An mRNA-based vaccine strategy against Zika

Cell Res. 2017 Sep;27(9):1077-1078. doi: 10.1038/cr.2017.53. Epub 2017 Apr 11.

Abstract

Infections with Zika virus are strongly associated with complications such as congenital microcephaly and can trigger Guillain-Barré syndrome in humans, highlighting the urgent need for a safe, efficacious vaccine as a preventative countermeasure. In a recent paper published in Cell, Richner et al. generated a lipid nanoparticle encapsulated modified mRNA vaccine encoding the prM and E genes from Zika virus, which showed protection and sterilizing immunity in immunocompetent mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Mice
  • Microcephaly*
  • RNA, Messenger
  • Viral Vaccines*
  • Zika Virus / genetics*
  • Zika Virus Infection*

Substances

  • RNA, Messenger
  • Viral Vaccines