S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021

Kevin A Brown; Jonathan Gubbay; Jessica Hopkins; Samir Patel; Sarah A Buchan; Nick Daneman; Lee William Goneau

doi:10.1001/jama.2021.5607

S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021

JAMA. 2021 May 25;325(20):2115-2116. doi: 10.1001/jama.2021.5607.

Authors

Kevin A Brown¹, Jonathan Gubbay¹, Jessica Hopkins¹, Samir Patel¹, Sarah A Buchan¹, Nick Daneman², Lee William Goneau³

Affiliations

¹ Public Health Ontario, Toronto, Canada.
² Sunnybrook Hospital, Toronto, Ontario, Canada.
³ Dynacare Laboratories, Brampton, Ontario, Canada.

Abstract

This study determined the spread of the B.1.1.7 SARs-CoV-2 variant in the Greater Toronto Area over 4 months by tracking S-gene target failure as marker.

MeSH terms

COVID-19 / transmission
COVID-19 / virology*
COVID-19 Nucleic Acid Testing
Genes, Viral*
Genetic Markers
Humans
Ontario
SARS-CoV-2 / genetics*
Spike Glycoprotein, Coronavirus / genetics*

Substances

Genetic Markers
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2