Dynamic behavior of Dengue and Zika viruses NS1 protein reveals monomer-monomer interaction mechanisms and insights to rational drug design

J Biomol Struct Dyn. 2020 Sep;38(14):4353-4363. doi: 10.1080/07391102.2019.1677504. Epub 2019 Oct 18.

Authors

Ricardo Lemes Gonçalves¹, Gabriela de Lima Menezes¹, Luciane Sussuchi¹, Marcos Lázaro Moreli¹, Melina Mottin², Carolina Horta Andrade², Maristela Pereira³, Roosevelt Alves da Silva¹

Affiliations

¹ Núcleo Colaborativo de BioSistemas, Universidade Federal de Goiás, Jataí, GO, Brazil.
² LabMol - Laboratory for Molecular Modeling and Drug Design, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil.
³ Laboratório de Biologia Molecular, Universidade Federal de Goiás, Goiânia, GO, Brazil.

PMID: 31594455
DOI: 10.1080/07391102.2019.1677504

Abstract

Communicated by Ramaswamy H. Sarma.

Publication types

Letter

MeSH terms

Dengue Virus*
Dengue* / drug therapy
Drug Design
Humans
Viral Nonstructural Proteins / genetics
Zika Virus Infection*
Zika Virus*

Substances

Viral Nonstructural Proteins