Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

Emerg Infect Dis. 2016 Nov;22(11):1953-1956. doi: 10.3201/eid2211.160956.

Abstract

We report the early growth and neurologic findings of 48 infants in Brazil diagnosed with probable congenital Zika virus syndrome and followed to age 1-8 months. Most of these infants had microcephaly (86.7%) and craniofacial disproportion (95.8%). The clinical pattern included poor head growth with increasingly negative z-scores, pyramidal/extrapyramidal symptoms, and epilepsy.

Keywords: Zika virus infection; birthweight; congenital abnormalities; epilepsy; growth; infants; microcephaly; neurologic; outcomes; viruses.

MeSH terms

  • Birth Weight
  • Body Weights and Measures
  • Brazil / epidemiology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Nervous System Malformations / diagnosis
  • Nervous System Malformations / epidemiology*
  • Nervous System Malformations / etiology*
  • Patient Outcome Assessment
  • Phenotype
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Zika Virus Infection / complications*
  • Zika Virus Infection / virology
  • Zika Virus*