed     Abstract available
    
    

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