Zika virus update II: Recent development of animal models-Proofs of association with human pathogenesis

Suzane Ramos da Silva; Shou-Jiang Gao

doi:10.1002/jmv.24582

Zika virus update II: Recent development of animal models-Proofs of association with human pathogenesis

J Med Virol. 2016 Oct;88(10):1657-8. doi: 10.1002/jmv.24582. Epub 2016 May 30.

Authors

Suzane Ramos da Silva¹, Shou-Jiang Gao¹

Affiliation

¹ Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California.

Abstract

Three recent studies in pregnant mice and one ongoing study in rhesus macaques evaluating the effect of ZIKV infection have provided important information about maternal-fetus transmission and ZIKV-related pathogenesis, confirming a causal role of ZIKV in neurological problems observed in humans. Here, we present an update of these works published in the past few weeks. J. Med. Virol. 88:1657-1658, 2016. © 2016 Wiley Periodicals, Inc.

Keywords: Zika virus; animal model; pathology.

MeSH terms

Animals
Disease Models, Animal*
Female
Humans
Infectious Disease Transmission, Vertical*
Macaca mulatta
Mice
Pregnancy
Pregnancy Complications, Infectious / virology*
Zika Virus / pathogenicity*
Zika Virus Infection / complications
Zika Virus Infection / transmission*
Zika Virus Infection / virology*

Grants and funding

R01 CA096512/CA/NCI NIH HHS/United States