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  Alzheimer's Disease

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20.04.2026

1 Acta Neuropathol
22 Alzheimers Dement
1 Am J Geriatr Psychiatry
2 BMC Geriatr
1 BMJ
1 Brain Res
9 J Alzheimers Dis
1 J Neurochem
2 J Neurol Neurosurg Psychiatry
1 Nat Neurosci
2 Nat Rev Neurol
4 Neurobiol Dis
4 Neurology
1 Neuropsychology
1 PLoS One
1 Rev Neurol (Paris)


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Acta Neuropathol

  1. LIU QR, Zhu M, Perez K, Yao Q, et al
    Ser423-phosphorylated MECP2 (MECP2-pS423) accumulates in human brain, cerebrospinal fluid and serum in sporadic Alzheimer's disease.
    Acta Neuropathol. 2026;151:38.
    PubMed         Abstract available


    Alzheimers Dement

  2. MONTAGNE B, Boulin M, Hamel A, Champetier P, et al
    Night-to-night rapid eye movement sleep variability: A relevant marker of early amyloid-beta deposition.
    Alzheimers Dement. 2026;22:e71376.
    PubMed         Abstract available

  3. YANG J, Wang J, Chai W, Zhang L, et al
    Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE epsilon4 carriers.
    Alzheimers Dement. 2026;22:e71397.
    PubMed         Abstract available

  4. FESTA EK, Heindel WC, Marangi CA, Escobedo B, et al
    Attenuated pupillary response during visual search in preclinical Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71363.
    PubMed         Abstract available

  5. SHEKARI M, Escalante AG, Mila-Aloma M, Falcon C, et al
    Associations of (18)F-RO-948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum.
    Alzheimers Dement. 2026;22:e71176.
    PubMed         Abstract available

  6. KARGAZHANOV A, Aiken R, Hawkins K, Lopez R, et al
    Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system.
    Alzheimers Dement. 2026;22:e71281.
    PubMed         Abstract available

  7. MILLER SJ, Prokopenko D, Bai P, Mondal P, et al
    Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71271.
    PubMed         Abstract available

  8. KANORIA S, Veitch DP, Miller MJ, Aisen PS, et al
    Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025).
    Alzheimers Dement. 2026;22:e71353.
    PubMed         Abstract available


  9. Correction to "Accelerating real-world prediction and research in Alzheimer's: The M3AD study".
    Alzheimers Dement. 2026;22:e71416.
    PubMed        

  10. WILSON JM, Dage JL, Qian HR, Irelan CL, et al
    Dulaglutide and neurodegeneration biomarkers: REWIND post hoc analysis.
    Alzheimers Dement. 2026;22:e71391.
    PubMed         Abstract available

  11. OH J, Lee K, Yeo D, Cho J, et al
    Herpes zoster vaccination and cognitive disorders in older adults.
    Alzheimers Dement. 2026;22:e71410.
    PubMed         Abstract available

  12. RUSSELL A, Vogeley A, Lovett R, O'Conor R, et al
    Patient views on blood-based biomarker tests for Alzheimer's disease in primary care.
    Alzheimers Dement. 2026;22:e71247.
    PubMed         Abstract available

  13. ARSLAN B, Gobom J, Andreasson U, Montoliu-Gaya L, et al
    Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation.
    Alzheimers Dement. 2026;22:e71374.
    PubMed         Abstract available

  14. CAVAILLES C, Carnethon MR, Knutson KL, Thomas SJ, et al
    Midlife sleep characteristics and Alzheimer's disease biomarkers 20 years later.
    Alzheimers Dement. 2026;22:e71342.
    PubMed         Abstract available

  15. BJORNHOLM KD, Butler PM, Francis AE, Varma C, et al
    Anti-amyloid antibody equilibrium binding to Abeta aggregates from human Alzheimer's disease brain.
    Alzheimers Dement. 2026;22:e71350.
    PubMed         Abstract available

  16. WANG M, Buthut M, Meinhardt J, Otto C, et al
    Immune-proteo-metabolomic changes link to Abeta and tau pathology in Alzheimer disease.
    Alzheimers Dement. 2026;22:e71359.
    PubMed         Abstract available

  17. HOLPER S, Barnham KJ, Churilov L, Yates P, et al
    A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71381.
    PubMed         Abstract available

  18. CRIVELLI L, Fernandez R, Corvalan N, Sosa AL, et al
    A harmonized framework for studying exceptional cognitive aging in Latin America.
    Alzheimers Dement. 2026;22:e71373.
    PubMed         Abstract available

  19. CARO I, Perez G, Bize JV, Ponferrada J, et al
    Benchmarking speech biomarkers of Alzheimer's against cognitive and neural measures.
    Alzheimers Dement. 2026;22:e71365.
    PubMed         Abstract available

  20. LI J, Yi Y, Gan L, Bezgin G, et al
    Elevation in network dynamics amplifies amyloid-dependent tau pathology.
    Alzheimers Dement. 2026;22:e71354.
    PubMed         Abstract available

  21. BOUCHOUCHA K, Collin L, Coquette C, Colmant L, et al
    Olfactory decline tracks central-to-peripheral spread of tau pathology in Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71402.
    PubMed         Abstract available

  22. XING L, Liu A, Gao W, Li J, et al
    Beyond the neuron: Exosomes as intercellular modulators of mitochondrial networks in the pathogenesis and treatment of Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71330.
    PubMed         Abstract available

  23. ABDULLAH LB, Zhang F, Petersen M, Hall J, et al
    The association between APOE ?4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome.
    Alzheimers Dement. 2026;22:e71338.
    PubMed         Abstract available


    Am J Geriatr Psychiatry

  24. JANG S, Qin X, Wang MQ, Chen J, et al
    Associations Between ACO Enrollment Status and Drug and Nondrug Costs Among Older Adults Newly Diagnosed With ADRD.
    Am J Geriatr Psychiatry. 2026;34:791-802.
    PubMed         Abstract available


    BMC Geriatr

  25. SHI Y, Fang Z, Chen Y, Lin R, et al
    Prevalence and risk factors of loneliness in older adults with preclinical and prodromal Alzheimer's disease: the impact of depression, frailty-weight loss and quality of life.
    BMC Geriatr. 2026 Apr 11. doi: 10.1186/s12877-026-07432.
    PubMed        

  26. MELENDEZ JC, Escudero J, Satorres E, Pitarque A, et al
    Combined home-delivered transcranial direct current stimulation and cognitive training in older adults with mild cognitive impairment due to Alzheimer's disease: a randomized, single-blind, sham-controlled trial.
    BMC Geriatr. 2026 Apr 11. doi: 10.1186/s12877-026-07481.
    PubMed        


    BMJ

  27. WISE J
    Alzheimer's drugs targeting amyloid do not produce clinically meaningful effects, concludes Cochrane review.
    BMJ. 2026;393:s719.
    PubMed        


    Brain Res

  28. XU G, Gao J, Wang T, Wu H, et al
    Differential modulation of EEG microstate spatiotemporal dynamics by rTMS and iTBS correlates with clinical improvement in Alzheimer's disease.
    Brain Res. 2026;1884:150323.
    PubMed         Abstract available


    J Alzheimers Dis

  29. TRAN D, Georgiadis M, DiGiacomo P, Nirschl J, et al
    Characterizing ferrous versus ferric iron in Alzheimer's disease using X-ray fluorescence imaging and XANES spectroscopy.
    J Alzheimers Dis. 2026 Apr 13:13872877261435561. doi: 10.1177/13872877261435561.
    PubMed         Abstract available

  30. LI Y, Wang G, Xiong C, Shan G, et al
    Statistical models for Alzheimer's disease clinical trials: Lessons learned from the DIAN-TU Platform Trial.
    J Alzheimers Dis. 2026 Apr 13:13872877261441645. doi: 10.1177/13872877261441645.
    PubMed         Abstract available

  31. HARRINGTON EE, Bock JE
    Honor culture and cognitive aging: Honor endorsement and deficits in memory aging and Alzheimer's disease knowledge.
    J Alzheimers Dis. 2026 Apr 13:13872877261441602. doi: 10.1177/13872877261441602.
    PubMed         Abstract available

  32. YANG D, Zhang B, Wang S, Chen J, et al
    Sex-dependent role of inflammatory biomarkers in Alzheimer's disease-related cognitive performance.
    J Alzheimers Dis. 2026 Apr 15:13872877261440932. doi: 10.1177/13872877261440932.
    PubMed         Abstract available

  33. ZHANG Z, Chowdhury N, Dong J, Wu L, et al
    Systematic identification of cell-cell interactions associated with the severity of patients with Alzheimer's disease.
    J Alzheimers Dis. 2026 Apr 15:13872877261441603. doi: 10.1177/13872877261441603.
    PubMed         Abstract available

  34. SUMMERS WK
    Even schizophrenics fear Alzheimer's disease.
    J Alzheimers Dis. 2026 Apr 15:13872877261441567. doi: 10.1177/13872877261441567.
    PubMed         Abstract available

  35. SAKURAI K, Kaneda D, Uchida Y, Shibata H, et al
    Intermediate structural covariance network abnormalities in argyrophilic grain disease between Alzheimer's disease and healthy controls.
    J Alzheimers Dis. 2026 Apr 15:13872877261440972. doi: 10.1177/13872877261440972.
    PubMed         Abstract available

  36. LIU K, Sun W, Ma G, Chen F, et al
    Global burden, trends, and projections of Alzheimer's disease and other dementias attributable to high body mass index from 1990 to 2040: A comprehensive analysis of the Global Burden of Disease Study 2021.
    J Alzheimers Dis. 2026 Apr 15:13872877261439948. doi: 10.1177/13872877261439948.
    PubMed         Abstract available

  37. HONG YJ, Huang SY, Hsiao IT, Wu HC, et al
    ADAS-Cog11 performance as a surrogate of tau PET burden in an Asian Alzheimer's disease cohort.
    J Alzheimers Dis. 2026 Apr 17:13872877261441801. doi: 10.1177/13872877261441801.
    PubMed         Abstract available


    J Neurochem

  38. WANG Y, Zhu J, Lizarazo S, Lee KY, et al
    E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model.
    J Neurochem. 2026;170:e70440.
    PubMed         Abstract available


    J Neurol Neurosurg Psychiatry

  39. BELDER CRS, Fox NC
    Comparing amyloid immunotherapy with cholinesterase inhibitors for Alzheimer's disease.
    J Neurol Neurosurg Psychiatry. 2026 Apr 17:jnnp-2026-338722.
    PubMed        

  40. MUMMERY CJ, Rasmussen J, Blackburn D, Coulthard E, et al
    Lecanemab appropriate use recommendations for clinical practice in the UK.
    J Neurol Neurosurg Psychiatry. 2026;97:372-384.
    PubMed         Abstract available


    Nat Neurosci

  41. ZHANG Z, Li S, Xu L, Xiao S, et al
    Amyloid-beta-driven glymphatic dysfunction in Alzheimer's disease model mice is driven by Ca(2+)-mediated increases in astrocytic cholesterol.
    Nat Neurosci. 2026 Apr 15. doi: 10.1038/s41593-026-02261.
    PubMed         Abstract available


    Nat Rev Neurol

  42. FYFE I
    Targeting gut pathology is effective in an Alzheimer disease model.
    Nat Rev Neurol. 2026 Apr 10. doi: 10.1038/s41582-026-01208.
    PubMed        

  43. WANG K, Bu G
    Alzheimer disease protection from the periphery.
    Nat Rev Neurol. 2026 Apr 14. doi: 10.1038/s41582-026-01211.
    PubMed        


    Neurobiol Dis

  44. CARROLL T, Pfendler D, Alhaj Arhayem H, Thoma R, et al
    Tunable tau expression in C. elegans neurons reveals that early-AD tau phosphorylation selectively impacts behavior and mitochondrial quality control.
    Neurobiol Dis. 2026;222:107350.
    PubMed         Abstract available

  45. OLMSTED ZT, Sofroniew MV
    APP as an innate injury-response molecule.
    Neurobiol Dis. 2026;222:107361.
    PubMed         Abstract available

  46. BALASUBRAMANIAN N, Gaudencio G, Khan KM, Biggerstaff N, et al
    Adolescent social isolation facilitates tau spread in raphe nuclei, linking depression and hyperalgesia in Alzheimer's disease.
    Neurobiol Dis. 2026;224:107393.
    PubMed         Abstract available

  47. WU F, Fan J, Yang Z, Huang M, et al
    alpha1A-adrenergic receptor activation ameliorates fragmented spatial exploration by improving astrocyte-neuronal coupling in the medial entorhinal cortex of Alzheimer's disease mice.
    Neurobiol Dis. 2026 Apr 15:107398. doi: 10.1016/j.nbd.2026.107398.
    PubMed         Abstract available


    Neurology

  48. SEWELL KR, Solis-Urra P, Huang H, Karikari TK, et al
    Cognitive and Brain Reserve as Modifiers of Early Alzheimer Disease-Related Cognitive Vulnerability.
    Neurology. 2026;106:e214833.
    PubMed         Abstract available

  49. CARRIGAN M, Groot C
    Can a "Youthful" Brain Moderate Vulnerability to Alzheimer Disease?
    Neurology. 2026;106:e214927.
    PubMed        

  50. BENDER AC, Berezuk C, Pellerin KR, You JC, et al
    Association of Sleep Spindle Activity With Cognitive Decline in Early Clinical Stages of Alzheimer Disease.
    Neurology. 2026;106:e214839.
    PubMed        

  51. GROOT C, Calandri IL, Bader I, Bocancea DI, et al
    Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic.
    Neurology. 2026;106:e214810.
    PubMed         Abstract available


    Neuropsychology

  52. GRANDOIT E, Choi SE, Rabin LA, Jutten RJ, et al
    Repeated presentation of a word list in a consistent order increases differences in total words recalled between those with and without Alzheimer's disease.
    Neuropsychology. 2026 Apr 16. doi: 10.1037/neu0001090.
    PubMed         Abstract available


    PLoS One

  53. ASGHAR S, Khan MU, Jawaid T, Rehman R, et al
    Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer's Therapy.
    PLoS One. 2026;21:e0346177.
    PubMed         Abstract available


    Rev Neurol (Paris)

  54. PIN G, Horowitz T, Guedj E, Felician O, et al
    Isolated medial temporal lobe amnesia (MTLA): Predictor of cerebral amyloidosis or marker of phenotype-specific vulnerability?
    Rev Neurol (Paris). 2026;182:290-300.
    PubMed         Abstract available


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