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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 53 articles:
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    April 2019
  1. COUGHLAN G, Coutrot A, Khondoker M, Minihane AM, et al
    Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Apr 23. pii: 1901600116.
    PubMed     Text format     Abstract available


  2. XIANG J, Wang ZH, Ahn EH, Liu X, et al
    Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
    Proc Natl Acad Sci U S A. 2019 Apr 19. pii: 1901348116.
    PubMed     Text format     Abstract available


  3. SHEA D, Hsu CC, Bi TM, Paranjapye N, et al
    alpha-Sheet secondary structure in amyloid beta-peptide drives aggregation and toxicity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Apr 19. pii: 1820585116.
    PubMed     Text format     Abstract available


    March 2019
  4. CATER JH, Kumita JR, Zeineddine Abdallah R, Zhao G, et al
    Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide.
    Proc Natl Acad Sci U S A. 2019 Mar 8. pii: 1817298116.
    PubMed     Text format     Abstract available


    February 2019
  5. O'CALLAGHAN C, Shine JM, Hodges JR, Andrews-Hanna JR, et al
    Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration.
    Proc Natl Acad Sci U S A. 2019;116:3316-3321.
    PubMed     Text format     Abstract available


    January 2019
  6. HORTI AG, Naik R, Foss CA, Minn I, et al
    PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R).
    Proc Natl Acad Sci U S A. 2019 Jan 11. pii: 1812155116.
    PubMed     Text format     Abstract available


  7. WU S, Song W, Wong CCL, Shi Y, et al
    Bax inhibitor 1 is a gamma-secretase-independent presenilin-binding protein.
    Proc Natl Acad Sci U S A. 2019;116:141-147.
    PubMed     Text format     Abstract available


    December 2018
  8. FICHOU Y, Lin Y, Rauch JN, Vigers M, et al
    Cofactors are essential constituents of stable and seeding-active tau fibrils.
    Proc Natl Acad Sci U S A. 2018;115:13234-13239.
    PubMed     Text format     Abstract available


  9. WALTI MA, Steiner J, Meng F, Chung HS, et al
    Probing the mechanism of inhibition of amyloid-beta(1-42)-induced neurotoxicity by the chaperonin GroEL.
    Proc Natl Acad Sci U S A. 2018;115:E11924-E11932.
    PubMed     Text format     Abstract available


  10. WANG H, Liu X, Chen S, Ye K, et al
    Spatiotemporal activation of the C/EBPbeta/delta-secretase axis regulates the pathogenesis of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Dec 10. pii: 1815915115.
    PubMed     Text format     Abstract available


    November 2018
  11. JANCZURA KJ, Volmar CH, Sartor GC, Rao SJ, et al
    Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.
    Proc Natl Acad Sci U S A. 2018 Nov 5. pii: 1805436115.
    PubMed     Text format     Abstract available


    October 2018
  12. LIU G, Jin S, Hu Y, Jiang Q, et al
    Disease status affects the association between rs4813620 and the expression of Alzheimer's disease susceptibility gene TRIB3.
    Proc Natl Acad Sci U S A. 2018 Oct 24. pii: 1812975115.
    PubMed     Text format    


  13. DIAZ-MORENO M, Armenteros T, Gradari S, Hortiguela R, et al
    Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology.
    Proc Natl Acad Sci U S A. 2018 Oct 23. pii: 1813205115.
    PubMed     Text format     Abstract available


  14. CHIA S, Habchi J, Michaels TCT, Cohen SIA, et al
    SAR by kinetics for drug discovery in protein misfolding diseases.
    Proc Natl Acad Sci U S A. 2018;115:10245-10250.
    PubMed     Text format     Abstract available


  15. SAYED FA, Telpoukhovskaia M, Kodama L, Li Y, et al
    Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
    Proc Natl Acad Sci U S A. 2018;115:10172-10177.
    PubMed     Text format     Abstract available


    September 2018
  16. BAKER SK, Chen ZL, Norris EH, Revenko AS, et al
    Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Sep 25. pii: 1811172115.
    PubMed     Text format     Abstract available


    August 2018
  17. TZENG TC, Hasegawa Y, Iguchi R, Cheung A, et al
    Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
    Proc Natl Acad Sci U S A. 2018 Aug 20. pii: 1801802115.
    PubMed     Text format     Abstract available


    July 2018
  18. PRASAD H, Rao R
    Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH.
    Proc Natl Acad Sci U S A. 2018;115:E6640-E6649.
    PubMed     Text format     Abstract available


    June 2018
  19. YANG X, Meisl G, Frohm B, Thulin E, et al
    On the role of sidechain size and charge in the aggregation of Abeta42 with familial mutations.
    Proc Natl Acad Sci U S A. 2018;115:E5849-E5858.
    PubMed     Text format     Abstract available


    May 2018
  20. CALLENDER JA, Yang Y, Lorden G, Stephenson NL, et al
    Protein kinase Calpha gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.
    Proc Natl Acad Sci U S A. 2018 May 29. pii: 1805046115.
    PubMed     Text format     Abstract available


    April 2018
  21. SHOKRI-KOJORI E, Wang GJ, Wiers CE, Demiral SB, et al
    beta-Amyloid accumulation in the human brain after one night of sleep deprivation.
    Proc Natl Acad Sci U S A. 2018;115:4483-4488.
    PubMed     Text format     Abstract available


    March 2018
  22. ADLER DH, Wisse LEM, Ittyerah R, Pluta JB, et al
    Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology.
    Proc Natl Acad Sci U S A. 2018 Mar 28. pii: 1801093115.
    PubMed     Text format     Abstract available


  23. BAO J, Qin M, Mahaman YAR, Zhang B, et al
    BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 1800498115.
    PubMed     Text format     Abstract available


  24. LORENZI M, Altmann A, Gutman B, Wray S, et al
    Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics.
    Proc Natl Acad Sci U S A. 2018 Mar 6. pii: 1706100115.
    PubMed     Text format     Abstract available


  25. PRADO LIMA MG, Schimidt HL, Garcia A, Dare LR, et al
    Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity.
    Proc Natl Acad Sci U S A. 2018;115:E2403-E2409.
    PubMed     Text format     Abstract available


    February 2018
  26. ZHOU HH, Singh V, Johnson SC, Wahba G, et al
    Statistical tests and identifiability conditions for pooling and analyzing multisite datasets.
    Proc Natl Acad Sci U S A. 2018;115:1481-1486.
    PubMed     Text format     Abstract available


  27. ZHOU X, Chen Y, Mok KY, Zhao Q, et al
    Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2018 Feb 5. pii: 1715554115.
    PubMed     Text format     Abstract available


  28. HOU Y, Lautrup S, Cordonnier S, Wang Y, et al
    NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
    Proc Natl Acad Sci U S A. 2018 Feb 5. pii: 1718819115.
    PubMed     Text format     Abstract available


    January 2018
  29. LERDKRAI C, Asavapanumas N, Brawek B, Kovalchuk Y, et al
    Intracellular Ca(2+) stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 22. pii: 1714409115.
    PubMed     Text format     Abstract available


  30. BENNETT RE, Robbins AB, Hu M, Cao X, et al
    Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 22. pii: 1710329115.
    PubMed     Text format     Abstract available


  31. HAN KH, Arlian BM, Macauley MS, Paulson JC, et al
    Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid beta.
    Proc Natl Acad Sci U S A. 2018;115:E372-E381.
    PubMed     Text format     Abstract available


  32. CONDELLO C, Lemmin T, Stohr J, Nick M, et al
    Structural heterogeneity and intersubject variability of Abeta in familial and sporadic Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 8. pii: 1714966115.
    PubMed     Text format     Abstract available


  33. CHEN C, Wang Z, Zhang Z, Liu X, et al
    The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 2. pii: 1718683115.
    PubMed     Text format     Abstract available


    November 2017
  34. RASMUSSEN J, Mahler J, Beschorner N, Kaeser SA, et al
    Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Nov 20. pii: 201713215.
    PubMed     Text format     Abstract available


  35. YANG J, Zhang X, Yuan P, Yang J, et al
    Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Nov 6. pii: 201706248.
    PubMed     Text format     Abstract available


    October 2017
  36. VOLMAR CH, Salah-Uddin H, Janczura KJ, Halley P, et al
    M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.
    Proc Natl Acad Sci U S A. 2017;114:E9135-E9144.
    PubMed     Text format     Abstract available


  37. ANDREW RJ, Fernandez CG, Stanley M, Jiang H, et al
    Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 23. pii: 201708568.
    PubMed     Text format     Abstract available


  38. MANO T, Nagata K, Nonaka T, Tarutani A, et al
    Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 17. pii: 201707151.
    PubMed     Text format     Abstract available


  39. RUBINSZTEIN DC
    RIPK1 promotes inflammation and beta-amyloid accumulation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201715241.
    PubMed     Text format    


    September 2017
  40. OFENGEIM D, Mazzitelli S, Ito Y, DeWitt JP, et al
    RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Sep 13. pii: 201714175.
    PubMed     Text format     Abstract available


  41. PARASKEVAIDI M, Morais CLM, Lima KMG, Snowden JS, et al
    Differential diagnosis of Alzheimer's disease using spectrochemical analysis of blood.
    Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201701517.
    PubMed     Text format     Abstract available


    July 2017
  42. KESKIN AD, Kekus M, Adelsberger H, Neumann U, et al
    BACE inhibition-dependent repair of Alzheimer's pathophysiology.
    Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708106.
    PubMed     Text format     Abstract available


    June 2017
  43. KUNDRA R, Ciryam P, Morimoto RI, Dobson CM, et al
    Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201618417.
    PubMed     Text format     Abstract available


    May 2017
  44. LI Q, Navakkode S, Rothkegel M, Soong TW, et al
    Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 May 8. pii: 201613700.
    PubMed     Text format     Abstract available


    March 2017
  45. WANG BJ, Her GM, Hu MK, Chen YW, et al
    ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 28. pii: 201618804.
    PubMed     Text format     Abstract available


  46. ZHANG Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, et al
    Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
    Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201615036.
    PubMed     Text format     Abstract available


    January 2017
  47. PERANI D, Farsad M, Ballarini T, Lubian F, et al
    The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia.
    Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201610909.
    PubMed     Text format     Abstract available


  48. KELLEHER RJ 3RD, Shen J
    Presenilin-1 mutations and Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Jan 12. pii: 201619574.
    PubMed     Text format    


    December 2016
  49. HABCHI J, Chia S, Limbocker R, Mannini B, et al
    Systematic development of small molecules to inhibit specific microscopic steps of Abeta42 aggregation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2016 Dec 23. pii: 201615613.
    PubMed     Text format     Abstract available


    November 2016
  50. WOERMAN AL, Aoyagi A, Patel S, Kazmi SA, et al
    Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.
    Proc Natl Acad Sci U S A. 2016 Nov 28. pii: 201616344.
    PubMed     Text format     Abstract available


    October 2016
  51. KATSOURI L, Lim YM, Blondrath K, Eleftheriadou I, et al
    PPARgamma-coactivator-1alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model.
    Proc Natl Acad Sci U S A. 2016;113:12292-12297.
    PubMed     Text format     Abstract available


  52. ZHANG X, Mormino EC, Sun N, Sperling RA, et al
    Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2016 Oct 4. pii: 201611073.
    PubMed     Text format     Abstract available


    April 2016
  53. PINOTSI D, Michel CH, Buell AK, Laine RF, et al
    Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
    Proc Natl Acad Sci U S A. 2016;113:3815-9.
    PubMed     Text format     Abstract available


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