Home The Word Brain	My Amedeo FAQ Privacy About
	Amedeo C49 English + 你好 (nǐ hǎo) = limitless possibilities. Start learning Mandarin Chinese today—for free, forever. Amedeo C49 is completely free, for life. Next week: +49.

Alzheimer's Disease

Free Subscription 22.09.2025 1 Acta Neuropathol 20 Alzheimers Dement 2 Am J Alzheimers Dis Other Demen 1 BMC Neurosci 1 Brain Res 2 Curr Alzheimer Res 13 J Alzheimers Dis 2 J Neurochem 2 J Neurol Neurosurg Psychiatry 1 J Neuropsychol 1 J Neurosci 1 Nat Med 1 Nat Ment Health 6 Nature 1 Neurobiol Aging 1 Neurology 1 Neuroscience 1 PLoS Genet 3 PLoS One 1 Proc Natl Acad Sci U S A

Retrieve available abstracts of this week’s articles: HTML format

Single Articles

Acta Neuropathol

1. TOME SO, Gawor K, Ospitalieri S, Ronisz A, et al
   Differences and overlaps in TDP-43 pathology of 'pure' LATE-NC compared to LATE-NC coexisting with Alzheimer's disease.
   Acta Neuropathol. 2025;150:28.
   PubMed         Abstract available
   
   

   
   Alzheimers Dement

2. TSUI JSM, Au DM, Uhm H, Wong WW, et al
   The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.
   Alzheimers Dement. 2025;21:e70586.
   PubMed         Abstract available
   
   
3. TIAN X, Rivera EK, Hwang I, Nikitina AA, et al
   Protective mechanisms against Alzheimer's disease in APOE3-Christchurch homozygous astrocytes.
   Alzheimers Dement. 2025;21:e70589.
   PubMed         Abstract available
   
   
4. CHEN CL, Son SJ, Schweitzer N, Jin H, et al
   Periventricular diffusivity reflects APOE epsilon4-modulated amyloid accumulation and cognitive impairment in the Alzheimer's disease continuum.
   Alzheimers Dement. 2025;21:e70659.
   PubMed         Abstract available
   
   
5. NGUYEN HO PT, Vernooij MW, Voortman T, Rodriguez-Ayllon M, et al
   Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.
   Alzheimers Dement. 2025;21:e70655.
   PubMed         Abstract available
   
   
6. CHOI SE, Mukherjee S, Gibbons LE, Trittschuh EH, et al
   Beyond NACC's Uniform Data Set for cognition: the impact of additional items on measurement precision.
   Alzheimers Dement. 2025;21:e70694.
   PubMed         Abstract available
   
   
7. CLEARY JA, Kumar A, Su Y, Singh S, et al
   MicroRNA cargo in neuron-derived vesicles as peripheral biomarkers of brain insulin dysregulation.
   Alzheimers Dement. 2025;21:e70597.
   PubMed         Abstract available
   
   
8. CHUN MY, Jung SH, Choe J, Lee SY, et al
   Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids.
   Alzheimers Dement. 2025;21:e70660.
   PubMed         Abstract available
   
   
9. MILLER ZA, Ossenkoppele R, Graff-Radford NR, Allen IE, et al
   Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.
   Alzheimers Dement. 2025;21:e70668.
   PubMed         Abstract available
   
   
10. SHI H, Lipworth L, Xiao Q, Han X, et al
    Five-year change in sleep duration and incident Alzheimer's Disease and Related Dementias among lower-income older adults.
    Alzheimers Dement. 2025;21:e70678.
    PubMed         Abstract available
    
    
11. YAARI R, Holdridge KC, Williamson M, Wessels AM, et al
    Donanemab in preclinical Alzheimer's disease: Screening and baseline data from TRAILBLAZER-ALZ 3.
    Alzheimers Dement. 2025;21:e70662.
    PubMed         Abstract available
    
    
12. EDLER MC, Faber K, Lacy K, Jackson J, et al
    NCRAD: Advancing Alzheimer's research through high-quality biospecimens and data.
    Alzheimers Dement. 2025;21:e70682.
    PubMed         Abstract available
    
    
13. HILLERSTROM H, Das A, Janicki MP, Rozas NS, et al
    Specialists' perceptions of clinical instruments, practices, and staging of DS-AD: Results from an international survey.
    Alzheimers Dement. 2025;21:e70356.
    PubMed         Abstract available
    
    
14. LUCKETT ES, Abakkouy Y, Lorenzini L, Collij LE, et al
    Harmonizing genotype array data to understand genetic risk for brain amyloid burden in the AMYPAD PNHS Consortium.
    Alzheimers Dement. 2025;21:e70376.
    PubMed         Abstract available
    
    
15. ATKINS AS, Marquis S, Creel K, Meunier J, et al
    The iADRS as an integrated measure of cognition and function: Psychometric evidence from recent clinical trials in early symptomatic Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70656.
    PubMed         Abstract available
    
    
16. GIBSON LL, Grinberg LT, Paes VR, Mueller C, et al
    Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.
    Alzheimers Dement. 2025;21:e70693.
    PubMed         Abstract available
    
    
17. DETCHEVERRY FE, Senthil S, Motue WLK, Hosein C, et al
    Investigating the oxidative stress-vascular brain injury axis in mild cognitive impairment of the Alzheimer's type.
    Alzheimers Dement. 2025;21:e70456.
    PubMed         Abstract available
    
    
18. GAYNOR LS, Lopez FV, Van Hulle CA, Li C, et al
    Measurement equivalence of the UDS version 2.0 and 3.0 neuropsychological batteries.
    Alzheimers Dement. 2025;21:e70720.
    PubMed         Abstract available
    
    
19. TRUDEL L, Therriault J, Macedo AC, Servaes S, et al
    Rates of clinical progression according to biological Alzheimer's disease stages.
    Alzheimers Dement. 2025;21:e70624.
    PubMed         Abstract available
    
    
20. LAO P, Edwards N, Flores-Aguilar L, Alshikho MJ, et al
    Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.
    Alzheimers Dement. 2025;21:e70679.
    PubMed         Abstract available
    
    
21. KANG M, Ang TFA, Devine SA, Sherva R, et al
    Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.
    Alzheimers Dement. 2025;21:e70681.
    PubMed         Abstract available
    
    

    
    Am J Alzheimers Dis Other Demen

22. DEMIRCIOGLU DIREN D
    Design and Validation of a Hybrid Machine Learning Model for Alzheimer's Detection Using Handwriting Data.
    Am J Alzheimers Dis Other Demen. 2025;40:15333175251374913.
    PubMed         Abstract available
    
    
23. FAZIO-EYNULLAYEVA E, Mystkowski P, Lv L, Aly A, et al
    A Real-World Analysis of the Clinical Journey, Diagnosis, and Monitoring Patterns of Patients With Alzheimer Disease by Stage in the United States.
    Am J Alzheimers Dis Other Demen. 2025;40:15333175251375378.
    PubMed         Abstract available
    
    

    
    BMC Neurosci

24. WANG C, Bu X, Cao M, Lian Y, et al
    Publisher Correction: Mir-199a-3p aggravates neuroinflammation in an Alzheimer's disease transgenic mouse model by promoting M1-polarization microglia.
    BMC Neurosci. 2025;26:58.
    PubMed        
    
    

    
    Brain Res

25. BI D, Gao B, Shen Y, Dai Z, et al
    Traumatic brain injury and neurodegenerative diseases: the role of axonal injury and amyloid-beta.
    Brain Res. 2025;1865:149873.
    PubMed         Abstract available
    
    

    
    Curr Alzheimer Res

26. BOUDI A, He J, Abd El Kader I, Liu X, et al
    Advancing Alzheimer's Disease Diagnosis Using VGG19 and XGBoost: A Neuroimaging-Based Method.
    Curr Alzheimer Res. 2025 Sep 15. doi: 10.2174/0115672050393604250904081342.
    PubMed         Abstract available
    
    
27. PAVITHRA R, Kanimozhi NV, Sonali L, Suneetha C, et al
    Unveiling Role of Gut Microbiota in Alzheimer's Disease: Mechanisms, Challenges and Future Perspectives.
    Curr Alzheimer Res. 2025 Sep 16. doi: 10.2174/0115672050403066250904112611.
    PubMed         Abstract available
    
    

    
    J Alzheimers Dis

28. WANG W, Liu H, Chen Y, Xiong Z, et al
    Identifying differential brain structures and genetic mechanisms between Alzheimer's disease and idiopathic normal pressure hydrocephalus.
    J Alzheimers Dis. 2025 Sep 17:13872877251379046. doi: 10.1177/13872877251379046.
    PubMed         Abstract available
    
    
29. MAO C, Zou Y, Wang T, Sha L, et al
    Comparison of diagnostic accuracy of Alzheimer's disease cerebrospinal fluid core biomarkers using INNOTEST, Lumipulse G, and Elecsys assays: Insights from the PUMCH dementia cohort study.
    J Alzheimers Dis. 2025 Sep 17:13872877251379084. doi: 10.1177/13872877251379084.
    PubMed         Abstract available
    
    
30. DENG T, Duan J, Yu W, Deng Z, et al
    Education as a domain-specific moderator: Shaping the impact of cerebral structural changes on clinical manifestations in Alzheimer's disease.
    J Alzheimers Dis. 2025 Sep 17:13872877251379078. doi: 10.1177/13872877251379078.
    PubMed         Abstract available
    
    
31. LIU Y, Chen Y, Chen Z, Wan H, et al
    Tau seeding activity in Alzheimer's disease: Characteristics, factors, and applications.
    J Alzheimers Dis. 2025 Sep 17:13872877251378772. doi: 10.1177/13872877251378772.
    PubMed         Abstract available
    
    
32. KITAYAMA Y, Nakano Y, Hirano S, Hanayama S, et al
    Multimodal neuroimaging related to cerebrospinal fluid biomarkers and cognitive function in Alzheimer's disease.
    J Alzheimers Dis. 2025 Sep 17:13872877251376601. doi: 10.1177/13872877251376601.
    PubMed         Abstract available
    
    
33. ZHANG J, Wang C, Chang K, Peng T, et al
    A novel traditional Chinese medicine formula restores sleep and cognitive function in APP/PS1 mice by targeting glycolytic pathways and neuroinflammatory responses.
    J Alzheimers Dis. 2025;107:617-627.
    PubMed         Abstract available
    
    
34. JIANG D, Yue A, Nan H, Hou J, et al
    Plasma glial fibrillary acidic protein and neurological diseases: A bidirectional Mendelian randomization study.
    J Alzheimers Dis. 2025;107:806-818.
    PubMed         Abstract available
    
    
35. FAKOREDE S, Sodiq TA, Ajagbe AO, Adeleke AJ, et al
    Interplay of Glut1 alteration and Alzheimer's disease: A narrative review on glucose transport and energy metabolism.
    J Alzheimers Dis. 2025 Sep 12:13872877251377793. doi: 10.1177/13872877251377793.
    PubMed         Abstract available
    
    
36. CARDOSO S, Montalvo A, Maroco J, Silva D, et al
    Long-term predictive accuracy of the 'mild cognitive impairment due to Alzheimer's disease' criteria.
    J Alzheimers Dis. 2025 Sep 15:13872877251375927. doi: 10.1177/13872877251375927.
    PubMed         Abstract available
    
    
37. LI H, Wu Y, Huang T, Sun Y, et al
    Development of a risk prediction model for Alzheimer's disease based on the UK Biobank prospective study.
    J Alzheimers Dis. 2025 Sep 15:13872877251375473. doi: 10.1177/13872877251375473.
    PubMed         Abstract available
    
    
38. HAALAND B, Dickson SP, Santana AF, Tanzi RE, et al
    Efficacy of AD04, an aluminum-based vaccine adjuvant, in patients with early Alzheimer's disease: Post hoc analysis of AFF006 (NCT01117818), a proof-of-concept, phase 2 randomized controlled trial.
    J Alzheimers Dis. 2025 Sep 15:13872877251375985. doi: 10.1177/13872877251375985.
    PubMed         Abstract available
    
    
39. SHAKER A, Ljunggren G, Vossen LE, Religa D, et al
    Impact of socio-economic and patient-centered characteristics on access to Alzheimer's disease medication in primary care: A population-based study in the Stockholm county, Sweden.
    J Alzheimers Dis. 2025 Sep 16:13872877251375900. doi: 10.1177/13872877251375900.
    PubMed         Abstract available
    
    
40. LEE J, Kim CW, Kim Y, Lee S, et al
    Environmental noise exposure and a new biomarker of Alzheimer's disease: A pilot study.
    J Alzheimers Dis. 2025 Sep 16:13872877251376920. doi: 10.1177/13872877251376920.
    PubMed         Abstract available
    
    

    
    J Neurochem

41. ESCAMILLA S, Perez-Gonzalez R, Marquez-Marco C, Camporesi E, et al
    Alterations of NMDAR Subunits in the Cerebrospinal Fluid Across Neurodegenerative and Immunological Disorders.
    J Neurochem. 2025;169:e70192.
    PubMed         Abstract available
    
    
42. ZHAO J, Chen J, Lu J, Shi Q, et al
    Nitration of Tyrosine Residue Y10 of Abeta(1-42) Ameliorates Abeta(1-42)-Induced Neurotoxicity and Memory Impairment In Vitro and In Vivo.
    J Neurochem. 2025;169:e70218.
    PubMed         Abstract available
    
    

    
    J Neurol Neurosurg Psychiatry

43. LEE M, Lee KJ, Kim J, Lee DY, et al
    Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models.
    J Neurol Neurosurg Psychiatry. 2025;96:981-989.
    PubMed         Abstract available
    
    
44. ZHAO Y, Fei L
    Smoking-attributable neurological health loss: age-specific burden and health disparities.
    J Neurol Neurosurg Psychiatry. 2025;96:937-946.
    PubMed         Abstract available
    
    

    
    J Neuropsychol

45. HEREDIA L, Marco M, Carrion N, Torrente M, et al
    Frontal Assessment Battery: Reliability, validity and discriminative ability in a Spanish sample of amnestic mild cognitive impairment and Alzheimer's disease.
    J Neuropsychol. 2025 Sep 18. doi: 10.1111/jnp.70011.
    PubMed         Abstract available
    
    

    
    J Neurosci

46. QU Y, Wu Y, Xu X, Cheng W, et al
    MiR-153 Prevents NRF2 Nuclear Translocation to Drive Hypoperfusion-Related Cognitive Deficits by Targeting KPNA5.
    J Neurosci. 2025;45:e2148242025.
    PubMed         Abstract available
    
    

    
    Nat Med

47. TIDEMAN P, Karlsson L, Strandberg O, Calling S, et al
    Primary care detection of Alzheimer's disease using a self-administered digital cognitive test and blood biomarkers.
    Nat Med. 2025 Sep 15. doi: 10.1038/s41591-025-03965.
    PubMed         Abstract available
    
    

    
    Nat Ment Health

48. CHAI Y, Shokri-Kojori E, Saykin AJ, Yu M, et al
    Anxious-depressive symptoms and sleep disturbances across the Alzheimer disease spectrum.
    Nat Ment Health. 2025;3:594-612.
    PubMed         Abstract available
    
    

    
    Nature

49. WILLYARD C
    The Vexing Promise of New Blood Tests for Alzheimer's.
    Nature. 2025;645:S13-S15.
    PubMed        
    
    
50. MADHUSOODANAN J
    The Hidden Link between Racism and Alzheimer's Risk.
    Nature. 2025;645:S19-S23.
    PubMed        
    
    
51. SEEGERT L
    Controversial New Alzheimer's Drugs Offer Hope-But at a High Cost.
    Nature. 2025;645:S10-S12.
    PubMed        
    
    
52. LANDHUIS E
    Alzheimer's Drugs Are Finally Tackling the Disease Itself. Here's How.
    Nature. 2025;645:S6-S9.
    PubMed        
    
    
53. HARRISON S
    Can Diet and Exercise Really Prevent Alzheimer's?
    Nature. 2025;645:S3-S5.
    PubMed        
    
    
54. GRAVITZ L
    New Hope in Alzheimer's Research.
    Nature. 2025;645:S2.
    PubMed        
    
    

    
    Neurobiol Aging

55. ANDERSON CL, Gross AL, Pettigrew C, Vazquez JP, et al
    Cognitive resilience in preclinical Alzheimer's disease: Higher NPTX2 and VGF levels are associated with reduced cognitive decline.
    Neurobiol Aging. 2025;156:133-142.
    PubMed         Abstract available
    
    

    
    Neurology

56. BOCCALINI C, Mathoux G, Hristovska I, Ribaldi F, et al
    Visual Classification of Tau-PET Detects 4 Subtypes With Different Long-Term Outcomes.
    Neurology. 2025;105:e213950.
    PubMed         Abstract available
    
    

    
    Neuroscience

57. ELENI I, Theofanis V, Zisis B, Eleni S, et al
    A review of the TGF-beta1 pathway in Alzheimer's disease and depression: Possible restoration potential of antidepressants.
    Neuroscience. 2025 Sep 12:S0306-4522(25)00925.
    PubMed         Abstract available
    
    

    
    PLoS Genet

58. XU K, Maydanchik N, Kang B, Chen J, et al
    Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics.
    PLoS Genet. 2025;21:e1011819.
    PubMed         Abstract available
    
    

    
    PLoS One

59. WANG Z, Xiao S, Wan M
    Association of CSF visinin-like protein 1 levels with cerebral glucose metabolism among older adults.
    PLoS One. 2025;20:e0329386.
    PubMed         Abstract available
    
    
60. PARK R, Chevalier C, Kieser S, Marizzoni M, et al
    Gut microbiome signatures in iNPH: Insights from a shotgun metagenomics study.
    PLoS One. 2025;20:e0330251.
    PubMed         Abstract available
    
    
61. JEON S, Alia AO, Popovic J, Vassar R, et al
    ACE1 does not influence cerebral Abeta degradation or amyloid plaque accumulation in 5XFAD mice.
    PLoS One. 2025;20:e0330193.
    PubMed         Abstract available
    
    

    
    Proc Natl Acad Sci U S A

62. MCKAY CE, Deans M, Connor J, Saunders JC, et al
    Employing deep mutational scanning in the Escherichia coli periplasm to decode the thermodynamic landscape for amyloid formation.
    Proc Natl Acad Sci U S A. 2025;122:e2516165122.
    PubMed         Abstract available
    
    

Thank you for your interest in scientific medicine.

AMEDEO Alzheimer's Disease is free of charge.