Dengue Antibodies, then Zika: A Fatal Sequence in Mice

Jonathan J Miner; Michael S Diamond

doi:10.1016/j.immuni.2017.04.023

Dengue Antibodies, then Zika: A Fatal Sequence in Mice

Immunity. 2017 May 16;46(5):771-773. doi: 10.1016/j.immuni.2017.04.023.

Authors

Jonathan J Miner¹, Michael S Diamond²

Affiliations

¹ Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: miner@wustl.edu.
² Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.

PMID: 28514683
DOI: 10.1016/j.immuni.2017.04.023

Abstract

Anti-Dengue virus (DENV) antibodies can be either protective or pathogenic in humans with prior DENV infection. In a recent issue of Science, Bardina et al. (2017) demonstrated that passive transfer of immune plasma against DENV and West Nile virus (WNV) can enhance Zika virus (ZIKV) infection and pathogenesis in mice.

Publication types

Comment

MeSH terms

Animals
Antibodies, Viral / immunology
Dengue / virology*
Dengue Virus / immunology*
Humans
Mice
West Nile virus / immunology
Zika Virus Infection

Substances

Antibodies, Viral