An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels

J Gen Virol. 2018 Jul;99(7):913-916. doi: 10.1099/jgv.0.001080.

Abstract

Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).

Keywords: Brazil; Rio de Janeiro; Zika virus; neurological disease; neurotropism; zika.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / cerebrospinal fluid*
  • Female
  • Genome, Viral
  • Humans
  • Immunoglobulin G / cerebrospinal fluid*
  • Neurogenic Inflammation / complications
  • Neurogenic Inflammation / diagnosis*
  • Neurogenic Inflammation / physiopathology
  • Neurogenic Inflammation / virology
  • Phylogeny
  • Tumor Necrosis Factor-alpha / cerebrospinal fluid*
  • Whole Genome Sequencing
  • Young Adult
  • Zika Virus / classification
  • Zika Virus / genetics*
  • Zika Virus / isolation & purification
  • Zika Virus / pathogenicity
  • Zika Virus Infection / complications
  • Zika Virus Infection / diagnosis*
  • Zika Virus Infection / physiopathology
  • Zika Virus Infection / virology

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Tumor Necrosis Factor-alpha