Abstract
The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that influenza virus replication in mouse bone marrow-derived DCs is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein, at least, being produced. Electron microscopy reveals that virus assembly, rather than release of virus from the cell surface, is defective.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Dendritic Cells / virology*
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Dogs
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Hemagglutinin Glycoproteins, Influenza Virus / genetics
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Hemagglutinin Glycoproteins, Influenza Virus / metabolism
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Humans
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Influenza A virus / genetics
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Influenza A virus / physiology*
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Influenza, Human / immunology
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Influenza, Human / virology*
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Mice
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Mice, Inbred C57BL
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Virus Release
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Virus Replication*
Substances
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Hemagglutinin Glycoproteins, Influenza Virus