Stem Cell Hydrogel, Jump-Starting Zika Drug Discovery, and Engineering RNA Recognition

Cell Chem Biol. 2016 Aug 18;23(8):885-6. doi: 10.1016/j.chembiol.2016.08.005.

Abstract

Every month the editors of Cell Chemical Biology bring you highlights of the most recent chemical biology literature that impressed them with creativity and potential for follow up work. Our August 2016 selection includes a description of hydrogels with self-tunable stiffness that are used to profile lipid metabolites during stems cell differentiation, a look at whether we can find a drug repurposing solution to Zika virus infection, and an engineered RNA recognition motif (RRM).

MeSH terms

  • Drug Discovery*
  • Drug Repositioning
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism*
  • RNA / genetics
  • RNA / metabolism*
  • RNA Recognition Motif / genetics
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Stem Cells / metabolism*
  • Zika Virus / drug effects*
  • Zika Virus Infection / drug therapy
  • Zika Virus Infection / virology

Substances

  • RNA-Binding Proteins
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • RNA