Infectious Zika virus in vaginal secretions from an HIV-infected woman, France, August 2016

Euro Surveill. 2017 Jan 19;22(3):30444. doi: 10.2807/1560-7917.ES.2017.22.3.30444.

Abstract

A woman with controlled HIV infection developed in late August 2016 a pruritic rash with fever and conjunctival hyperaemia after a trip to the French Caribbean islands. On day 3 after symptom onset, Zika virus RNA was detected in plasma, urine and vaginal samples with respective viral loads of 3.8, 6.1 and 5.3 log copies/mL. Notably, we demonstrated the presence of infectious Zika virus particles in the vaginal samples by isolation in cell culture.

Keywords: Zika virus; imported viral disease; sexually transmitted infections; vector-borne infections.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active
  • Body Fluids / virology*
  • Female
  • Fever / virology*
  • France
  • Guadeloupe
  • HIV Infections / drug therapy
  • Humans
  • Martinique
  • Myalgia / etiology
  • RNA, Viral / blood
  • RNA, Viral / urine
  • Travel
  • Vagina / virology*
  • Zika Virus / genetics
  • Zika Virus / isolation & purification*
  • Zika Virus Infection / diagnosis*
  • Zika Virus Infection / virology

Substances

  • RNA, Viral