Advancement in the Development of Therapeutics Against Zika Virus Infection

Front Cell Infect Microbiol. 2022 Jul 8:12:946957. doi: 10.3389/fcimb.2022.946957. eCollection 2022.

Abstract

Zika virus (ZIKV), a re-emerging arbovirus, causes teratogenic effects on the fetus and normal nerve functions, resulting in harmful autoimmune responses, which call for the development of therapeutics against ZIKV infection. In this review, we introduce the pathogenesis of ZIKV infection and summarize the advancement in the development of therapeutics against ZIKV infection. It provides guidance for the development of effective therapeutics against ZIKV infection.

Keywords: E protein inhibitors; NS2B–NS3 protease inhibitors; NS3 protease inhibitors; NS5 protease inhibitors; Zika virus; host protein inhibitors; pathogenesis; therapeutics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Viral Nonstructural Proteins
  • Zika Virus Infection* / therapy
  • Zika Virus*

Substances

  • Viral Nonstructural Proteins