We evaluated performance of 5 case definitions for Zika virus disease surveillance in a human cohort during an outbreak in Singapore, August 26-September 5, 2016. Because laboratory tests are largely inaccessible, use of case definitions that include rash as a required clinical feature are useful in identifying this disease.
Keywords: Centers for Disease Control and Prevention; European Centre for Disease Control and Prevention; Pan American Health Organization; Singapore; Singapore Ministry of Health; World Health Organization; Zika virus; Zika virus disease; case definitions; performance; positive likelihood ratio; rash; sensitivity; specificity; surveillance; viruses.