A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern

Panjing Lv; Bing Hu; Rong Hua; Jun Zhang; Haoran Zhang; Zhang Liu; Liqiong Xu; Zhen He; Xiang Li; Ming Guo; Kai Pan; Zhen Zhang; Qili Zeng; Zhi Wu; Li Sun; Meng Guo; Li Zhou; Xiuzhen Xu; Bo Yu; Junqiang Xu; Shuai Yuan; Min Guo; Kun Cai; Yuchen Xia; Yan Li

doi:10.1016/j.jinf.2022.06.001

A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern

J Infect. 2022 Sep;85(3):e72-e76. doi: 10.1016/j.jinf.2022.06.001. Epub 2022 Jun 3.

Authors

Panjing Lv¹, Bing Hu², Rong Hua³, Jun Zhang⁴, Haoran Zhang¹, Zhang Liu⁴, Liqiong Xu⁴, Zhen He¹, Xiang Li², Ming Guo⁵, Kai Pan², Zhen Zhang⁵, Qili Zeng², Zhi Wu⁴, Li Sun¹, Meng Guo², Li Zhou⁵, Xiuzhen Xu⁴, Bo Yu², Junqiang Xu², Shuai Yuan⁶, Min Guo⁷, Kun Cai⁸, Yuchen Xia⁹, Yan Li¹⁰

Affiliations

¹ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China.
² Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention (Hubei CDC), Wuhan, Hubei, 430079, China.
³ State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430071, China.
⁴ Kangma Healthcode (Shanghai) Biotech, Co., Ltd., 118 Furonghua Road, Building No.15, Shanghai, 201203, China.
⁵ State Key Laboratory of Virology, Modern Virology Research Center, RNA Institute, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Institute for Vaccine Research, Animal Bio-Safety Level III Laboratory at Center for Animal Experiments, Wuhan University School of Medicine, Wuhan, 430071, China.
⁶ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
⁷ Kangma Healthcode (Shanghai) Biotech, Co., Ltd., 118 Furonghua Road, Building No.15, Shanghai, 201203, China. Electronic address: guomin@healthcodon.com.
⁸ Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention (Hubei CDC), Wuhan, Hubei, 430079, China. Electronic address: ckreal@163.com.
⁹ State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430071, China. Electronic address: yuchenxia@whu.edu.cn.
¹⁰ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address: yanli@hust.edu.cn.

No abstract available

Keywords: ACE2; Broad-spectrum neutralization; De novo design; Omicron; Protein antagonist; SARS-CoV-2.

Publication types

Letter

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
COVID-19*
Humans
Neutralization Tests
SARS-CoV-2*
Spike Glycoprotein, Coronavirus / genetics

Substances

Antibodies, Neutralizing
Antibodies, Viral
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2

Supplementary concepts

SARS-CoV-2 variants