In utero negativization of Zika virus in a foetus with serious central nervous system abnormalities

Clin Microbiol Infect. 2018 May;24(5):549.e1-549.e3. doi: 10.1016/j.cmi.2017.09.022. Epub 2017 Oct 10.

Abstract

We describe a case of a pregnant woman with Zika virus (ZIKV) infection and a foetus with severe brain malformations. ZIKV tested positive in amniotic fluid at 19 weeks but was negative at delivery. The newborn did not meet the case definition of congenital ZIKV syndrome because neither ZIKV RNA nor IgM antibodies were detected; however, prenatal brain lesions were confirmed after birth (Graphical Abstract).

Keywords: Amniotic fluid; Brain diseases; Congenital; Foetus; Prenatal diagnosis; Zika virus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers
  • Brain / abnormalities
  • Central Nervous System Diseases / diagnosis*
  • Central Nervous System Diseases / etiology*
  • Female
  • Genes, Viral
  • Humans
  • Infant, Newborn
  • Nervous System Malformations / diagnosis*
  • Nervous System Malformations / etiology*
  • Phenotype
  • Phylogeny
  • Polymerase Chain Reaction
  • Pregnancy
  • Pregnancy Complications, Infectious / virology*
  • Prenatal Diagnosis
  • Zika Virus Infection / complications*
  • Zika Virus Infection / virology*
  • Zika Virus* / classification
  • Zika Virus* / genetics

Substances

  • Biomarkers