Prospects for a Zika Virus Vaccine

Dan H Barouch; Stephen J Thomas; Nelson L Michael

doi:10.1016/j.immuni.2017.02.005

Prospects for a Zika Virus Vaccine

Immunity. 2017 Feb 21;46(2):176-182. doi: 10.1016/j.immuni.2017.02.005.

Authors

Dan H Barouch¹, Stephen J Thomas², Nelson L Michael³

Affiliations

¹ Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: dbarouch@bidmc.harvard.edu.
² Upstate Medical University, State University of New York, Syracuse, NY 13210, USA.
³ Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Abstract

A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Humans
Viral Vaccines*
Zika Virus Infection / prevention & control*
Zika Virus*

Substances

Viral Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding