Zika Virus Infection and Guillain-Barré Syndrome in Three Patients from Suriname

Front Neurol. 2016 Dec 22:7:233. doi: 10.3389/fneur.2016.00233. eCollection 2016.

Abstract

We present three patients from Suriname who were diagnosed with Guillain-Barré syndrome (GBS) during the Zika virus (ZIKV) outbreak in this country. One patient had a positive ZIKV urine real-time RT-PCR (qRT-PCR) result. The other two patients had a negative ZIKV urine qRT-PCR but a positive virus neutralization test and presence of IgG antibodies against ZIKV in the serum. Considering the evidence of a past ZIKV infection and absence of evidence for recent infections with the most common preceding infections of GBS, it is very likely that these GBS cases were triggered by ZIKV.

Keywords: Flavivirus infections; Guillain–Barré syndrome; Zika virus; acute flaccid paralysis; emerging infectious disease.

Publication types

  • Case Reports