Vaccination strategies against Zika virus

Curr Opin Virol. 2017 Apr:23:59-67. doi: 10.1016/j.coviro.2017.03.006. Epub 2017 Apr 19.

Abstract

The epidemic emergence of Zika virus (ZIKV) in 2015-2016 has been associated with congenital malformations and neurological sequela. Current efforts to develop a ZIKV vaccine build on technologies that successfully reduced infection or disease burden against closely related flaviviruses or other RNA viruses. Subunit-based (DNA plasmid and modified mRNA), viral vectored (adeno- and measles viruses) and inactivated viral vaccines are already advancing to clinical trials in humans after successful mouse and non-human primate studies. Among the greatest challenges for the rapid implementation of immunogenic and protective ZIKV vaccines will be addressing the potential for exacerbating Dengue virus infection or causing Guillain-Barré syndrome through production of cross-reactive immunity targeting related viral or host proteins. Here, we review vaccine strategies under development for ZIKV and the issues surrounding their usage.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Dengue / epidemiology
  • Drug Evaluation, Preclinical
  • Drug-Related Side Effects and Adverse Reactions / epidemiology
  • Guillain-Barre Syndrome / epidemiology
  • Humans
  • Mice
  • Vaccines, DNA / adverse effects
  • Vaccines, DNA / immunology*
  • Vaccines, DNA / isolation & purification*
  • Vaccines, Inactivated / adverse effects
  • Vaccines, Inactivated / immunology
  • Vaccines, Inactivated / isolation & purification
  • Vaccines, Subunit / adverse effects
  • Vaccines, Subunit / immunology
  • Vaccines, Subunit / isolation & purification
  • Vaccines, Synthetic / adverse effects
  • Vaccines, Synthetic / immunology
  • Vaccines, Synthetic / isolation & purification
  • Viral Vaccines / adverse effects
  • Viral Vaccines / immunology*
  • Viral Vaccines / isolation & purification*
  • Zika Virus / immunology*
  • Zika Virus Infection / prevention & control*

Substances

  • Vaccines, DNA
  • Vaccines, Inactivated
  • Vaccines, Subunit
  • Vaccines, Synthetic
  • Viral Vaccines