Abstract
Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain-Barré syndrome (GBS) in the adult. In this review, we focus on the underlying cellular and molecular mechanisms by which vertically transmitted microorganisms reach the fetus and trigger neuropathies.
Keywords:
Guillain–Barré syndrome; Microcephaly; Neurodevelopment; Zika virus.
Publication types
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Review
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Research Support, Non-U.S. Gov't
MeSH terms
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Aedes / virology*
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Animals
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Disease Models, Animal
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Female
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Fetus
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Guillain-Barre Syndrome / genetics
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Guillain-Barre Syndrome / pathology
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Guillain-Barre Syndrome / virology*
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Host-Pathogen Interactions / genetics
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Humans
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Infectious Disease Transmission, Vertical
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Insect Vectors / virology*
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Mice
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Microcephaly / genetics
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Microcephaly / pathology
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Microcephaly / virology*
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Pregnancy
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Pregnancy Complications, Infectious / genetics
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Pregnancy Complications, Infectious / pathology
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Pregnancy Complications, Infectious / virology*
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Zika Virus / genetics
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Zika Virus / growth & development
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Zika Virus / pathogenicity*
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Zika Virus Infection / genetics
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Zika Virus Infection / pathology
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Zika Virus Infection / transmission
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Zika Virus Infection / virology*