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  Alzheimer's Disease

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26.10.2026

2 Acta Neuropathol
1 Alzheimer Dis Assoc Disord
6 Alzheimers Dement
1 Am J Alzheimers Dis Other Demen
1 Am J Geriatr Psychiatry
1 Ann Neurol
1 BMC Neurosci
1 BMJ
1 Brain Res
1 Dement Geriatr Cogn Disord
1 Drugs
1 Exp Gerontol
3 Exp Neurol
1 J Alzheimers Dis
2 J Am Geriatr Soc
4 J Neurol
1 JAMA
2 Nature
1 Neurobiol Aging
2 Neurology
1 Neuroscience
2 Proc Natl Acad Sci U S A


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Acta Neuropathol

  1. YUAN S, Essepian N, Roberts R, Sherman E, et al
    Correction: Tau oligomerization induces nuclear lamina invagination and chromatin remodeling in Alzheimer's disease.
    Acta Neuropathol. 2026;152:57.
    PubMed        

  2. LILLEY MT, Ren Y, Soni D, Sanborn EC, et al
    Tau A152T risk variant drives distinct cell type transcriptional signatures in AD and PSP.
    Acta Neuropathol. 2026;152:60.
    PubMed         Abstract available


    Alzheimer Dis Assoc Disord

  3. DA SILVA AMP, Santos DH
    Comment on "Alzheimer Disease Patients Who Survived COVID-19 Have Rapid Disease Progression and a Higher Risk of Death at 5-Year Follow-Up".
    Alzheimer Dis Assoc Disord. 2026 Oct 20. doi: 10.1097/WAD.0000000000000765.
    PubMed        


    Alzheimers Dement

  4. GONZALES MM, Ho NH, Wang DH, Rashid T, et al
    Integration of neuroimaging signatures of aging and Alzheimer's with fluid biomarkers.
    Alzheimers Dement. 2026;22:e71889.
    PubMed         Abstract available

  5. KAIKINI A, Shi A, Francis P, Swerdlow R, et al
    Why diabetes matters in dementia studies: Failure to account for diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71870.
    PubMed         Abstract available

  6. FUCHS DT, Vit JP, Rentsendorj A, Koronyo Y, et al
    H3K9me3 inhibition reverses Alzheimer's progression by restoring synaptic and immune proteostasis across the brain-retina axis.
    Alzheimers Dement. 2026;22:e71918.
    PubMed         Abstract available

  7. HUANG Y, Huang L, Cui L, Pan F, et al
    Direction-specific biomarker profiles and clinical significance of plasma p-tau217/amyloid PET discordance in cognitively normal adults.
    Alzheimers Dement. 2026;22:e71922.
    PubMed         Abstract available

  8. ZHU Y, Damera N, Singh RK, Bekena S, et al
    Biomarker profiles in late-life depression and Alzheimer's disease across and beyond the A/T/N framework: A scoping review.
    Alzheimers Dement. 2026;22:e71739.
    PubMed         Abstract available

  9. QUIRING M, Kapoor A, Alitin JPM, Lashin B, et al
    Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE varepsilon4 carriers.
    Alzheimers Dement. 2026;22:e71934.
    PubMed         Abstract available


    Am J Alzheimers Dis Other Demen

  10. ZHANG L, Zhang X, Zhang Q, Chang X, et al
    Associations of Serum Lipids With Clinical-Amyloid Groups, CSF Abeta42, and SHBG in ADNI-1.
    Am J Alzheimers Dis Other Demen. 2026;41:15333175261498635.
    PubMed         Abstract available


    Am J Geriatr Psychiatry

  11. RUSSELL JK, Newhouse PA, Rafii MS, Wilson JE, et al
    Neuropsychiatric Symptom Emergence in Down Syndrome-Associated Alzheimer's Disease is Associated With Tau but not Amyloid Accumulation.
    Am J Geriatr Psychiatry. 2026 Sep 25:S1064-7481(26)00536.
    PubMed         Abstract available


    Ann Neurol

  12. CHO G, Chen A, Choi E, Buxton OM, et al
    An Investigation of Sleep Macro- and Microarchitecture by APOE Genotype.
    Ann Neurol. 2026;100:1012-1022.
    PubMed         Abstract available


    BMC Neurosci

  13. DUAN K, Zhan F, Zhang Y, Wang X, et al
    Whole-transcriptome sequencing reveals Alzheimer's disease-associated ceRNA regulatory networks and downstream pathways.
    BMC Neurosci. 2026;27:47.
    PubMed         Abstract available


    BMJ

  14. IACOBUCCI G
    AD-Smart: Alzheimer's trial will test diabetes and ADHD drugs on patients.
    BMJ. 2026;395:e101219.
    PubMed        


    Brain Res

  15. LOU H, Huang C, Shen J, Wang D, et al
    Plasma p-tau181, Abeta1-42, and GFAP across Alzheimer's disease, mixed-type Alzheimer's disease, mild cognitive impairment, anxiety disorders, and depressive disorders.
    Brain Res. 2026 Oct 23:150606. doi: 10.1016/j.brainres.2026.150606.
    PubMed         Abstract available


    Dement Geriatr Cogn Disord

  16. HENDRICKS E, Pei Q, Li A, Guo Y, et al
    Alzheimer's Disease and Related Dementias is Associated with Worse Clinical and Patient-centered Outcomes in Patient Admitted for Heart Failure.
    Dement Geriatr Cogn Disord. 2026 Oct 21:1. doi: 10.1159.
    PubMed         Abstract available


    Drugs

  17. HEY JA, Abushakra S, Power A, Watson D, et al
    Correction: Plasma Biomarker Effects of Oral Valiltramiprosate/ALZ-801 in Early Alzheimer's Disease from Phase 3 and Phase 2 Trials: Analysis of Core Biomarkers and Correlations with Clinical and Neuroimaging Outcomes.
    Drugs. 2026 Oct 23. doi: 10.1007/s40265-026-02407.
    PubMed        


    Exp Gerontol

  18. CHEN X, Fu P, Kang C, Wu Y, et al
    The mechanism of cerebellar involvement in cognitive disorders and therapeutic prospects.
    Exp Gerontol. 2026;225:113324.
    PubMed         Abstract available


    Exp Neurol

  19. GREEN J, Liu Z, Timis S, Nelson C, et al
    Deletion of NLRP3 gene blocks traumatic brain injury induced abnormal immune response in mice with a genetic background for AD.
    Exp Neurol. 2027;407:116030.
    PubMed         Abstract available

  20. KAO S, Yousaf F, Ishaq S, Shah IA, et al
    Effectiveness of exercise training on hippocampal mitochondrial regulation in Alzheimer's disease: A mechanistic systematic review.
    Exp Neurol. 2026 Oct 20:116070. doi: 10.1016/j.expneurol.2026.116070.
    PubMed         Abstract available

  21. LIU Y, Li X, Wang M, Fan X, et al
    NEFL contributes to DJ-1-mediated neuroprotection and autophagic flux regulation in Alzheimer's disease-like injury.
    Exp Neurol. 2026 Oct 22:116092. doi: 10.1016/j.expneurol.2026.116092.
    PubMed         Abstract available


    J Alzheimers Dis

  22. DOESWIJK T, Axenhus M, Malik SC, Winblad B, et al
    Neuronal maturation is altered during pre-pathological stages in the App(NL-F) mouse model of Alzheimer's disease.
    J Alzheimers Dis. 2026 Oct 22:13872877261491991. doi: 10.1177/13872877261491991.
    PubMed         Abstract available


    J Am Geriatr Soc

  23. MALONE ML
    Editor's Note on Home-Based Medical Care in Traditional Medicare vs. Medicare Advantage Among Older Adults With Alzheimer's Disease and Related Dementias.
    J Am Geriatr Soc. 2026 Oct 18. doi: 10.1111/jgs.70785.
    PubMed        

  24. YANG M, Nothelle SK, Kinosian B, Abdelfattah L, et al
    Home-Based Medical Care in Traditional Medicare vs. Medicare Advantage Among Older Adults With Alzheimer's Disease and Related Dementias.
    J Am Geriatr Soc. 2026 Oct 18. doi: 10.1111/jgs.70781.
    PubMed         Abstract available


    J Neurol

  25. CHEN Y, Tong Z, Wang H, Xu X, et al
    Dynamic long-term modulation of cognition, brain structure and covariance networks in mild cognitive impairment due to AD by donepezil: A 36-month longitudinal study.
    J Neurol. 2026;273:677.
    PubMed         Abstract available

  26. WU Y, Zhu L, Chen J, Liu J, et al
    Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis.
    J Neurol. 2026;273:675.
    PubMed         Abstract available

  27. LIN YS, Tsai MJ, Lai CL, Ho HL, et al
    Clinical performance and decision thresholds of an automated plasma p-tau217 assay for amyloid pathology in a Taiwanese memory clinic.
    J Neurol. 2026;273:674.
    PubMed         Abstract available

  28. STAPF CD, Uzelac Z, Iterbeke L, Guthknecht A, et al
    Serum p-tau181 and p-tau217 levels in adolescents and adults with 5q spinal muscular atrophy.
    J Neurol. 2026;273:672.
    PubMed         Abstract available


    JAMA

  29. DEVI G
    Testing for Alzheimer Disease in Asymptomatic Adults.
    JAMA. 2026 Oct 19. doi: 10.1001/jama.2026.18839.
    PubMed        


    Nature

  30. BELK JA, Zhang Y, Reilly EE, Shi Q, et al
    Somatic mutations reveal the ontogeny of microglia in human ageing.
    Nature. 2026;658:963-971.
    PubMed         Abstract available

  31. LOVESTAM S, Shimozawa A, Tarutani A, Ohtani R, et al
    Prion-like transmission of human tau strains in the mouse brain.
    Nature. 2026;658:972-976.
    PubMed         Abstract available


    Neurobiol Aging

  32. MAGAKI S, Tung S, Sinclair DJ, Williams CK, et al
    Neuropathology of centenarians and supercentenarians: An autopsy study.
    Neurobiol Aging. 2027;169:110-124.
    PubMed         Abstract available


    Neurology

  33. CHEN Y, Chen A, Power MC, Grodstein F, et al
    Associations of Alzheimer Disease and Related Dementia Neuropathologies With Timely Diagnosis of Dementia in Health Care Settings.
    Neurology. 2026;107:e218725.
    PubMed        

  34. RAO Y, Liu L, Ostaszewski BL, Anderson AK, et al
    Association Between Plasma N-Terminal Tau, Cognitive Decline, and Neurodegeneration in the ADNI Cohort.
    Neurology. 2026;107:e218564.
    PubMed         Abstract available


    Neuroscience

  35. KANG J, Li Y, Yan W
    Zona incerta circuits in cognition and the regulation of sleep and wakefulness: potential relevance to Alzheimer's disease.
    Neuroscience. 2026 Oct 18:S0306-4522(26)00700.
    PubMed         Abstract available


    Proc Natl Acad Sci U S A

  36. BARCELLOS SH, Carvalho LS, Langa KM, Nimmagadda S, et al
    Education reduces dementia incidence and mitigates genetic risk.
    Proc Natl Acad Sci U S A. 2026;123:e2529506123.
    PubMed         Abstract available

  37. BERMUDEZ S, Choi JH, Mahmood N, Vogel JW, et al
    Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins.
    Proc Natl Acad Sci U S A. 2026;123:e2610766123.
    PubMed         Abstract available


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