Abstract
Infection with Zika virus (ZIKV) during pregnancy may cause severe developmental defects in the human brain via unknown mechanisms. In a recent issue of Science, Chavali et al. (2017) identified a neural progenitor cell (NPC)-specific RNA binding protein that may underlie the high levels of ZIKV replication and apoptosis observed in these cells during congenital infections.
Copyright © 2017 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Apoptosis
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Brain / embryology
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Brain / virology
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Cell Line
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Cell Movement / physiology
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Female
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Gene Expression Regulation
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Humans
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Infant, Newborn
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Microcephaly / etiology*
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Microcephaly / genetics
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Microcephaly / metabolism
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Microcephaly / virology
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology*
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Neural Stem Cells / virology
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Pregnancy
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Pregnancy Complications, Infectious / virology
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RNA, Viral
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / physiology*
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Virus Replication / physiology*
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Zika Virus / genetics
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Zika Virus / pathogenicity
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Zika Virus / physiology*
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Zika Virus Infection / complications
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Zika Virus Infection / congenital*
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Zika Virus Infection / transmission
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Zika Virus Infection / virology
Substances
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MSI1 protein, human
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Nerve Tissue Proteins
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RNA, Viral
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RNA-Binding Proteins